Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 • 4,853 citations

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

Tolerogenic Dendritic Cells

2003 • 3,131 citations

Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.

1992 • 2,906 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

2001 • 2,746 citations

Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

1999 • 2,574 citations

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.

1995 • 2,090 citations

Antigen Presentation and T Cell Stimulation by Dendritic Cells

2002 • 1,860 citations

Dendritic Cells Induce Peripheral T Cell Unresponsiveness under Steady State Conditions in Vivo

2001 • 1,845 citations

Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice

2001 • 1,761 citations

Induction of Interleukin 10–Producing, Nonproliferating Cd4+ T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic Cells

2000 • 1,577 citations

Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes

1996 • 1,473 citations

Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8+ T Cell Tolerance

2002 • 1,296 citations

Co-inhibitory molecules of the B7–CD28 family in the control of T-cell immunity

2004 • 1,213 citations

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

2001 • 1,043 citations

Induction of Peripheral T Cell Tolerance In Vivo Requires CTLA-4 Engagement

1997 • 736 citations

Induction and Exhaustion of Lymphocytic Choriomeningitis Virus–specific Cytotoxic T Lymphocytes Visualized Using Soluble Tetrameric Major Histocompatibility Complex Class I–Peptide Complexes

1998 • 733 citations

Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T Cells

1997 • 719 citations

The enemy within: keeping self-reactive T cells at bay in the periphery

2002 • 586 citations

In Vivo Detection of Dendritic Cell Antigen Presentation to CD4+ T Cells

1997 • 560 citations

Cutting Edge: Human CD4+CD25+ T Cells Restrain the Maturation and Antigen-Presenting Function of Dendritic Cells

2004 • 472 citations

The CD8α+ Dendritic Cell Is Responsible for Inducing Peripheral Self-Tolerance to Tissue-associated Antigens

2002 • 468 citations

Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24- or 96-well plates

1991 • 460 citations

Lymphocytic Choriomeningitis Virus

2016 • 423 citations

Dendritic Cell Function in Vivo during the Steady State: A Role in Peripheral Tolerance

2003 • 420 citations

CTLA-4-Mediated Inhibition of Early Events of T Cell Proliferation

1999 • 412 citations

Induction of CD4+/CD25+ regulatory T cells by targeting of antigens to immature dendritic cells

2003 • 392 citations

Constitutive Presentation of a Natural Tissue Autoantigen Exclusively by Dendritic Cells in the Draining Lymph Node

2002 • 387 citations

Impact of Negative Selection on the T Cell Repertoire Reactive to a Self-Peptide

2000 • 377 citations

Antigen-bearing immature dendritic cells induce peptide-specific CD8+ regulatory T cells in vivo in humans

2002 • 368 citations

Characterization of CTLA-4 structure and expression on human T cells.

1993 • 319 citations

Inducible Transgenic Mice Reveal Resting Dendritic Cells as Potent Inducers of CD8+ T Cell Tolerance

2003 • 309 citations

Metabolites, pharmacodynamics, and pharmacokinetics of tamoxifen in rats and mice compared to the breast cancer patient.

1991 • 267 citations

A Transgenic Model to Analyze the Immunoregulatory Role of IL-10 Secreted by Antigen-Presenting Cells

1999 • 257 citations

Death-defying immunity: do apoptotic cells influence antigen processing and presentation?

2004 • 254 citations

Dendritic Cells in Immunity and Tolerance—Do They Display Opposite Functions?

2003 • 237 citations

New regulatory co-receptors: inducible co-stimulator and PD-1

2002 • 227 citations

The anatomy of T-cell activation and tolerance.

1996 • 225 citations

Phenotypic and Functional Analysis of Cd8+ T Cells Undergoing Peripheral Deletion in Response to Cross-Presentation of Self-Antigen

2001 • 220 citations

Peripheral tolerance to an islet cell‐specific hemagglutinin transgene affects both CD4⁺ and CD8⁺ T cells

1992 • 217 citations

Promiscuous gene expression and central T-cell tolerance: more than meets the eye

2002 • 198 citations

A Bcl-2-dependent molecular timer regulates the lifespan and immunogenicity of dendritic cells

2004 • 190 citations

Facilitation of β Selection and Modification of Positive Selection in the Thymus of Pd-1–Deficient Mice

2000 • 181 citations

Antigen Concentration and Precursor Frequency Determine the Rate of CD8+ T Cell Tolerance to Peripherally Expressed Antigens

1999 • 174 citations

CTLA-4 Regulates Tolerance Induction and T Cell Differentiation In Vivo

1998 • 174 citations

Gene defect behind APECED: a new clue to autoimmunity

1998 • 154 citations

Tolerance to Islet Antigens and Prevention from Diabetes Induced by Limited Apoptosis of Pancreatic β Cells

2002 • 151 citations

Absence of Programmed Death Receptor 1 Alters Thymic Development and Enhances Generation of CD4/CD8 Double-Negative TCR-Transgenic T Cells

2003 • 110 citations

Immunodominance of an Antiviral Cytotoxic T Cell Response Is Shaped by the Kinetics of Viral Protein Expression

2003 • 104 citations

Myeloid marker expression on antiviral CD8⁺ T cells following an acute virus infection

2003 • 71 citations

Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Can Regulate Dendritic Cell–induced Activation and Cytotoxicity of CD8+ T Cells Independently of CD4+T Cell Help

1999 • 69 citations

Cutting Edge: Competition for APC by CTLs of Different Specificities Is Not Functionally Important During Induction of Antiviral Responses

2002 • 45 citations