Cell migration and the anatomic control of thymocyte precursor differentiation

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

Chemokines

2000 • 3,773 citations

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

1998 • 2,496 citations

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

1991 • 1,693 citations

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

1994 • 1,572 citations

Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1

1999 • 1,392 citations

The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus

1988 • 1,390 citations

CADHERINS: A MOLECULAR FAMILY IMPORTANT IN SELECTIVE CELL-CELL ADHESION

1990 • 1,293 citations

A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression.

1993 • 833 citations

EXPERIMENTAL STUDIES ON THE DEVELOPMENT OF THE THYMUS

1967 • 504 citations

Cellular Interactions in Thymocyte Development

1996 • 503 citations

An Activated Form of Notch Influences the Choice between CD4 and CD8 T Cell Lineages

1996 • 488 citations

Tracing of cells of the avian thymus through embryonic life in interspecific chimeras.

1975 • 409 citations

Notch Activity Influences the αβ versus γδ T Cell Lineage Decision

1997 • 399 citations

Bone Morphogenetic Proteins Regulate the Developmental Program of Human Hematopoietic Stem Cells

1999 • 383 citations

Correlating Notch Signaling with Thymocyte Maturation

1998 • 350 citations

Development and Function of Subpopulations of Thymocytes and T Lymphocytes

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Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes

1995 • 295 citations

Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment

1998 • 292 citations

Development in the thymus: it takes two to tango

1993 • 281 citations

Differential Expression of the Fibroblast Growth Factor Receptor (FGFR) Multigene Family in Normal Human Adult Tissues

1997 • 271 citations

EVIDENCE FOR A BLOOD-THYMUS BARRIER USING ELECTRON-OPAQUE TRACERS

1972 • 258 citations

Jagged2: A Serrate-like Gene Expressed during Rat Embryogenesis

1996 • 243 citations

Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells.

1995 • 237 citations

Thymocyte binding to human thymic epithelial cells is inhibited by monoclonal antibodies to CD-2 and LFA-3 antigens.

1987 • 213 citations

Intrathymically expressed c-kit ligand (stem cell factor) is a major factor driving expansion of very immature thymocytes in vivo

1995 • 201 citations

Expression pattern of Notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand–receptor interactions in intrathymic T cell development

1999 • 197 citations

A Role for Pref-1 and HES-1 in Thymocyte Development

2000 • 196 citations

Isolation and Functional Analysis of a cDNA for Human Jagged2, a Gene Encoding a Ligand for the Notch1 Receptor

1997 • 192 citations

Expression of CXCR4, the receptor for stromal cell-derived factor-1 on fetal and adult human lymphohematopoietic progenitors

1999 • 188 citations

A murine early thymocyte developmental sequence is marked by transient expression of the interleukin 2 receptor.

1989 • 185 citations

Steel factor and c-kit regulate cell-matrix adhesion

1994 • 178 citations

Stem cell factor modulates avidity of alpha 4 beta 1 and alpha 5 beta 1 integrins expressed on hematopoietic cell lines

1995 • 173 citations

Demonstration of a cyclic renewal of the lymphocyte precursor cells in the quail thymus during embryonic and perinatal life.

1982 • 172 citations

Differentiation potential of subsets of CD4−8− thymocytes

1987 • 169 citations

Differential Chemotactic Behavior of Developing T Cells in Response to Thymic Chemokines

1998 • 169 citations

Modulated expression of notch1 during thymocyte development

1996 • 147 citations

Wnt signaling and dorso-ventral axis specification in vertebrates

1999 • 146 citations

Analysis of cytokine gene expression in subpopulations of freshly isolated thymocytes and thymic stromal cells using semiquantitative polymerase chain reaction

1993 • 138 citations

CXCR4 and CCR5 on Human Thymocytes: Biological Function and Role in HIV-1 Infection

1998 • 135 citations

T Cell Receptor (TCR)-β Gene Recombination: Dissociation from Cell Cycle Regulation and Developmental Progression During T Cell Ontogeny

1997 • 128 citations

Steel factor and c-kit regulate cell-matrix adhesion

1994 • 124 citations

Pertussis Toxin-Sensitive Signal Controls the Trafficking of Thymocytes Across the Corticomedullary Junction in the Thymus

1999 • 123 citations

Induction of TCR Gene Rearrangements in Uncommitted Stem Cells by a Subset of IL-7 Producing, MHC Class II–Expressing Thymic Stromal Cells

1997 • 119 citations

Seeding of thymic microenvironments defined by distinct thymocyte-stromal cell interactions is developmentally controlled.

1987 • 112 citations

CXCR4 and CCR5 Expression Delineates Targets for HIV-1 Disruption of T Cell Differentiation

1998 • 112 citations

Seeding of the 10-day mouse embryo thymic rudiment by lymphocyte precursors in vitro.

1981 • 109 citations

Sequential events in thymocyte differentiation and thymus regeneration revealed by a combination of bromodeoxyuridine DNA labeling and antimitotic drug treatment.

1988 • 107 citations

The role of LFA-1/ICAM-1 interactions during murine T lymphocyte development.

1991 • 105 citations

Adhesion of immature thymocytes to thymic stromal cells through fibronectin molecules and its significance for the induction of thymocyte differentiation.

1991 • 104 citations

Signal transduction by the α6β4 integrin: charting the path between laminin binding and nuclear events

1996 • 101 citations

Factors Regulating Stem Cell Recruitment to the Fetal Thymus

1999 • 97 citations

Murine Wnt10a and Wnt10b: cloning and expression in developing limbs, face and skin of embryos and in adults.

1996 • 93 citations

Cell adhesion and migration are regulated at distinct stages of thymic T cell development: the roles of fibronectin, VLA4, and VLA5.

1996 • 93 citations

Thymic Regeneration after Lethal Irradiation: Evidence for an Intra-Thymic Radioresistant T Cell Precursor

1975 • 92 citations

VLA-4 integrin mediates lymphocyte migration on the inducible endothelial cell ligand VCAM-1 and the extracellular matrix ligand fibronectin.

1993 • 90 citations

Subcellular and developmental expression of alternatively spliced forms of fibroblast growth factor 14

2000 • 89 citations

Constitutive activation of integrin alpha 4 beta 1 defines a unique stage of human thymocyte development.

1994 • 87 citations

Expression of the c-kit Gene is Critical for Migration of Neonatal Rat Gonocytes in Vitro1

1997 • 86 citations

Thymic microvascular system

1997 • 83 citations

Maturation of medullary thymic epithelium requires thymocytes expressing fully assembled CD3-TCR complexes

1994 • 79 citations

Involvement of Insulin-Like Growth Factors in Early T Cell Development: A Study Using Fetal Thymic Organ Cultures¹

2000 • 79 citations

A scanning electron-microscopic study of the rat thymus with special reference to cell types and migration of lymphocytes into the general circulation

1986 • 74 citations

Phenotypically diverse mouse thymic stromal cell lines which induce proliferation and differentiation of hematopoietic cells

1993 • 74 citations

Vascular Cell Adhesion Molecule-1 Is Expressed by Cortical Thymic Epithelial Cells and Mediates Thymocyte Adhesion. Implications for the Function of α4β1 (VLA4) Integrin in T-Cell Development

1997 • 69 citations

Expression of the homotypic adhesion molecule E-cadherin by immature murine thymocytes and thymic epithelial cells.

1994 • 63 citations

Expression of VLA-4 on thymocytes. Maturation stage-associated transition and its correlation with their capacity to adhere to thymic stromal cells.

1992 • 60 citations

Involvement of E-Cadherin in Thymus Organogenesisand Thymocyte Maturation

1997 • 59 citations

Developmentally regulated expression of the beta 4 integrin on immature mouse thymocytes.

1992 • 56 citations

Detection of growth hormone-producing cells in human thymus by immunohistochemistry and non-radioactive in situ hybridization.

1994 • 55 citations

IL-7 activates alpha4beta1 integrin in murine thymocytes.

1997 • 50 citations

Distinct roles of the interleukin-7 receptor α chain in fetal and adult thymocyte development revealed by analysis of interleukin-7 receptor α-deficient mice

1998 • 50 citations

Molecular Biology of B-Cell and T-Cell Development

1998 • 49 citations

Only dull CD3⁺ thymocytes bind to thymic epithelial cells. the binding is elicited by both CD2/LFA‐3 and LFA‐1/ICAM‐1 interactions

1989 • 46 citations

Migration of Cells to the Thymus Demonstrated by Parabiosis.

1967 • 45 citations

Microvasculature of Normal and Involuted Mouse Thymus

1989 • 41 citations

Adhesion molecules involved in the interactions between early T cells and mesenchymal bone marrow stromal cells

1999 • 41 citations

Roles of Integrins and CD44 on the Adhesion and Migration of Fetal Liver Cells to the Fetal Thymus

1999 • 39 citations

Activation Dependent and Independent VLA-4 Binding Sites on Vascular Cell Adhesion Molecule-1

1994 • 39 citations

Phenotypic characterization and ontogeny of components of the human thymic microenvironment.

1984 • 36 citations

Phenotypic analysis of the early events during repopulation of the thymus by the bone marrow prothymocyte

1990 • 35 citations

Lymphoid microenvironments in the thymus and lymph node.

1988 • 34 citations

CD4+8- and CD4-8+ mature thymocytes require different post-selection processing for final development.

1993 • 34 citations

Immunohistochemical localization of host and donor-derived cells in the regenerating thymus of radiation bone marrow chimeras.

1984 • 31 citations

Upregulated Expression of Fibronectin Receptors Underlines the Adhesive Capability of Thymocytes to Thymic Epithelial Cells During the Early Stages of Differentiation: Lessons From Sublethally Irradiated Mice

1999 • 30 citations

Cloning, Sequence Analysis, and Distribution of Rat Metallocarboxypeptidase z

1998 • 28 citations

Requirement of Cell Interactions through Adhesion Molecules in the Early Phase of T Cell Development

1996 • 26 citations

Modulation of integrin‐mediated intercellular adhesion during the interaction of thymocytes with stromal cells expressing VLA‐4 and LFA‐1 ligands

1996 • 15 citations

Epidermal Growth Factor Modulates Fetal Thymocyte Growth and Differentiation

1997 • 13 citations

Phenotypic Analysis of the Chicken Thymic Microenvironment During Ontogenic Development

1992 • 12 citations

TCR-Independent Development of Pluripotent T-Cell Precursors

1998 • 9 citations

Expression of protein tyrosine kinases in the murine thymus stroma

1996 • 7 citations