The Common γ-Chain Cytokines IL-2, IL-7, IL-15, and IL-21 Induce the Expression of Programmed Death-1 and Its Ligands

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 • 4,853 citations

Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

2002 • 4,625 citations

Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.

1992 • 2,906 citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

2001 • 2,746 citations

THE B7 FAMILY REVISITED

2005 • 2,239 citations

Programmed Death-1 Ligand 1 Interacts Specifically with the B7-1 Costimulatory Molecule to Inhibit T Cell Responses

2007 • 1,603 citations

The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection

2007 • 1,416 citations

Tissue expression of PD-L1 mediates peripheral T cell tolerance

2006 • 1,145 citations

SHP-1 and SHP-2 Associate with Immunoreceptor Tyrosine-Based Switch Motif of Programmed Death 1 upon Primary Human T Cell Stimulation, but Only Receptor Ligation Prevents T Cell Activation

2004 • 1,128 citations

Blockade of Programmed Death-1 Ligands on Dendritic Cells Enhances T Cell Activation and Cytokine Production

2003 • 933 citations

PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection

2006 • 859 citations

Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function

2005 • 684 citations

Homeostatic Expansion of T Cells during Immune Insufficiency Generates Autoimmunity

2004 • 682 citations

IL-21 Induces Differentiation of Human Naive and Memory B Cells into Antibody-Secreting Plasma Cells

2005 • 641 citations

Endothelial expression of PD‐L1 and PD‐L2 down‐regulates CD8⁺ T cell activation and cytolysis

2003 • 436 citations

Increases in CD4 T Lymphocytes with Intermittent Courses of Interleukin-2 in Patients with Human Immunodeficiency Virus Infection — A Preliminary Study

1995 • 430 citations

Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation

2005 • 428 citations

IL-7 Administration to Humans Leads to Expansion of CD8+ and CD4+ Cells but a Relative Decrease of CD4+ T-Regulatory Cells

2006 • 427 citations

PD-1 and its ligands in T-cell immunity

2007 • 419 citations

Reinvigorating exhausted HIV-specific T cells via PD-1–PD-1 ligand blockade

2006 • 396 citations

Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo

2003 • 384 citations

Cytokines and T-cell homeostasis

2007 • 278 citations

Program Death-1 Engagement Upon TCR Activation Has Distinct Effects on Costimulation and Cytokine-Driven Proliferation: Attenuation of ICOS, IL-4, and IL-21, But Not CD28, IL-7, and IL-15 Responses

2003 • 272 citations

IL-21 Enhances and Sustains CD8+ T Cell Responses to Achieve Durable Tumor Immunity: Comparative Evaluation of IL-2, IL-15, and IL-21

2004 • 259 citations

Autoimmunity during lymphopenia: A two-hit model

2006 • 176 citations

Activation-Induced Expression of Human Programmed Death-1 Gene in T-Lymphocytes

1997 • 144 citations

Elevated Expression Levels of Inhibitory Receptor Programmed Death 1 on Simian Immunodeficiency Virus-Specific CD8 T Cells during Chronic Infection but Not after Vaccination

2007 • 132 citations

T cell homeostasis in tolerance and immunity

2005 • 128 citations

A causal link between lymphopenia and autoimmunity

2004 • 128 citations

Induction of prolonged survival of CD4+ T lymphocytes by intermittent IL-2 therapy in HIV-infected patients

2005 • 126 citations

The new paradigm of T-cell homeostatic proliferation-induced autoimmunity

2004 • 122 citations

An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2

2007 • 121 citations

Differential effects of IL-21 and IL-15 on perforin expression, lysosomal degranulation, and proliferation in CD8 T cells of patients with human immunodeficiency virus-1 (HIV)

2006 • 117 citations

The dichotomous role of IL-2: tolerance versus immunity

2006 • 81 citations

Interleukin-21: A new modulator of immunity, infection, and cancer

2007 • 80 citations

The balance of immune responses: costimulation verse coinhibition

2005 • 71 citations

Common γ chain cytokines: Dissidence in the details

2006 • 69 citations

Lymphopenia and autoimmune diseases.

2004 • 69 citations

Cytokine Signals in T-Cell Homeostasis

2005 • 55 citations

Co-inhibitory role of T-cell-associated B7-H1 and B7-DC in the T-cell immune response

2005 • 54 citations

Interleukin 7 reduces the levels of spontaneous apoptosis in CD4⁺and CD8⁺T cells from HIV-1-infected individuals

2007 • 53 citations

IL-7 enhancement of antigen-driven activation/expansion of HIV-1-specific cytotoxic T lymphocyte precursors (CTLp)

1995 • 52 citations

Interleukin-15 but Not Interleukin-7 Abrogates Vaccine-Induced Decrease in Virus Level in Simian Immunodeficiency Virusmac251-Infected Macaques

2007 • 51 citations

Turning on the off switch: Regulation of anti-viral T cell responses in the liver by the PD-1/PD-L1 pathway

2006 • 50 citations

A novel mimovirus vaccine containing survivin epitope with adjuvant IL-15 induces long-lasting cellular immunity and high antitumor efficiency

2007 • 33 citations

Induction of protective immune responses against NXS2 neuroblastoma challenge in mice by immunotherapy with GD2 mimotope vaccine and IL-15 and IL-21 gene delivery

2007 • 31 citations

γ_c cytokines provide multiple homeostatic signals to naive CD4⁺ T cells

2007 • 31 citations

Cytokine-adjuvanted HIV-DNA vaccination strategies

2006 • 29 citations

Interleukin-15 Increases Vaccine Efficacy through a Mechanism Linked to Dendritic Cell Maturation and Enhanced Antibody Titers

2007 • 26 citations

The Role of Cytokines which Signal through the Common γ Chain Cytokine Receptor in the Reversal of HIV Specific CD4+ and CD8+ T Cell Anergy

2007 • 24 citations

Cytokine therapies in HIV-1 infection: present and future

2003 • 22 citations

Depressed in vitro T cell responses concomitant with augmented interleukin-2 responses by lymphocytes from cancer patients following in vivo treatment with interleukin-2.

1990 • 22 citations

Differential effect of interleukin-2 treatment on primary and secondary immunizations in HIV infected individuals

2005 • 13 citations

Immunothérapie de l’infection par le VIH par l’utilisation de cytokines

2006 • 10 citations