Thymus organogenesis and molecular mechanisms of thymic epithelial cell differentiation

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1996 • 3,041 citations

Hox genes in vertebrate development

1994 • 2,057 citations

Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse.

1995 • 1,782 citations

Fate of the mammalian cardiac neural crest

2000 • 1,123 citations

An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination

1998 • 1,048 citations

The ikaros gene is required for the development of all lymphoid lineages

1994 • 976 citations

Mesenchymal derivatives of the neural crest: analysis of chimaeric quail and chick embryos

1975 • 966 citations

Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5

1991 • 856 citations

Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities

1998 • 817 citations

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family

1995 • 810 citations

Expression of relB is required for the development of thymic medulla and dendritic cells

1995 • 794 citations

Requirement of FGF-4 for Postimplantation Mouse Development

1995 • 743 citations

New member of the winged-helix protein family disrupted in mouse and rat nude mutations

1994 • 651 citations

Selective Defects in the Development of the Fetal and Adult Lymphoid System in Mice with an Ikaros Null Mutation

1996 • 619 citations

A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells

1990 • 611 citations

EXPERIMENTAL STUDIES ON THE DEVELOPMENT OF THE THYMUS

1967 • 504 citations

Dependence of Thymus Development on Derivatives of the Neural Crest

1984 • 463 citations

The thymic microenvironment

1993 • 459 citations

Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects inBMP7 deficient embryos

1997 • 448 citations

The role of Hoxa-3 in mouse thymus and thyroid development

1995 • 421 citations

Tracing of cells of the avian thymus through embryonic life in interspecific chimeras.

1975 • 409 citations

Pax genes and organogenesis

1997 • 362 citations

MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus

1993 • 359 citations

Morphogenetic interactions in the development of the mouse thymus gland

1960 • 336 citations

Pax3 is required for cardiac neural crest migration in the mouse: evidence from the splotch (Sp 2H) mutant

1997 • 313 citations

TISSUE INTERACTION IN THE DEVELOPMENT OF THYMUS LYMPHOCYTES

1969 • 295 citations

Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes

1995 • 295 citations

Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment

1998 • 292 citations

HoxGroup 3 Paralogs Regulate the Development and Migration of the Thymus, Thyroid, and Parathyroid Glands

1998 • 286 citations

Development in the thymus: it takes two to tango

1993 • 281 citations

Development of thymus, parathyroids, and ultimo‐branchial bodies in NMRI and nude mice

1980 • 264 citations

Characterization and Developmental Expression of Pax9, a Paired-Box-Containing Gene Related to Pax1

1995 • 263 citations

Cell kinetics in the fetal mouse thymus: precursor cell input, proliferation, and emigration.

1987 • 230 citations

Pax1 is expressed during development of the thymus epithelium and is required for normal T-cell maturation

1996 • 228 citations

The nu gene acts cell-autonomously and is required for differentiation of thymic epithelial progenitors.

1996 • 225 citations

Pharyngeal arch patterning in the absence of neural crest

1999 • 196 citations

Disorganization and restoration of thymic medullary epithelial cells in T cell receptor‐negative scid mice: Evidence that receptor‐bearing lymphocytes influence maturation of the thymic microenvironment

1991 • 190 citations

PAX genes

1994 • 190 citations

Ontogeny of primary lymphoid organs and lymphoid stem cells

1984 • 169 citations

An Essential Role for Thymic Mesenchyme in Early T Cell Development

2000 • 157 citations

Expression of bone morphogenetic protein-4 (BMP-4), bone morphogenetic protein-7 (BMP-7), fibroblast growth factor-8 (FGF-8) and sonic hedgehog (SHH) during branchial arch development in the chick

1995 • 151 citations

Lineage relationships and developmental kinetics of immature thymocytes: CD3, CD4, and CD8 acquisition in vivo and in vitro.

1990 • 143 citations

undulated Phenotypes Suggest a Role of Pax-1 for the Development of Vertebral and Extravertebral Structures

1995 • 121 citations

Seeding of the 10-day mouse embryo thymic rudiment by lymphocyte precursors in vitro.

1981 • 109 citations

Development of host defenses

1978 • 105 citations

Factors Regulating Stem Cell Recruitment to the Fetal Thymus

1999 • 97 citations

Development, organization and function of the thymic medulla in normal, immunodeficient or autoimmune mice

1999 • 84 citations

Lymphoid stem cell homing to the early thymic primordium of the avian embryo

1980 • 83 citations

Hoxa3 and Pax1 Transcription Factors Regulate the Ability of Fetal Thymic Epithelial Cells to Promote Thymocyte Development

2000 • 80 citations

Fibroblast dependency during early thymocyte development maps to the CD25⁺ CD44⁺ stage and involves interactions with fibroblast matrix molecules

1997 • 78 citations

Development of host defenses

1977 • 65 citations

Studies on the thymus of the mammal. XIV. Histology and histochemistry of embryonic and early postnatal thymuses of C57Bl/6 and AKR strain mice

1965 • 51 citations

A Common Stem Cell for Murine Cortical and Medullary Thymic Epithelial Cells?

1994 • 49 citations

The human thymic microenvironment: new approaches to functional analysis

1999 • 48 citations

Thymocytes and RelB‐dependent medullary epithelial cells provide growth‐promoting and organization signals, respectively, to thymic medullary stromal cells

1997 • 46 citations

The junctional modifications of a T cell receptor gamma chain are determined at the level of thymic precursors.

1991 • 45 citations

Studies on the phenotype of migrant thymic stem cells

1999 • 41 citations

Ikaros in hemopoietic lineage determination and homeostasis

1998 • 37 citations

Epidermal growth factor can replace thymic mesenchyme in induction of embryonic thymus morphogenesis in vitro

1996 • 37 citations

Limited development capacity of the earliest embryonic murine thymus

1995 • 35 citations

Studies in vitro on the mechanism of the epithelial/mesenchymal interaction in the early fetal thymus

1997 • 35 citations

Development and function of T lymphocytes and natural killer cells after bone marrow transplantation of severely immunodeficient mice

1997 • 35 citations

Thymic Medulla Epithelial Cells Acquire Specific Markers by Post-Mitotic Maturation

1996 • 26 citations

Embryonic mouse thymus development: stem cell entry and differentiation.

1978 • 20 citations