Aberrant Regulation of Synovial T Cell Activation by Soluble Costimulatory Molecules in Rheumatoid Arthritis

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 • 4,853 citations

Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

2002 • 4,625 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

2001 • 2,746 citations

Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

1999 • 2,574 citations

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice

2001 • 1,761 citations

CTLA-4 is a second receptor for the B cell activation antigen B7.

1991 • 1,662 citations

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.

1991 • 1,132 citations

Treatment of Rheumatoid Arthritis by Selective Inhibition of T-Cell Activation with Fusion Protein CTLA4Ig

2003 • 1,060 citations

B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells

2001 • 850 citations

PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine

2001 • 786 citations

The Programmed Death-1 (PD-1) Pathway Regulates Autoimmune Diabetes in Nonobese Diabetic (NOD) Mice

2003 • 766 citations

Effects of Abatacept in Patients with Methotrexate-Resistant Active Rheumatoid Arthritis

2006 • 706 citations

The Interaction Properties of Costimulatory Molecules Revisited

2002 • 640 citations

Scurfin (FOXP3) Acts as a Repressor of Transcription and Regulates T Cell Activation

2001 • 551 citations

Critical Role of the Programmed Death-1 (PD-1) Pathway in Regulation of Experimental Autoimmune Encephalomyelitis

2003 • 486 citations

Treatment of rheumatoid arthritis with the selective costimulation modulator abatacept: Twelve‐month results of a phase iib, double‐blind, randomized, placebo‐controlled trial

2005 • 446 citations

B7-1 and B7-2 Selectively Recruit CTLA-4 and CD28 to the Immunological Synapse

2004 • 415 citations

Apoptosis in rheumatoid arthritis synovium.

1995 • 378 citations

Structural and Functional Analysis of the Costimulatory Receptor Programmed Death-1

2004 • 365 citations

CTLA4Ig: Bridging the Basic Immunology with Clinical Application

2006 • 266 citations

Induction of CD4⁺CD25⁺regulatory T cells by copolymer-I through activation of transcription factor Foxp3

2005 • 265 citations

Structure and Chromosomal Localization of the Human PD-1 Gene (PDCD1)

1994 • 234 citations

Costimulatory B7 Molecules in the Pathogenesis of Infectious and Autoimmune Diseases

1996 • 217 citations

Alternative splice variants of the human PD-1 gene

2005 • 197 citations

Costimulating aberrant T cell responses by B7-H1 autoantibodies in rheumatoid arthritis

2003 • 185 citations

The Yin and Yang of T Cell Costimulation

1995 • 180 citations

Role of osteopontin in amplification and perpetuation of rheumatoid synovitis

2005 • 135 citations

Role of osteopontin in amplification and perpetuation of rheumatoid synovitis

2005 • 122 citations

The human PD-1 gene: complete cDNA, genomic organization, and developmentally regulated expression in B cell progenitors

1997 • 110 citations

CTLA-4 in Filarial Infections: Implications for a Role in Diminished T Cell Reactivity

2003 • 109 citations

The presence of costimulatory molecules CD86 and CD28 in rheumatoid arthritis synovium

1996 • 69 citations

Autoantibodies to T Cell Costimulatory Molecules in Systemic Autoimmune Diseases

1999 • 66 citations

Expression and function of the co-stimulator H4/ICOS on activated T cells of patients with rheumatoid arthritis.

2003 • 53 citations

T cell receptor of Fas-sensitive T cells in rheumatoid synovium.

1997 • 32 citations

Autoantibodies to T cell co-stimulatory molecules in systemic autoimmune diseases

1999 • 4 citations