PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

2006 • 6,720 citations

PD-1 and Its Ligands in Tolerance and Immunity

2008 • 4,838 citations

Regulatory T Cells and Immune Tolerance

2008 • 4,778 citations

Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

2002 • 4,625 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

Restoring function in exhausted CD8 T cells during chronic viral infection

2005 • 3,743 citations

How regulatory T cells work

2008 • 3,048 citations

Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

2002 • 2,879 citations

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism

2007 • 2,575 citations

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

2001 • 2,503 citations

Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3

2005 • 2,256 citations

The inhibitory cytokine IL-35 contributes to regulatory T-cell function

2007 • 1,886 citations

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

2006 • 1,702 citations

The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection

2007 • 1,416 citations

Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

2005 • 1,189 citations

Tissue expression of PD-L1 mediates peripheral T cell tolerance

2006 • 1,145 citations

Cutting Edge: TGF-β Induces a Regulatory Phenotype in CD4+CD25− T Cells through Foxp3 Induction and Down-Regulation of Smad7

2004 • 1,123 citations

Foxp3-dependent programme of regulatory T-cell differentiation

2007 • 1,106 citations

Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

2008 • 1,088 citations

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation

2008 • 999 citations

Blockade of B7-H1 and PD-1 by Monoclonal Antibodies Potentiates Cancer Therapeutic Immunity

2005 • 972 citations

TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

2005 • 955 citations

Blockade of Programmed Death-1 Ligands on Dendritic Cells Enhances T Cell Activation and Cytokine Production

2003 • 933 citations

Clinical Significance and Therapeutic Potential of the Programmed Death-1 Ligand/Programmed Death-1 Pathway in Human Pancreatic Cancer

2007 • 843 citations

Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3

2007 • 819 citations

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

2008 • 814 citations

Myelin Oligodendrocyte Glycoprotein–specific T Cell Receptor Transgenic Mice Develop Spontaneous Autoimmune Optic Neuritis

2003 • 796 citations

Clinical Significance of Programmed Death-1 Ligand-1 and Programmed Death-1 Ligand-2 Expression in Human Esophageal Cancer

2005 • 758 citations

Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target

2004 • 742 citations

The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

2008 • 710 citations

Rapamycin Promotes Expansion of Functional CD4+CD25+FOXP3+ Regulatory T Cells of Both Healthy Subjects and Type 1 Diabetic Patients

2006 • 693 citations

Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells

2003 • 674 citations

B7-H1 Expression on Non-Small Cell Lung Cancer Cells and Its Relationship with Tumor-Infiltrating Lymphocytes and Their PD-1 Expression

2004 • 664 citations

PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells

2004 • 609 citations

Foxp3 Transcription-Factor-Dependent and -Independent Regulation of the Regulatory T Cell Transcriptional Signature

2007 • 599 citations

Interaction of PD-L1 on tumor cells with PD-1 on tumor-specific T cells as a mechanism of immune evasion: implications for tumor immunotherapy

2004 • 571 citations

Scurfin (FOXP3) Acts as a Repressor of Transcription and Regulates T Cell Activation

2001 • 551 citations

Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4

2005 • 532 citations

Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans

2007 • 516 citations

B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma.

2003 • 481 citations

Immunohistochemical localization of programmed death-1 ligand-1 (PD-L1) in gastric carcinoma and its clinical significance

2006 • 474 citations

Regulatory T cell development in the absence of functional Foxp3

2007 • 467 citations

Overexpression of B7-H1 (PD-L1) significantly associates with tumor grade and postoperative prognosis in human urothelial cancers

2006 • 447 citations

PD-1 and its ligands in T-cell immunity

2007 • 419 citations

PD‐L1 (B7‐H1) expression by urothelial carcinoma of the bladder and BCG‐induced granulomata

2007 • 407 citations

618: Costimulatory B7-H1 In Renal Cell Carcinoma Patients: Indicator of Tumor Aggressiveness and Potential Therapeutic Target

2005 • 358 citations

Programmed Death-1 (PD-1) is a Marker of Germinal Center-associated T Cells and Angioimmunoblastic T-Cell Lymphoma

2006 • 343 citations

Selective Survival of Naturally Occurring Human CD4+CD25+Foxp3+ Regulatory T Cells Cultured with Rapamycin

2007 • 335 citations

Regulation of immunity by self-reactive T cells

2005 • 306 citations

Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors

2002 • 300 citations

TGFβ signalling in control of T-cell-mediated self-reactivity

2007 • 294 citations

Foxp3 and Natural Regulatory T Cells

2003 • 278 citations

Conversion of CD4+ CD25− cells into CD4+ CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus

2005 • 271 citations

Contrasting Effects of Cyclosporine and Rapamycin in De Novo Generation of Alloantigen-Specific Regulatory T Cells

2007 • 258 citations

Chemopreventive agents induce programmed death-1-ligand 1 (PD-L1) surface expression in breast cancer cells and promote PD-L1-mediated T cell apoptosis

2007 • 245 citations

PD-1 Regulates Self-Reactive CD8+ T Cell Responses to Antigen in Lymph Nodes and Tissues

2007 • 237 citations

Cellular and molecular characterization of the scurfy mouse mutant.

1999 • 197 citations

Regulatory T cells in the periphery

2006 • 189 citations

Expression of B7-H1 on Gastric Epithelial Cells: Its Potential Role in Regulating T Cells during Helicobacter pylori Infection

2006 • 172 citations

CD4+CD25+FOXP3+ Regulatory T Cells Increase De Novo in Kidney Transplant Patients After Immunodepletion with Campath-1H

2008 • 169 citations

Rapamycin, not cyclosporine, permits thymic generation and peripheral preservation of CD4+CD25+FoxP3+ T cells

2007 • 161 citations

Cellular and Molecular Characterization of thescurfyMouse Mutant

1999 • 160 citations

Cutting Edge: Murine Vascular Endothelium Activates and Induces the Generation of Allogeneic CD4+25+Foxp3+ Regulatory T Cells

2005 • 148 citations

CD4 ⁺ CD25 ⁺ Regulatory Cells from Human Peripheral Blood Express Very High Levels of CD25 Ex Vivo

2003 • 138 citations

CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity

2008 • 123 citations

Role of Foxp3‐positive regulatory T cells during infection

2008 • 114 citations

The effect of immunosuppressive drug rapamycin on regulatory CD4+CD25+Foxp3+T cells in mice

2007 • 112 citations

TGF-β1 modulates Foxp3 expression and regulatory activity in distinct CD4+ T cell subsets

2007 • 111 citations

Expression of the Programmed Death Ligand 1, B7-H1, on Gastric Epithelial Cells afterHelicobacter pyloriExposure Promotes Development of CD4⁺CD25⁺FoxP3⁺Regulatory T Cells

2007 • 100 citations

Cutting Edge: TGF-β-Induced Expression of Foxp3 in T cells Is Mediated through Inactivation of ERK

2008 • 73 citations

Regulatory CD4+CD25+Foxp3+ T Cells Selectively Inhibit the Spontaneous Form of Lymphopenia-Induced Proliferation of Naive T Cells

2008 • 70 citations

Activation of MAP kinase p38 is critical for the cell-cycle–controlled suppressor function of regulatory T cells

2007 • 68 citations

Combination of rapamycin and IL-2 increases de novo induction of human CD4+CD25+FOXP3+ T cells

2008 • 66 citations

P38 MAP Kinase Signaling Is Required for the Conversion of CD4+CD25− T Cells into iTreg

2008 • 60 citations

Costimulation Light: Activation of CD4+ T Cells with CD80 or CD86 Rather Than Anti-CD28 Leads to a Th2 Cytokine Profile

2000 • 46 citations

Plasticity of Regulatory T Cells: Subversion of Suppressive Function and Conversion to Enhancement of Lung Allergic Responses

2008 • 35 citations

Intracellular Cytokine Staining

2005 • 14 citations