Stepwise development of thymic microenvironments in vivo is regulated by thymocyte subsets

Wnt signaling: a common theme in animal development

1997 • 2,579 citations

Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens*

1979 • 1,989 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors.

1979 • 1,301 citations

Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors.

1989 • 778 citations

Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae

2001 • 590 citations

Cellular Interactions in Thymocyte Development

1996 • 503 citations

Dependence of Thymus Development on Derivatives of the Neural Crest

1984 • 463 citations

The thymic microenvironment

1993 • 459 citations

Two Genetically Separable Steps in the Differentiation of Thymic Epithelium

1996 • 447 citations

The role of Hoxa-3 in mouse thymus and thyroid development

1995 • 421 citations

T Cell Selection in the Thymus

1988 • 405 citations

MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus

1993 • 359 citations

Identification and initial characterization of a rat monoclonal antibody reactive with the murine interleukin 2 receptor-ligand complex.

1983 • 348 citations

Thymic nurse cells. Lymphoepithelial cell complexes in murine thymuses: morphological and serological characterization

1980 • 343 citations

Morphogenetic interactions in the development of the mouse thymus gland

1960 • 336 citations

Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes

1995 • 295 citations

Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment

1998 • 292 citations

Crosstalk in the mouse thymus

1994 • 275 citations

A monoclonal antibody that recognizes B cells and B cell precursors in mice.

1981 • 260 citations

Early αβ T cell development in the thymus of normal and genetically altered mice

1997 • 249 citations

T-Cell Differentiation is Influenced by Thymic Microenvironments

1991 • 239 citations

A differential-avidity model for T-cell selection

1994 • 239 citations

A block in both early T lymphocyte and natural killer cell development in transgenic mice with high-copy numbers of the human CD3E gene.

1994 • 233 citations

Pax1 is expressed during development of the thymus epithelium and is required for normal T-cell maturation

1996 • 228 citations

Monoclonal antibodies to stromal cell types of the mouse thymus

1984 • 228 citations

The nu gene acts cell-autonomously and is required for differentiation of thymic epithelial progenitors.

1996 • 225 citations

Severe colitis in mice with aberrant thymic selection

1995 • 186 citations

T-cell selection

1998 • 168 citations

Thymic microenvironments, 3-D versus 2-D?

1999 • 139 citations

In Thymic Selection, Peptide Diversity Gives and Takes Away

1997 • 136 citations

Understanding the mechanism of the age-change of thymic function to promote T cell differentiation

1994 • 119 citations

Stromal cell types in the developing thymus of the normal and nude mouse embryo

1985 • 108 citations

Thymic cortical epithelium is sufficient for the development of mature T cells in relB-deficient mice.

1997 • 83 citations

L3T4 antigen expression by hemopoietic precursor cells.

1989 • 75 citations

Genetic characterization of a polymorphic murine cell-surface glycoprotein

1982 • 75 citations

Cell surface topography of thymic microenvironments.

1988 • 69 citations

Thymic nurse cells are sites of thymocyte apoptosis.

1994 • 66 citations

Differential Effects of Peptide Diversity and Stromal Cell Type in Positive and Negative Selection in the Thymus

1998 • 64 citations

Using thymus anatomy to dissect T cell repertoire selection

1999 • 62 citations

Early events in T lymphocyte genesis in the fetal thymus

1984 • 53 citations

Thymic stromal cell specialization and the T-cell receptor repertoire

1997 • 51 citations

The Murine Thymic Microenvironment: Changes with Age

1996 • 51 citations

Over-expression of CD3ε transgenes blocks T lymphocyte development

1995 • 51 citations

A Common Stem Cell for Murine Cortical and Medullary Thymic Epithelial Cells?

1994 • 49 citations

Phenotype of stromal cell‐associated thymocytes in situ is compatible with selection of the T cell repertoire at an “immature” stage of thymic T cell differentiation

1987 • 48 citations

Transcription factors that control development of the thymic microenvironment

1995 • 30 citations

A Mouse Carrying Genetic Defect in the Choice Between T and B Lymphocytes

1998 • 30 citations

Thymic Medulla Epithelial Cells Acquire Specific Markers by Post-Mitotic Maturation

1996 • 26 citations

Positive Selection by Thymic Nurse Cells Requires IL-1β and Is Associated with an Increased Bcl-2 Expression

1996 • 22 citations

Thymic nurse cells: Their functional ultrastructure

1997 • 21 citations

Inductive Role of Fibroblastic Cell Lines in Development of the Mouse Thymus Anlage in Organ Culture

1998 • 17 citations

Thymic nurse cell clone supports the differentiation of CD4−8− thymocytes into CD4+8+ thymocytes in vitro

1993 • 10 citations

Developmental changes predispose the fetal thymus to positive selection of CD4+CD8- T cells.

1995 • 9 citations