Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress

Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues

1969 • 6,007 citations

Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

1984 • 2,884 citations

Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones

1984 • 2,822 citations

Excitatory Amino Acid Transmitters

1981 • 2,488 citations

Leukotrienes and Lipoxins: Structures, Biosynthesis, and Biological Effects

1987 • 2,237 citations

Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation.

1983 • 1,808 citations

Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

1984 • 1,689 citations

Calcium Dependence of Toxic Cell Death: A Final Common Pathway

1979 • 1,478 citations

Glutamate neurotoxicity in cortical cell culture

1987 • 1,400 citations

Oxidants and human disease: some new concepts ¹

1987 • 1,171 citations

Glutamate activates multiple single channel conductances in hippocampal neurons

1987 • 691 citations

Exchange of cystine and glutamate across plasma membrane of human fibroblasts.

1986 • 499 citations

Primary culture of identified neurons from the visual cortex of postnatal rats

1986 • 443 citations

Transport interaction of L-cystine and L-glutamate in human diploid fibroblasts in culture.

1980 • 409 citations

Menadione-induced cytotoxicity is associated with protein thiol oxidation and alteration in intracellular Ca2+ homeostasis

1984 • 376 citations

Mechanism of Kainate Toxicity to Cerebellar Neurons In Vitro Is Analogous to Reperfusion Tissue Injury

1987 • 334 citations

Kainate-induced degeneration of neostriatal neurons: dependency upon corticostriatal tract

1978 • 330 citations

Transport of cystine and cysteine in mammalian cells

1984 • 329 citations

THE SPECIFIC AMINO ACID REQUIREMENTS OF A HUMAN CARCINOMA CELL (STRAIN H<scp>E</scp>L<scp>A</scp>) IN TISSUE CULTURE

1955 • 320 citations

Vulnerability of cultured cortical neurons to damage by excitotoxins: differential susceptibility of neurons containing NADPH-diaphorase

1988 • 309 citations

The cluster-tray method for rapid measurement of solute fluxes in adherent cultured cells

1981 • 263 citations

The nucleic acid of polyoma virus

1960 • 227 citations

Effects of In Vivo Administration of Kainic Acid on the Extracellular Amino Acid Pool in the Rabbit Hippocampus

1983 • 213 citations

CSF amino acids and plasma‐CSF amino acid ratios in adults¹

1975 • 195 citations

Influence of Complete and Pronounced Incomplete Cerebral Ischemia and Subsequent Recirculation on Cortical Concentrations of Oxidized and Reduced Glutathione in the Rat

1980 • 188 citations

Kainic acid selectively stimulates the release of endogenous excitatory acidic amino acids.

1983 • 184 citations

Adhesion of chicken hepatocytes to polyacrylamide gels derivatized with N-acetylglucosamine

1978 • 171 citations

Contrasts in transport systems for anionic amino acids in hepatocytes and a hepatoma cell line HTC.

1982 • 131 citations

Glutamate receptors in the rat central nervous system

1974 • 124 citations

Effect of antioxidants on cultured human diploid fibroblasts exposed to cystine-free medium

1977 • 121 citations

The uptake of various amino acids by the mouse brainin vivo

1971 • 120 citations

A novel function of glutamine in cell culture: Utilization of glutamine for the uptake of cystine in human fibroblasts

1988 • 113 citations

Effects of cortical ablation on the neurotoxicity and receptor binding of kainic acid in striatum

1979 • 113 citations

The free amino acids in human cerebrospinal fluid

1972 • 107 citations

Role of proton dissociation in the transport of cystine and glutamate in human diploid fibroblasts in culture.

1981 • 98 citations

Amino acid neurotoxicity: Relationship to neuronal depolarization in rat cerebellar slices

1986 • 90 citations

Calcium-dependent glutamate cytotoxicity in a neuronal cell line

1988 • 85 citations

Superoxide dismutase protects cultured neurons against death by starvation.

1987 • 79 citations

Quisqualate‐sensitive, chloride‐dependent transport of glutamate into rat brain synaptosomes

1987 • 66 citations

Characteristics of chloride-dependent incorporation of glutamate into brain membranes argue against a receptor binding site

1987 • 60 citations

Characterization of a glutamic acid neurotransmitter binding site on neuroblastoma hybrid cells.

1984 • 55 citations

Use of cystine to distinguish glutamate binding from glutamate sequestration

1987 • 52 citations

Glutamate cytotoxicity in a neuronal cell line is blocked by membrane depolarization

1988 • 42 citations

Dissociation between the excitatory and "excitotoxic" effects of quinolinic acid analogs on the striatal cholinergic interneuron.

1985 • 40 citations

Arachidonic Acid Metabolism in Glutamate Neurotoxicity

1989 • 32 citations

The mechanism of glutamate-induced degeneration of cultured Huntington's disease and control fibroblasts

1985 • 25 citations

Assay of phospholipase A2 activity of synaptic membranes using a phospholipid transfer protein: stimulation by depolarization

1986 • 16 citations

l‐Glutamate Binding Site on N18‐RE‐105 Neuroblastoma Hybrid Cells Is Not Coupled to an Ion Channel

1988 • 10 citations

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