Mechanisms of neuronal death in brain aging and alzheimer's disease: Role of endocrine‐mediated calcium dyshomeostasis

Cell Death During Development of the Nervous System

1991 • 3,033 citations

Two Receptor Systems for Corticosterone in Rat Brain: Microdistribution and Differential Occupation

1985 • 2,530 citations

Optimized survival of hippocampal neurons in B27‐supplemented neurobasal™, a new serum‐free medium combination

1993 • 2,272 citations

The Neuroendocrinology of Stress and Aging: The Glucocorticoid Cascade Hypothesis*

1986 • 2,235 citations

Calbindin D-28k and parvalbumin in the rat nervous system

1990 • 2,068 citations

Cell Damage in the Brain: A Speculative Synthesis

1981 • 1,827 citations

Ionic dependence of glutamate neurotoxicity

1987 • 1,811 citations

Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported

1989 • 1,630 citations

Adrenal steroid receptors and actions in the nervous system

1986 • 1,231 citations

Unbiased stereological estimation of the number of neurons in the human hippocampus

1990 • 1,146 citations

Prevalence of Alzheimer's Disease in a Community Population of Older Persons

1989 • 1,128 citations

Effect of Neonatal Handling on Age-Related Impairments Associated with the Hippocampus

1988 • 1,068 citations

Excitotoxity and the NMDA receptor

1987 • 1,053 citations

Guam Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Linked to a Plant Excitant Neurotoxin

1987 • 881 citations

Some morphometric aspects of the brain in senile dementia of the alzheimer type

1981 • 803 citations

Alzheimer's Disease: Senile Dementia and Related Disorders

1979 • 801 citations

Neuron numbers and dendritic extent in normal aging and Alzheimer's disease

1987 • 769 citations

Intraneuronal Aluminum Accumulation in Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia of Guam

1982 • 678 citations

Neocortical cell counts in normal human adult aging

1987 • 676 citations

Elementary properties and pharmacological sensitivities of calcium channels in mammalian peripheral neurons

1989 • 667 citations

Organization of the cerebral cortex. III. A study of aging in the human cerebral cortex

1955 • 624 citations

Basic fibroblast growth factor prevents death of lesioned cholinergic neurons in vivo

1988 • 599 citations

Progress in Brain Research

1969 • 591 citations

A calcium-activated hyperpolarization follows repetitive firing in hippocampal neurons

1980 • 576 citations

Brain Aging Correlates: Retardation by Hormonal-Pharmacological Treatments

1981 • 519 citations

Prolonged Ca ²⁺ -Dependent Afterhyperpolarizations in Hippocampal Neurons of Aged Rats

1984 • 489 citations

Hippocampal Aging and Adrenocorticoids: Quantitative Correlations

1978 • 486 citations

Excitatory amino acids and Alzheimer's disease

1989 • 485 citations

Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases

1989 • 470 citations

Epileptiform Burst Afterhyperpolarization: Calcium-Dependent Potassium Potential in Hippocampal CA1 Pyramidal Cells

1980 • 435 citations

Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain.

1990 • 415 citations

Quantitative assessment of cortical synaptic density in Alzheimer's disease

1990 • 415 citations

Two types of calcium channels in the somatic membrane of new‐born rat dorsal root ganglion neurones.

1985 • 412 citations

Voltage-activated calcium channels that must be phosphorylated to respond to membrane depolarization.

1987 • 393 citations

Calcium-binding protein distribution in the rat brain

1982 • 391 citations

β-Adrenergic modulation of calcium channels in frog ventricular heart cells

1984 • 387 citations

Hypoxia and calcium

1979 • 385 citations

Calcium and the aging nervous system

1987 • 384 citations

Effects of Glucocorticoids and Norepinephrine on the Excitability in the Hippocampus

1989 • 383 citations

Specific reduction of calcium-binding protein (28-kilodalton calbindin-D) gene expression in aging and neurodegenerative diseases.

1990 • 382 citations

Advances in Alzheimer's disease

1991 • 358 citations

Nimodipine Facilitates Associative Learning in Aging Rabbits

1989 • 305 citations

Antigenic changes similar to those seen in neurofibrillary tangles are elicited by glutamate and Ca2+ influx in cultured hippocampal neurons

1990 • 283 citations

Corticosteroid Modulation of Hippocampal Potentials: Increased Effect with Aging

1989 • 274 citations

Cell counts in human cerebral cortex in normal adults throughout life using an image analysing computer

1980 • 267 citations

Biochemistry of Altered Brain Proteins in Alzheimer's Disease

1989 • 261 citations

ALZHEIMER'S DISEASE, PARKINSON'S DISEASE, AND MOTONEURONE DISEASE: ABIOTROPIC INTERACTION BETWEEN AGEING AND ENVIRONMENT?

1986 • 257 citations

Chronic stress-induced acceleration of electrophysiologic and morphometric biomarkers of hippocampal aging

1991 • 255 citations

Pharmacological basis for the use of nimodipine in central nervous system disorders

1989 • 248 citations

Calcium currents in internally perfused nerve cell bodies of Limnea stagnalis

1982 • 246 citations

Hippocampal glucocorticoid receptor activation enhances voltage-dependent Ca2+ conductances: relevance to brain aging.

1992 • 241 citations

Cyclic AMP-dependent protein kinase decreases GABAA receptor current in mouse spinal neurons

1990 • 225 citations

Glucose metabolism as the site of the primary abnormality in early-onset dementia of Alzheimer type?

1988 • 223 citations

Phorbol esters mimic some cholinergic actions in hippocampal pyramidal neurons

1986 • 219 citations

Patterns of Astroglial Hypertrophy and Neuronal Degeneration in the Hippocampus of Aged, Memory-deficient Rats

1977 • 219 citations

Quantitative evidence for selective dendritic growth in normal human aging but not in senile dementia

1981 • 218 citations

The role of calcium regulation in brain aging: reexamination of a hypothesis

1989 • 211 citations

The neuropathology of Alzheimer's disease: A review with pathogenetic, aetiological and therapeutic considerations

1985 • 199 citations

Treatment Development Strategies for Alzheimer’s Disease

1987 • 198 citations

Brain trace elements in Alzheimer's disease.

1986 • 194 citations

‘Increased calcium-current’ hypothesis of brain aging

1987 • 192 citations

Characterization of the calcium-induced disruption of neurofilaments in rat peripheral nerve

1979 • 183 citations

Morphology of the Aging Brain, Human and Animal

1973 • 171 citations

Handbook of Studies on Psychiatry and Old Age

1985 • 164 citations

Protein kinase C activators block specific calcium and potassium current components in isolated hippocampal neurons

1988 • 160 citations

The effects of high Mg2+-to-Ca2+ ratios on frequency potentiation in hippocampal slices of young and aged rats

1986 • 158 citations

An immunohistochemical quantification of fibrous astrocytes in the aging human cerebral cortex

1987 • 152 citations

Aged rats need a preserved complement of perforated axospinous synapses per hippocampal neuron to maintain good spatial memory

1986 • 149 citations

31P Nuclear Magnetic Resonance Study of the Brain in Alzheimerʼs Disease

1988 • 149 citations

Correlation of Phosphorus-31 Magnetic Resonance Spectroscopy and Morphologic Findings in Alzheimer's Disease

1988 • 146 citations

Relationship of aluminum to Alzheimer's disease.

1985 • 143 citations

Intracellular messengers in the generation and degeneration of hippocampal neuroarchitecture

1988 • 131 citations

Age-dependent alterations in synaptic membrane systems for Ca2+ regulation

1984 • 130 citations

Aging-related prolongation of calcium spike duration in rat hippocampal slice neurons

1990 • 128 citations

Protein kinase C alteration is an early biochemical marker in Alzheimer's disease

1991 • 127 citations

Altered metabolic properties of cultured skin fibroblasts in Alzheimer's disease

1987 • 121 citations

Hippocampal Neurons Predisposed to Neurofibrillary Tangle Formation Are Enriched in Type II Calcium/Calmodulin-Dependent Protein Kinase

1990 • 112 citations

Chapter 25 Modulation of brain aging correlates by long-term alterations of adrenal steroids and neurally-active peptides

1987 • 111 citations

Protein kinases and phosphorylation in neurologic disorders and cell death.

1991 • 108 citations

Calcium binding to the cytosol and calcium extrusion mechanisms in intact synaptosomes and their alterations with aging.

1992 • 102 citations

Hypertrophy of astroglial processes in the dentate gyrus of the senescent rat

1978 • 95 citations

Association of an apolipoprotein CII allele with familial dementia of the Alzheimer type

1987 • 86 citations

Food additives as a source of behavioral disturbances in children.

1986 • 81 citations

Calcium, membranes, aging, and Alzheimer's disease

1989 • 77 citations

Corticosterone regulates calbindin-D28k mRNA and protein levels in rat hippocampus.

1990 • 77 citations

Chronically elevating plasma Mg2+ improves hippocampal frequency potentiation and reversal learning in aged and young rats

1984 • 75 citations

Spin label and biochemical studies of erythrocyte membranes in Alzheimer's disease

1980 • 73 citations

Calpain and calpastatin in normal and Alzheimer-degenerated human brain tissue

1990 • 64 citations

Glucocorticoid Endangerment of Hippocampal Neurons Does not Involve Deoxyribonucleic Acid Cleavage

1989 • 60 citations

Aging-Related Increases in Voltage-Sensitive, Inactivating Calcium Currents in Rat Hippocampus Implications for Mechanisms of Brain Aging and Alzheimer's Disease

1989 • 57 citations

The glucocorticoid hypothesis of brain aging and neurodegeneration: recent modifications.

1991 • 55 citations

Mammalian aging: Theoretical implications of changes in brain and endocrine systems during mid- and late-life in rats

1980 • 54 citations

Apparent age-related resistance of type II hippocampal corticosteroid receptors to down-regulation during chronic escape training

1989 • 53 citations

Phorbol esters: voltage-dependent effects on calcium-dependent action potentials of mouse central and peripheral neurons in cell culture

1987 • 43 citations

Muscle-specific decrease in presynaptic calcium dependence and clearance during neuromuscular transmission in aged rats

1988 • 42 citations

Amyotrophic Lateral Sclerosis

1972 • 39 citations

Phosphate/calcium alterations in the first stages of Alzheimer's disease: Implications for etiology and pathogenesis

1991 • 33 citations

Increased affinity of type II corticosteroid binding in aged rat hippocampus

1989 • 33 citations

Neuropathology of the Aging Brain and Dementia of the Alzheimer Type

1985 • 33 citations

Probable Ca2+-mediated inactivation of Ca2+ currents in mammalian brain neurons

1987 • 31 citations

Cyclic AMP selectively reduces the N-type calcium current component of mouse sensory neurons in culture by enhancing inactivation

1989 • 27 citations

Mechanisms of Altered Hormone and Neurotransmitter Action during Aging: The Role of Impaired Calcium Mobilization

1988 • 26 citations

The effects of postsynaptic levels of cyclic AMP on excitatory and inhibitory responses of an identified central neuron

1989 • 25 citations

Alzheimer's disease. A critical review.

1988 • 24 citations

Calcium Homeostasis in Brain Aging and Alzheimer’s Disease

1989 • 20 citations

STRUCTURE – FUNCTION CORRELATIONS IN ALZHEIMER DISEASE

1990 • 18 citations

Vitamin D-independent expression of chick brain calbindin-D28K

1991 • 14 citations

Understanding the Etiology of Alzheimer’s Disease: Current Approaches

1986 • 9 citations

Alterations of the Neuronal Cytoskeleton in Alzheimer’s Disease and Related Conditions

1987 • 8 citations

A conservative viewpoint on linkage in Alzheimer's disease

1989 • 6 citations

CONFOCAL LASER IMAGING OF SYNAPSE-PLAQUE RELATIONSHIPS IN ALZHEIMER DISEASE (AD)

1990 • 4 citations