Scurfin (FOXP3) Acts as a Repressor of Transcription and Regulates T Cell Activation

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

2001 • 3,260 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

2001 • 2,503 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

2001 • 1,831 citations

Unified nomenclature for the winged helix/forkhead transcription factors

2000 • 1,136 citations

JM2, encoding a fork head–related protein, is mutated in X-linked autoimmunity–allergic disregulation syndrome

2000 • 909 citations

Negative Regulation of the Forkhead Transcription Factor FKHR by Akt

1999 • 763 citations

Five years on the wings of fork head

1996 • 657 citations

The Emerging Role of CTLA-4 as an Immune Attenuator

1997 • 637 citations

Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending.

1994 • 430 citations

Lymphoproliferation in CTLA-4–Deficient Mice Is Mediated by Costimulation-Dependent Activation of CD4 + T Cells

1997 • 405 citations

The DNA-binding specificity of the hepatocyte nuclear factor 3/forkhead domain is influenced by amino-acid residues adjacent to the recognition helix.

1994 • 357 citations

Characterization of a New Subfamily of Winged-helix/Forkhead (Fox) Genes That Are Expressed in the Lung and Act as Transcriptional Repressors

2001 • 345 citations

X-linked lymphoreticular disease in the scurfy (sf) mutant mouse.

1991 • 339 citations

Novel NFAT Sites That Mediate Activation of the Interleukin-2 Promoter in Response to T-Cell Receptor Stimulation

1995 • 259 citations

Tumor Necrosis Factor Alpha Gene Regulation in Activated T Cells Involves ATF-2/Jun and NFATp

1996 • 252 citations

Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23)

1997 • 247 citations

Two essential regulatory elements in the human interferon gamma promoter confer activation specific expression in T cells.

1993 • 203 citations

Cellular and molecular characterization of the scurfy mouse mutant.

1999 • 197 citations

The scurfy mouse mutant has previously unrecognized hematological abnormalities and resembles Wiskott-Aldrich syndrome.

1990 • 195 citations

CD4+CD8- T cells are the effector cells in disease pathogenesis in the scurfy (sf) mouse.

1994 • 182 citations

Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in a sf thymic environment: potential model for thymic education.

1991 • 175 citations

, a Winged Helix Transcriptional Repressor with Expression Restricted to Embryonic Stem Cells

1996 • 167 citations

Cellular and Molecular Characterization of thescurfyMouse Mutant

1999 • 160 citations

Human Granulocyte-Macrophage Colony-Stimulating Factor Enhancer Function Is Associated with Cooperative Interactions between AP-1 and NFATp/c

1995 • 133 citations

Disease in the scurfy (sf) mouse is associated with overexpression of cytokine genes

1996 • 120 citations

Role of Transcriptional Repressor ICER in Cyclic AMP-mediated Attenuation of Cytokine Gene Expression in Human Thymocytes

1998 • 112 citations

Dynamic DNA Contacts Observed in the NMR Structure of Winged Helix Protein-DNA Complex

1999 • 103 citations

The whn transcription factor encoded by the nude locus contains an evolutionarily conserved and functionally indispensable activation domain.

1996 • 92 citations

The Human gp39 Promoter

1995 • 86 citations

FREAC-1 Contains a Cell-Type-Specific Transcriptional Activation Domain and Is Expressed in Epithelial–Mesenchymal Interfaces

1998 • 82 citations

Dominant negative mutant of c-Jun inhibits NF-AT transcriptional activity and prevents IL-2 gene transcription.

1994 • 81 citations

Transplantation of T cell-mediated, lymphoreticular disease from the scurfy (sf) mouse.

1994 • 75 citations

Structural changes in the region directly adjacent to the DNA-binding helix highlight a possible mechanism to explain the observed changes in the sequence-specific binding of winged helix proteins 1 1Edited by P. E. Wright

1998 • 72 citations

DNA-binding properties and secondary structural model of the hepatocyte nuclear factor 3/fork head domain.

1993 • 68 citations

The Human Forkhead Protein FREAC-2 Contains Two Functionally Redundant Activation Domains and Interacts with TBP and TFIIB

1998 • 65 citations

Role of the forkhead transcription family member, FKHR, in thymocyte differentiation

2000 • 64 citations

Suppression of T cell function: a potential role for transcriptional repressor ICER

2000 • 63 citations

The Thyroid Transcription Factor 2 (TTF-2) Is a Promoter-Specific DNA-Binding Independent Transcriptional Repressor

2000 • 61 citations

The Mouse Homolog of the Wiskott–Aldrich Syndrome Protein (WASP) Gene Is Highly Conserved and Maps near the Scurfy (sf) Mutation on the X Chromosome

1995 • 46 citations

The murine mutation scurfy (sf) results in an antigen-dependent lymphoproliferative disease with altered T cell sensitivity

2001 • 43 citations

The proximal promoter of the IL-4 gene is composed of multiple essential regulatory sites that bind at least two distinct factors.

1995 • 35 citations

The mouse scurfy (sf) mutation is tightly linked to Gata1 and Tfe3 on the proximal X Chromosome

1994 • 24 citations

Molecular cloning of FKHRL1P2, a member of the developmentally regulated fork head domain transcription factor family

1998 • 4 citations