Regulatory T cells in the periphery

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

1998 • 2,658 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

CD4+CD25+ suppressor T cells: more questions than answers

2002 • 2,202 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Dendritic Cells Induce Peripheral T Cell Unresponsiveness under Steady State Conditions in Vivo

2001 • 1,845 citations

Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

2002 • 1,745 citations

A function for interleukin 2 in Foxp3-expressing regulatory T cells

2005 • 1,744 citations

CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity

2002 • 1,733 citations

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 • 1,659 citations

Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β

2001 • 1,609 citations

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

1998 • 1,579 citations

Induction of Tumor Immunity by Removing CD25+CD4+ T Cells: A Common Basis Between Tumor Immunity and Autoimmunity

1999 • 1,475 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 1,434 citations

T Cell Anergy

2003 • 1,418 citations

Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation.

1996 • 1,335 citations

Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells

2003 • 1,252 citations

Inducing and expanding regulatory T cell populations by foreign antigen

2005 • 1,245 citations

In Vitro–expanded Antigen-specific Regulatory T Cells Suppress Autoimmune Diabetes

2004 • 1,192 citations

Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

2005 • 1,189 citations

The immunology of susceptibility and resistance to Leishmania major in mice

2002 • 1,173 citations

In Vitro Generation of Interleukin 10–producing Regulatory CD4+ T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines

2002 • 1,163 citations

Donor-type CD4+CD25+ Regulatory T Cells Suppress Lethal Acute Graft-Versus-Host Disease after Allogeneic Bone Marrow Transplantation

2002 • 1,117 citations

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1995 • 1,079 citations

Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody.

1999 • 1,066 citations

Natural regulatory T cells in infectious disease

2005 • 1,035 citations

TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

2005 • 955 citations

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.

1996 • 909 citations

Direct Expansion of Functional CD25+ CD4+ Regulatory T Cells by Antigen-processing Dendritic Cells

2003 • 893 citations

CD4+CD25+ T Cells Inhibit Both the Induction and Effector Function of Autoreactive T Cells and Represent a Unique Lineage of Immunoregulatory Cells

1998 • 893 citations

Origin of regulatory T cells with known specificity for antigen

2002 • 854 citations

Antigen-specific regulatory T cells develop via the ICOS–ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity

2002 • 785 citations

CD4 Regulatory T Cells Prevent Lethal Autoimmunity in IL-2Rβ-Deficient Mice

2002 • 783 citations

Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice

2005 • 783 citations

Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signalsin vivo

2004 • 761 citations

CD4+CD25+ TR Cells Suppress Innate Immune Pathology Through Cytokine-dependent Mechanisms

2003 • 748 citations

In Vivo Instruction of Suppressor Commitment in Naive T Cells

2004 • 726 citations

Recognition of the Peripheral Self by Naturally Arising CD25+ CD4+ T Cell Receptors

2004 • 690 citations

Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo

2001 • 658 citations

Natural and Induced CD4+CD25+ Cells Educate CD4+CD25− Cells to Develop Suppressive Activity: The Role of IL-2, TGF-β, and IL-10

2004 • 657 citations

TGF-β1 Plays an Important Role in the Mechanism of CD4+CD25+ Regulatory T Cell Activity in Both Humans and Mice

2004 • 643 citations

Interleukin 2 Signaling Is Required for CD4+ Regulatory T Cell Function

2002 • 630 citations

The Cellular Mechanism of Aire Control of T Cell Tolerance

2005 • 622 citations

CD4+CD25+ Regulatory T Cells Can Mediate Suppressor Function in the Absence of Transforming Growth Factor β1 Production and Responsiveness

2002 • 614 citations

Infectious Tolerance

2002 • 614 citations

Antigen-dependent Proliferation of CD4+ CD25+ Regulatory T Cells In Vivo

2003 • 600 citations

The lifestyle of naturally occurring CD4⁺CD25⁺Foxp3⁺ regulatory T cells

2006 • 589 citations

Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter

2005 • 583 citations

Cd4+Cd25+ Immune Regulatory Cells Are Required for Induction of Tolerance to Alloantigen via Costimulatory Blockade

2001 • 580 citations

CD25+ CD4+ T Cells Regulate the Expansion of Peripheral CD4 T Cells Through the Production of IL-10

2001 • 564 citations

A history of prostate cancer treatment

2002 • 563 citations

T cells that cannot respond to TGF-β escape control by CD4+CD25+ regulatory T cells

2005 • 508 citations

Large-scale in vitro expansion of polyclonal human CD4+CD25high regulatory T cells

2004 • 505 citations

Human CD4+CD25+ Regulatory, Contact-dependent T Cells Induce Interleukin 10–producing, Contact-independent Type 1-like Regulatory T Cells

2002 • 484 citations

Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells

2004 • 482 citations

Homeostasis of Peripheral CD4+ T Cells: IL-2Rα and IL-2 Shape a Population of Regulatory Cells That Controls CD4+ T Cell Numbers

2002 • 477 citations

Immune Responses in Interleukin-2-Deficient Mice

1993 • 476 citations

Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling

2005 • 473 citations

Generation Ex Vivo of TGF-β-Producing Regulatory T Cells from CD4+CD25− Precursors

2002 • 461 citations

Human CD25+CD4+ T Suppressor Cell Clones Produce Transforming Growth Factor β, but not Interleukin 10, and Are Distinct from Type 1 T Regulatory Cells

2002 • 440 citations

Generation of Anergic and Potentially Immunoregulatory CD25+CD4 T Cells In Vivo After Induction of Peripheral Tolerance with Intravenous or Oral Antigen

2001 • 429 citations

TGF-β regulatesin vivoexpansion of Foxp3-expressing CD4⁺CD25⁺regulatory T cells responsible for protection against diabetes

2004 • 425 citations

Cutting Edge: TGF-β Signaling Is Required for the In Vivo Expansion and Immunosuppressive Capacity of Regulatory CD4+CD25+ T Cells

2004 • 395 citations

Induction of CD4+/CD25+ regulatory T cells by targeting of antigens to immature dendritic cells

2003 • 392 citations

Anergic T Cells as Suppressor Cells in Vitro

1994 • 389 citations

In vivodynamics of antigen-specific regulatory T cells not predicted from behaviorin vitro

2003 • 384 citations

CD25− T Cells Generate CD25+Foxp3+ Regulatory T Cells by Peripheral Expansion

2004 • 373 citations

Both CD4+CD25+ and CD4+CD25− Regulatory Cells Mediate Dominant Transplantation Tolerance

2002 • 372 citations

L-Selectinhi but not the L-selectinlo CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection

2004 • 360 citations

Engagement of Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Induces Transforming Growth Factor β (TGF-β) Production by Murine CD4+ T Cells

1998 • 359 citations

Regulatory Dendritic Cells Protect Mice from Murine Acute Graft-versus-Host Disease and Leukemia Relapse

2003 • 326 citations

Induction of T helper type 1–like regulatory cells that express Foxp3 and protect against airway hyper-reactivity

2004 • 313 citations

Sequential development of interleukin 2–dependent effector and regulatory T cells in response to endogenous systemic antigen

2005 • 296 citations

IFN-γ production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo

2005 • 292 citations

De novogeneration of antigen-specific CD4⁺CD25⁺regulatory T cells from human CD4⁺CD25^–cells

2005 • 284 citations

Conversion of CD4+ CD25− cells into CD4+ CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus

2005 • 271 citations

T Cell Regulation as a Side Effect of Homeostasis and Competition

2003 • 263 citations

Modified myeloid dendritic cells act as regulatory dendritic cells to induce anergic and regulatory T cells

2003 • 257 citations

Generation of CD4+CD25+ Regulatory T Cells from Autoreactive T Cells Simultaneously with Their Negative Selection in the Thymus and from Nonautoreactive T Cells by Endogenous TCR Expression

2002 • 253 citations

CD4+ regulatory T cells: Mechanisms of induction and effector function

2005 • 205 citations

Direct Evidence That Functionally Impaired CD4+ T Cells Persist In Vivo Following Induction of Peripheral Tolerance

1998 • 196 citations

A novel immunodeficiency associated with hypomorphic RAG1 mutations and CMV infection

2005 • 192 citations

Control of T cell hyperactivation in IL-2-deficient mice by CD4+CD25- and CD4+CD25+ T cells: evidence for two distinct regulatory mechanisms

2001 • 183 citations

Cutting Edge: Self-Peptides Drive the Peripheral Expansion of CD4+CD25+ Regulatory T Cells

2003 • 177 citations

The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens

2003 • 177 citations

Autoimmunity in human primary immunodeficiency diseases

2002 • 173 citations

A Comparative Study between T Regulatory Type 1 and CD4+CD25+ T Cells in the Control of Inflammation

2003 • 153 citations

Anergic T cells act as suppressor cellsin vitro andin vivo

1999 • 144 citations

Tolerance induction of alloreactive T cells via ex vivo blockade of the CD40:CD40L costimulatory pathway results in the generation of a potent immune regulatory cell

2002 • 134 citations

Systemic Overexpression of IL-10 Induces CD4+CD25+ Cell Populations In Vivo and Ameliorates Type 1 Diabetes in Nonobese Diabetic Mice in a Dose-Dependent Fashion

2003 • 132 citations

A causal link between lymphopenia and autoimmunity

2004 • 128 citations

Competition for self ligands restrains homeostatic proliferation of naive CD4 T cells

2003 • 121 citations

Immune deficiency and autoimmunity

2003 • 111 citations

Epicutaneous Immunization with Autoantigenic Peptides Induces T Suppressor Cells that Prevent Experimental Allergic Encephalomyelitis

2003 • 106 citations

Homeostasis and T cell regulation

2004 • 81 citations

Role of B7 in T Cell Tolerance

2004 • 79 citations

Cutting Edge: The Link between Lymphocyte Deficiency and Autoimmunity: Roles of Endogenous T and B Lymphocytes in Tolerance

2005 • 68 citations

Lack of a role for transforming growth factor-β in cytotoxic T lymphocyte antigen-4-mediated inhibition of T cell activation

2001 • 57 citations

Protection against Autoimmunity in Nonlymphopenic Hosts by CD4+CD25+ Regulatory T Cells Is Antigen-Specific and Requires IL-10 and TGF-β

2005 • 48 citations

CD25+ regulatory T cells and tumor immunity

2003 • 30 citations

T cell expression of CIITA represses Th1 immunity

2004 • 19 citations