Calcium Homeostasis and Free Radical Metabolism as Convergence Points in the Pathophysiology of Dementia

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1995 • 3,985 citations

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

1993 • 3,693 citations

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1991 • 2,981 citations

Protein Oxidation and Aging

1992 • 2,687 citations

Candidate Gene for the Chromosome 1 Familial Alzheimer's Disease Locus

1995 • 2,548 citations

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1995 • 2,456 citations

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

1993 • 2,423 citations

Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?

1993 • 2,146 citations

Hydrogen peroxide mediates amyloid β protein toxicity

1994 • 2,065 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

Calcium signaling

1995 • 1,905 citations

Amyloid β-peptide is produced by cultured cells during normal metabolism

1992 • 1,888 citations

Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

1992 • 1,701 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

Rapid induction of Alzheimer A beta amyloid formation by zinc

1994 • 1,483 citations

An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp ₇₁₇ ) Mutants

1994 • 1,463 citations

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

1993 • 1,422 citations

Nuclear Factor Kb: An Oxidative Stress-Responsive Transcription Factor of Eukaryotic Cells (A Review)

1992 • 1,421 citations

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

1994 • 1,313 citations

Activation of microglial cells by β-amyloid protein and interferon-γ

1995 • 1,298 citations

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.

1994 • 1,085 citations

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.

1993 • 1,035 citations

Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress

1989 • 987 citations

Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs.

1992 • 982 citations

Glutamate becomes neurotoxic via the N-methyl-d-aspartate receptor when intracellular energy levels are reduced

1988 • 972 citations

The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling

1994 • 934 citations

Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor

1993 • 909 citations

Release of Alzheimer Amyloid Precursor Derivatives Stimulated by Activation of Muscarinic Acetylcholine Receptors

1992 • 899 citations

Guam Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Linked to a Plant Excitant Neurotoxin

1987 • 881 citations

Estrogens Attenuate and Corticosterone Exacerbates Excitotoxicity, Oxidative Injury, and Amyloid β‐Peptide Toxicity in Hippocampal Neurons

1996 • 833 citations

Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus

1994 • 815 citations

Complement activation by beta-amyloid in Alzheimer disease.

1992 • 804 citations

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein

1993 • 800 citations

Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.

1990 • 735 citations

Apolipoprotein E and Alzheimer disease.

1995 • 697 citations

Structure‐Activity Analyses of β‐Amyloid Peptides: Contributions of the β25–35 Region to Aggregation and Neurotoxicity

1995 • 691 citations

Calcium‐binding protein (calbindin‐D_28k) and parvalbumin immunocytochemistry: Localization in the rat hippocampus with specific reference to the selective vulnerability of hippocampal neurons to seizure activity

1989 • 689 citations

β-Amyloid-mediated vasoactivity and vascular endothelial damage

1996 • 686 citations

Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis

1994 • 672 citations

Apolipoprotein E in animal models of CNS injury and in alzheimer's disease

1994 • 651 citations

Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation.

1995 • 632 citations

Neurotrophic Factors Attenuate Glutamate‐Induced Accumulation of Peroxides, Elevation of Intracellular Ca²⁺ Concentration, and Neurotoxicity and Increase Antioxidant Enzyme Activities in Hippocampal Neurons

1995 • 616 citations

17-β Estradiol Protects Neurons from Oxidative Stress-Induced Cell Death in Vitro

1995 • 612 citations

Cholinergic function and intellectual decline in Alzheimer's disease

1986 • 605 citations

Estrogen Replacement Therapy in Older Women

1994 • 596 citations

Activation of the Sphingomyelin Cycle Through the Low-Affinity Neurotrophin Receptor

1994 • 583 citations

Aggregation and secondary structure of synthetic amyloid βA4 peptides of Alzheimer's disease

1991 • 580 citations

β-Amyloid fibrils induce tau phosphorylation and loss of microtubule binding

1995 • 580 citations

Inverse association of anti‐inflammatory treatments and Alzheimer's disease

1994 • 567 citations

Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death

1995 • 559 citations

Alzheimer–associated presenilins 1 and 2 : Neuronal expression in brain and localization to intracellular membranes in mammalian cells

1996 • 549 citations

Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes.

1993 • 549 citations

β-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease

1993 • 520 citations

Evidence for calcium-reducing and excitoprotective roles for the calcium-binding protein calbindin-1328k in cultured hippocampal neurons

1991 • 518 citations

Nitric Oxide in the Nervous System

1995 • 503 citations

Fibroblast growth factor and glutamate: opposing roles in the generation and degeneration of hippocampal neuroarchitecture

1989 • 492 citations

Brain‐Derived Neurotrophic Factor Protects Dopamine Neurons Against 6‐Hydroxydopamine and N‐Methyl‐4‐Phenylpyridinium Ion Toxicity: Involvement of the Glutathione System

1992 • 465 citations

Secreted Forms of β-Amyloid Precursor Protein Protect Hippocampal Neurons against Amyloid β-Peptide-Induced Oxidative Injury

1994 • 445 citations

Relative sparing in Parkinson's disease of substantia nigra dopamine neurons containing calbindin-D28K

1990 • 433 citations

Antioxidant effects of estradiol and 2-hydroxyestradiol on iron-induced lipid peroxidation of rat liver microsomes

1994 • 424 citations

Physiological production of the β-amyloid protein and the mechanism of Alzheimer's disease

1993 • 423 citations

The effect of ovariectomy and estradiol replacement on brain-derived neurotrophic factor messenger ribonucleic acid expression in cortical and hippocampal brain regions of female Sprague-Dawley rats.

1995 • 422 citations

β-Amyloid Peptide Free Radical Fragments Initiate Synaptosomal Lipoperoxidation in a Sequence-Specific Fashion: Implications to Alzheimer′s Disease

1994 • 406 citations

NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults

1994 • 402 citations

Structural model for the β-amyloid fibril based on interstrand alignment of an antiparallel-sheet comprising a C-terminal peptide

1995 • 393 citations

Formation of β-amyloid protein deposits in brains of transgenic mice

1991 • 385 citations

Calcium-destabilizing and neurodegenerative effects of aggregated β-amyloid peptide are attenuated by basic FGF

1993 • 383 citations

A role for IGF-1 in the rescue of CNS neurons following hypoxic-ischemic injury

1992 • 381 citations

pH-dependent structural transitions of Alzheimer amyloid peptides

1991 • 376 citations

Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative.

1994 • 373 citations

Amyloid peptides are toxic via a common oxidative mechanism.

1995 • 372 citations

Secondary structure of amyloid beta peptide correlates with neurotoxic activity in vitro.

1994 • 363 citations

Calcium buffering properties of calbindin D28k and parvalbumin in rat sensory neurones.

1993 • 348 citations

Amyloidogenicity of beta A4 and beta A4-bearing amyloid protein precursor fragments by metal-catalyzed oxidation.

1992 • 344 citations

Apoptosis mediated neurotoxicity induced by chronic application of β amyloid fragment 25–35

1993 • 343 citations

Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation.

1994 • 338 citations

Activation of K+ channels and suppression of neuronal activity by secreted β-amyloid-precursor protein

1996 • 336 citations

Amelioration of delayed neuronal death in the hippocampus by nerve growth factor

1991 • 333 citations

Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease.

1995 • 332 citations

Stress exacerbates neuron loss and cytoskeletal pathology in the hippocampus

1994 • 325 citations

Thrombin modulates and reverses neuroblastoma neurite outgrowth.

1988 • 318 citations

Endogenous Neuroprotection Factors and Traumatic Brain Injury: Mechanisms of Action and Implications for Therapy

1994 • 308 citations

Pathological alterations of the cerebral microvasculature in Alzheimer's disease and related dementing disorders

1994 • 297 citations

Apolipoprotein E polymorphisms affect atherosclerosis in young males. Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group.

1991 • 291 citations

Inflammatory mechanisms in Alzheimer's disease

1994 • 285 citations

Age- and peroxidative stress-related modifications of the cerebral enzymatic activities linked to mitochondria and the glutathione system

1995 • 284 citations

Antigenic changes similar to those seen in neurofibrillary tangles are elicited by glutamate and Ca2+ influx in cultured hippocampal neurons

1990 • 283 citations

Synaptotrophic effects of human amyloid β protein precursors in the cortex of transgenic mice

1994 • 278 citations

Astrocytes: Form, Functions, and Roles in Disease

1994 • 278 citations

Secreted Forms of β‐Amyloid Precursor Protein Protect Against Ischemic Brain Injury

1994 • 267 citations

Localization of Alzheimer βA4 amyloid precursor protein at central and peripheral synaptic sites

1991 • 259 citations

Fibrillogenesis in Alzheimer's disease of amyloid β peptides and apolipoprotein E

1995 • 255 citations

Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor.

1994 • 252 citations

Calcium as sculptor and destroyer of neural circuitry

1992 • 250 citations

K‐252 Compounds: Modulators of Neurotrophin Signal Transduction

1992 • 248 citations

Imaging of calcium and aluminum in neurofibrillary tangle-bearing neurons in parkinsonism-dementia of Guam.

1984 • 244 citations

17 beta-estradiol preserves endothelial vasodilator function and limits low-density lipoprotein oxidation in hypercholesterolemic swine.

1994 • 240 citations

Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices.

1993 • 236 citations

Ceramide Protects Hippocampal Neurons Against Excitotoxic and Oxidative Insults, and Amyloid β‐Peptide Toxicity

1996 • 229 citations

Cellular localization of thrombin receptor mRNA in rat brain: expression by mesencephalic dopaminergic neurons and codistribution with prothrombin mRNA

1995 • 228 citations

Transforming Growth Factor-β₁ Prevents Glutamate Neurotoxicity in Rat Neocortical Cultures and Protects Mouse Neocortex from Ischemic Injury in vivo

1993 • 228 citations

Cellular targets and trophic functions of neurotrophin-3 in the developing rat hippocampus

1992 • 225 citations

Amyloid β peptide induces necrosis rather than apoptosis

1994 • 221 citations

Rapid Communication: Ca²⁺ Channel Blockers Attenuate β‐Amyloid Peptide Toxicity to Cortical Neurons in Culture

1994 • 214 citations

Trophic effect of β-amyloid precursor protein on cerebral cortical neurons in culture

1991 • 213 citations

Amyloid beta-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons.

1996 • 212 citations

Glia protect hippocampal neurons against excitatory amino acid‐induced degeneration: Involvement of fibroblast growth factor

1990 • 211 citations

Differential degeneration of the cerebral microvasculature in Alzheimerʼs disease

1995 • 205 citations

The Intracellular Component of Cellular 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐Diphenyltetrazolium Bromide (MTT) Reduction Is Specifically Inhibited by β‐Amyloid Peptides

1995 • 204 citations

Nordihydroguaiaretic acid protects hippocampal neurons against amyloid β-peptide toxicity, and attenuates free radical and calcium accumulation

1994 • 202 citations

β-Amyloid and the Pathogenesis of Alzheimer's Disease

1991 • 201 citations

Basic FGF, NGF, and IGFs Protect Hippocampal and Cortical Neurons against Iron-Induced Degeneration

1993 • 199 citations

Basic FGF regulates the expression of a functional 71 kDa NMDA receptor protein that mediates calcium influx and neurotoxicity in hippocampal neurons

1993 • 198 citations

Induction of neuroprotective κB-dependent transcription by secreted forms of the Alzheimer's β-amyloid precursor

1996 • 192 citations

Different amyloidogenic peptides share a similar mechanism of neurotoxicity involving reactive oxygen species and calcium

1995 • 187 citations

Genetics and molecular advances in Alzheimer's disease

1993 • 183 citations

Degeneration of vascular muscle cells in cerebral amyloid angiopathy of Alzheimer disease

1993 • 183 citations

Metyrapone, an Inhibitor of Glucocorticoid Production, Reduces Brain Injury Induced by Focal and Global Ischemia and Seizures

1996 • 182 citations

Soluble β-Amyloid Induction of Alzheimer's Phenotype for Human Fibroblast K ⁺ Channels

1994 • 168 citations

Amyloid β‐Protein Induces Its Own Production in Cultured Degenerating Cerebrovascular Smooth Muscle Cells

1995 • 162 citations

Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation.

1994 • 161 citations

The Role of Iron in Beta Amyloid Toxicity

1995 • 160 citations

Exposure toN-methyl-d-aspartate increases release of arachidonic acid in primary cultures of rat hippocampal neurons and not in astrocytes

1990 • 155 citations

Neurotrophic factor gene expression in astrocytes during development and following injury

1994 • 155 citations

Secreted forms of β‐amyloid precursor protein modulate dendrite outgrowth and calcium responses to glutamate in cultured embryonic hippocampal neurons

1994 • 154 citations

Calcium and neuronal injury in Alzheimer's disease. Contributions of beta-amyloid precursor protein mismetabolism, free radicals, and metabolic compromise.

1994 • 154 citations

Pretreatment with intraventricular basic fibroblast growth factor decreases infarct size following focal cerebral ischemia in rats

1994 • 153 citations

β-Amyloid-induced changes in cultured astrocytes parallel reactive astrocytosis associated with senile plaques in Alzheimer's disease

1994 • 151 citations

Loss of high‐affinity agonist binding to M1 muscarinic receptors in Alzheimer's disease: Implications for the failure of cholinergic replacement therapies

1991 • 145 citations

Amino acid sequence RERMS represents the active domain of amyloid beta/A4 protein precursor that promotes fibroblast growth.

1993 • 143 citations

Role of Cyclic GMP in the Regulation of Neuronal Calcium and Survival by Secreted Forms of β‐Amyloid Precursor

1995 • 142 citations

Deposits of Amyloid β Protein in the Central Nervous System of Transgenic Mice

1991 • 140 citations

The Physiological Relevance of Glucocorticoid Endangerment of the Hippocampusa

1994 • 140 citations

Glucose deprivation elicits neurofibrillary tangle-like antigenic changes in hippocampal neurons: Prevention by NGF and bFGF

1992 • 137 citations

β-Amyloid induces neuritic dystrophy in vitro

1992 • 132 citations

The expression of amyloid beta protein precursor protects nerve cells from β-amyloid and glutamate toxicity and alters their interaction with the extracellular matrix

1993 • 130 citations

Calcium and Neuronal Injury in Alzheimer's Disease

1994 • 129 citations

Corticosterone Exacerbates Kainate‐Induced Alterations in Hippocampal Tau Immunoreactivity and Spectrin Proteolysis In Vivo

1993 • 129 citations

Increased antioxidant enzyme activity in amyloid beta protein-resistant cells

1996 • 128 citations

Controlled induction of paired helical filaments of the Alzheimer type in cultured human neurons, by glutamate and aspartate

1985 • 128 citations

Receptors and G proteins as primary components of transmembrane signal transduction

1995 • 123 citations

Neurotoxicity of Human Amylin in Rat Primary Hippocampal Cultures: Similarity to Alzheimer's Disease Amyloid‐β Neurotoxicity

1993 • 122 citations

Non-Fibrillar β-Amyloid Protein is Associated with Smooth Muscle Cells of Vessel Walls in Alzheimer Disease

1994 • 120 citations

Effects of Nerve Growth Factor on Glutathione Peroxidase and Catalase in PC 12 Cells

1994 • 118 citations

Mechanisms of neuronal death in brain aging and alzheimer's disease: Role of endocrine‐mediated calcium dyshomeostasis

1992 • 118 citations

Protease nexin-1 and thrombin modulate neuronal Ca2+ homeostasis and sensitivity to glucose deprivation-induced injury

1995 • 114 citations

Anticonvulsants attenuate amyloid β-peptide neurotoxicity, Ca2+ deregulation, and cytoskeletal pathology

1995 • 113 citations

Impaired brain microcirculation may trigger Alzheimer's disease

1994 • 112 citations

Low-calcium, high-aluminum diet-induced motor neuron pathology in cynomolgus monkeys

1989 • 111 citations

B- Amyloid increases neuronal susceptibility to injufy by glucose deprivation

1991 • 111 citations

Hypothalamic-pituitary-adrenal system function in patients with alzheimer's disease

1995 • 104 citations

Trophic Effects of Estradiol on Fetal Rat Hypothalamic Neurons

1992 • 104 citations

Early Detection of Alzheimer's Disease: A Statistical Approach Using Positron Emission Tomographic Data

1993 • 104 citations

Glial Expression of the β-Amyloid Precursor Protein (APP) in Global Ischemia

1995 • 103 citations

Intra- and extracellular amyloid fibrils are formed in cultured pancreatic islets of transgenic mice expressing human islet amyloid polypeptide.

1994 • 100 citations

Apoptosis: molecular mechanisms and implications for human disease

1995 • 99 citations

Fibroblast growth factor-2 protects entorhinal layer II glutamatergic neurons from axotomy-induced death

1996 • 98 citations

Bcl-2 Prevents Killing of Neuronal Cells by Glutamate but Not by Amyloid β Protein

1993 • 98 citations

Changes in Brain Glucose Metabolism as a Key to the Pathogenesis of Alzheimer’s Disease

1994 • 97 citations

Basic Fibroblast Growth Factor Selectively Increases AMPA‐Receptor Subunit GluR1 Protein Level and Differentially Modulates Ca²⁺ Responses to AMPA and NMDA in Hippocampal Neurons

1995 • 96 citations

K+ channel openers protect hippocampal neurons against oxidative injury and amyloid β-peptide toxicity

1996 • 96 citations

Protection against HIV-1 gp120-induced brain damage by neuronal expression of human amyloid precursor protein.

1995 • 92 citations

Pathological Proteins in Senile Plaques.

1994 • 92 citations

Domoic acid-treated cynomolgus monkeys (M. fascicularis): effects of dose on hippocampal neuronal and terminal degeneration

1993 • 89 citations

Ischemic Injury in the Brain Role of Oxygen Radical‐Mediated Processesa

1989 • 88 citations

Pacific paradigms of environmentally-induced neurological disorders: clinical, epidemiological and molecular perspectives.

1991 • 86 citations

In vitro production of β-amyloid in smooth muscle cells isolated from amyloid angiopathy-affected vessels

1995 • 85 citations

Evidence That Actin Depolymerization Protects Hippocampal Neurons against Excitotoxicity by Stabilizing [Ca2+]i

1995 • 83 citations

β-Amyloid peptides induce degeneration of cultured rat microglia

1993 • 82 citations

β‐Amyloid Neurotoxicity in Human Cortical Culture Is Not Mediated by Excitotoxins

1993 • 82 citations

Glutamate induces the growth factors NGF, bFGF, the receptor FGF-R1 and c-fos mRNA expression in rat astrocyte culture

1993 • 79 citations

Reactive Oxygen Species Inhibit High‐Affinity Glutamate Uptake: Molecular Mechanism and Neuropathological Implications

1994 • 75 citations

Increased numbers of βAPP-immunoreactive neurones in the entorhinal cortex after head injury

1994 • 72 citations

Postmenopausal hormone therapy and atherosclerotic disease

1994 • 72 citations

Vascular β-amyloid in Alzheimer's disease angiopathy is produced by proliferating and degenerating smooth muscle cells

1994 • 71 citations

Transforming growth factor-β protects human neurons against β-amyloid-induced injury

1994 • 71 citations

Protease Nexin-1 and Thrombin: Injury-related Processes in the Brain

1993 • 68 citations

Amyloid β protein-induced irreversible current in rat cortical neurones

1994 • 68 citations

Microvascular pathology and vascular basement membrane components in Alzheimer's disease

1994 • 67 citations

AIDS‐Related Dementia and Calcium Homeostasis^a

1994 • 67 citations

Attenuation of the Neurotoxic Effect of Aβ Amyloid Peptide by Apolipoprotein E

1994 • 66 citations

Coupling of ml Muscarinic Receptors to G Protein in Alzheimer Disease

1991 • 65 citations

Expression of the human beta-amyloid protein of Alzheimer's disease specifically in the brains of transgenic mice.

1991 • 64 citations

Calbindin-D_ a potential neuroprotective protein.

1994 • 64 citations

β-Amyloid Protein Amplifies Calcium Signaling in Central Neurons from the Adult Mouse

1993 • 62 citations

Coupling of muscarinic receptors to GTP proteins in postmortem human brain — alterations in Alzheimer's disease

1993 • 62 citations

Regional Differences in Reactive Gliosis Induced by Substrate-Bound β-Amyloid

1994 • 61 citations

Mechanisms of Phospholipase A₂ Activation and Neuronal Injury

1993 • 60 citations

Staurosporine and K-252 compounds protect hippocampal neurons against amyloid β-peptide toxicity and oxidative injury

1994 • 59 citations

Amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam: quantitative neuropathology, immunohistochemical analysis of neuronal vulnerability, and comparison with related neurodegenerative disorders

1994 • 58 citations

Opposing Actions of Thrombin and Protease Nexin‐1 on Amyloid β‐Peptide Toxicity and on Accumulation of Peroxides and Calcium in Hippocampal Neurons

1995 • 57 citations

G-proteins involved in the calcium channel signalling system

1993 • 56 citations

The Vasculopathy of Aging

1994 • 56 citations

Cytochalasins Protect Hippocampal Neurons Against Amyloid β‐Peptide Toxicity: Evidence that Actin Depolymerization Suppresses Ca²⁺ Influx

1995 • 55 citations

Glutathione prevents N -methyl-d-aspartate receptor-mediated neurotoxicity

1991 • 55 citations

Reduction of Neurological Damage by a Peptide Segment of the Amyloid β/A4 Protein Precursor in a Rabbit Spinal Cord Ischemia Model

1994 • 54 citations

The secreted form of the Alzheimer's β-amyloid precursor protein stimulates a membrane-associated guanylate cyclase

1995 • 52 citations

Taxol stabilizes [Ca2+]i and protects hippocampal neurons against excitotoxicity

1995 • 52 citations

K‐252a Induces Tyrosine Phosphorylation of the Focal Adhesion Kinase and Neurite Outgrowth in Human Neuroblastoma SH‐SY5Y Cells

1995 • 50 citations

Neurite Degeneration Elicited by Apolipoprotein E Peptides

1994 • 50 citations

Calretinin-immunoreactive neurons are resistant to β-amyloid toxicity in vitro

1995 • 48 citations

Free radicals and disruption of neuronal ion homeostasis in AD: A role for amyloid β-peptide?

1995 • 44 citations

β‐Amyloid protein enhances the mitogen‐induced calcium response in circulating human lymphocytes

1993 • 41 citations

Staurosporine, K‐252a, and K‐252b Stabilize Calcium Homeostasis and Promote Survival of CNS Neurons in the Absence of Glucose

1994 • 38 citations

Secretion of apolipoprotein E by an astrocytoma cell line

1992 • 36 citations

Excitatory Amino Acid Metabotropic Receptor Subtypes and Calcium Regulation

1995 • 31 citations

Tau antigenic changes induced by glutamate in rat primary culture model: A biochemical approach

1992 • 31 citations

Heat shock alters Alzheimer's β amyloid precursor protein expression in human endothelial cells

1994 • 31 citations

Bacterial Alkaloids Mitigate Seizure-Induced Hippocampal Damage and Spatial Memory Deficits

1996 • 24 citations

Memory loss following domoic acid intoxication from ingestion of toxic mussels.

1990 • 21 citations

Programmed Cell Life: Neuroprotective Signal Transduction and Ischemic Brain Injury**This work was supported by grants to M.P.M. from the NIH, the Alzheimer's Association, and the Metropolitan Life Foundation, and by a National Research Service Award to S.W.B.

1995 • 18 citations

Amyloid β-peptide alters thrombin-induced calcium responses in cultured human neural cells

1996 • 14 citations

Molecular mechanisms of associative memory and their clinical implications

1995 • 9 citations