CD4 T Cell Tolerance to Human C-reactive Protein, an Inducible Serum Protein, Is Mediated by Medullary Thymic Epithelium

The acute phase response

1994 • 2,927 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens*

1979 • 1,989 citations

F4/80, a monoclonal antibody directed specifically against the mouse macrophage

1981 • 1,582 citations

Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule.

1983 • 1,307 citations

The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes

1997 • 931 citations

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus

1997 • 806 citations

Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors.

1989 • 778 citations

The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies.

1990 • 561 citations

The Repertoire of T Cells Shaped by a Single MHC/Peptide Ligand

1996 • 417 citations

Mice lacking the MHC class II-associated invariant chain

1993 • 385 citations

Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen.

1994 • 353 citations

How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model

1994 • 309 citations

Lower receptor avidity required for thymic clonal deletion than for effector T-cell function

1991 • 263 citations

Amyloid deposition is delayed in mice with targeted deletion of the serum amyloid P component gene

1997 • 257 citations

Autoimmune diabetes as a consequence of locally produced interleukin-2

1992 • 242 citations

Levels of Peripheral T Cell Tolerance Induced by Different Doses of Tolerogen

1994 • 229 citations

Monoclonal antibodies to stromal cell types of the mouse thymus

1984 • 228 citations

T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus.

1994 • 223 citations

Human C-reactive protein is protective against fatal Streptococcus pneumoniae infection in transgenic mice.

1995 • 206 citations

Quantitative Impact of Thymic Clonal Deletion on the T Cell Repertoire

1997 • 198 citations

Expression of C-reactive protein by alveolar macrophages.

1996 • 193 citations

Thymic expression of autoantigens correlates with resistance to autoimmune disease.

1997 • 193 citations

Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance

1997 • 183 citations

A Range of CD4 T Cell Tolerance: Partial Inactivation to Organ-Specific Antigen Allows Nondestructive Thyroiditis or Insulitis

1997 • 178 citations

Cassette vectors directing expression of T cell receptor genes in transgenic mice

1995 • 159 citations

Mouse thymus dendritic cells: kinetics of development and changes in surface markers during maturation

1995 • 138 citations

Pathogenesis of myasthenia gravis

1997 • 132 citations

Pathogenesis of myasthenia gravis. Acetylcholine receptor-related antigenic determinants in tumor-free thymuses and thymic epithelial tumors.

1988 • 129 citations

Inducible and tissue-specific expression of human C-reactive protein in transgenic mice.

1987 • 127 citations

Selection of a Broad Repertoire of CD4+ T Cells in H-2Ma0/0 Mice

1997 • 122 citations

Limited capacity for tolerization of CD4+ T cells specific for a pancreatic β cell neo-antigen

1995 • 121 citations

Tolerance induction by thymic medullary epithelium.

1992 • 121 citations

B7 expression on thymic medullary epithelium correlates with epithelium-mediated deletion of V beta 5+ thymocytes.

1994 • 118 citations

Antigen presenting cells in the thymus that can negatively select MHC class II-restricted T cells recognizing a circulating self antigen

1997 • 109 citations

Thymic cortical epithelial cells can present self-antigens in vivo

1989 • 108 citations

Identification of an embryonic isoform of myelin basic protein that is expressed widely in the mouse embryo.

1993 • 104 citations

Expression in transgenic mice of class I histocompatibility antigens controlled by the metallothionein promoter.

1989 • 104 citations

Intrathymic presentation of circulating non-major histocompatibility complex antigens

1984 • 102 citations

Anergy induced by thymic medullary epithelium

1992 • 101 citations

Clonal deletion of specific thymocytes by an immunoglobulin idiotype.

1993 • 100 citations

The major myelin protein genes are expressed in the human thymus

1996 • 100 citations

Tolerance induction by clonal deletion of CD4⁺8⁺ thymocytes in vitro does not require dedicated antigen‐presenting cells

1993 • 97 citations

Monoclonal antibodies reactive with subsets of mouse and human thymic epithelial cells.

1988 • 94 citations

Antigen-presenting cells in the thymus that can negatively select MHC class II-restricted T cells recognizing a circulating self antigen.

1997 • 93 citations

Characterization and isolation of a C-reactive protein receptor from the human monocytic cell line U-937.

1990 • 90 citations

CD4 T Cell Tolerance to Nuclear Proteins Induced by Medullary Thymic Epithelium

1996 • 83 citations

Mechanisms of immune tolerance induction through the thymic expression of a peripheral tissue-specific protein

1995 • 74 citations

The thymic repertoire of neuroendocrine self-antigens: physiological implications in T-cell life and death

1996 • 70 citations

Antigen compartmentation and T helper cell tolerance induction.

1996 • 68 citations

The transcapsular route: a new way for (self-) antigens to by-pass the blood-thymus barrier?

1988 • 67 citations

The T cell receptor V alpha 11 gene family. Analysis of allelic sequence polymorphism and demonstration of J alpha region-dependent recognition by allele-specific antibodies.

1991 • 62 citations

Thymic expression of myelin basic protein (MBP). Activation of MBP-specific T cells by thymic cells in the absence of exogenous MBP.

1996 • 59 citations

The murine homolog of human Ep‐CAM, a homotypic adhesion molecule, is expressed by thymocytes and thymic epithelial cells

1996 • 56 citations

Developmental regulation of thymocyte susceptibility to deletion by "self"-peptide.

1992 • 50 citations

Induction of tolerance to self MHC class I molecules expressed under the control of milk protein or β-globin gene promoters

1994 • 48 citations

Regulation of the Human C-reactive Protein Gene in Transgenic Mice

1995 • 46 citations

Expression of major histocompatibility complex class I antigens at low levels in the thymus induces T cell tolerance via a non‐deletional mechanism

1992 • 42 citations

Presentation and intercellular transfer of self antigen within the thymic microenvironment: expression of the Eα peptide-l-A^b complex by isolated thymic stromal cells

1994 • 41 citations

Direct Visualization of thymocyte apoptosis in neglect, acute and steady-state negative selection

1996 • 41 citations

Extrahepatic transcription of human C-reactive protein.

1991 • 40 citations

Half‐life of antigen/major histocompatibility complex class II complexes in vivo: intra‐ and interorgan variations

1993 • 35 citations

The thymus and self-tolerance: co-existence of encephalitogenic S100 beta-specific T cells and their nominal autoantigen in the normal adult rat thymus

1997 • 35 citations

A functionally compromised intermediate in extrathymic CD8+ T cell deletion

1995 • 34 citations

Membrane-associated C-reactive protein on rat liver macrophages is synthesized within the macrophages, expressed as Neo–C-reactive protein and bound through a C-reactive protein-specific membrane receptor

1993 • 31 citations

Transgenesis and Targeted Mutagenesis in Immunology

1994 • 24 citations

Ig-specific T cell receptor-transgenic T cells are not deleted in the thymus and are functional in vivo.

1996 • 23 citations

Tolerance and immunity to the inducible self antigen C‐reactive protein in transgenic mice

1995 • 18 citations

The MHC class II-restricted T cell response of C57BL/6 mice to human C-reactive protein: Homology to self and the selection of T cell epitopes and T cell receptors

1997 • 9 citations

Peripheral T Cell Tolerance: Distinct Levels and Multistep Mechanisms

1994 • 5 citations

Thymocyte Selection and Peripheral Tolerance Using the Lymphocytic Choriomeningitis Virus as a Model Antigen

1994 • 3 citations