Wnt genes

Mutations affecting segment number and polarity in Drosophila

1980 • 4,280 citations

Oncogenes and signal transduction

1991 • 2,816 citations

Growth Factors and Cancer

1991 • 2,044 citations

Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome

1982 • 1,790 citations

Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis

1981 • 1,611 citations

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

1990 • 1,531 citations

The molecular genetics of embryonic pattern formation in Drosophila

1988 • 1,048 citations

Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes

1984 • 906 citations

The Drosophila homology of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless

1987 • 906 citations

Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development

1990 • 896 citations

Synergistic induction of mesoderm by FGF and TGF-β and the identification of an mRNA coding for FGF in the early xenopus embryo

1987 • 883 citations

Peptide growth factors are multifunctional

1988 • 835 citations

Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice

1988 • 745 citations

Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A

1990 • 660 citations

Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center

1991 • 651 citations

A Homolog of the armadillo Protein in Drosophila (Plakoglobin) Associated with E-Cadherin

1991 • 632 citations

Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation

1989 • 612 citations

Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15

1984 • 609 citations

Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures

1990 • 600 citations

SOME POSSIBLE EFFECTS OF NURSING ON THE MAMMARY GLAND TUMOR INCIDENCE IN MICE

1936 • 596 citations

A dual receptor system is required for basic fibroblast growth factor activity

1991 • 589 citations

The midbrain-hindbrain phenotype of Wnt-1−Wnt-1− mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum

1992 • 579 citations

Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo

1987 • 578 citations

Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis

1989 • 518 citations

Injected Wnt RNA induces a complete body axis in Xenopus embryos

1991 • 501 citations

The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin

1990 • 474 citations

Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development.

1990 • 458 citations

Distribution of the wingless gene product in drosophila embryos: A protein involved in cell-cell communication

1989 • 452 citations

Molecular cloning of sequences from wingless , a segment polarity gene in Drosophila : the spatial distribution of a transcript in embryos

1987 • 437 citations

Role of the Drosophila patched gene in positional signalling

1991 • 414 citations

Expression patterns of the homeo box-containing genes En-1 and En-2 and the proto-oncogene int-1 diverge during mouse development.

1988 • 393 citations

Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis

1988 • 383 citations

Role of segment polarity genes in the definition and maintenance of cell states in the Drosophila embryo

1988 • 381 citations

D11S287, a putative oncogene on chromosome 11q13, is amplified and expressed in squamous cell and mammary carcinomas and linked to BCL-1.

1991 • 376 citations

Spatial expression of the Drosophila segment polarity gene armadillo is posttranscriptionally regulated by wingless

1990 • 374 citations

Xwnt-8, a Xenopus Wnt-1/int-1-related gene responsive to mesoderminducing growth factors, may play a role in ventral mesodermal patterning during embryogenesis

1991 • 373 citations

The Presence of Fibroblast Growth Factor in the Frog Egg: Its Role as a Natural Mesoderm Inducer

1988 • 367 citations

Tumorigenesis by mouse mammary tumor virus: Proviral activation of a cellular gene in the common integration region int-2

1984 • 356 citations

Induction across germ layers in Drosophila mediated by a genetic cascade

1990 • 342 citations

Differentiation of PC12 phaeochromocytoma cells induced by v-src oncogene

1985 • 306 citations

A new approach to the development of the cerebellum provided by the quail–chick marker system

1990 • 305 citations

Roles of wingless in patterning the larval epidermis of Drosophila

1991 • 295 citations

cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity.

1987 • 293 citations

Transgenic Models of Tumor Development

1991 • 289 citations

Translocations, master genes, and differences between the origins of acute and chronic leukemias

1991 • 286 citations

Molecular analysis of the armadillo locus: uniformly distributed transcripts and a protein with novel internal repeats are associated with a Drosophila segment polarity gene.

1989 • 284 citations

The proto-oncogene int-1 encodes a secreted protein associated with the extracellular matrix.

1990 • 280 citations

Expression of two members of the Wnt family during mouse development--restricted temporal and spatial patterns in the developing neural tube.

1991 • 279 citations

Expression of the proto-oncogene int-1 is restricted to postmeiotic male germ cells and the neural tube of mid-gestational embryos

1987 • 261 citations

Phenocopies induced with antisense RNA identify the wingless gene

1987 • 259 citations

Multiple modes of engrailed regulation in the progression towards cell fate determination

1991 • 248 citations

Mouse mammary tumor gene int-3: a member of the notch gene family transforms mammary epithelial cells

1992 • 246 citations

Involvement of gap junctions in tumorigenesis: transfection of tumor cells with connexin 32 cDNA retards growth in vivo.

1991 • 246 citations

Secretion and movement of wingless protein in the epidermis of the Drosophila embryo

1991 • 244 citations

Swaying is a mutant allele of the proto-oncogene Wnt-1

1991 • 242 citations

The role of segment polarity genes during Drosophila neurogenesis.

1989 • 235 citations

Embryonic and imaginal requirements for wingless, a segment-polarity gene in Drosophila

1988 • 228 citations

Structure and nucleotide sequence of the putative mammary oncogene int-1; proviral insertions leave the protein-encoding domain intact

1984 • 222 citations

Oncogenic conversion by regulatory changes in transcription factors

1991 • 215 citations

Secreted int-1 protein is associated with the cell surface.

1990 • 215 citations

Specification of limb development in the Drosophila embryo by positional cues from segmentation genes

1990 • 211 citations

Two proto-oncogenes implicated in mammary carcinogenesis, int-1 and int-2, are independently regulated during mouse development.

1986 • 211 citations

Mammary tumorigenesis in feral mice: identification of a new int locus in mouse mammary tumor virus (Czech II)-induced mammary tumors

1987 • 203 citations

Zygotic lethals with specific maternal effect phenotypes in Drosophila melanogaster. I. Loci on the X chromosome.

1989 • 200 citations

Integration of the DNA of mouse mammary tumor virus in virus-infected normal and neoplastic tissue of the mouse

1979 • 195 citations

Regulation of segment polarity genes in the Drosophila blastoderm by fushi tarazu and even skipped

1988 • 194 citations

A retrovirus vector expressing the putative mammary oncogene int-1 causes partial transformation of a mammary epithelial cell line

1986 • 189 citations

The development of wingless, a homeotic mutation of Drosophila

1977 • 185 citations

Homeobox gene expression plus autocrine growth factor production elicits myeloid leukemia.

1990 • 174 citations

Differential regulation of the Wnt gene family during pregnancy and lactation suggests a role in postnatal development of the mammary gland.

1992 • 156 citations

Xwnt-8 modifies the character of mesoderm induced by bFGF in isolated Xenopus ectoderm.

1992 • 155 citations

Concerted activation of two potential proto-oncogenes in carcinomas induced by mouse mammary tumour virus

1986 • 137 citations

Genomic structure and restricted neural expression of the zebrafish wnt-1 (int-1) gene.

1991 • 129 citations

Effect of Wnt-1 and Related Proteins on Gap Junctional Communication in Xenopus Embryos

1991 • 129 citations

Transgenes expressing the Wnt-1 and int-2 proto-oncogenes cooperate during mammary carcinogenesis in doubly transgenic mice.

1992 • 128 citations

Identification of genes from pattern formation, tyrosine kinase, and potassium channel families by DNA amplification.

1989 • 123 citations

Transfection of the int-1 mammary oncogene in cuboidal RAC mammary cell line results in morphological transformation and tumorigenicity.

1987 • 116 citations

The amplification unit on chromosome 11q13 in aggressive primary human breast tumors entails the bcl-1, int-2 and hst loci.

1989 • 114 citations

Nucleotide sequence and expression in vitro of cDNA derived from mRNA of int-1, a provirally activated mouse mammary oncogene.

1985 • 110 citations

The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells.

1992 • 109 citations

Mutational analysis of mouse Wnt-1 identifies two temperature-sensitive alleles and attributes of Wnt-1 protein essential for transformation of a mammary cell line.

1992 • 109 citations

The nucleotide sequence of the human int-1 mammary oncogene; evolutionary conservation of coding and non-coding sequences.

1985 • 106 citations

A gradient of homeodomain protein in developing forelimbs of Xenopus and mouse embryos

1988 • 105 citations

Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless.

1988 • 95 citations

The int-1 proto-oncogene products are glycoproteins that appear to enter the secretory pathway.

1987 • 91 citations

Identification of protein products encoded by the proto-oncogene int-1.

1987 • 80 citations

Isolation of cDNAs partially encoding four Xenopus - proteins and characterization of their transient expression during embryonic development

1991 • 77 citations

The segment polarity phenotype of Drosophila involves differential tendencies toward transformation and cell death

1989 • 77 citations

The molecular biology of breast cancer

1991 • 74 citations

Isolation of theXenopusbomolog ofint-1/winglessand expression during neurula stages of early development

1989 • 73 citations

Nucleotide sequence, chromosomal localization and developmental expression of the mouse int-1-related gene

1989 • 70 citations

Isolation and expression of two novel Wnt/wingless gene homologues in Drosophila

1992 • 63 citations

Inducible overexpression and secretion of int-1 protein.

1989 • 62 citations

The Molecular Genetic Basis of Positional Information in Insect Segments

1992 • 56 citations

Secretory and inductive properties of Drosophila wingless protein in Xenopus oocytes and embryos

1992 • 53 citations

Distinct effects of ectopic expression of Wnt-1, activin B, and bFGF on gap junctional permeability in 32-cell Xenopus embryos

1992 • 51 citations

Molecular cloning and chromosomal assignment of the human homolog of int-1, a mouse gene implicated in mammary tumorigenesis.

1984 • 48 citations

Early developmental subdivisions of the wing disk in Drosophila

1977 • 47 citations

Activation of int-1 and int-2 mammary oncogenes in hormone-dependent and -independent mammary tumors of GR mice

1987 • 47 citations

The biochemical properties and transforming potential of human Wnt-2 are similar to Wnt-1.

1992 • 47 citations

Interaction of Wnt-1 proteins with the binding protein BiP.

1992 • 47 citations

Amplification and proviral activation of several Wnt genes during progression and clonal variation of mouse mammary tumors.

1992 • 42 citations

Patterns of dye coupling in the imaginal wing disk of Drosophila melanogaster

1985 • 39 citations

The Wnt-1 (int-1) oncogene promoter and its mechanism of activation by insertion of proviral DNA of the mouse mammary tumor virus.

1990 • 38 citations

On the manner in which the disposition to carcinoma of the mammary gland is inherited in mice

1936 • 36 citations

Oncogene expression during progression of mouse mammary tumor cells; activity of a proviral enhancer and the resulting expression of int-2 is influenced by the state of differentiation.

1987 • 33 citations

The int-1 proto-oncogene is transcriptionally activated during neuroectodermal differentiation of P19 mouse embryonal carcinoma cells.

1989 • 32 citations

Transient expression of the proto-oncogene int-1 during differentiation of P19 embryonal carcinoma cells.

1989 • 25 citations

Restrictions in gap junctional communication in the Drosophila larval epidermis

1992 • 22 citations

The Int-2/Fgf-3 oncogene product is secreted and associates with extracellular matrix: implications for cell transformation.

1991 • 20 citations

Expression of a Wnt gene in embryonic epithelium of the leech

1992 • 20 citations

Drosophila homolog of the murine Int-1 protooncogene.

1988 • 16 citations

Proto-oncogenes in mammalian development

1992 • 10 citations

Cell Activation: Genetic Approaches

1991 • 8 citations

The Role of Fibroblast Growth Factor in Early Xenopus Development

1991 • 7 citations

Learning about cancer genes through invertebrate genetics

1992 • 6 citations

Nucleotide sequence of a cDNA encoding Wnt-1 of the Mexican axolotlAmbystoma mexicanum

1990 • 5 citations

The promise of gene ablation

1990 • 3 citations