Hedgehog Signaling Regulates Differentiation from Double-Negative to Double-Positive Thymocyte

Mutations affecting segment number and polarity in Drosophila

1980 • 4,280 citations

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

1993 • 2,146 citations

Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein

1996 • 1,952 citations

MOUSE CD1-SPECIFIC NK1 T CELLS: Development, Specificity, and Function

1997 • 1,326 citations

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

1996 • 1,106 citations

Dual Roles for Patched in Sequestering and Transducing Hedgehog

1996 • 889 citations

Two Critical Periods of Sonic Hedgehog Signaling Required for the Specification of Motor Neuron Identity

1996 • 866 citations

Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.

1996 • 829 citations

Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein

1999 • 772 citations

Identification of a Palmitic Acid-modified Form of Human Sonic hedgehog

1998 • 735 citations

Notochord repression of endodermal Sonic hedgehog permits pancreas development

1998 • 621 citations

Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo

1987 • 578 citations

The world according to bedgebog

1997 • 549 citations

Expression of Three Mouse Homologs of the Drosophila Segment Polarity Gene cubitus interruptus, Gli, Gli-2, and Gli-3, in Ectoderm- and Mesoderm-Derived Tissues Suggests Multiple Roles during Postimplantation Development

1994 • 478 citations

The thymic microenvironment

1993 • 459 citations

Transducing Hedgehog: the story so far

1998 • 444 citations

Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas

1997 • 443 citations

Productive T-cell receptor beta-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo.

1996 • 343 citations

Sonic hedgehog signaling by the Patched–Smoothened receptor complex

1999 • 326 citations

Gli proteins and Hedgehog signaling: development and cancer

1999 • 249 citations

Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon.

1993 • 214 citations

The MAP Kinase Pathway Controls Differentiation from Double-Negative to Double-Positive Thymocyte

1996 • 213 citations

Regulation of V(D)J Recombination Activator Protein RAG-2 by Phosphorylation

1993 • 209 citations

Pleiotropic changes controlled by the pre-T-cell receptor

1999 • 199 citations

T-cell lineage commitment and cytokine responses of thymic progenitors

1995 • 164 citations

Immature Thymocytes Employ Distinct Signaling Pathways for Allelic Exclusion versus Differentiation and Expansion

1999 • 120 citations

Cell-fate decisions in early T cell development: regulation by cytokine receptors and the pre-TCR

1999 • 110 citations

T-cell differentiation in thymus organ cultures.

1990 • 100 citations

V(D)J recombination and the cell cycle

1995 • 98 citations

Overexpression of ptc1 Inhibits Induction of Shh Target Genes and Prevents Normal Patterning in the Neural Tube

1999 • 77 citations

Events that regulate differentiation of αβ TCR+and γδ TCR+T cells from a common precursor

1997 • 73 citations

A transgenic T cell receptor restores thymocyte differentiation in interleukin-7 receptor α chain-deficient mice

1997 • 51 citations

Ontogeny of fetal CD8^lo4^lo thymocytes: Expression of CD44, CD25 and early expression of TcR α mRNA

1993 • 19 citations