Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

The Fas Death Factor

1995 • 4,070 citations

Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.

1992 • 2,906 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Murine Models of Systemic Lupus Erythematosus

1985 • 1,572 citations

Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes

1996 • 1,473 citations

Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease

1991 • 1,185 citations

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.

1991 • 876 citations

Augmented humoral and anaphylactic responses in FcγRII-deficient mice

1996 • 828 citations

Negative selection of lymphocytes

1994 • 810 citations

Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FeγRIIB

1996 • 770 citations

Positive and negative selection of an antigen receptor on T cells in transgenic mice

1988 • 758 citations

Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease

1995 • 710 citations

Systemic Lupus Erythematosus

1996 • 677 citations

Peripheral Selection of the T Cell Repertoire

1991 • 666 citations

Developmental Biology of T Cells in T Cell-Receptor Transgenic Mice

1990 • 637 citations

A Role in B Cell Activation for CD22 and the Protein Tyrosine Phosphatase SHP

1995 • 551 citations

Hyperresponsive B Cells in CD22-Deficient Mice

1996 • 530 citations

Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice

1988 • 505 citations

Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice

1995 • 475 citations

Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses

1998 • 469 citations

CD22 Is Both a Positive and Negative Regulator of B Lymphocyte Antigen Receptor Signal Transduction: Altered Signaling in CD22-Deficient Mice

1996 • 437 citations

A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases

1991 • 401 citations

CD22 regulates thymus-independent responses and the lifespan of B cells

1996 • 395 citations

Induction of various autoantibodies by mutant gene lpr in several strains of mice.

1984 • 390 citations

Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences.

1992 • 367 citations

Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13.

1992 • 349 citations

Self-Tolerance Checkpoints in B Lymphocyte Development

1995 • 329 citations

Deficiency in CD22, a B Cell–specific Inhibitory Receptor, Is Sufficient to Predispose to Development of High Affinity Autoantibodies

1999 • 321 citations

GENETIC SUSCEPTIBILITY TO SYSTEMIC LUPUS ERYTHEMATOSUS

1998 • 313 citations

Isolation of a src homology 2-containing tyrosine phosphatase.

1992 • 304 citations

Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling.

1995 • 260 citations

Developmentally regulated expression of the PD-1 protein on the surface of double-negative(CD4^–CD8^–) thymocytes

1996 • 243 citations

Induction of a cationic shift in IgG anti-DNA autoantibodies. Role of T helper cells with classical and novel phenotypes in three murine models of lupus nephritis.

1987 • 236 citations

Structure and Chromosomal Localization of the Human PD-1 Gene (PDCD1)

1994 • 234 citations

The anatomy of T-cell activation and tolerance.

1996 • 225 citations

Peripheral T Cell Tolerance

1992 • 223 citations

X-linked B-lymphocyte immune defect in CBA/HN mice. I. Studies of the function and composition of spleen cells.

1975 • 216 citations

X-linked B-lymphocyte immune defect in CBA/N mice. II. Studies of the mechanisms underlying the immune defect.

1975 • 200 citations

Immunoprecipitation of cell surface structures of cloned cytotoxic T lymphocytes by clone-specific antisera.

1984 • 183 citations

An Immunological Renal Disease in Transgenic Mice That Overexpress Fli-1, a Member of the ets Family of Transcription Factor Genes

1995 • 146 citations

IgG3 production in MRL/lpr mice is responsible for development of lupus nephritis.

1991 • 142 citations

Of ITAMs and ITIMs: turning on and off the B cell antigen receptor.

1995 • 124 citations

Immunoglobulin subclass-specific immunodeficiency in mice with an X-linked B-lymphocyte defect.

1979 • 115 citations

The human PD-1 gene: complete cDNA, genomic organization, and developmentally regulated expression in B cell progenitors

1997 • 110 citations

Breakdown of B cell tolerance in a mouse model of systemic lupus erythematosus.

1995 • 107 citations

Autoimmune lpr/lpr mice deficient in CD40 ligand: spontaneous Ig class switching with dichotomy of autoantibody responses.

1996 • 91 citations

The Yaa Gene Model of Systemic Lupus Erythematosus

1995 • 84 citations

Isotypes of spontaneous and mitogen-induced autoantibodies in SLE-prone mice.

1984 • 79 citations

Regulation through inhibitory receptors: Lessons from natural killer cells

1997 • 76 citations

Studies of congenic MRL-Ipr/Ipr.xid mice.

1983 • 72 citations

Genetic Contributions to Lupus‐like Disease in (NZB×NZW)F₁ Mice

1995 • 64 citations

T-cell tolerance and autoimmunity in transgenic models of central and peripheral tolerance

1994 • 64 citations

Cloning and cDNA sequence analysis of nephritogenic monoclonal antibodies derived from an MRL/lpr lupus mouse

1993 • 51 citations

Sequential Immunohistologic Analysis of the Skin Following Allogeneic Bone Marrow Transplantation

1988 • 43 citations

Characterization of target injury of murine acute graft-versus-host disease directed to multiple minor histocompatibility antigens elicited by either CD4+ or CD8+ effector cells.

1991 • 40 citations

Positive and negative selection of the αβ T-cell repertoire in vivo

1991 • 33 citations

A new T cell subset expressing B220 and CD4 in lpr mice: defects in the response to mitogens and in the production of IL-2.

1988 • 24 citations

Ontogeny and function of B220+ L3T4+ T-cell subset of MRL/Mp-lpr/lpr mice

1988 • 14 citations

Induction of cutaneousgraft-versus-hostdisease by local injection of unprimed T cells

1991 • 6 citations