The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation

Manipulating the mouse embryo: A laboratory manual

1986 • 4,548 citations

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

1993 • 2,146 citations

The Atlas of Mouse Development

1992 • 1,782 citations

The atlas of mouse development

1993 • 1,427 citations

Pax-6, a murine paired box gene, is expressed in the developing CNS

1991 • 1,226 citations

The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary.

1996 • 1,208 citations

The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo

1995 • 1,175 citations

An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination

1998 • 1,048 citations

HNF-3β is essential for node and notochord formation in mouse development

1994 • 985 citations

A Requirement for Flk1 in Primitive and Definitive Hematopoiesis and Vasculogenesis

1997 • 938 citations

Requirement for Wnt3 in vertebrate axis formation

1999 • 882 citations

The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain

1991 • 882 citations

FGF and Shh Signals Control Dopaminergic and Serotonergic Cell Fate in the Anterior Neural Plate

1998 • 868 citations

Clonal analysis of epiblast fate during germ layer formation in the mouse embryo

1991 • 865 citations

Disruption of overlapping transcripts in the ROSA βgeo 26 gene trap strain leads to widespread expression of β-galactosidase in mouse embryos and hematopoietic cells

1997 • 851 citations

über Induktion von Embryonalanlagen durch Implantation artfremder Organisatoren

1924 • 817 citations

Requirement for LIml in head-organizer function

1995 • 801 citations

Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse

1998 • 769 citations

Axis Development and Early Asymmetry in Mammals

1999 • 740 citations

Midbrain development induced by FGF8 in the chick embryo

1996 • 734 citations

flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors

1993 • 707 citations

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

1997 • 705 citations

Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo

1993 • 680 citations

Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development

1995 • 662 citations

Inductive interactions direct early regionalization of the mouse forebrain

1997 • 651 citations

Longitudinal organization of the anterior neural plate and neural tube

1995 • 647 citations

The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins

1993 • 619 citations

An assessment of the developmental potential of embryonic stem cells in the midgestation mouse embryo

1989 • 596 citations

Mouse gastrulation: the formation of a mammalian body plan

1997 • 595 citations

Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres

1995 • 569 citations

Anterior primitive endoderm may be responsible for patterning the anterior neural plate in the mouse embryo

1996 • 548 citations

REGIONALIZATION OF THE PROSENCEPHALIC NEURAL PLATE

1998 • 544 citations

Hex: a homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors

1998 • 520 citations

Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 α, β and γ genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm

1993 • 505 citations

Cerberus-like is a secreted factor with neuralizing activity expressed in the anterior primitive endoderm of the mouse gastrula

1997 • 452 citations

Induction of a second neural axis by the mouse node

1994 • 420 citations

Production of homozygous mutant ES cells with a single targeting construct.

1992 • 418 citations

Telencephalon-restricted expression of BF-1, a new member of the HNF-3/ fork head gene family, in the developing rat brain

1992 • 417 citations

FGF8 induces formation of an ectopic isthmic organizer and isthmocerebellar development via a repressive effect on Otx2 expression

1999 • 407 citations

nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation

1997 • 384 citations

The transcription factor HNF3β is required in visceral endoderm for normal primitive streak morphogenesis

1998 • 335 citations

Positive and negative signals from mesoderm regulate the expression of mouse Otx2 in ectoderm explants

1994 • 333 citations

A mouse model for hereditary thyroid dysgenesis and cleft palate

1998 • 326 citations

Rpx: a novel anterior-restricted homeobox gene progressively activated in the prechordal plate, anterior neural plate and Rathke’s pouch of the mouse embryo

1996 • 286 citations

Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification

1998 • 284 citations

TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation

1997 • 268 citations

FGF8 can activate Gbx2 and transform regions of the rostral mouse brain into a hindbrain fate

1999 • 212 citations

Hepatocyte differentiation initiates during endodermal-mesenchymal interactions prior to liver formation

1991 • 212 citations

Sequential expression of HNF-3β and HNF-3α by embryonic organizing centers: the dorsal lip/node, notochord and floor plate

1993 • 189 citations

Murine Cerberus Homologue mCer-1: A Candidate Anterior Patterning Molecule

1998 • 185 citations

Msg1 and Mrg1, founding members of a gene family, show distinct patterns of gene expression during mouse embryogenesis

1998 • 172 citations

Identification of a novel vertebrate homeobox gene expressed in haematopoietic cells

1992 • 166 citations

Lim1 is required in both primitive streak-derived tissues and visceral endoderm for head formation in the mouse

1999 • 163 citations

Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation

1998 • 158 citations

Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4

1999 • 153 citations

HEX: a novel homeobox gene expressed during haematopoiesis and conserved between mouse and human

1993 • 145 citations

The XHex homeobox gene is expressed during development of the vascular endothelium: overexpression leads to an increase in vascular endothelial cell number

1997 • 143 citations

A role for the extraembryonic yolk syncytial layer in patterning the zebrafish embryo suggested by properties of the hex gene

1999 • 139 citations

Anterior patterning by synergistic activity of the early gastrula organizer and the anterior germ layer tissues of the mouse embryo

1999 • 138 citations

Expression of the mousecerberus-related gene,Cerr1, suggests a role in anterior neural induction and somitogenesis

1998 • 132 citations

Thyroid-specific enhancer-binding protein/thyroid transcription factor 1 is not required for the initial specification of the thyroid and lung primordia

1999 • 102 citations

An anterior signalling centre in Xenopus revealed by the homeobox gene XHex

1999 • 91 citations

cDNA cloning and expression of rat homeobox gene, Hex, and functional characterization of the protein

1999 • 77 citations

Early liver differentiation: genetic potentiation and multilevel growth control

1998 • 72 citations

Expression of the homeobox gene Hex during early stages of chick embryo development

1999 • 68 citations

Expression of Hex mRNA in early murine postimplantation embryo development

1998 • 52 citations

Molecular genetics of congenital hypothyroidism

1999 • 45 citations

Axis duplication and anterior identity in the mouse embryo.

1997 • 36 citations

oto is a homeotic locus with a role in anteroposterior development that is partially redundant with Lim1

1999 • 23 citations