The diversity of costimulatory and inhibitory receptor pathways and the regulation of antiviral T cell responses

Restoring function in exhausted CD8 T cells during chronic viral infection

2005 • 3,743 citations

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

2006 • 2,521 citations

THE B7 FAMILY REVISITED

2005 • 2,239 citations

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

2008 • 1,887 citations

Siglecs and their roles in the immune system

2007 • 1,801 citations

CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms

2005 • 1,746 citations

Programmed Death-1 Ligand 1 Interacts Specifically with the B7-1 Costimulatory Molecule to Inhibit T Cell Responses

2007 • 1,603 citations

Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

2006 • 1,485 citations

T Cell Anergy

2003 • 1,418 citations

Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

2007 • 1,375 citations

The CD28 Signaling Pathway Regulates Glucose Metabolism

2002 • 1,331 citations

TNF/TNFR FAMILY MEMBERS IN COSTIMULATION OF T CELL RESPONSES

2004 • 1,320 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection

2006 • 859 citations

Characterization of Hepatitis B Virus (HBV)-Specific T-Cell Dysfunction in Chronic HBV Infection

2007 • 847 citations

Enhancing SIV-specific immunity in vivo by PD-1 blockade

2008 • 731 citations

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

2008 • 715 citations

PD‐1 inhibits T‐cell receptor induced phosphorylation of the ZAP70/CD3ζ signalosome and downstream signaling to PKCθ

2004 • 697 citations

PD-1:PD-L inhibitory pathway affects both CD4+ and CD8+ T cells and is overcome by IL-2

2002 • 646 citations

Signals required for programming effector and memory development by CD8⁺ T cells

2006 • 574 citations

PD-1 Expression in Acute Hepatitis C Virus (HCV) Infection Is Associated with HCV-Specific CD8 Exhaustion

2006 • 558 citations

Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction

2007 • 502 citations

Selective expansion of a subset of exhausted CD8 T cells by αPD-L1 blockade

2008 • 500 citations

Liver-Infiltrating Lymphocytes in Chronic Human Hepatitis C Virus Infection Display an Exhausted Phenotype with High Levels of PD-1 and Low Levels of CD127 Expression

2006 • 465 citations

Evolutionary struggles between NK cells and viruses

2008 • 435 citations

A critical function for CD200 in lung immune homeostasis and the severity of influenza infection

2008 • 421 citations

CTLA-4-Mediated Inhibition of Early Events of T Cell Proliferation

1999 • 412 citations

The TIM gene family: emerging roles in immunity and disease

2003 • 378 citations

PD-1 Inhibits Antiviral Immunity at the Effector Phase in the Liver

2003 • 373 citations

Upregulation of PD-1 Expression on Circulating and Intrahepatic Hepatitis C Virus-Specific CD8⁺T Cells Associated with Reversible Immune Dysfunction

2007 • 365 citations

CD8 T cell dysfunction during chronic viral infection

2007 • 335 citations

Lymphocyte Activation Gene-3 (CD223) Regulates the Size of the Expanding T Cell Population Following Antigen Activation In Vivo

2004 • 328 citations

CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator

2008 • 323 citations

Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors

2002 • 300 citations

PD-1 up-regulation is correlated with HIV-specific memory CD8+ T-cell exhaustion in typical progressors but not in long-term nonprogressors

2007 • 293 citations

Functional Restoration of HCV-Specific CD8 T Cells by PD-1 Blockade Is Defined by PD-1 Expression and Compartmentalization

2008 • 288 citations

A coreceptor interaction between the CD28 and TNF receptor family members B and T lymphocyte attenuator and herpesvirus entry mediator

2005 • 241 citations

Programmed Death 1 Expression on HIV-Specific CD4+ T Cells Is Driven by Viral Replication and Associated with T Cell Dysfunction

2007 • 240 citations

Costimulation of T cells by OX40, 4-1BB, and CD27

2003 • 229 citations

Peripheral Tolerance of CD8 T Lymphocytes

2005 • 227 citations

2B4 Acts As a Non–Major Histocompatibility Complex Binding Inhibitory Receptor on Mouse Natural Killer Cells

2004 • 201 citations

Role of CD28-B7 Interactions in Generation and Maintenance of CD8 T Cell Memory

2001 • 192 citations

Expression of the Interleukin-7 Receptor Alpha Chain (CD127) on Virus-Specific CD8 ⁺ T Cells Identifies Functionally and Phenotypically Defined Memory T Cells during Acute Resolving Hepatitis B Virus Infection

2006 • 191 citations

Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells

2007 • 187 citations

Oscillating CD8+ T Cell Effector Functions after Antigen Recognition in the Liver

2005 • 185 citations

SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection

2007 • 174 citations

Dynamic Programmed Death 1 Expression by Virus-Specific CD8 T Cells Correlates With the Outcome of Acute Hepatitis B

2008 • 160 citations

CD40-CD40 Ligand Costimulation Is Required for Generating Antiviral CD4 T Cell Responses But Is Dispensable for CD8 T Cell Responses

1999 • 153 citations

Programmed Death-1 (PD-1):PD-Ligand 1 Interactions Inhibit TCR-Mediated Positive Selection of Thymocytes

2005 • 138 citations

Elevated Expression Levels of Inhibitory Receptor Programmed Death 1 on Simian Immunodeficiency Virus-Specific CD8 T Cells during Chronic Infection but Not after Vaccination

2007 • 132 citations

Control of Memory CD8+ T Cell Differentiation by CD80/CD86-CD28 Costimulation and Restoration by IL-2 during the Recall Response

2008 • 100 citations

Detrimental Contribution of the Immuno-Inhibitor B7-H1 to Rabies Virus Encephalitis

2008 • 94 citations

Role of T cell costimulation in anti-viral immunity

2004 • 93 citations

Functional Analysis of B and T Lymphocyte Attenuator Engagement on CD4+ and CD8+ T Cells

2005 • 86 citations

4-1BBL Induces TNF Receptor-Associated Factor 1-Dependent Bim Modulation in Human T Cells and Is a Critical Component in the Costimulation-Dependent Rescue of Functionally Impaired HIV-Specific CD8 T Cells

2007 • 79 citations

Normal Responsiveness of CTLA-4-Deficient Anti-Viral Cytotoxic T Cells

1998 • 75 citations

PDL-1 Blockade Impedes T Cell Expansion and Protective Immunity Primed by Attenuated Listeria monocytogenes

2008 • 59 citations

Lack of Intrinsic CTLA-4 Expression Has Minimal Effect on Regulation of Antiviral T-Cell Immunity

2005 • 55 citations

Direct CD28 Costimulation Is Required for CD8+ T Cell-Mediated Resistance to an Acute Viral Disease in a Natural Host

2006 • 53 citations

CD137 Costimulation of CD8+ T Cells Confers Resistance to Suppression by Virus-Induced Regulatory T Cells

2008 • 50 citations

Blockade of endogenous B7‐H1 suppresses antibacterial protection after primary Listeria monocytogenes infection

2007 • 43 citations

Costimulation Requirements for Antiviral CD8+ T Cells Differ for Acute and Persistent Phases of Polyoma Virus Infection

2006 • 33 citations

CD8+ T Cell Dysfunction and Increase in Murine Gammaherpesvirus Latent Viral Burden in the Absence of 4-1BB Ligand

2007 • 33 citations

Cutting Edge: Distinct NK Receptor Profiles Are Imprinted on CD8 T Cells in the Mucosa and Periphery during the Same Antigen Challenge: Role of Tissue-Specific Factors

2007 • 28 citations

Pivotal Advance: CTLA-4+ T cells exhibit normal antiviral functions during acute viral infection

2007 • 14 citations