Tbx1, a DiGeorge Syndrome Candidate Gene, Is Regulated by Sonic Hedgehog during Pharyngeal Arch Development

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1996 • 3,041 citations

Msx1 deficient mice exhibit cleft palate and abnormalities of craniofacial and tooth development

1994 • 1,271 citations

Spectrum of clinical features associated with interstitial chromosome 22q11 deletions: a European collaborative study.

1997 • 1,187 citations

Mutations in human cause limb and cardiac malformation in Holt-Oram syndrome

1997 • 1,066 citations

Nonsteroid nuclear receptors: What Are genetic studies telling us about their role in real life?

1995 • 1,011 citations

Elevated blood pressure and craniofaclal abnormalities in mice deficient in endothelin-1

1994 • 1,002 citations

The triple origin of skull in higher vertebrates: a study in quail-chick chimeras

1993 • 981 citations

Direct and Long-Range Action of a DPP Morphogen Gradient

1996 • 896 citations

Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5

1991 • 856 citations

The role of the neural crest in patterning of avian cranial skeletal, connective, and muscle tissues

1983 • 852 citations

Cloning of the T gene required in mesoderm formation in the mouse

1990 • 847 citations

Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities

1998 • 817 citations

Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud

1994 • 801 citations

Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND

1997 • 716 citations

A positive feedback loop coordinates growth and patterning in the vertebrate limb

1994 • 702 citations

Sonic hedgehog is essential to foregut development

1998 • 685 citations

Rhombencephalic neural crest segmentation is preserved throughout craniofacial ontogeny

1996 • 681 citations

Expression of the T-box family genes,Tbx1-Tbx5, during early mouse development

1996 • 654 citations

Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice

1998 • 643 citations

RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis.

1994 • 632 citations

A new syndrome involving cleft palate, cardiac anomalies, typical facies, and learning disabilities: velo-cardio-facial syndrome.

1978 • 593 citations

Morphogens, Compartments, and Pattern: Lessons from Drosophila?

1996 • 559 citations

A Subclass of bHLH Proteins Required for Cardiac Morphogenesis

1995 • 544 citations

Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome

1997 • 536 citations

Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch

1999 • 519 citations

DiGeorge syndrome: part of CATCH 22.

1993 • 510 citations

The 22q11 deletion syndromes

2000 • 492 citations

Role of the Dlx Homeobox Genes in Proximodistal Patterning of the Branchial Arches: Mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 Alter Morphogenesis of Proximal Skeletal and Soft Tissue Structures Derived from the First and Second Arches

1997 • 463 citations

The role of Hoxa-3 in mouse thymus and thyroid development

1995 • 421 citations

A genetic etiology for DiGeorge syndrome: consistent deletions and microdeletions of 22q11.

1992 • 420 citations

Congenital heart disease in mice deficient for the DiGeorge syndrome region

1999 • 410 citations

Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1.

1995 • 393 citations

Role of neural crest in congenital heart disease.

1990 • 390 citations

Cardiovascular anomalies in digeorge syndrome and importance of neural crest as a possible pathogenetic factor

1986 • 359 citations

Specific spatial and temporal distribution of retinoic acid receptor gamma transcripts during mouse embryogenesis

1990 • 351 citations

Lighting the fuse at fertilization

1993 • 328 citations

The T-box gene family

1998 • 307 citations

A signaling cascade involving endothelin-1, dHAND and Msx1 regulates development of neural-crest-derived branchial arch mesenchyme

1998 • 271 citations

Sonic hedgehogParticipates in Craniofacial Morphogenesis and Is Down-regulated by Teratogenic Doses of Retinoic Acid

1997 • 258 citations

T-box genes: what they do and how they do it

1999 • 241 citations

An ancient family of embryonically expressed mouse genes sharing a conserved protein motif with the T locus

1994 • 225 citations

Migration of cardiac neural crest cells in Splotch embryos

2000 • 221 citations

More Surprises in the Hedgehog Signaling Pathway

2000 • 219 citations

Retinoid signaling is essential for patterning the endoderm of the third and fourth pharyngeal arches

2000 • 210 citations

Signaling Pathways Crucial for Craniofacial Development Revealed by Endothelin-A Receptor-Deficient Mice

2000 • 207 citations

Evolutionary-conserved enhancers direct region-specific expression of the murine Hoxa-1 and Hoxa-2 loci in both mice and Drosophila

1995 • 202 citations

Key roles of retinoic acid receptors alpha and beta in the patterning of the caudal hindbrain, pharyngeal arches and otocyst in the mouse

1999 • 180 citations

Isolation and Characterization of a Gene from the DiGeorge Chromosomal Region Homologous to the MouseTbx1Gene

1997 • 163 citations

Expression of bone morphogenetic protein-4 (BMP-4), bone morphogenetic protein-7 (BMP-7), fibroblast growth factor-8 (FGF-8) and sonic hedgehog (SHH) during branchial arch development in the chick

1995 • 151 citations

Molecular and clinical study of 183 patients with conotruncal anomaly face syndrome

1998 • 123 citations

undulated Phenotypes Suggest a Role of Pax-1 for the Development of Vertebral and Extravertebral Structures

1995 • 121 citations

A conserved retinoic acid responsive element in the murine Hoxb-1 gene is required for expression in the developing gut

1998 • 116 citations

Independent regulation of Dlx2 expression in the epithelium and mesenchyme of the first branchial arch

2000 • 112 citations

Barx2 , a new homeobox gene of the Bar class, is expressed in neural and craniofacial structures during development

1997 • 101 citations

The branchial Hox code and its implications for gene regulation, patterning of the nervous system and head evolution

1991 • 93 citations

Patient with a 22q11.2 deletion with no overlap of the minimal DiGeorge syndrome critical region (MDGCR)

1999 • 70 citations

Sequence Analysis, Chromosomal Location, and Developmental Expression of the Mouse Preproendothelin-1 Gene

1996 • 49 citations

The Genetic Basis of Conotruncal Cardiac Defects

1999 • 37 citations