Defective Suppressor Function in CD4+CD25+ T-Cells From Patients With Type 1 Diabetes

Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus

2002 • 10,002 citations

Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus

1997 • 6,073 citations

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

CD4+CD25+ suppressor T cells: more questions than answers

2002 • 2,202 citations

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

2003 • 2,181 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

CD4+CD25high Regulatory Cells in Human Peripheral Blood

2001 • 1,882 citations

Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis

2004 • 1,835 citations

Regulatory T Cells

2000 • 1,827 citations

Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral Blood

2001 • 1,293 citations

Anti-CD3 Monoclonal Antibody in New-Onset Type 1 Diabetes Mellitus

2002 • 1,189 citations

Ex Vivo Isolation and Characterization of Cd4+Cd25+ T Cells with Regulatory Properties from Human Blood

2001 • 1,168 citations

Human Cd25+Cd4+ T Regulatory Cells Suppress Naive and Memory T Cell Proliferation and Can Be Expanded in Vitro without Loss of Function

2001 • 1,008 citations

CTLA-4: new insights into its biological function and use in tumor immunotherapy

2002 • 923 citations

Cutting Edge: Control of CD8+ T Cell Activation by CD4+CD25+ Immunoregulatory Cells

2001 • 743 citations

Type-I Diabetes: A Chronic Autoimmune Disease of Human, Mouse, and Rat

1990 • 650 citations

Multiple immuno-regulatory defects in type-1 diabetes

2002 • 645 citations

Human CD4+CD25+ cells: a naturally occurring population of regulatory T cells

2001 • 615 citations

Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes.

1992 • 592 citations

The enemy within: keeping self-reactive T cells at bay in the periphery

2002 • 586 citations

Multiple immuno-regulatory defects in type-1 diabetes

2002 • 548 citations

CD80 (B7-1) Binds Both CD28 and CTLA-4 with a Low Affinity and Very Fast Kinetics

1997 • 525 citations

Human CD4+CD25+ thymocytes and peripheral T cells have immune suppressive activityin vitro

2001 • 498 citations

Cytotoxic T Lymphocyte Antigen-4 Accumulation in the Immunological Synapse Is Regulated by TCR Signal Strength

2002 • 497 citations

Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health

2004 • 482 citations

CYCLOSPORIN INCREASES THE RATE AND LENGTH OF REMISSIONS IN INSULIN-DEPENDENT DIABETES OF RECENT ONSET

1986 • 443 citations

Regulatory T cells under scrutiny

2003 • 427 citations

The role of T-cells in the pathogenesis of Type 1 diabetes: From cause to cure

2003 • 410 citations

CTLA4 Alanine-17 Confers Genetic Susceptibility to Graves’ Disease and to Type 1 Diabetes Mellitus¹

1997 • 408 citations

Defective Suppressor Function of Human CD4+ CD25+ Regulatory T Cells in Autoimmune Polyglandular Syndrome Type II

2004 • 359 citations

The interleukin-2 receptor.

1991 • 354 citations

Suppressor T cells – they’re back and critical for regulation of autoimmunity!

2001 • 289 citations

A polymorphism in the human cytotoxic T-lymphocyte antigen 4 ( CTLA4 ) gene (exon 1 +49) alters T-cell activation

2002 • 288 citations

Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes

1992 • 275 citations

CTLA4 Alanine-17 Confers Genetic Susceptibility to Graves' Disease and to Type 1 Diabetes Mellitus

1997 • 270 citations

Inhibition of Human CD4+CD25+high Regulatory T Cell Function

2002 • 266 citations

CD4+ regulatory T cells

2001 • 241 citations

A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin

2001 • 210 citations

T cell autoreactivity to insulin in diabetic and related non-diabetic individuals.

1988 • 100 citations

T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes.

2000 • 74 citations

Kinetics of Cytokine Release and Expression of Lymphocyte Cell‐Surface Activation Markers After In Vitro Stimulation of Human Peripheral Blood Mononuclear Cells with Streptococcus pneumoniae

1999 • 50 citations

Antigen presenting cells and the immunogenetics of autoimmune diabetes in NOD mice.

1992 • 37 citations

The majority of the activated T cells in the blood of insulin-dependent diabetes mellitus (IDDM) patients are CD4+.

1988 • 32 citations

Islet autoantibodies and their use in predicting insulin-dependent diabetes

1997 • 29 citations

Detection of GAD65-Reactive T-Cells in Type 1 Diabetes by Immunoglobulin-Free ELISPOT Assays

2002 • 27 citations

Increased CD69 and Human Leukocyte Antigen-DR Expression on T Lymphocytes in Insulin-Dependent Diabetes Mellitus of Long Standing

1998 • 19 citations

Regulation of Virally Induced Autoimmunity and Immunopathology: Contribution of LCMV Transgenic Models to Understanding Autoimmune Insulin-Dependent Diabetes Mellitus

2002 • 16 citations