Pertussis Toxin Reduces the Number of Splenic Foxp3+ Regulatory T Cells

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3

2005 • 2,256 citations

Toll Pathway-Dependent Blockade of CD4 ⁺ CD25 ⁺ T Cell-Mediated Suppression by Dendritic Cells

2003 • 2,023 citations

Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis

2004 • 1,835 citations

A function for interleukin 2 in Foxp3-expressing regulatory T cells

2005 • 1,744 citations

C<scp>hemokines in</scp>I<scp>nnate and</scp>A<scp>daptive</scp>H<scp>ost</scp>D<scp>efense</scp>: Basic Chemokinese Grammar for Immune Cells

2004 • 1,199 citations

Regulatory T Cells Selectively Express Toll-like Receptors and Are Activated by Lipopolysaccharide

2003 • 976 citations

TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

2005 • 955 citations

Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane protein.

1982 • 808 citations

Cutting Edge: CD4+CD25+ Regulatory T Cells Suppress Antigen-Specific Autoreactive Immune Responses and Central Nervous System Inflammation During Active Experimental Autoimmune Encephalomyelitis

2002 • 779 citations

Toll-Like Receptor 8-Mediated Reversal of CD4 ⁺ Regulatory T Cell Function

2005 • 734 citations

Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network

2005 • 681 citations

Hepatic T cells and liver tolerance

2003 • 650 citations

Modes of action of Freund's adjuvants in experimental models of autoimmune diseases

2001 • 579 citations

Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling

2005 • 473 citations

Human anergic/suppressive CD4+CD25+ T cells: a highly differentiated and apoptosis-prone population

2001 • 460 citations

Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis

2005 • 439 citations

Prospective study on the relationship between infections and multiple sclerosis exacerbations

2002 • 427 citations

Cutting Edge: TGF-β Signaling Is Required for the In Vivo Expansion and Immunosuppressive Capacity of Regulatory CD4+CD25+ T Cells

2004 • 395 citations

The Subpopulation of CD4+CD25+ Splenocytes That Delays Adoptive Transfer of Diabetes Expresses L-Selectin and High Levels of CCR7

2002 • 383 citations

Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor

2005 • 371 citations

Cloning and sequencing of the pertussis toxin genes: operon structure and gene duplication.

1986 • 343 citations

CCR6 expression defines regulatory effector/memory-like cells within the CD25+CD4+ T-cell subset

2004 • 314 citations

Specificity requirements for selection and effector functions of CD25⁺4⁺regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice

2002 • 267 citations

Critical role for CCR5 in the function of donor CD4+CD25+ regulatory T cells during acute graft-versus-host disease

2005 • 243 citations

Foxp3⁺CD25^–CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion

2005 • 228 citations

TLR4 Contributes to Disease-Inducing Mechanisms Resulting in Central Nervous System Autoimmune Disease

2004 • 208 citations

Acute experimental autoimmune encephalomyelitis in mice

1982 • 207 citations

Functional expression of the lymphoid chemokines CCL19 (ELC) and CCL 21 (SLC) at the blood-brain barrier suggests their involvement in G-protein-dependent lymphocyte recruitment into the central nervous system during experimental autoimmune encephalomyelitis

2002 • 204 citations

Regulatory T Cell Suppression and Anergy Are Differentially Regulated by Proinflammatory Cytokines Produced by TLR-Activated Dendritic Cells

2004 • 202 citations

Activation of antigen-presenting cells by microbial products breaks self tolerance and induces autoimmune disease

2004 • 198 citations

G Protein-Coupled Chemokine Receptors Induce Both Survival and Apoptotic Signaling Pathways

2002 • 189 citations

Myelin proteolipid protein-specific CD4⁺CD25⁺regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis

2004 • 186 citations

Differential response of murine CD4⁺CD25⁺ and CD4⁺CD25^– T cells to dexamethasone‐induced cell death

2004 • 186 citations

Pertussis toxin inhibits migration of B and T lymphocytes into splenic white pulp cords.

1995 • 183 citations

Dual Role of CCR2 during Initiation and Progression of Collagen-Induced Arthritis: Evidence for Regulatory Activity of CCR2+ T Cells

2004 • 183 citations

Modulation by islet-activating protein of adenylate cyclase activity in C6 glioma cells.

1982 • 164 citations

Pertussis toxin potentiates Th1 and Th2 responses to co-injected antigen: adjuvant action is associated with enhanced regulatory cytokine production and expression of the co-stimulatory molecules B7- 1, B7-2 and CD28

1998 • 164 citations

Acute autoimmune encephalomyelitis in mice. II. Susceptibility is controlled by the combination of H-2 and histamine sensitization genes.

1982 • 162 citations

Pertussis Toxin Modulates the Immune Response to Neuroantigens Injected in Incomplete Freund’s Adjuvant: Induction of Th1 Cells and Experimental Autoimmune Encephalomyelitis in the Presence of High Frequencies of Th2 Cells

2002 • 159 citations

Receptor analogs and monoclonal antibodies that inhibit adherence of Bordetella pertussis to human ciliated respiratory epithelial cells.

1988 • 140 citations

Immunopathology of murine experimental allergic orchitis.

1983 • 139 citations

The Sphingosine 1-Phosphate Receptor Agonist FTY720 Differentially Affects the Sequestration of CD4+/CD25+ T-Regulatory Cells and Enhances Their Functional Activity

2005 • 137 citations

Bordetella pertussisInfection in 2-Month-Old Infants Promotes Type 1 T Cell Responses

2003 • 132 citations

CD4⁺CD25⁺regulatory T cells limit the risk of autoimmune disease arising from T cell receptor crossreactivity

2005 • 125 citations

Binding of pertussis toxin to eucaryotic cells and glycoproteins

1989 • 119 citations

Proinflammatory Bacterial Peptidoglycan as a Cofactor for the Development of Central Nervous System Autoimmune Disease

2005 • 116 citations

Regulation of experimental autoimmune encephalomyelitis by CD4+, CD25+ and CD8+ T cells: analysis using depleting antibodies

2004 • 115 citations

Lectin-like binding of pertussis toxin to a 165-kilodalton Chinese hamster ovary cell glycoprotein.

1988 • 113 citations

Modulation of Fas-Dependent Apoptosis: A Dynamic Process Controlling Both the Persistence and Death of CD4 Regulatory T Cells and Effector T Cells

2002 • 112 citations

Primary Role for GI Protein Signaling in the Regulation of Interleukin 12 Production and the Induction of T Helper Cell Type 1 Responses

2000 • 108 citations

TGF regulates the CD4+CD25+ T-cell pool and the expression of Foxp3 in vivo

2004 • 106 citations

Elicitation of experimental allergic encephalomyelitis (EAE) in mice with the aid of pertussigen

1984 • 101 citations

Pertussis toxin as an adjuvant suppresses the number and function of CD4⁺CD25⁺ T regulatory cells

2006 • 99 citations

Repertoire Requirements of CD4+ T Cells That Prevent Spontaneous Autoimmune Encephalomyelitis

2000 • 97 citations

Pertussis Toxin Enhances Th1 Responses by Stimulation of Dendritic Cells

2003 • 94 citations

Triggers of autoimmune disease in a murine TCR-transgenic model for multiple sclerosis.

1997 • 92 citations

Stimulation of specific GTP binding and hydrolysis activities in lymphocyte membrane by interleukin-2

1987 • 83 citations

PTX cruiser: driving autoimmunity via TLR4

2005 • 78 citations

The enhanced antigen-specific production of cytokines induced by pertussis toxin is due to clonal expansion of T cells and not to altered effector functions of long-term memory cells

2000 • 75 citations

Permeabilization in a cerebral endothelial barrier model by pertussis toxin involves the PKC effector pathway and is abolished by elevated levels of cAMP

2003 • 74 citations

Bordetella pertussis toxin induces the release of inflammatory cytokines and dendritic cell activation in whole blood: impaired responses in human newborns

2002 • 67 citations

Pertussis toxin prevents the induction of peripheral T cell anergy and enhances the T cell response to an encephalitogenic peptide of myelin basic protein.

1991 • 65 citations

Development of acute autoimmune encephalomyelitis in mice: Factors regulating the effector phase of the disease

1982 • 56 citations

Properties of the B oligomer of pertussis toxin

1991 • 50 citations

Interaction of Bordetella pertussis with mast cells, modulation of cytokine secretion by pertussis toxin

2001 • 45 citations

Pertussis Toxin Inhibits Induction of Tissue-Specific Autoimmune Disease by Disrupting G Protein-Coupled Signals

2001 • 43 citations

The Third Signal in T Cell-Mediated Autoimmune Disease?

2004 • 42 citations

Pertussis toxin alters the innate and the adaptive immune responses in a pertussis-dependent model of autoimmunity

2002 • 34 citations

Cell‐surface bound pertussis toxin induces polyclonal T cell responses with high levels of interferon‐γ in the absence of interleukin‐12

2003 • 33 citations

Impaired TGF-β Responses in Peripheral T Cells of Gαi2−/− Mice

2005 • 20 citations

Experimental Autoimmune Inflammatory Myopathy

1987 • 17 citations

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