Absence of Programmed Death Receptor 1 Alters Thymic Development and Enhances Generation of CD4/CD8 Double-Negative TCR-Transgenic T Cells

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 • 4,853 citations

Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

2002 • 4,625 citations

Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.

1992 • 2,906 citations

Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

2002 • 2,879 citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

2001 • 2,746 citations

Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

1999 • 2,574 citations

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

1999 • 2,380 citations

Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice

2001 • 1,761 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes

1996 • 1,473 citations

Negative selection of lymphocytes

1994 • 810 citations

PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine

2001 • 786 citations

Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice

1988 • 505 citations

Selective Events in T Cell Development

1994 • 486 citations

Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses

1998 • 469 citations

Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression

2000 • 448 citations

The thymus selects the useful, neglects the useless and destroys the harmful

1989 • 378 citations

Fine Tuning of TCR Signaling by CD5

2001 • 270 citations

Mice lacking major histocompatibility complex class I and class II molecules.

1993 • 259 citations

Developmentally regulated expression of the PD-1 protein on the surface of double-negative(CD4^–CD8^–) thymocytes

1996 • 243 citations

Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules.

1989 • 231 citations

Facilitation of β Selection and Modification of Positive Selection in the Thymus of Pd-1–Deficient Mice

2000 • 181 citations

Attachment of an anti-receptor antibody to non-target cells renders them susceptible to lysis by a clone of cytotoxic T lymphocytes.

1984 • 178 citations

Most gamma delta T cells develop normally in beta 2-microglobulin-deficient mice.

1992 • 147 citations

The level of CD8 expression can determine the outcome of thymic selection

1992 • 134 citations

Tumor rejection requires a CTLA4 ligand provided by the host or expressed on the tumor: superiority of B7-1 over B7-2 for active tumor immunization.

1996 • 128 citations

B7-1 but not B7-2 efficiently costimulates CD8+ T lymphocytes in the P815 tumor system in vitro.

1996 • 123 citations

Premature Expression of T Cell Receptor (Tcr)αβ Suppresses Tcrγδ Gene Rearrangement but Permits Development of γδ Lineage T Cells

2000 • 123 citations

Production, selection, and maturation of thymocytes with high surface density of TCR.

1994 • 113 citations

The kinetics of immature murine thymocyte development in vivo

1990 • 77 citations

Positive and Negative Thymocyte Selection

1998 • 72 citations

Improved efficacy of dendritic cell vaccines and successful immunization with tumor antigen peptide-pulsed peripheral blood mononuclear cells by coadministration of recombinant murine interleukin-12

1999 • 68 citations

Positive selection is not required for thymic maturation of transgenic gamma delta T cells.

1996 • 66 citations

Interactions between double positive thymocytes and high affinity ligands presented by cortical epithelial cells generate double negative thymocytes with T cell regulatory activity

2002 • 54 citations

CD5-mediated inhibition of TCR signaling during intrathymic selection and development does not require the CD5 extracellular domain

2002 • 48 citations

Defective development of thymocytes overexpressing the costimulatory molecule, heat-stable antigen.

1994 • 48 citations

Absence of CTLA-4 Lowers the Activation Threshold of Primed CD8+ TCR-Transgenic T Cells: Lack of Correlation with Src Homology Domain 2-Containing Protein Tyrosine Phosphatase

2001 • 47 citations

Early TCRα expression generates TCRαγ complexes that signal the DN-to-DP transition and impair development

2002 • 42 citations

Reduced generation but efficient TCR beta-chain selection of CD4+8+ double-positive thymocytes in mice with compromised CD3 complex signaling.

1999 • 17 citations

Reduced Generation but Efficient TCRβ-Chain Selection of CD4+8+ Double-Positive Thymocytes in Mice with Compromised CD3 Complex Signaling

1999 • 13 citations

Early Onset of CD8 Transgene Expression Inhibits the Transition from DN3 to DP Thymocytes

2000 • 12 citations

A signal strength hypothesis of thymic selection: preliminary considerations

1995 • 11 citations

Positive Selection of Thymocytes Expressing the Same TCR by Different MHC Ligands Results in the Production of Functionally Distinct Thymocytes Distinguished by Differential Expression of the Heat Stable Antigen

1998 • 11 citations

The influence of rearranged T cell receptor αβ transgenes on early thymocyte development

1993 • 9 citations

B7-1 Overexpression by Thymic Epithelial Cells Results in Transient and Long-Lasting Effects on Thymocytes and Peripheral T Helper Cells but Does Not Result in Immunodeficiency

1999 • 9 citations

Enhanced T Cell Maturation and Altered Lineage Commitment in T Cell Receptor/CD4-Transgenic Mice

1995 • 7 citations