Separation of Notch1 Promoted Lineage Commitment and Expansion/Transformation in Developing T Cells

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1

1999 • 1,392 citations

Signalling downstream of activated mammalian Notch

1995 • 1,375 citations

Notch Signaling: From the Outside In

2000 • 958 citations

Notch1 Expression in Early Lymphopoiesis Influences B versus T Lineage Determination

1999 • 956 citations

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles.

1996 • 717 citations

MAML1, a human homologue of Drosophila Mastermind, is a transcriptional co-activator for NOTCH receptors

2000 • 576 citations

The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver.

1993 • 573 citations

Requirement for the Leukocyte-Specific Adapter Protein SLP-76 for Normal T Cell Development

1998 • 405 citations

Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes

1993 • 403 citations

Impaired Viability and Profound Block in Thymocyte Development in Mice Lacking the Adaptor Protein SLP-76

1998 • 360 citations

Correlating Notch Signaling with Thymocyte Maturation

1998 • 350 citations

Notch1 Signaling Promotes the Maturation of CD4 and CD8 SP Thymocytes

2000 • 317 citations

Essential Roles for Ankyrin Repeat and Transactivation Domains in Induction of T-Cell Leukemia by Notch1

2000 • 284 citations

Notch Inhibition of E47 Supports the Existence of a Novel Signaling Pathway

1998 • 261 citations

SKIP, a CBF1-Associated Protein, Interacts with the Ankyrin Repeat Domain of NotchIC To Facilitate NotchIC Function

2000 • 244 citations

Functional Interaction between the Mouse Notch1 Intracellular Region and Histone Acetyltransferases PCAF and GCN5

2000 • 239 citations

The bHLH gene Hes1 is essential for expansion of early T cell precursors

1999 • 208 citations

Notch signal transduction: a real Rip and more

2000 • 199 citations

Human deltex is a conserved regulator of Notch signalling

1998 • 189 citations

Notch1 Regulates Maturation of CD4+ and CD8+ Thymocytes by Modulating TCR Signal Strength

2001 • 182 citations

HIRA, a mammalian homologue of Saccharomyces cerevisiae transcriptional co-repressors, interacts with Pax3

1998 • 165 citations

An activated Ick transgene promotes thymocyte development in rag-1 mutant mice

1994 • 157 citations

Ras pathway signals are required for notch-mediated oncogenesis

2000 • 150 citations

Notch and the Immune System

1999 • 141 citations

Pre-TCR Signaling and Inactivation of p53 Induces Crucial Cell Survival Pathways in Pre-T Cells

1999 • 122 citations

Immature Thymocytes Employ Distinct Signaling Pathways for Allelic Exclusion versus Differentiation and Expansion

1999 • 120 citations

Cell-fate decisions in early T cell development: regulation by cytokine receptors and the pre-TCR

1999 • 110 citations

Restoration of Thymopoiesis in pTα−/− Mice by Anti-CD3ε Antibody Treatment or with Transgenes Encoding Activated Lck or Tailless pTα

1997 • 106 citations

Critical role for Atm in suppressing V(D)J recombination-driven thymic lymphoma

1999 • 104 citations

Distinct Signals Mediate Maturation and Allelic Exclusion in Lymphocyte Progenitors

1999 • 89 citations

No Requirement for V(D)J Recombination in p53-Deficient Thymic Lymphoma

1998 • 84 citations

Subunit Composition of Pre–T Cell Receptor Complexes Expressed by Primary Thymocytes: CD3δ Is Physically Associated but Not Functionally Required

1997 • 80 citations

Recombinase-activating gene (RAG) 2-mediated V(D)J recombination is not essential for tumorigenesis in Atm -deficient mice

2000 • 75 citations

Signals transduced by CD3epsilon, but not by surface pre-TCR complexes, are able to induce maturation of an early thymic lymphoma in vitro.

1999 • 58 citations

Signals Transduced by CD3ε, But Not by Surface Pre-TCR Complexes, Are Able to Induce Maturation of an Early Thymic Lymphoma In Vitro

1999 • 49 citations