Blockade of B7-H1 on Macrophages Suppresses CD4+ T Cell Proliferation by Augmenting IFN-γ-Induced Nitric Oxide Production

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 • 4,853 citations

NITRIC OXIDE AND MACROPHAGE FUNCTION

1997 • 4,106 citations

Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.

1992 • 2,906 citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

2001 • 2,746 citations

Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

1999 • 2,574 citations

Prevention of Allogeneic Fetal Rejection by Tryptophan Catabolism

1998 • 2,538 citations

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

1999 • 2,380 citations

Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice

2001 • 1,761 citations

The B7–CD28 superfamily

2002 • 1,646 citations

Inhibition of T Cell Proliferation by Macrophage Tryptophan Catabolism

1999 • 1,560 citations

Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes

1996 • 1,473 citations

Altered immune responses in mice lacking inducible nitric oxide synthase

1995 • 1,296 citations

SHP-1 and SHP-2 Associate with Immunoreceptor Tyrosine-Based Switch Motif of Programmed Death 1 upon Primary Human T Cell Stimulation, but Only Receptor Ligation Prevents T Cell Activation

2004 • 1,128 citations

Potential Regulatory Function of Human Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase

2002 • 1,035 citations

Expression of Programmed Death 1 Ligands by Murine T Cells and APC

2002 • 908 citations

The B7 Family of Ligands and Its Receptors: New Pathways for Costimulation and Inhibition of Immune Responses

2002 • 884 citations

B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells

2001 • 850 citations

The Programmed Death-1 (PD-1) Pathway Regulates Autoimmune Diabetes in Nonobese Diabetic (NOD) Mice

2003 • 766 citations

PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells

2004 • 609 citations

Macrophage-Derived Nitric Oxide Regulates T Cell Activation via Reversible Disruption of the Jak3/STAT5 Signaling Pathway

1998 • 473 citations

PD-1: an inhibitory immunoreceptor involved in peripheral tolerance

2001 • 467 citations

Prevention of T cell–driven complement activation and inflammation by tryptophan catabolism during pregnancy

2001 • 425 citations

Nitric oxide production is required for murine resident peritoneal macrophages to suppress mitogen-stimulated T cell proliferation. Role of IFN-gamma in the induction of the nitric oxide-synthesizing pathway.

1991 • 384 citations

Inhibition of insulin secretion by interleukin‐1β and tumour necrosis factor‐α via an L‐arginine‐dependent nitric oxide generating mechanism

1990 • 362 citations

Interleukin-lβ-Induced Nitric Oxide Production in Isolated Rat Pancreatic Islets Requires Gene Transcription and May Lead to Inhibition of the Krebs Cycle Enzyme Aconitase*

1991 • 317 citations

Nitric oxide and arthritis

1993 • 299 citations

Interleukin-1 beta-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans. Role of nitric oxide in interleukin-1 beta-induced inhibition of insulin secretion.

1991 • 257 citations

Transfer of diabetes in mice prevented by blockade of adhesion-promoting receptor on macrophages

1990 • 245 citations

Alloantigen-induced activation of rat splenocytes is regulated by the oxidative metabolism of L-arginine.

1990 • 230 citations

Experimental Autoimmune Encephalomyelitis Is Exacerbated in Mice Lacking theNOS2Gene

1998 • 226 citations

B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function

2001 • 220 citations

CD28-Independent Costimulation of T Cells by OX40 Ligand and CD70 on Activated B Cells

1999 • 180 citations

Activation-Induced Expression of Human Programmed Death-1 Gene in T-Lymphocytes

1997 • 144 citations

Our shifting understanding of the role of nitric oxide in autoimmune encephalomyelitis: a review

1999 • 141 citations

Nitric oxide mediates suppression of T cell responses in murine Trypanosoma brucei infection

1992 • 136 citations

Suppression of lymphocyte proliferation through the nitric oxide synthesizing pathway

1991 • 135 citations

Preferential contribution of B7‐H1 to programmed death‐1‐mediated regulation of hapten‐specific allergic inflammatory responses

2003 • 121 citations

Elevated nitric oxide production in rheumatoid arthritis: Detection using the fasting urinary nitrate:creatinine ratio

1996 • 120 citations

Nitric oxide suppresses human T lymphocyte proliferation through IFN-gamma-dependent and IFN-gamma-independent induction of apoptosis.

1999 • 105 citations

Alveolar macrophages from humans and rodents selectively inhibit T-cell proliferation but permit T-cell activation and cytokine secretion.

1995 • 85 citations

Regulation of T‐cell activation in the lung: alveolar macrophages induce reversible T‐cell anergy in vitro associated with inhibition of interleukin‐2 receptor signal transduction

1996 • 82 citations

Nitric Oxide Suppresses Human T Lymphocyte Proliferation Through IFN-γ-Dependent and IFN-γ-Independent Induction of Apoptosis

1999 • 77 citations

Psoriasis genomics: analysis of proinflammatory (type 1) gene expression in large plaque (Western) and small plaque (Asian) psoriasis vulgaris

2004 • 67 citations

Nitric Oxide Inhibits the Proliferation of T-Helper 1 and 2 Lymphocytes without Reduction in Cytokine Secretion

1999 • 66 citations

Macrophage-Derived Nitric Oxide Inhibits the Proliferation of Activated T Helper Cells and Is Induced during Antigenic Stimulation of Resting T Cells

2000 • 62 citations

Essential contribution of macrophages to islet cell destruction in vivo and in vitro

1990 • 57 citations

Inhibition of inducible nitric oxide synthase intensifies injury and functional deterioration in autoimmune interstitial nephritis.

1997 • 48 citations

CD40‐mediated stimulation of B1 and B2 cells: implication in autoantibody production in murine lupus

1996 • 44 citations

Double-Stranded Ribonucleic Acid (RNA) Induces β-Cell Fas Messenger RNA Expression and Increases Cytokine-Induced β-Cell Apoptosis*

2001 • 40 citations

Suppression of T-cell activation by pulmonary alveolar macrophages: dissociation of effects on TcR, IL-2R expression, and proliferation

1994 • 38 citations

Nitric Oxide in the Local Host Reaction to Total Hip Replacement

1998 • 35 citations

Experimental autoimmune encephalomyelitis in mice with a targeted deletion of the inducible nitric oxide synthase gene: increased T-helper 1 response

2004 • 30 citations

Double-stranded RNA Inhibits β-Cell Function and Induces Islet Damage by Stimulating β-Cell Production of Nitric Oxide

1999 • 28 citations

Alveolar macrophages. VI. Regulation of alveolar macrophage-mediated suppression of lymphocyte proliferation by a putative T cell.

1981 • 23 citations