Yin–Yang of costimulation: crucial controls of immune tolerance and function

Innate Immune Recognition

2002 • 8,157 citations

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 • 4,853 citations

Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

2005 • 4,573 citations

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

2005 • 4,165 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.

1992 • 2,906 citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

2001 • 2,746 citations

Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

1999 • 2,574 citations

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

1999 • 2,380 citations

IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

2007 • 2,031 citations

IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells

2007 • 1,808 citations

Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice

2001 • 1,761 citations

Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma

2003 • 1,564 citations

T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines.

1996 • 1,496 citations

Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes

1996 • 1,473 citations

Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

2007 • 1,446 citations

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

1999 • 1,418 citations

T Cell Anergy

2003 • 1,418 citations

Follicular B Helper T Cells Express Cxc Chemokine Receptor 5, Localize to B Cell Follicles, and Support Immunoglobulin Production

2000 • 1,379 citations

Suppression of Immune Induction of Collagen-Induced Arthritis in IL-17-Deficient Mice

2003 • 1,280 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

Cxc Chemokine Receptor 5 Expression Defines Follicular Homing T Cells with B Cell Helper Function

2000 • 1,188 citations

Tissue expression of PD-L1 mediates peripheral T cell tolerance

2006 • 1,145 citations

Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell Lineages

2008 • 1,138 citations

TH17 cells in development: an updated view of their molecular identity and genetic programming

2008 • 1,040 citations

Human IL-17: a novel cytokine derived from T cells.

1995 • 1,014 citations

Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium

1999 • 943 citations

B7-H3: A costimulatory molecule for T cell activation and IFN-γ production

2001 • 916 citations

Expression of Programmed Death 1 Ligands by Murine T Cells and APC

2002 • 908 citations

ICOS co-stimulatory receptor is essential for T-cell activation and function

2001 • 902 citations

A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

2005 • 856 citations

B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells

2001 • 850 citations

PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine

2001 • 786 citations

Antigen-specific regulatory T cells develop via the ICOS–ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity

2002 • 785 citations

The Programmed Death-1 (PD-1) Pathway Regulates Autoimmune Diabetes in Nonobese Diabetic (NOD) Mice

2003 • 766 citations

T-cell co-stimulation through B7RP-1 and ICOS

1999 • 758 citations

B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma

2006 • 705 citations

A Fundamental Role for Interleukin-21 in the Generation of T Follicular Helper Cells

2008 • 702 citations

PD‐1 inhibits T‐cell receptor induced phosphorylation of the ZAP70/CD3ζ signalosome and downstream signaling to PKCθ

2004 • 697 citations

ICOS is essential for effective T-helper-cell responses

2001 • 666 citations

B7-H4, a Molecule of the B7 Family, Negatively Regulates T Cell Immunity

2003 • 665 citations

Regulation of B Cell Differentiation and Plasma Cell Generation by IL-21, a Novel Inducer of Blimp-1 and Bcl-6

2004 • 648 citations

ICOS is critical for CD40-mediated antibody class switching

2001 • 646 citations

Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses

2003 • 594 citations

Follicular B helper T cells in antibody responses and autoimmunity

2005 • 592 citations

PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells

2003 • 584 citations

The B7 family member B7-H3 preferentially down-regulates T helper type 1–mediated immune responses

2003 • 516 citations

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

2004 • 512 citations

The CD28-Related Molecule ICOS Is Required for Effective T Cell–Dependent Immune Responses

2000 • 507 citations

B7-1 and B7-2 Have Overlapping, Critical Roles in Immunoglobulin Class Switching and Germinal Center Formation

1997 • 499 citations

Critical Role of the Programmed Death-1 (PD-1) Pathway in Regulation of Experimental Autoimmune Encephalomyelitis

2003 • 486 citations

Sarcoidosis is associated with a truncating splice site mutation in BTNL2

2005 • 477 citations

CD4+CD25+ T Regulatory Cells Dependent on ICOS Promote Regulation of Effector Cells in the Prediabetic Lesion

2004 • 443 citations

B7h, a Novel Costimulatory Homolog of B7.1 and B7.2, Is Induced by TNFα

1999 • 440 citations

Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation

2005 • 428 citations

Mouse Inducible Costimulatory Molecule (ICOS) Expression Is Enhanced by CD28 Costimulation and Regulates Differentiation of CD4+ T Cells

2000 • 423 citations

Establishment of NOD-Pdcd1^-/-mice as an efficient animal model of type I diabetes

2005 • 409 citations

Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA

2007 • 408 citations

B7S1, a Novel B7 Family Member that Negatively Regulates T Cell Activation

2003 • 407 citations

IL-1-Independent Role of IL-17 in Synovial Inflammation and Joint Destruction During Collagen-Induced Arthritis

2001 • 396 citations

Costimulatory regulation of T cell function

1999 • 391 citations

B7x: A widely expressed B7 family member that inhibits T cell activation

2003 • 380 citations

The Transcription Factor c-Maf Controls the Production of Interleukin-4 but Not Other Th2 Cytokines

1999 • 377 citations

ICOS Deficiency Is Associated with a Severe Reduction of CXCR5+CD4 Germinal Center Th Cells

2006 • 375 citations

The Role of ICOS in the CXCR5+ Follicular B Helper T Cell Maintenance In Vivo

2005 • 360 citations

B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome

2007 • 358 citations

Murine B7-H3 Is a Negative Regulator of T Cells

2004 • 332 citations

c-maf Promotes T Helper Cell Type 2 (Th2) and Attenuates Th1 Differentiation by Both Interleukin 4–dependent and –independent Mechanisms

1998 • 303 citations

B7-H4 expression in renal cell carcinoma and tumor vasculature: Associations with cancer progression and survival

2006 • 289 citations

Molecular Modeling and Functional Mapping of B7-H1 and B7-DC Uncouple Costimulatory Function from PD-1 Interaction

2003 • 285 citations

GRAIL

2003 • 280 citations

Cutting Edge: Induction of B7-H4 on APCs through IL-10: Novel Suppressive Mode for Regulatory T Cells

2006 • 277 citations

Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal γδ T cells

2008 • 273 citations

Blockade of the interleukin‐21/interleukin‐21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis

2007 • 273 citations

Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues

2002 • 269 citations

Characterization of Mouse and Human B7-H3 Genes

2002 • 267 citations

Molecular Characterization of Human 4Ig-B7-H3, a Member of the B7 Family with Four Ig-Like Domains

2004 • 252 citations

Expression of ICOS In Vivo Defines CD4+ Effector T Cells with High Inflammatory Potential and a Strong Bias for Secretion of Interleukin 10

2003 • 247 citations

Genomic Organization and Expression Analysis of B7-H4, an Immune Inhibitory Molecule of the B7 Family

2003 • 238 citations

T-cell tolerance or function is determined by combinatorial costimulatory signals

2006 • 229 citations

E3 ubiquitin ligases as T cell anergy factors

2004 • 224 citations

The BTNL2 Gene and Sarcoidosis Susceptibility in African Americans and Whites

2005 • 218 citations

Impaired Regulatory T-Cell Response and Enhanced Atherosclerosis in the Absence of Inducible Costimulatory Molecule

2006 • 212 citations

Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses

2008 • 203 citations

Cutting Edge: Critical Role of Inducible Costimulator in Germinal Center Reactions

2001 • 203 citations

Studies using antigen-presenting cells lacking expression of both B7-1 (CD80) and B7-2 (CD86) show distinct requirements for B7 molecules during priming versus restimulation of Th2 but not Th1 cytokine production.

1998 • 198 citations

BTNL2, a Butyrophilin-Like Molecule That Functions to Inhibit T Cell Activation

2006 • 179 citations

Studies Using Antigen-Presenting Cells Lacking Expression of Both B7-1 (CD80) and B7-2 (CD86) Show Distinct Requirements for B7 Molecules During Priming Versus Restimulation of Th2 But Not Th1 Cytokine Production

1998 • 175 citations

Blockade of B7-H1 Suppresses the Development of Chronic Intestinal Inflammation

2003 • 168 citations

Duplication of primate and rodent B7-H3 immunoglobulin V- and C-like domains: divergent history of functional redundancy and exon loss

2003 • 163 citations

A Critical Role for B7/CD28 Costimulation in Experimental Autoimmune Encephalomyelitis: A Comparative Study Using Costimulatory Molecule-Deficient Mice and Monoclonal Antibody Blockade

2000 • 160 citations

Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection

2004 • 160 citations

Regulation of T cell activation and tolerance by PDL2

2006 • 159 citations

In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responses

2005 • 152 citations

Overexpression of IL-17 in the knee joint of collagen type II immunized mice promotes collagen arthritis and aggravates joint destruction

2002 • 151 citations

Transcriptional Regulation of Th2 Differentiation by Inducible Costimulator

2003 • 149 citations

Cloning and analysis of cDNA encoding bovine butyrophilin, an apical glycoprotein expressed in mammary tissue and secreted in association with the milk-fat globule membrane during lactation.

1990 • 148 citations

Amelioration of Collagen-Induced Arthritis by Blockade of Inducible Costimulator-B7 Homologous Protein Costimulation

2002 • 143 citations

BTNL2, a Butyrophilin/B7-Like Molecule, Is a Negative Costimulatory Molecule Modulated in Intestinal Inflammation

2007 • 133 citations

Cutting Edge: Programed Death (PD) Ligand-1/PD-1 Interaction Is Required for CD8+ T Cell Tolerance to Tissue Antigens

2006 • 131 citations

Evolutionary study of multigenic families mapping close to the human MHC class I region

1993 • 123 citations

Oral tolerance induced by continuous feeding: enhanced up-regulation of transforming growth factor-β/interleukin-10 and suppression of experimental autoimmune encephalomyelitis

2003 • 120 citations

B30.2-like domain proteins: update and new insights into a rapidly expanding family of proteins

1998 • 113 citations

B7h is required for T cell activation, differentiation, and effector function

2003 • 109 citations

Interleukin‐21 Induces T‐cell Activation and Proinflammatory Cytokine Secretion in Rheumatoid Arthritis

2006 • 103 citations

CD28-Deficient Mice Are Highly Resistant to Collagen-Induced Arthritis

1999 • 99 citations

The Gene Related to Anergy in Lymphocytes, an E3 Ubiquitin Ligase, Is Necessary for Anergy Induction in CD4 T Cells

2004 • 99 citations

Regulation of immune and autoimmune responses by ICOS

2003 • 87 citations

The immune regulatory protein B7-H3 promotes osteoblast differentiation and bone mineralization

2004 • 87 citations

A 1.1-Mb Transcript Map of the Hereditary Hemochromatosis Locus

1997 • 84 citations

BTL-II : a polymorphic locus with homology to the butyrophilin gene family, located at the border of the major histocompatibility complex class II and class III regions in human and mouse

2000 • 77 citations

Extending the B7 (CD80) gene family

1994 • 75 citations

The ICOS Molecule Plays a Crucial Role in the Development of Mucosal Tolerance

2005 • 75 citations

Generation and Characterization of B7-H4/B7S1/B7x-Deficient Mice

2006 • 74 citations

Impaired germinal center formation and recall T-cell–dependent immune responses in mice lacking the costimulatory ligand B7-H2

2003 • 74 citations

Analysis of a Functional BTNL2 Polymorphism in Type 1 Diabetes, Rheumatoid Arthritis, and Systemic Lupus Erythematosus

2005 • 73 citations

Interactions of T Cells with Fibroblast-Like Synoviocytes: Role of the B7 Family Costimulatory Ligand B7-H3

2008 • 66 citations

Butyrophilin Is Expressed in Mammary Epithelial Cells from a Single-sized Messenger RNA as a Type I Membrane Glycoprotein

1998 • 64 citations

Two major histocompatibility complex haplotypes influence susceptibility to sporadic inclusion body myositis: critical evaluation of an association with HLA‐DR3

2004 • 63 citations

Cloning, structural analysis, and mapping of the B30 and B7 multigenic families to the major histocompatibility complex (MHC) and other chromosomal regions

1997 • 56 citations

E3 Ligases in T Cell Anergy—Turning Immune Responses into Tolerance

2004 • 54 citations

B7-H3 regulates the development of experimental allergic conjunctivitis in mice

2007 • 48 citations

Cloning, localization, and structure of new members of the butyrophilin gene family in the juxta-telomeric region of the major histocompatibility complex

1997 • 48 citations

Association of the truncating splice site mutation in BTNL2 with multiple sclerosis is secondary to HLA-DRB1*15

2005 • 45 citations

Intranasal peptide-induced peripheral tolerance: the role of IL-10 in regulatory T cell function within the context of experimental autoimmune encephalomyelitis

2002 • 36 citations

A Costimulation-Initiated Signaling Pathway Regulates NFATc1 Transcription in T Lymphocytes

2007 • 33 citations

B7-H3 Contributes to the Development of Pathogenic Th2 Cells in a Murine Model of Asthma

2008 • 29 citations

Characterization of B7S3 as a Novel Negative Regulator of T Cells

2007 • 18 citations