Regulatory T cells and autoimmune disease

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

CD4+CD25+ suppressor T cells: more questions than answers

2002 • 2,202 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

Toll Pathway-Dependent Blockade of CD4 ⁺ CD25 ⁺ T Cell-Mediated Suppression by Dendritic Cells

2003 • 2,023 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

2002 • 1,745 citations

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 • 1,659 citations

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

1998 • 1,579 citations

Immunologic tolerance maintained by CD25⁺ CD4⁺ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

2001 • 1,515 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 1,434 citations

The Immunology of Mucosal Models of Inflammation

2002 • 1,323 citations

Modulation of tryptophan catabolism by regulatory T cells

2003 • 1,323 citations

Regulatory T cells in transplantation tolerance

2003 • 1,323 citations

In Vitro–expanded Antigen-specific Regulatory T Cells Suppress Autoimmune Diabetes

2004 • 1,192 citations

In Vitro Generation of Interleukin 10–producing Regulatory CD4+ T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines

2002 • 1,163 citations

CTLA-4–Ig regulates tryptophan catabolism in vivo

2002 • 1,150 citations

Potential Regulatory Function of Human Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase

2002 • 1,035 citations

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo

1994 • 967 citations

Origin of regulatory T cells with known specificity for antigen

2002 • 854 citations

CD4 Regulatory T Cells Prevent Lethal Autoimmunity in IL-2Rβ-Deficient Mice

2002 • 783 citations

Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signalsin vivo

2004 • 761 citations

CD25+ CD4+ T Cells, Expanded with Dendritic Cells Presenting a Single Autoantigenic Peptide, Suppress Autoimmune Diabetes

2004 • 741 citations

In Vivo Instruction of Suppressor Commitment in Naive T Cells

2004 • 726 citations

Selecting and maintaining a diverse T-cell repertoire

1999 • 712 citations

Following a diabetogenic T cell from genesis through pathogenesis

1993 • 708 citations

Recognition of the Peripheral Self by Naturally Arising CD25+ CD4+ T Cell Receptors

2004 • 690 citations

Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells

2003 • 674 citations

Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo

2001 • 658 citations

IL-10-Secreting Regulatory T Cells Do Not Express Foxp3 but Have Comparable Regulatory Function to Naturally Occurring CD4+CD25+ Regulatory T Cells

2004 • 654 citations

TGF-β1 Plays an Important Role in the Mechanism of CD4+CD25+ Regulatory T Cell Activity in Both Humans and Mice

2004 • 643 citations

The Interaction Properties of Costimulatory Molecules Revisited

2002 • 640 citations

The Emerging Role of CTLA-4 as an Immune Attenuator

1997 • 637 citations

CD4+CD25+ Regulatory T Cells Can Mediate Suppressor Function in the Absence of Transforming Growth Factor β1 Production and Responsiveness

2002 • 614 citations

TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes

2003 • 595 citations

CD25+ CD4+ T Cells Regulate the Expansion of Peripheral CD4 T Cells Through the Production of IL-10

2001 • 564 citations

Control of T‐cell activation by CD4⁺ CD25⁺ suppressor T cells

2001 • 560 citations

Certified Professionals

2001 • 533 citations

B7-1 and B7-2 Have Overlapping, Critical Roles in Immunoglobulin Class Switching and Germinal Center Formation

1997 • 499 citations

Frontline: Neuropilin‐1: a surface marker of regulatory T cells

2004 • 447 citations

CD4+CD25+ T Regulatory Cells Dependent on ICOS Promote Regulation of Effector Cells in the Prediabetic Lesion

2004 • 443 citations

CD4 ⁺ CD25 ⁺ T regulatory cells control anti-islet CD8 ⁺ T cells through TGF-β–TGF-β receptor interactions in type 1 diabetes

2003 • 439 citations

An X-linked syndrome of diarrhea, polyendocrinopathy, and fatal infection in infancy

1982 • 436 citations

TGF-β regulatesin vivoexpansion of Foxp3-expressing CD4⁺CD25⁺regulatory T cells responsible for protection against diabetes

2004 • 425 citations

CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice.

1997 • 414 citations

Major Histocompatibility Complex Class II–Positive Cortical Epithelium Mediates the Selection of Cd4+25+ Immunoregulatory T Cells

2001 • 406 citations

In vivodynamics of antigen-specific regulatory T cells not predicted from behaviorin vitro

2003 • 384 citations

Impact of Negative Selection on the T Cell Repertoire Reactive to a Self-Peptide

2000 • 377 citations

Frontline: GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations

2004 • 358 citations

CD25 Is a Marker for CD4+ Thymocytes That Prevent Autoimmune Diabetes in Rats, But Peripheral T Cells with This Function Are Found in Both CD25+ and CD25− Subpopulations

2000 • 334 citations

Analysis of regulatory CD8 T cells in Qa-1-deficient mice

2004 • 330 citations

Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease

2004 • 322 citations

Functional Impairment of CD8+ T Cells by Regulatory T Cells during Persistent Retroviral Infection

2004 • 318 citations

Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Regulates the Unfolding of Autoimmune Diabetes

1998 • 295 citations

CD40 Ligation Releases Immature Dendritic Cells from the Control of Regulatory CD4+CD25+ T Cells

2003 • 292 citations

Costimulation via Glucocorticoid-Induced TNF Receptor in Both Conventional and CD25+ Regulatory CD4+ T Cells

2004 • 288 citations

Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells

2001 • 270 citations

Generation of CD4+CD25+ Regulatory T Cells from Autoreactive T Cells Simultaneously with Their Negative Selection in the Thymus and from Nonautoreactive T Cells by Endogenous TCR Expression

2002 • 253 citations

Differential Cytokine Requirements for Regulation of Autoimmune Gastritis and Colitis by CD4+CD25+T Cells

2001 • 246 citations

CD25+CD4+ T cells contribute to the control of memory CD8+ T cells

2002 • 241 citations

CD4+ regulatory T cells in autoimmunity and allergy

2002 • 236 citations

CD4+CD25+ Regulatory T Cells Suppress Differentiation and Functions of Th1 and Th2 Cells, Leishmania major Infection, and Colitis in Mice

2003 • 230 citations

Studies in B7-Deficient Mice Reveal a Critical Role for B7 Costimulation in Both Induction and Effector Phases of Experimental Autoimmune Encephalomyelitis

1999 • 219 citations

A Defect in Tryptophan Catabolism Impairs Tolerance in Nonobese Diabetic Mice

2003 • 213 citations

CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice.

1997 • 187 citations

IL-6 Inhibits the Tolerogenic Function of CD8α+ Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase

2001 • 185 citations

Defective CD95/APO-1/Fas signal complex formation in the human autoimmune lymphoproliferative syndrome, type Ia

1999 • 179 citations

4-1BB-dependent inhibition of immunosuppression by activated CD4+CD25+ T cells

2003 • 172 citations

Damage control, rather than unresponsiveness, effected by protective DX5+ T cells in autoimmune diabetes

2001 • 166 citations

Negative Selection during the Peripheral Immune Response to Antigen

2000 • 165 citations

Regulatory T cells in spontaneous autoimmune encephalomyelitis

2001 • 162 citations

CD40 and Dendritic Cell Function

2003 • 146 citations

Qa-1 restriction of CD8+ suppressor T cells

2004 • 142 citations

Regulation of Murine Inflammatory Bowel Disease by CD25+ and CD25− CD4+ Glucocorticoid-Induced TNF Receptor Family-Related Gene+ Regulatory T Cells

2003 • 142 citations

T cell vaccination induces T cell receptor Vβ-specific Qa-1-restricted regulatory CD8⁺T cells

1998 • 140 citations

Analysis of the Relationship between Viral Infection and Autoimmune Disease

2001 • 120 citations

Resistance to CD4+CD25+ Regulatory T Cells and TGF-β in Cbl-b−/− Mice

2004 • 120 citations

Cloning and characterization of GITR ligand

2003 • 108 citations

TGF regulates the CD4+CD25+ T-cell pool and the expression of Foxp3 in vivo

2004 • 106 citations

CD4+CD25+ T-cell development is regulated by at least 2 distinct mechanisms

2002 • 90 citations

CD28 disruption exacerbates inflammation in Tgf-β1-/- mice: in vivo suppression by CD4+CD25+ regulatory T cells independent of autocrine TGF-β1

2004 • 78 citations

The Role of Lymphocyte Subsets in Accelerated Diabetes in Nonobese Diabetic–Rat Insulin Promoter–B7-1 (NOD-RIP-B7-1) Mice

1998 • 74 citations

Glycosylphosphatidylinositol-modified murine B7-1 and B7-2 retain costimulator function.

1995 • 48 citations

In vitro generation of IL-10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by Th1- and Th2-inducing cytokines

2003 • 43 citations

GENERAL DISCUSSION. I

1950 • 42 citations

Preferential Escape of Subdominant CD8+ T Cells During Negative Selection Results in an Altered Antiviral T Cell Hierarchy

2003 • 39 citations

Thymic Generation and Selection of CD25 ⁺ CD4 ⁺ Regulatory T Cells: Implications of Their Broad Repertoire and High Self‐Reactivity for the Maintenance of Immunological Self‐Tolerance

2003 • 37 citations

Recovery from EAE is associated with decreased survival of encephalitogenic T cells in the CNS of B7‐1/B7‐2‐deficient mice

2003 • 37 citations

T cells are the main cell type expressing B7-1 and B7-2 in the central nervous system during acute, relapsing and chronic experimental autoimmune encephalomyelitis

1999 • 28 citations

Negative regulation of T cell receptor signals

2004 • 25 citations

T-cell receptor crossreactivity and autoimmune disease

2000 • 24 citations

CD154 is a negative regulator of autoaggressive CD8 ⁺ T cells in type 1 diabetes

2004 • 16 citations

Qa-1 restriction of CD8+ suppressor T cells

2004 • 14 citations