Sampling of complementing self-antigen pools by thymic stromal cells maximizes the scope of central T cell tolerance

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Regulatory T Cells

2000 • 1,827 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 • 1,659 citations

Regulatory T Cells in Autoimmmunity

2000 • 1,267 citations

In situ hybridization; a practical approach

1993 • 1,247 citations

The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes

1997 • 931 citations

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus

1997 • 806 citations

Efficient Presentation of Phagocytosed Cellular Fragments on the Major Histocompatibility Complex Class II Products of Dendritic Cells

1998 • 649 citations

Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells

2000 • 399 citations

Mechanisms of antigen uptake for presentation

1996 • 354 citations

Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen.

1994 • 353 citations

High Frequency of Autoreactive Myelin Proteolipid Protein–Specific T Cells in the Periphery of Naive Mice

2000 • 275 citations

The third function of the thymus

2000 • 213 citations

Thymic expression of autoantigens correlates with resistance to autoimmune disease.

1997 • 193 citations

Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunity

1998 • 188 citations

Thymic emigration: conveyor belts or lucky dips?

1995 • 186 citations

Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance

1997 • 183 citations

Thymic Epithelium Tolerizes for Histocompatibility Antigens

1990 • 179 citations

A Range of CD4 T Cell Tolerance: Partial Inactivation to Organ-Specific Antigen Allows Nondestructive Thyroiditis or Insulitis

1997 • 178 citations

Tolerance Induced by Thymic Epithelial Grafts in Birds

1987 • 167 citations

CD4 T Cell Tolerance to Human C-reactive Protein, an Inducible Serum Protein, Is Mediated by Medullary Thymic Epithelium

1998 • 162 citations

T Lymphocyte Tolerance: From Thymic Deletion to Peripheral Control Mechanisms

1998 • 158 citations

Self-antigen presentation by thymic stromal cells: a subtle division of labor

2000 • 135 citations

Tissue Distribution of the DEC-205 Protein That Is Detected by the Monoclonal Antibody NLDC-145

1995 • 129 citations

HLA-G in the human thymus: a subpopulation of medullary epithelial but not CD83+ dendritic cells expresses HLA-G as a membrane-bound and soluble protein

1999 • 126 citations

Intrathymic presentation of circulating non-MHC antigens by medullary dendritic cells. An antigen-dependent microenvironment for T cell differentiation.

1986 • 126 citations

Self‐Ignorance in the Peripheral T‐Cell Pool

1993 • 124 citations

Tolerance induction by thymic medullary epithelium.

1992 • 121 citations

Promiscuous expression of tissue antigens in the thymus: a key to T-cell tolerance and autoimmunity?

2000 • 117 citations

Medullary Thymic Epithelium: A Mosaic of Epithelial “Self”?

1998 • 114 citations

Seeding of thymic microenvironments defined by distinct thymocyte-stromal cell interactions is developmentally controlled.

1987 • 112 citations

Thymus epithelium induces tissue-specific tolerance.

1993 • 111 citations

Antigen presenting cells in the thymus that can negatively select MHC class II-restricted T cells recognizing a circulating self antigen

1997 • 109 citations

Anergy induced by thymic medullary epithelium

1992 • 101 citations

Dendritic cells but not B cells present antigenic complexes to class II-restricted T cells after administration of protein in adjuvant.

1996 • 99 citations

Antigen-presenting cells in the thymus that can negatively select MHC class II-restricted T cells recognizing a circulating self antigen.

1997 • 93 citations

Immune responses of thymusf/ymphocyte embryonic chimeras: studies on tolerance and major histocompatibility complex restriction in Xenopus

1985 • 90 citations

Break of T Cell Ignorance to a Viral Antigen in the Liver Induces Hepatitis

2000 • 85 citations

CD4 T Cell Tolerance to Nuclear Proteins Induced by Medullary Thymic Epithelium

1996 • 83 citations

Mechanisms of immune tolerance induction through the thymic expression of a peripheral tissue-specific protein

1995 • 74 citations

Self-Reactive T Cells Selected on Thymic Cortical Epithelium Are Polyclonal and Are Pathogenic In Vivo

1999 • 65 citations

An acetylcholine receptor alpha subunit promoter confers intrathymic expression in transgenic mice. Implications for tolerance of a transgenic self-antigen and for autoreactivity in myasthenia gravis.

1998 • 49 citations

Presentation and intercellular transfer of self antigen within the thymic microenvironment: expression of the Eα peptide-l-A^b complex by isolated thymic stromal cells

1994 • 41 citations

Half‐life of antigen/major histocompatibility complex class II complexes in vivo: intra‐ and interorgan variations

1993 • 35 citations

The thymus and self-tolerance: co-existence of encephalitogenic S100 beta-specific T cells and their nominal autoantigen in the normal adult rat thymus

1997 • 35 citations

Selectivity of the major histocompatibility complex class II presentation pathway of cortical thymic epithelial cell lines

1997 • 34 citations

Peripheral T‐cell tolerance: the contribution of permissive T‐cell migration into parenchymal tissues of the neonate

1999 • 31 citations

Thymic epithelium induces full tolerance to skin and heart but not to B lymphocyte grafts

1995 • 29 citations

Induction of Immunological Unresponsiveness in vivo and in vitro by Conventional and Super‐Antigens in Developing and Mature T Cells

1991 • 29 citations

On the intrathymic intercellular transfer of self-determinants

1999 • 29 citations

The antigen presentation pathway in medullary thymic epithelial cells, but not that in cortical thymic epithelial cells, conforms to the endocytic pathway

1998 • 26 citations

In Vivo T-Lymphocyte Tolerance in the Absence of Thymic Clonal Deletion Mediated by Hematopoietic Cells

1999 • 25 citations

Intrathymic deletion of MHC class I-restricted cytotoxic T cell precursors by constitutive cross-presentation of exogenous antigen

1999 • 22 citations

Tolerance and immunity to the inducible self antigen C‐reactive protein in transgenic mice

1995 • 18 citations

The MHC class II-restricted T cell response of C57BL/6 mice to human C-reactive protein: Homology to self and the selection of T cell epitopes and T cell receptors

1997 • 9 citations