PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 • 4,853 citations

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

2005 • 4,165 citations

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

2005 • 3,961 citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

2001 • 2,746 citations

Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

1999 • 2,574 citations

THE B7 FAMILY REVISITED

2005 • 2,239 citations

Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice

2001 • 1,761 citations

Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes

1996 • 1,473 citations

Tissue expression of PD-L1 mediates peripheral T cell tolerance

2006 • 1,145 citations

Blockade of Programmed Death-1 Ligands on Dendritic Cells Enhances T Cell Activation and Cytokine Production

2003 • 933 citations

The B7 Family of Ligands and Its Receptors: New Pathways for Costimulation and Inhibition of Immune Responses

2002 • 884 citations

B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells

2001 • 850 citations

The Programmed Death-1 (PD-1) Pathway Regulates Autoimmune Diabetes in Nonobese Diabetic (NOD) Mice

2003 • 766 citations

PD-L1/B7H-1 Inhibits the Effector Phase of Tumor Rejection by T Cell Receptor (TCR) Transgenic CD8+ T Cells

2004 • 748 citations

PD-1:PD-L inhibitory pathway affects both CD4+ and CD8+ T cells and is overcome by IL-2

2002 • 646 citations

PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells

2004 • 609 citations

Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses

2003 • 594 citations

PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells

2003 • 584 citations

Critical Role of the Programmed Death-1 (PD-1) Pathway in Regulation of Experimental Autoimmune Encephalomyelitis

2003 • 486 citations

IL-6-Deficient Mice Are Resistant to Experimental Autoimmune Encephalomyelitis: Roles of IL-6 in the Activation and Differentiation of Autoreactive T Cells

1998 • 448 citations

Treatment of rheumatoid arthritis with the selective costimulation modulator abatacept: Twelve‐month results of a phase iib, double‐blind, randomized, placebo‐controlled trial

2005 • 446 citations

Endothelial expression of PD‐L1 and PD‐L2 down‐regulates CD8⁺ T cell activation and cytolysis

2003 • 436 citations

Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis

2005 • 415 citations

Establishment of NOD-Pdcd1^-/-mice as an efficient animal model of type I diabetes

2005 • 409 citations

Long-range disruption of gene expression by a selectable marker cassette

1996 • 377 citations

Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE

1995 • 326 citations

Blockade of Programmed Death-1 Engagement Accelerates Graft-Versus-Host Disease Lethality by an IFN-γ-Dependent Mechanism

2003 • 315 citations

B7-H1 Is Expressed by Human Endothelial Cells and Suppresses T Cell Cytokine Synthesis

2002 • 313 citations

IL-6-deficient mice resist myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis

1998 • 307 citations

Program Death-1 Engagement Upon TCR Activation Has Distinct Effects on Costimulation and Cytokine-Driven Proliferation: Attenuation of ICOS, IL-4, and IL-21, But Not CD28, IL-7, and IL-15 Responses

2003 • 272 citations

IL-6-deficient mice are resistant to the induction of experimental autoimmune encephalomyelitis provoked by myelin oligodendrocyte glycoprotein

1998 • 229 citations

A PD‐1 polymorphism is associated with disease progression in multiple sclerosis

2005 • 229 citations

Studies in B7-Deficient Mice Reveal a Critical Role for B7 Costimulation in Both Induction and Effector Phases of Experimental Autoimmune Encephalomyelitis

1999 • 219 citations

Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosis

1999 • 219 citations

The Clinical Course of Experimental Autoimmune Encephalomyelitis and Inflammation Is Controlled by the Expression of Cd40 within the Central Nervous System

2001 • 215 citations

The Roles of the New Negative T Cell Costimulatory Pathways in Regulating Autoimmunity

2004 • 208 citations

Interleukin‐6 functions in autoimmune encephalomyelitis: a study in gene‐targeted mice

1998 • 156 citations

Microglial Expression of the B7 Family Member B7 Homolog 1 Confers Strong Immune Inhibition: Implications for Immune Responses and Autoimmunity in the CNS

2005 • 156 citations

Cytosolic phospholipase A2α–deficient mice are resistant to experimental autoimmune encephalomyelitis

2005 • 143 citations

Interleukin-6 functions in autoimmune encephalomyelitis: a study in gene-targeted mice

1998 • 143 citations

Blockade of CD28 During In Vitro Activation of Encephalitogenic T Cells or After Disease Onset Ameliorates Experimental Autoimmune Encephalomyelitis

1999 • 123 citations

Expression of Programmed Death–1 Ligand (PD‐L) 1, PD‐L2, B7‐H3, and Inducible Costimulator Ligand on Human Respiratory Tract Epithelial Cells and Regulation by Respiratory Syncytial Virus and Type 1 and 2 Cytokines

2006 • 96 citations

Statistical analysis of data from studies on experimental autoimmune encephalomyelitis

2005 • 91 citations

Cytotoxic T lymphocyte antigen-4 (CTLA-4) limits the expansion of encephalitogenic T cells in experimental autoimmune encephalomyelitis (EAE)-resistant BALB/c mice

2002 • 79 citations

CD28-independent induction of experimental autoimmune encephalomyelitis

2001 • 75 citations

The balance of immune responses: costimulation verse coinhibition

2005 • 71 citations

Role of costimulatory pathways in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis

2003 • 53 citations

Targeted insertion results in a Rhombomere 2‐specific Hoxa2 knockdown and ectopic activation of Hoxa1 expression

2002 • 40 citations

Immunotherapeutic approaches in multiple sclerosis

2004 • 39 citations

Expression of B7-H1 and B7-DC on the airway epithelium is enhanced by double-stranded RNA

2005 • 34 citations

Therapeutic opportunities in the B7/CD28 family of ligands and receptors

2005 • 31 citations

T cell costimulatory pathways: blockade for autoimmunity

2003 • 28 citations

New immunosuppressants with potential implication in multiple sclerosis

2004 • 27 citations

Blocking Costimulatory Signals to Induce Transplantation Tolerance and Prevent Autoimmune Disease

1999 • 27 citations