PD‐1 signaling in primary T cells

PD-1 and Its Ligands in Tolerance and Immunity

2008 • 4,838 citations

Restoring function in exhausted CD8 T cells during chronic viral infection

2005 • 3,743 citations

Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.

1992 • 2,906 citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

2001 • 2,746 citations

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

2006 • 2,521 citations

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

1999 • 2,380 citations

THE B7 FAMILY REVISITED

2005 • 2,239 citations

Siglecs and their roles in the immune system

2007 • 1,801 citations

CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms

2005 • 1,746 citations

The B7–CD28 superfamily

2002 • 1,646 citations

Programmed Death-1 Ligand 1 Interacts Specifically with the B7-1 Costimulatory Molecule to Inhibit T Cell Responses

2007 • 1,603 citations

Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

2006 • 1,485 citations

The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection

2007 • 1,416 citations

Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

2007 • 1,375 citations

The CD28 Signaling Pathway Regulates Glucose Metabolism

2002 • 1,331 citations

PD-1 and PD-1 ligands: from discovery to clinical application

2007 • 1,199 citations

The ‘Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

2003 • 1,192 citations

SHP-1 and SHP-2 Associate with Immunoreceptor Tyrosine-Based Switch Motif of Programmed Death 1 upon Primary Human T Cell Stimulation, but Only Receptor Ligation Prevents T Cell Activation

2004 • 1,128 citations

Control of peripheral T‐cell tolerance and autoimmunity via the CTLA‐4 and PD‐1 pathways

2008 • 951 citations

CTLA-4: new insights into its biological function and use in tumor immunotherapy

2002 • 923 citations

PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection

2006 • 859 citations

BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1

2003 • 816 citations

Fuel feeds function: energy metabolism and the T-cell response

2005 • 813 citations

PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine

2001 • 786 citations

Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FeγRIIB

1996 • 770 citations

The PD-1–PD-L pathway in immunological tolerance

2006 • 681 citations

PD-1:PD-L inhibitory pathway affects both CD4+ and CD8+ T cells and is overcome by IL-2

2002 • 646 citations

Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src

1991 • 630 citations

Jurkat T cells and development of the T-cell receptor signalling paradigm

2004 • 540 citations

Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4

2005 • 532 citations

PD-1 and its ligands in T-cell immunity

2007 • 419 citations

Establishment of NOD-Pdcd1^-/-mice as an efficient animal model of type I diabetes

2005 • 409 citations

Reinvigorating exhausted HIV-specific T cells via PD-1–PD-1 ligand blockade

2006 • 396 citations

Direct Regulation of ZAP-70 by SHP-1 in T Cell Antigen Receptor Signaling

1996 • 390 citations

LAIR-1, a Novel Inhibitory Receptor Expressed on Human Mononuclear Leukocytes

1997 • 386 citations

Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation.

1994 • 369 citations

Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling

2003 • 368 citations

Stable antibody expression at therapeutic levels using the 2A peptide

2005 • 365 citations

Deficiency of PTEN in Jurkat T Cells Causes Constitutive Localization of Itk to the Plasma Membrane and Hyperresponsiveness to CD3 Stimulation

2000 • 345 citations

Variability and Robustness in T Cell Activation from Regulated Heterogeneity in Protein Levels

2008 • 343 citations

Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation

2002 • 334 citations

Roles of the SHP-1 tyrosine phosphatase in the negative regulation of cell signalling

2000 • 320 citations

Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors

2002 • 300 citations

The CD28 family: a T-cell rheostat for therapeutic control of T-cell activation

2004 • 297 citations

The Tyrosine Phosphatase SHP-2 Is Required for Sustained Activation of Extracellular Signal-Regulated Kinase and Epithelial Morphogenesis Downstream from the Met Receptor Tyrosine Kinase

2000 • 278 citations

Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling.

1995 • 260 citations

Engineering Artificial Antigen-presenting Cells to Express a Diverse Array of Co-stimulatory Molecules

2007 • 253 citations

Multiple Requirements for SHPTP2 in Epidermal Growth Factor-Mediated Cell Cycle Progression

1996 • 247 citations

Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor

2008 • 238 citations

SHP2 and SOCS3 Contribute to Tyr-759-dependent Attenuation of Interleukin-6 Signaling through gp130

2002 • 237 citations

Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signaling and for association with protein tyrosine phosphatase 1C.

1996 • 213 citations

Loss of Siglec expression on T lymphocytes during human evolution

2006 • 201 citations

Nonreceptor Protein-Tyrosine Phosphatases in Immune Cell Signaling

2007 • 185 citations

Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness.

1996 • 174 citations

B and T Lymphocyte Attenuator Exhibits Structural and Expression Polymorphisms and Is Highly Induced in Anergic CD4+ T Cells

2005 • 171 citations

CD28 and Inducible Costimulatory Protein Src Homology 2 Binding Domains Show Distinct Regulation of Phosphatidylinositol 3-Kinase, Bcl-xL, and IL-2 Expression in Primary Human CD4 T Lymphocytes

2003 • 164 citations

Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor

2005 • 163 citations

Analysis of the Role of Negative T Cell Costimulatory Pathways in CD4 and CD8 T Cell-Mediated Alloimmune Responses In Vivo

2005 • 149 citations

Involvement of SH2-containing Phosphotyrosine Phosphatase Syp in Erythropoietin Receptor Signal Transduction Pathways

1995 • 147 citations

CTLA-4 ligation delivers a unique signal to resting human CD4 T cells that inhibits interleukin-2 secretion but allows Bcl-X(L) induction.

1998 • 137 citations

SHP-1- and Phosphotyrosine-Independent Inhibitory Signaling by a Killer Cell Ig-Like Receptor Cytoplasmic Domain in Human NK Cells

2002 • 134 citations

Mutation of the SHP-2 Binding Site in Growth Hormone (GH) Receptor Prolongs GH-Promoted Tyrosyl Phosphorylation of GH Receptor, JAK2, and STAT5B

2000 • 131 citations

Growth Factor Receptor-bound Protein 2 SH2/SH3 Domain Binding to CD28 and Its Role in Co-signaling

1998 • 127 citations

Ligation of CD28 receptor by B7 induces formation of D‐3 phosphoinositides in T lymphocytes independently of T cell receptor/CD3 activation

1993 • 121 citations

Evidence That SHIP-1 Contributes to Phosphatidylinositol 3,4,5-Trisphosphate Metabolism in T Lymphocytes and Can Regulate Novel Phosphoinositide 3-Kinase Effectors

2002 • 118 citations

Cutting Edge: CTLA-4 Ligation Delivers a Unique Signal to Resting Human CD4 T Cells That Inhibits Interleukin-2 Secretion but Allows Bcl-XL Induction

1998 • 111 citations

Siglec-5 (CD170) Can Mediate Inhibitory Signaling in the Absence of Immunoreceptor Tyrosine-based Inhibitory Motif Phosphorylation

2005 • 103 citations

A Single Amino Acid Alteration in Cytoplasmic Domain Determines IL-2 Promoter Activation by Ligation of CD28 but Not Inducible Costimulator (ICOS)

2003 • 96 citations

A Cell-Based Artificial Antigen-Presenting Cell Coated with Anti-CD3 and CD28 Antibodies Enables Rapid Expansion and Long-Term Growth of CD4 T Lymphocytes

2002 • 93 citations

Lentiviral Vectors Encoding Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Receptor Genes Efficiently Convert Peripheral Blood CD8 T Lymphocytes into Cytotoxic T Lymphocytes with Potent In Vitro and In Vivo HIV-1-Specific Inhibitory Activity

2008 • 84 citations

Investigations into the Regulation and Function of the SH2 Domain-Containing Protein-Tyrosine Phosphatase, SHP-1

2006 • 81 citations

Phosphoinositide Lipid Phosphatases: Natural Regulators of Phosphoinositide 3-Kinase Signaling in T Lymphocytes

2007 • 81 citations

B and T Lymphocyte Attenuator-Mediated Signal Transduction Provides a Potent Inhibitory Signal to Primary Human CD4 T Cells That Can Be Initiated by Multiple Phosphotyrosine Motifs

2006 • 77 citations

Programmed Death 1 Ligand (PD-L) 1 and PD-L2 Limit Autoimmune Kidney Disease: Distinct Roles

2007 • 77 citations

Adapter Function of Protein-tyrosine Phosphatase 1D in Insulin Receptor/Insulin Receptor Substrate-1 Interaction

1995 • 73 citations

Association of Grb-2 and PI3K p85 with phosphotyrosile peptides derived from BTLA

2006 • 72 citations

Grb2 Forms an Inducible Protein Complex with CD28 through a Src Homology 3 Domain-Proline Interaction

1998 • 69 citations

Constitutive Association of SHP-1 with Leukocyte-Associated Ig-Like Receptor-1 in Human T Cells

2001 • 68 citations

Systematic identification of immunoreceptor tyrosine-based inhibitory motifs in the human proteome

2003 • 66 citations

GRID: A Novel Grb-2-Related Adapter Protein That Interacts with the Activated T Cell Costimulatory Receptor CD28

2000 • 63 citations

Leukocyte‐associated Ig‐like receptor‐1 has SH2 domain‐containing phosphatase‐independent function and recruits C‐terminal Src kinase

2005 • 63 citations

STAT5 Is Essential for Akt/p70S6 Kinase Activity during IL-2-Induced Lymphocyte Proliferation

2007 • 58 citations

Grb2 and Gads Exhibit Different Interactions with CD28 and Play Distinct Roles in CD28-Mediated Costimulation

2006 • 58 citations

Turning on the off switch: Regulation of anti-viral T cell responses in the liver by the PD-1/PD-L1 pathway

2006 • 50 citations

PD-1 deficiency reveals various tissue-specific autoimmunity by H-2^band dose-dependent requirement of H-2^g7for diabetes in NOD mice

2008 • 45 citations

Recruitment of C-terminal Src kinase by the leukocyte inhibitory receptor CD85j

2004 • 44 citations

Differential contribution of the immunoreceptor tyrosine-based inhibitory motifs of human leukocyte-associated Ig-like receptor-1 to inhibitory function and phosphatase recruitment

2003 • 41 citations

Dendritic Cells in Transplantation and Immune-Based Therapies

2007 • 34 citations

Novel strategies to eliminate persistent viral infections

2008 • 33 citations

The road to recovery: translating PD-1 biology into clinical benefit

2006 • 32 citations

Regulation of cell signaling by the protein tyrosine phosphatases, CD45 and SHP-1

1997 • 25 citations

The interchain disulfide linkage is not a prerequisite but enhances CD28 costimulatory function

2006 • 23 citations