The PD‐1 pathway in tolerance and autoimmunity

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

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2003 • 4,529 citations

The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer

2017 • 4,003 citations

Restoring function in exhausted CD8 T cells during chronic viral infection

2005 • 3,743 citations

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

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How regulatory T cells work

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Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.

1992 • 2,906 citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

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CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

1998 • 2,658 citations

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2008 • 2,656 citations

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism

2007 • 2,575 citations

Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

1999 • 2,574 citations

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

2006 • 2,521 citations

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

2006 • 2,516 citations

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

2001 • 2,503 citations

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

1999 • 2,380 citations

Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3

2005 • 2,256 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

Toll Pathway-Dependent Blockade of CD4 ⁺ CD25 ⁺ T Cell-Mediated Suppression by Dendritic Cells

2003 • 2,023 citations

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

2009 • 1,887 citations

The inhibitory cytokine IL-35 contributes to regulatory T-cell function

2007 • 1,886 citations

Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis

2004 • 1,835 citations

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

2001 • 1,831 citations

Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid

2007 • 1,816 citations

CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms

2005 • 1,746 citations

A function for interleukin 2 in Foxp3-expressing regulatory T cells

2005 • 1,744 citations

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

2006 • 1,702 citations

Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression

2009 • 1,688 citations

Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β

2001 • 1,609 citations

An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation

1999 • 1,607 citations

Programmed Death-1 Ligand 1 Interacts Specifically with the B7-1 Costimulatory Molecule to Inhibit T Cell Responses

2007 • 1,603 citations

Making sense of latent TGFβ activation

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Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

1998 • 1,579 citations

Induction of Interleukin 10–Producing, Nonproliferating Cd4+ T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic Cells

2000 • 1,577 citations

Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells

2006 • 1,496 citations

Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes

1996 • 1,473 citations

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

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The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection

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1996 • 1,335 citations

Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma

2006 • 1,254 citations

Compromised Function of Regulatory T Cells in Rheumatoid Arthritis and Reversal by Anti-TNFα Therapy

2004 • 1,242 citations

PD-1 and PD-1 ligands: from discovery to clinical application

2007 • 1,199 citations

CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation–mediated apoptosis of effector CD4+ T cells

2007 • 1,161 citations

Tissue expression of PD-L1 mediates peripheral T cell tolerance

2006 • 1,145 citations

SHP-1 and SHP-2 Associate with Immunoreceptor Tyrosine-Based Switch Motif of Programmed Death 1 upon Primary Human T Cell Stimulation, but Only Receptor Ligation Prevents T Cell Activation

2004 • 1,128 citations

Cutting Edge: TGF-β Induces a Regulatory Phenotype in CD4+CD25− T Cells through Foxp3 Induction and Down-Regulation of Smad7

2004 • 1,123 citations

Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

2008 • 1,088 citations

Pillars Article: Control of Regulatory T Cell Development by the Transcription Factor Foxp3. Science 2003. 299: 1057-1061.

2017 • 986 citations

TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

2005 • 955 citations

Redefining Chronic Viral Infection

2009 • 941 citations

Granzyme B and Perforin Are Important for Regulatory T Cell-Mediated Suppression of Tumor Clearance

2007 • 871 citations

Cutting Edge: Contact-Mediated Suppression by CD4+CD25+ Regulatory Cells Involves a Granzyme B-Dependent, Perforin-Independent Mechanism

2005 • 870 citations

B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells

2001 • 850 citations

Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression

2007 • 846 citations

Defective Suppressor Function in CD4+CD25+ T-Cells From Patients With Type 1 Diabetes

2005 • 825 citations

Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3

2007 • 819 citations

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

2008 • 814 citations

Immunoregulatory functions of mTOR inhibition

2009 • 808 citations

Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation

2007 • 804 citations

PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine

2001 • 786 citations

Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice

2005 • 783 citations

Cutting Edge: CD4+CD25+ Regulatory T Cells Suppress Antigen-Specific Autoreactive Immune Responses and Central Nervous System Inflammation During Active Experimental Autoimmune Encephalomyelitis

2002 • 779 citations

TNF downmodulates the function of human CD4+CD25hi T-regulatory cells

2006 • 768 citations

The Programmed Death-1 (PD-1) Pathway Regulates Autoimmune Diabetes in Nonobese Diabetic (NOD) Mice

2003 • 766 citations

PD‐1 signaling in primary T cells

2009 • 712 citations

The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

2008 • 710 citations

Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction

2008 • 705 citations

PD‐1 inhibits T‐cell receptor induced phosphorylation of the ZAP70/CD3ζ signalosome and downstream signaling to PKCθ

2004 • 697 citations

Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal

2009 • 694 citations

Rapamycin Promotes Expansion of Functional CD4+CD25+FOXP3+ Regulatory T Cells of Both Healthy Subjects and Type 1 Diabetic Patients

2006 • 693 citations

Recognition of the Peripheral Self by Naturally Arising CD25+ CD4+ T Cell Receptors

2004 • 690 citations

Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells

2003 • 674 citations

Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)

2008 • 658 citations

PD-1:PD-L inhibitory pathway affects both CD4+ and CD8+ T cells and is overcome by IL-2

2002 • 646 citations

Multiple immuno-regulatory defects in type-1 diabetes

2002 • 645 citations

CD4+CD25+ Regulatory T Cells Can Mediate Suppressor Function in the Absence of Transforming Growth Factor β1 Production and Responsiveness

2002 • 614 citations

PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells

2004 • 609 citations

Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses

2003 • 594 citations

Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3− precursor cells in the absence of interleukin 10

2007 • 576 citations

Oral tolerance

2005 • 573 citations

Cutting Edge: IL-2 Is Critically Required for the In Vitro Activation of CD4+CD25+ T Cell Suppressor Function

2004 • 572 citations

Plasma cells from multiple myeloma patients express B7-H1 (PD-L1) and increase expression after stimulation with IFN-γ and TLR ligands via a MyD88-, TRAF6-, and MEK-dependent pathway

2007 • 553 citations

Scurfin (FOXP3) Acts as a Repressor of Transcription and Regulates T Cell Activation

2001 • 551 citations

Multiple immuno-regulatory defects in type-1 diabetes

2002 • 548 citations

Natural Recovery and Protection from Autoimmune Encephalomyelitis: Contribution of CD4+CD25+ Regulatory Cells within the Central Nervous System

2005 • 545 citations

Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4

2005 • 532 citations

PD-1 Is Expressed by Tumor-Infiltrating Immune Cells and Is Associated with Poor Outcome for Patients with Renal Cell Carcinoma

2007 • 527 citations

A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells

2008 • 520 citations

Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells

2004 • 519 citations

Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans

2007 • 516 citations

Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo

2006 • 502 citations

Cutting Edge: IL-2 Is Essential for TGF-β-Mediated Induction of Foxp3+ T Regulatory Cells

2007 • 502 citations

Heterogeneity of natural Foxp3 ⁺ T cells: A committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity

2009 • 493 citations

Critical Role of the Programmed Death-1 (PD-1) Pathway in Regulation of Experimental Autoimmune Encephalomyelitis

2003 • 486 citations

The Common γ-Chain Cytokines IL-2, IL-7, IL-15, and IL-21 Induce the Expression of Programmed Death-1 and Its Ligands

2008 • 485 citations

Activated CD4+CD25+ T cells selectively kill B lymphocytes

2006 • 484 citations

Anti–TNF-α therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-β

2007 • 475 citations

Cutting Edge: Human CD4+CD25+ T Cells Restrain the Maturation and Antigen-Presenting Function of Dendritic Cells

2004 • 472 citations

PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis

2009 • 465 citations

Oral tolerance.

1994 • 456 citations

Characterization of Foxp3+CD4+CD25+ and IL-10-Secreting CD4+CD25+ T Cells during Cure of Colitis

2006 • 448 citations

CD4 ⁺ CD25 ⁺ T regulatory cells control anti-islet CD8 ⁺ T cells through TGF-β–TGF-β receptor interactions in type 1 diabetes

2003 • 439 citations

Endothelial expression of PD‐L1 and PD‐L2 down‐regulates CD8⁺ T cell activation and cytolysis

2003 • 436 citations

Interferon regulatory factor‐1 is prerequisite to the constitutive expression and IFN‐γ‐induced upregulation of B7‐H1 (CD274)

2006 • 413 citations

Establishment of NOD-Pdcd1^-/-mice as an efficient animal model of type I diabetes

2005 • 409 citations

CD4+CD25bright Regulatory T Cells Actively Regulate Inflammation in the Joints of Patients with the Remitting Form of Juvenile Idiopathic Arthritis

2004 • 403 citations

Reinvigorating exhausted HIV-specific T cells via PD-1–PD-1 ligand blockade

2006 • 396 citations

IL-12p35-Deficient Mice Are Susceptible to Experimental Autoimmune Encephalomyelitis: Evidence for Redundancy in the IL-12 System in the Induction of Central Nervous System Autoimmune Demyelination

2002 • 395 citations

Functional Defects and the Influence of Age on the Frequency of CD4+CD25+ T-Cells in Type 1 Diabetes

2005 • 384 citations

Effective treatment of collagen‐induced arthritis by adoptive transfer of CD25+ regulatory T cells

2005 • 378 citations

Induction of Treg by monocyte‐derived DC modulated by vitamin D₃ or dexamethasone: Differential role for PD‐L1

2009 • 373 citations

Foxp3+ Regulatory T Cells, Th17 Effector Cells, and Cytokine Environment in Inflammatory Bowel Disease

2009 • 368 citations

Structural and Functional Analysis of the Costimulatory Receptor Programmed Death-1

2004 • 365 citations

NFATc1 Regulates PD-1 Expression upon T Cell Activation

2008 • 362 citations

CD25brightCD4+regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease

2004 • 354 citations

Selective Survival of Naturally Occurring Human CD4+CD25+Foxp3+ Regulatory T Cells Cultured with Rapamycin

2007 • 335 citations

Mechanisms of costimulation

2009 • 329 citations

CD4+FoxP3+ regulatory T cells confer infectious tolerance in a TGF-β–dependent manner

2008 • 323 citations

CD4+ CD25+ T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis

2005 • 317 citations

CD25+ cell depletion hastens the onset of severe disease in collagen‐induced arthritis

2003 • 313 citations

Activation requirements for the induction of CD4⁺CD25⁺ T cell suppressor function

2004 • 307 citations

TGFβ signalling in control of T-cell-mediated self-reactivity

2007 • 294 citations

The Effector T Cells of Diabetic Subjects Are Resistant to Regulation via CD4+FOXP3+ Regulatory T Cells

2008 • 294 citations

CD40 Ligation Releases Immature Dendritic Cells from the Control of Regulatory CD4+CD25+ T Cells

2003 • 292 citations

Neuron-mediated generation of regulatory T cells from encephalitogenic T cells suppresses EAE

2006 • 291 citations

Control of immune pathology by regulatory T cells

1998 • 289 citations

Program Death-1 Engagement Upon TCR Activation Has Distinct Effects on Costimulation and Cytokine-Driven Proliferation: Attenuation of ICOS, IL-4, and IL-21, But Not CD28, IL-7, and IL-15 Responses

2003 • 272 citations

Costimulatory and coinhibitory receptors in anti‐tumor immunity

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The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells

2007 • 263 citations

T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD mice.

1989 • 257 citations

Expression and Regulation of the PD-L1 Immunoinhibitory Molecule on Microvascular Endothelial Cells

2002 • 256 citations

The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells

2008 • 251 citations

Differential Cytokine Requirements for Regulation of Autoimmune Gastritis and Colitis by CD4+CD25+T Cells

2001 • 246 citations

Endothelial Programmed Death-1 Ligand 1 (PD-L1) Regulates CD8 ⁺ T-Cell–Mediated Injury in the Heart

2007 • 244 citations

Developmentally regulated expression of the PD-1 protein on the surface of double-negative(CD4^–CD8^–) thymocytes

1996 • 243 citations

PD-1 Regulates Self-Reactive CD8+ T Cell Responses to Antigen in Lymph Nodes and Tissues

2007 • 237 citations

A PD‐1 polymorphism is associated with disease progression in multiple sclerosis

2005 • 229 citations

T-cell tolerance or function is determined by combinatorial costimulatory signals

2006 • 229 citations

Estrogen-mediated immunomodulation involves reduced activation of effector T cells, potentiation of treg cells, and enhanced expression of the PD-1 costimulatory pathway

2006 • 225 citations

PD-1 and CTLA-4 Inhibitory Cosignaling Pathways in HIV Infection and the Potential for Therapeutic Intervention

2009 • 225 citations

Aberrant Regulation of Synovial T Cell Activation by Soluble Costimulatory Molecules in Rheumatoid Arthritis

2006 • 221 citations

Regulatory T cells and autoimmune disease

2005 • 208 citations

Acute experimental autoimmune encephalomyelitis in mice

1982 • 207 citations

Autoantigen-Specific TGFβ-Induced Foxp3+ Regulatory T Cells Prevent Autoimmunity by Inhibiting Dendritic Cells from Activating Autoreactive T Cells

2007 • 204 citations

CD4+CD25high regulatory T cells in human autoimmune diabetes

2005 • 202 citations

MicroRNA-513 Regulates B7-H1 Translation and Is Involved in IFN-γ-Induced B7-H1 Expression in Cholangiocytes

2009 • 199 citations

Cellular and molecular characterization of the scurfy mouse mutant.

1999 • 197 citations

Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis

2009 • 196 citations

The scurfy mouse mutant has previously unrecognized hematological abnormalities and resembles Wiskott-Aldrich syndrome.

1990 • 195 citations

PD-1 on dendritic cells impedes innate immunity against bacterial infection

2009 • 195 citations

Human CD4+CD25+Foxp3+ Regulatory T Cells Do Not Constitutively Express IL-35

2008 • 194 citations

Regulatory T cells in the periphery

2006 • 189 citations

Myelin proteolipid protein-specific CD4⁺CD25⁺regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis

2004 • 186 citations

Antigen-specific peripheral shaping of the natural regulatory T cell population

2008 • 185 citations

CD4+CD8- T cells are the effector cells in disease pathogenesis in the scurfy (sf) mouse.

1994 • 182 citations

Facilitation of β Selection and Modification of Positive Selection in the Thymus of Pd-1–Deficient Mice

2000 • 181 citations

Defective Central Tolerance Induction in NOD Mice: Genomics and Genetics

2005 • 179 citations

PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis

2006 • 176 citations

T Cell-Mediated Maintenance of Natural Self-Tolerance: its Breakdown as a Possible Cause of Various Autoimmune Diseases

1996 • 175 citations

Expression of B7-H1 on Gastric Epithelial Cells: Its Potential Role in Regulating T Cells during Helicobacter pylori Infection

2006 • 172 citations

T-cell Clonal Anergy

1989 • 163 citations

The expression and function of costimulatory molecules B7H and B7-H1 on colonic epithelial cells

2004 • 160 citations

Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection

2004 • 160 citations

Cellular and Molecular Characterization of thescurfyMouse Mutant

1999 • 160 citations

Failure to induce oral tolerance to a soluble protein in patients with inflammatory bowel disease☆

2004 • 159 citations

Microglial Expression of the B7 Family Member B7 Homolog 1 Confers Strong Immune Inhibition: Implications for Immune Responses and Autoimmunity in the CNS

2005 • 156 citations

Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells

2004 • 150 citations

Cutting Edge: Murine Vascular Endothelium Activates and Induces the Generation of Allogeneic CD4+25+Foxp3+ Regulatory T Cells

2005 • 148 citations

Role of Lymphokine and Antigen in the Control of Specific T Cell Responses

1980 • 147 citations

Yin–Yang of costimulation: crucial controls of immune tolerance and function

2009 • 145 citations

Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells

2004 • 141 citations

CD4 ⁺ CD25 ⁺ Regulatory Cells from Human Peripheral Blood Express Very High Levels of CD25 Ex Vivo

2003 • 138 citations

Blockade of B7-H1 on Macrophages Suppresses CD4+ T Cell Proliferation by Augmenting IFN-γ-Induced Nitric Oxide Production

2005 • 134 citations

Mature mainstream TCR alpha beta+CD4+ thymocytes expressing L-selectin mediate "active tolerance" in the nonobese diabetic mouse.

1998 • 134 citations

The diversity of costimulatory and inhibitory receptor pathways and the regulation of antiviral T cell responses

2009 • 133 citations

Cutting Edge: Programed Death (PD) Ligand-1/PD-1 Interaction Is Required for CD8+ T Cell Tolerance to Tissue Antigens

2006 • 131 citations

TGF‐β‐induced Foxp3⁺ regulatory T cells rescue scurfy mice

2008 • 130 citations

The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells.

2005 • 126 citations

CD4⁺CD25⁺regulatory T cells limit the risk of autoimmune disease arising from T cell receptor crossreactivity

2005 • 125 citations

Disease in the scurfy (sf) mouse is associated with overexpression of cytokine genes

1996 • 120 citations

Role of Foxp3‐positive regulatory T cells during infection

2008 • 114 citations

Analysis of Adhesion Molecules, Target Cells, and Role of IL-2 in Human FOXP3+ Regulatory T Cell Suppressor Function

2009 • 112 citations

Cutting Edge: CD4+CD25+ Regulatory T Cells Contribute to Gender Differences in Susceptibility to Experimental Autoimmune Encephalomyelitis

2005 • 111 citations

Absence of Programmed Death Receptor 1 Alters Thymic Development and Enhances Generation of CD4/CD8 Double-Negative TCR-Transgenic T Cells

2003 • 110 citations

Blocking the Monocyte Chemoattractant Protein-1/CCR2 Chemokine Pathway Induces Permanent Survival of Islet Allografts through a Programmed Death-1 Ligand-1-Dependent Mechanism

2003 • 108 citations

Patients with relapsing-remitting multiple sclerosis have normal Treg function when cells expressing IL-7 receptor α-chain are excluded from the analysis

2008 • 105 citations

Mature Mainstream TCRαβ+CD4+ Thymocytes Expressing L-Selectin Mediate “Active Tolerance” in the Nonobese Diabetic Mouse

1998 • 103 citations

Expression of the Programmed Death Ligand 1, B7-H1, on Gastric Epithelial Cells afterHelicobacter pyloriExposure Promotes Development of CD4⁺CD25⁺FoxP3⁺Regulatory T Cells

2007 • 100 citations

Pertussis toxin as an adjuvant suppresses the number and function of CD4⁺CD25⁺ T regulatory cells

2006 • 99 citations

CD4+ PD-1+ T cells accumulate as unique anergic cells in rheumatoid arthritis synovial fluid.

2003 • 92 citations

Reevaluation of P-Selectin and α4 Integrin as Targets for the Treatment of Experimental Autoimmune Encephalomyelitis

2006 • 90 citations

Interferon-sensitive response element (ISRE) is mainly responsible for IFN-α-induced upregulation of programmed death-1 (PD-1) in macrophages

2008 • 85 citations

Protective Role of Programmed Death 1 Ligand 1 (PD-L1)in Nonobese Diabetic Mice

2008 • 81 citations

T cell Clones to Epitopes of Glutamic Acid Decarboxylase 65 Raised from Normal Subjects and Patients with Insulin-dependent Diabetes

1996 • 79 citations

PTX cruiser: driving autoimmunity via TLR4

2005 • 78 citations

Permeabilization in a cerebral endothelial barrier model by pertussis toxin involves the PKC effector pathway and is abolished by elevated levels of cAMP

2003 • 74 citations

FOXP3 Identifies Regulatory CD25^brightCD4⁺ T Cells in Rheumatic Joints

2006 • 71 citations

A Protective Role for C5a in the Development of Allergic Asthma Associated with Altered Levels of B7-H1 and B7-DC on Plasmacytoid Dendritic Cells

2009 • 70 citations

Pertussis Toxin Reduces the Number of Splenic Foxp3+ Regulatory T Cells

2006 • 66 citations

Control of Experimental Inflammatory Bowel Disease by Regulatory T cells

2000 • 63 citations

The effects of PDL-Ig on collagen-induced arthritis

2009 • 59 citations

The PD-1/PD-L pathway is up-regulated during IL-12-induced suppression of EAE mediated by IFN-gamma

2007 • 57 citations

Regulation of murine chronic colitis by CD4+CD25- programmed death-1+ T cells

2005 • 49 citations

FOXP3 expression in blood, synovial fluid and synovial tissue during inflammatory arthritis and intra-articular corticosteroid treatment

2008 • 46 citations

Interaction of Bordetella pertussis with mast cells, modulation of cytokine secretion by pertussis toxin

2001 • 45 citations

Down‐modulation of programmed death 1 alters regulatory T cells and promotes experimental autoimmune encephalomyelitis

2009 • 42 citations

Constitutive Neuronal Expression of the Immune Regulator, Programmed Death 1 (PD-1), Identified During Experimental Autoimmune Uveitis

2009 • 40 citations

Plasticity of Regulatory T Cells: Subversion of Suppressive Function and Conversion to Enhancement of Lung Allergic Responses

2008 • 35 citations

Minor myelin proteins can be majot targets for peripheral blood T cells from both multiple sclerosis patients and healthy subjects

1993 • 28 citations

CD21/35 Promotes Protective Immunity to Streptococcus pneumoniae through a Complement-Independent but CD19-Dependent Pathway That Regulates PD-1 Expression

2009 • 28 citations

Immunosenescent colitogenic CD4⁺ T cells convert to regulatory cells and suppress colitis

2008 • 28 citations

Expression and Regulation of the PD-L1 Immunoinhibitory Molecule on Microvascular Endothelial Cells

2002 • 25 citations