Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal

PD-1 and Its Ligands in Tolerance and Immunity

2008 • 4,838 citations

Restoring function in exhausted CD8 T cells during chronic viral infection

2005 • 3,743 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms

2005 • 1,746 citations

T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases

2004 • 1,657 citations

Programmed Death-1 Ligand 1 Interacts Specifically with the B7-1 Costimulatory Molecule to Inhibit T Cell Responses

2007 • 1,603 citations

Two-Photon Imaging of Lymphocyte Motility and Antigen Response in Intact Lymph Node

2002 • 1,177 citations

Tissue expression of PD-L1 mediates peripheral T cell tolerance

2006 • 1,145 citations

SHP-1 and SHP-2 Associate with Immunoreceptor Tyrosine-Based Switch Motif of Programmed Death 1 upon Primary Human T Cell Stimulation, but Only Receptor Ligation Prevents T Cell Activation

2004 • 1,128 citations

Control of peripheral T‐cell tolerance and autoimmunity via the CTLA‐4 and PD‐1 pathways

2008 • 951 citations

Expression of Programmed Death 1 Ligands by Murine T Cells and APC

2002 • 908 citations

Stromal Cell Networks Regulate Lymphocyte Entry, Migration, and Territoriality in Lymph Nodes

2006 • 907 citations

Visualizing dendritic cell networks in vivo

2004 • 790 citations

Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice

2005 • 783 citations

The Programmed Death-1 (PD-1) Pathway Regulates Autoimmune Diabetes in Nonobese Diabetic (NOD) Mice

2003 • 766 citations

Following a diabetogenic T cell from genesis through pathogenesis

1993 • 708 citations

Transcriptional Mechanisms Underlying Lymphocyte Tolerance

2002 • 658 citations

Reversal of the TCR Stop Signal by CTLA-4

2006 • 584 citations

Imaging the Single Cell Dynamics of CD4+ T Cell Activation by Dendritic Cells in Lymph Nodes

2004 • 537 citations

Two-photon tissue imaging: seeing the immune system in a fresh light

2002 • 482 citations

Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses

1998 • 469 citations

Polarity of T Cell Shape, Motility, and Sensitivity to Antigen

1996 • 438 citations

Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4 ⁺ T Cells

1996 • 438 citations

Antigen receptor engagement delivers a stop signal to migrating T lymphocytes

1997 • 386 citations

Distinct T cell dynamics in lymph nodes during the induction of tolerance and immunity

2004 • 354 citations

Stable T cell–dendritic cell interactions precede the development of both tolerance and immunity in vivo

2005 • 322 citations

Insulin-induced remission in new-onset NOD mice is maintained by the PD-1–PD-L1 pathway

2006 • 303 citations

Transgenic mice with green fluorescent protein-labeled pancreatic β-cells

2003 • 299 citations

Intravital Microscopy

2004 • 289 citations

Dynamic imaging of the immune system: progress, pitfalls and promise

2006 • 270 citations

Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues

2002 • 269 citations

Developmentally regulated expression of the PD-1 protein on the surface of double-negative(CD4^–CD8^–) thymocytes

1996 • 243 citations

Intercellular Adhesion Molecule-1-Dependent Stable Interactions between T Cells and Dendritic Cells Determine CD8+ T Cell Memory

2008 • 243 citations

Identification of MHC Class II-Restricted Peptide Ligands, Including a Glutamic Acid Decarboxylase 65 Sequence, that Stimulate Diabetogenic T Cells from Transgenic BDC2.5 Nonobese Diabetic Mice

2001 • 213 citations

Real-Time Manipulation of T Cell-Dendritic Cell Interactions In Vivo Reveals the Importance of Prolonged Contacts for CD4+ T Cell Activation

2007 • 187 citations

INHIBITION OF TRANSPLANT REJECTION FOLLOWING TREATMENT WITH ANTI-B7-2 AND ANTI-B7-1 ANTIBODIES

1995 • 165 citations

Dendritic Cell Maturation Controls Adhesion, Synapse Formation, and the Duration of the Interactions with Naive T Lymphocytes

2004 • 141 citations

Negative Regulation of T Cell Receptor–Lipid Raft Interaction by Cytotoxic T Lymphocyte–associated Antigen 4

2003 • 122 citations

Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells

2000 • 102 citations

Dynamic Behavior of T Cells and Thymocytes in Lymphoid Organs as Revealed by Two-Photon Microscopy

2004 • 99 citations

Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice

2007 • 95 citations

CTLA-4 and Tolerance: The Biochemical Point of View

2003 • 77 citations

Tyrosine Phosphatase SHP-2 Binding to CTLA-4: Absence of Direct YVKM/YFIP Motif Recognition

2000 • 71 citations

Restricted Clonal Expression of IL-2 By Naive T Cells Reflects Differential Dynamic Interactions with Dendritic Cells

2003 • 52 citations

Cellular orchestration of T cell priming in lymph nodes

2006 • 31 citations

Phospho-specific flow cytometry: intersection of immunology and biochemistry at the single-cell level.

2006 • 26 citations

TCR/CD3 mediated stop-signal is decoupled in T-cells from Ctla4 deficient mice

2007 • 22 citations

In Vivo Anergized T Cells Form Altered Immunological Synapses In Vitro

2006 • 17 citations

Inverse Rap1 and Phospho-ERK Expression Discriminate the Maintenance Phase of Tolerance and Priming of Antigen-Specific CD4+ T Cells In Vitro and In Vivo

2007 • 17 citations