Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

2012 • 10,051 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau

1991 • 1,397 citations

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein

1989 • 1,237 citations

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

1992 • 948 citations

Abnormal tau phosphorylation at Ser396 in alzheimer's disease recapitulates development and contributes to reduced microtubule binding

1993 • 856 citations

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein

1993 • 800 citations

Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases

1992 • 714 citations

Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state.

1992 • 563 citations

An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P.

1991 • 516 citations

Glycogen synthase kinase‐3 and the Alzheimer‐like state of microtubule‐associated protein tau

1992 • 507 citations

Epitopes that span the tau molecule are shared with paired helical filaments

1988 • 494 citations

Secreted form of amyloid β protein precursor is involved in the growth regulation of fibroblasts

1989 • 477 citations

Amyloid β Protein Enhances the Survival of Hippocampal Neurons in Vitro

1989 • 470 citations

The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region.

1992 • 468 citations

The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II

1989 • 460 citations

The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth

1992 • 455 citations

Mitogen-activated protein kinases: versatile transducers for cell signaling

1992 • 439 citations

The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development.

1993 • 439 citations

Protease nexin-II, a potent anti-chymotrypsin, shows identity to amyloid β-protein precursor

1989 • 437 citations

Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain.

1992 • 415 citations

The regulation of amyloid β protein precursor secretion and its modulatory role in cell adhesion

1989 • 355 citations

Expression of β-amyloid precursor protein in reactive astrocytes following neuronal damage

1989 • 345 citations

Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein.

1991 • 288 citations

Alzheimer's disease: a cell biological perspective

1992 • 274 citations

p42 map kinase phosphorylation sites in microtubule‐associated protein tau are dephosphorylated by protein phosphatase 2A₁ Implications for Alzheimer's disease

1992 • 273 citations

In vivo phosphorylation sites in fetal and adult rat tau.

1993 • 233 citations

Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade.

1992 • 219 citations

Trophic effect of β-amyloid precursor protein on cerebral cortical neurons in culture

1991 • 213 citations

Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease

1992 • 190 citations

Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage.

1992 • 180 citations

Secretion of the beta/A4 amyloid precursor protein. Identification of a cleavage site in cultured mammalian cells.

1991 • 178 citations

Amyloid precursor protein accumulates in regions of neurodegeneration following focal cerebral ischemia in the rat

1992 • 162 citations

The Amyloid Precursor Protein Is Developmentally Regulated and Correlated with Synaptogenesis

1994 • 158 citations

Phosphorylation-dependent epitopes of neurofilament antibodies on tau protein and relationship with Alzheimer tau.

1992 • 157 citations

Defined neurofilament, tau, and beta-amyloid precursor protein epitopes distinguish Alzheimer from non-Alzheimer senile plaques.

1990 • 154 citations

Amyloid precursor protein in the cerebral cortex is rapidly and persistently induced by loss of subcortical innervation.

1993 • 115 citations

Brain Protein Kinase PK40erk Converts TAU into a PHF-like Form as Found in Alzheimer′s Disease

1993 • 113 citations

Extracellular signal regulated kinases. Localization of protein and mRNA in the human hippocampal formation in Alzheimer's disease.

1994 • 94 citations

Functional studies of Alzheimer's disease tau protein

1993 • 93 citations

Localization of the mitogen activated protein kinase ERK2 in Alzheimer's disease neurofibrillary tangles and senile plaque neurites

1993 • 90 citations

Familial Alzheimer's disease with the amyloid precursor protein position 717 mutation and sporadic Alzheimer's disease have the same cytoskeletal pathology

1992 • 87 citations

Antibodies to non-beta regions of the beta-amyloid precursor protein detect a subset of senile plaques.

1991 • 86 citations

Amyloid precursor protein is localized in growing neurites of neonatal rat brain

1992 • 83 citations

Bacterial expression, purification, and functional mapping of the amyloid beta/A4 protein precursor.

1992 • 62 citations

Synthetic amyloid β-protein fails to produce specific neurotoxicity in monkey cerebral cortex

1992 • 60 citations

p^44mpk MAP kinase induces aizheimer type alterations in tau function and in primary hippocampal neurons

1993 • 58 citations

Sodium-phosphate cotransport in human red blood cells. Kinetics and role in membrane metabolism.

1988 • 41 citations

A calcium-stimulated serine protease from monkey brain degrades the β-amyloid precursor protein

1992 • 40 citations

Tau pathology in a case of familial Alzheimer's disease with a valine to glycine mutation at position 717 in the amyloid precursor protein

1992 • 21 citations