Entry into the Thymic Microenvironment Triggers Notch Activation in the Earliest Migrant T Cell Progenitors

Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow

1997 • 2,205 citations

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

1999 • 2,051 citations

Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1

1999 • 1,392 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

Notch1 Expression in Early Lymphopoiesis Influences B versus T Lineage Determination

1999 • 956 citations

Lymphostromal interactions in thymic development and function

2001 • 461 citations

Notch 1–Deficient Common Lymphoid Precursors Adopt a B Cell Fate in the Thymus

2001 • 392 citations

Correlating Notch Signaling with Thymocyte Maturation

1998 • 350 citations

Differential Effects of Notch Ligands Delta-1 and Jagged-1 in Human Lymphoid Differentiation

2001 • 348 citations

Inactivation of Notch1 Impairs VDJβ Rearrangement and Allows pre-TCR-Independent Survival of Early αβ Lineage Thymocytes

2002 • 342 citations

Notch1 Signaling Promotes the Maturation of CD4 and CD8 SP Thymocytes

2000 • 317 citations

Inactivation of Notch1 in immature thymocytes does not perturb CD4 or CD8 T cell development

2001 • 300 citations

Deltex1 Redirects Lymphoid Progenitors to the B Cell Lineage by Antagonizing Notch1

2002 • 251 citations

Studies on T cell maturation on defined thymic stromal cell populations in vitro.

1992 • 249 citations

BLNK

2000 • 221 citations

The bHLH gene Hes1 is essential for expansion of early T cell precursors

1999 • 208 citations

Identification of pro-thymocytes in murine fetal blood: T lineage commitment can precede thymus colonization.

1994 • 206 citations

Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway

2002 • 204 citations

Redefinition of lymphoid progenitors

2002 • 197 citations

Thymic epithelial cells provide unique signals for positive selection of CD4+CD8+ thymocytes in vitro.

1994 • 197 citations

A Role for Pref-1 and HES-1 in Thymocyte Development

2000 • 196 citations

Subversion of the T/B Lineage Decision in the Thymus by Lunatic Fringe-Mediated Inhibition of Notch-1

2001 • 195 citations

T Cell Progenitors Emerge Earlier Than B Cell Progenitors in the Murine Fetal Liver

2000 • 164 citations

An Essential Role for Thymic Mesenchyme in Early T Cell Development

2000 • 157 citations

Direct evidence for the commitment of hematopoietic stem cells to T, B and myeloid lineages in murine fetal liver

1997 • 144 citations

Notch and the Immune System

1999 • 141 citations

Analysis of cytokine gene expression in subpopulations of freshly isolated thymocytes and thymic stromal cells using semiquantitative polymerase chain reaction

1993 • 138 citations

Requirement for the Thymus in αβ T Lymphocyte Lineage Commitment

1998 • 99 citations

Factors Regulating Stem Cell Recruitment to the Fetal Thymus

1999 • 97 citations

Notch ligand-bearing thymic epithelial cells initiate and sustain Notch signaling in thymocytes independently of T cell receptor signaling

2001 • 81 citations

Studies on the phenotype of migrant thymic stem cells

1999 • 41 citations