Endothelial expression of PD‐L1 and PD‐L2 down‐regulates CD8⁺ T cell activation and cytolysis

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 • 4,853 citations

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

2001 • 2,746 citations

Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

1999 • 2,574 citations

Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice

2001 • 1,761 citations

The B7–CD28 superfamily

2002 • 1,646 citations

Blockade of Programmed Death-1 Ligands on Dendritic Cells Enhances T Cell Activation and Cytokine Production

2003 • 933 citations

The B7 Family of Ligands and Its Receptors: New Pathways for Costimulation and Inhibition of Immune Responses

2002 • 884 citations

Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses

2003 • 594 citations

B7-H1 Is Expressed by Human Endothelial Cells and Suppresses T Cell Cytokine Synthesis

2002 • 313 citations

Endothelial-leukocyte adhesion molecule-1-dependent and leukocyte (CD11/CD18)-dependent mechanisms contribute to polymorphonuclear leukocyte adhesion to cytokine-activated human vascular endothelium.

1989 • 288 citations

Functional interactions of T cells with endothelial cells: the role of CD40L-CD40-mediated signals.

1995 • 280 citations

Program Death-1 Engagement Upon TCR Activation Has Distinct Effects on Costimulation and Cytokine-Driven Proliferation: Attenuation of ICOS, IL-4, and IL-21, But Not CD28, IL-7, and IL-15 Responses

2003 • 272 citations

Interferon-gamma deficiency prevents coronary arteriosclerosis but not myocardial rejection in transplanted mouse hearts.

1997 • 272 citations

B7-H1 (Programmed Death-1 Ligand) on Dendritic Cells Is Involved in the Induction and Maintenance of T Cell Anergy

2003 • 263 citations

Expression and Regulation of the PD-L1 Immunoinhibitory Molecule on Microvascular Endothelial Cells

2002 • 256 citations

Programmed Death-1 Targeting Can Promote Allograft Survival

2002 • 236 citations

Non-hematopoietic allograft cells directly activate CD8+ T cells and trigger acute rejection: An alternative mechanism of allorecognition

2002 • 231 citations

Human interleukin 1 induces interleukin 1 gene expression in human vascular smooth muscle cells.

1987 • 223 citations

Induction of ovalbumin-specific cytotoxic T cells by in vivo peptide immunization.

1989 • 220 citations

Costimulating aberrant T cell responses by B7-H1 autoantibodies in rheumatoid arthritis

2003 • 185 citations

Negative co-receptors on lymphocytes

2002 • 164 citations

CAN GRAFT ENDOTHELIAL CELLS INITIATE A HOST ANTI-GRAFT IMMUNE RESPONSE?1

1996 • 163 citations

Heterogeneity of Endothelial Cells from Different Organ Sites in T-Cell Subset Recruitment

2003 • 148 citations

Endothelial cells augment T cell interleukin 2 production by a contact-dependent mechanism involving CD2/LFA-3 interaction.

1990 • 143 citations

Human Endothelial Cells Effectively Costimulate Cytokine Production by, But Not Differentiation of, Naive CD4+ T Cells

1998 • 136 citations

Dual Role of the IL-12/IFN-γ Axis in the Development of Autoimmune Myocarditis: Induction by IL-12 and Protection by IFN-γ

2001 • 134 citations

Immunologic Interactions of T Lymphocytes with Vascular Endothelium

1991 • 123 citations

Human Endothelial Cell Presentation of Antigen and the Homing of Memory/Effector T Cells to Skin

2001 • 116 citations

The right place at the right time: novel B7 family members regulate effector T cell responses

2002 • 113 citations

Immunobiology of human vascular endothelium

1999 • 106 citations

Human Vascular Endothelial Cells Stimulate Memory But Not Naive CD8+ T Cells to Differentiate into CTL Retaining an Early Activation Phenotype

2000 • 101 citations

IL-12 is required for differentiation of pathogenic CD8+ T cell effectors that cause myocarditis

2003 • 95 citations

IL-12 is required for differentiation of pathogenic CD8+ T cell effectors that cause myocarditis

2003 • 91 citations

Human Endothelial Cells Induce and Regulate Cytolytic T Cell Differentiation

1998 • 80 citations

Mouse Vascular Endothelium Activates CD8+ T Lymphocytes in a B7-Dependent Fashion

2002 • 79 citations

Naturally Occurring Human IgM Antibody That Binds B7-DC and Potentiates T Cell Stimulation by Dendritic Cells

2003 • 69 citations

Human vascular endothelial cells process and present autoantigen to human T cell lines

1995 • 65 citations

Endothelial cell lymphocyte function-associated antigen-3 and an unidentified ligand act in concert to provide costimulation to human peripheral blood CD4+ T cells

1991 • 65 citations

Human endothelial cell costimulation of T cell IFN-gamma production.

1997 • 58 citations

Endothelial Antigen Presentation: Stimulation of Previously Activated but Not Naı̈ve TCR-Transgenic Mouse T Cells

1998 • 49 citations

Activated Murine Endothelial Cells Have Reduced Immunogenicity for CD8+ T Cells: A Mechanism of Immunoregulation?

2000 • 47 citations

The problem of chronic rejection: influence of leukocyte-endothelial interactions.

1997 • 26 citations

Expression and Regulation of the PD-L1 Immunoinhibitory Molecule on Microvascular Endothelial Cells

2002 • 25 citations