Calcium and neuronal injury in Alzheimer's disease. Contributions of beta-amyloid precursor protein mismetabolism, free radicals, and metabolic compromise.

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1991 • 4,533 citations

Glutamate and the pathophysiology of hypoxic–ischemic brain damage

1986 • 2,428 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

Amyloid β-peptide is produced by cultured cells during normal metabolism

1992 • 1,888 citations

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

1992 • 1,723 citations

Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

1992 • 1,701 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N–terminus of β–amyloid

1992 • 1,453 citations

Growth factor signaling by receptor tyrosine kinases

1992 • 1,450 citations

Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing

1992 • 1,438 citations

Physiological and pathophysiological roles of excitatory amino acids during central nervous system development

1990 • 1,427 citations

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

1993 • 1,422 citations

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

1990 • 1,388 citations

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

1991 • 1,290 citations

Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene

1991 • 1,191 citations

NMDA receptors - their role in long-term potentiation

1987 • 1,177 citations

A mutation in the Amyloid Precursor Protein Associated with Hereditary Alzheimer's Disease

1991 • 1,121 citations

Increased Nigral Iron Content and Alterations in Other Metal Ions Occurring in Brain in Parkinson's Disease

1989 • 1,117 citations

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.

1994 • 1,085 citations

PRIMARY RESPONSE GENES INDUCED BY GROWTH FACTORS AND TUMOR PROMOTERS

1991 • 1,078 citations

Tau proteins of alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms

1992 • 1,058 citations

Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs.

1992 • 982 citations

Glutamate becomes neurotoxic via the N-methyl-d-aspartate receptor when intracellular energy levels are reduced

1988 • 972 citations

Genetic Linkage Evidence for a Familial Alzheimer's Disease Locus on Chromosome 14

1992 • 941 citations

Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau.

1992 • 936 citations

Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor

1993 • 909 citations

Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum.

1993 • 901 citations

Release of Alzheimer Amyloid Precursor Derivatives Stimulated by Activation of Muscarinic Acetylcholine Receptors

1992 • 899 citations

Evidence that β-Amyloid Protein in Alzheimer's Disease Is Not Derived by Normal Processing

1990 • 895 citations

Guam Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Linked to a Plant Excitant Neurotoxin

1987 • 881 citations

In vitro aging of ß-amyloid protein causes peptide aggregation and neurotoxicity

1991 • 833 citations

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein

1993 • 800 citations

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

1992 • 737 citations

Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.

1990 • 735 citations

Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.

1991 • 734 citations

Limbic Seizures Increase Neuronal Production of Messenger RNA for Nerve Growth Factor

1989 • 624 citations

β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

1990 • 620 citations

Basic fibroblast growth factor prevents death of lesioned cholinergic neurons in vivo

1988 • 599 citations

Calcium regulation of the neuronal growth cone

1988 • 581 citations

Aggregation and secondary structure of synthetic amyloid βA4 peptides of Alzheimer's disease

1991 • 580 citations

Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state.

1992 • 563 citations

Outgrowth-regulating actions of glutamate in isolated hippocampal pyramidal neurons

1988 • 557 citations

Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide

1993 • 546 citations

Solution Structures of β Peptide and Its Constituent Fragments: Relation to Amyloid Deposition

1991 • 531 citations

Neurotransmitters in the regulation of neuronal cytoarchitecture

1988 • 525 citations

Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma.

1992 • 521 citations

β-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease

1993 • 520 citations

Evidence for calcium-reducing and excitoprotective roles for the calcium-binding protein calbindin-1328k in cultured hippocampal neurons

1991 • 518 citations

Fibroblast growth factor and glutamate: opposing roles in the generation and degeneration of hippocampal neuroarchitecture

1989 • 492 citations

Excitatory amino acids and Alzheimer's disease

1989 • 485 citations

Secreted form of amyloid β protein precursor is involved in the growth regulation of fibroblasts

1989 • 477 citations

Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases

1989 • 470 citations

βA4 amyloid protein deposition in brain after head trauma

1991 • 465 citations

Stimulation of Protein Tyrosine Phosphorylation by NMDA Receptor Activation

1991 • 464 citations

NGF and bFGF protect rat hippocampal and human cortical neurons against hypoglycemic damage by stabilizing calcium homeostasis

1991 • 462 citations

The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II

1989 • 460 citations

The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth

1992 • 455 citations

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation.

1990 • 453 citations

Secreted Forms of β-Amyloid Precursor Protein Protect Hippocampal Neurons against Amyloid β-Peptide-Induced Oxidative Injury

1994 • 445 citations

Protease nexin-II, a potent anti-chymotrypsin, shows identity to amyloid β-protein precursor

1989 • 437 citations

Alzheimer amyloid protein precursor complexes with brain GTP-binding protein Go

1993 • 430 citations

Physiological production of the β-amyloid protein and the mechanism of Alzheimer's disease

1993 • 423 citations

Calcium regulation of neurite elongation and growth cone motility

1987 • 423 citations

A mechanism for glucocorticoid toxicity in the hippocampus: increased neuronal vulnerability to metabolic insults

1985 • 406 citations

NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults

1994 • 402 citations

Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease.

1988 • 392 citations

Calcium-destabilizing and neurodegenerative effects of aggregated β-amyloid peptide are attenuated by basic FGF

1993 • 383 citations

Increased basic fibroblast growth factor (bFGF) immunoreactivity at the site of focal brain wounds

1988 • 382 citations

A role for IGF-1 in the rescue of CNS neurons following hypoxic-ischemic injury

1992 • 381 citations

The regulation of amyloid β protein precursor secretion and its modulatory role in cell adhesion

1989 • 355 citations

Expression of β-amyloid precursor protein in reactive astrocytes following neuronal damage

1989 • 345 citations

Amyloidogenicity of beta A4 and beta A4-bearing amyloid protein precursor fragments by metal-catalyzed oxidation.

1992 • 344 citations

Amelioration of delayed neuronal death in the hippocampus by nerve growth factor

1991 • 333 citations

Stress exacerbates neuron loss and cytoskeletal pathology in the hippocampus

1994 • 325 citations

Nerve growth factor affects11C-nicotine binding, blood flow, EEG, and verbal episodic memory in an Alzheimer patient (Case Report)

1992 • 319 citations

Reduced Glucose Transporter at the Blood‐Brain Barrier and in Cerebral Cortex in Alzheimer Disease

1989 • 319 citations

Blood-Brain Barrier Penetration and in Vivo Activity of an NGF Conjugate

1993 • 316 citations

NMDA-Receptor-Independent Long-Term Potentiation

1992 • 310 citations

Platelet Coagulation Factor XI _a -Inhibitor, a Form of Alzheimer Amyloid Precursor Protein

1990 • 299 citations

Phosphorylation of microtubule-associated protein tau: identification of the site for Ca2(+)-calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles.

1990 • 298 citations

Hippocampal damage and kainic acid injection induce a rapid increase in mRNA for BDNF and NGF in the rat brain

1991 • 295 citations

Protection of Dentate Hilar Cells from Prolonged Stimulation by Intracellular Calcium Chelation

1989 • 292 citations

Antigenic changes similar to those seen in neurofibrillary tangles are elicited by glutamate and Ca2+ influx in cultured hippocampal neurons

1990 • 283 citations

Alzheimer neurofibrillary tangles in diseases other than senile and presenile dementia

1979 • 279 citations

Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for appl gene

1992 • 275 citations

Corticosteroid Modulation of Hippocampal Potentials: Increased Effect with Aging

1989 • 274 citations

p42 map kinase phosphorylation sites in microtubule‐associated protein tau are dephosphorylated by protein phosphatase 2A₁ Implications for Alzheimer's disease

1992 • 273 citations

Secreted Forms of β‐Amyloid Precursor Protein Protect Against Ischemic Brain Injury

1994 • 267 citations

Growth Factors Prevent Mitochondrial Dysfunction, Loss of Calcium Homeostasis, and Cell Injury, but Not ATP Depletion in Hippocampal Neurons Deprived of Glucose

1993 • 265 citations

Biochemistry of Altered Brain Proteins in Alzheimer's Disease

1989 • 261 citations

IGF-I and IGF-II protect cultured hippocampal and septal neurons against calcium-mediated hypoglycemic damage

1992 • 253 citations

Calcium as sculptor and destroyer of neural circuitry

1992 • 250 citations

Beta amyloid precursor protein mediates neuronal cell‐cell and cell‐surface adhesion

1991 • 244 citations

Activation of MAP kinases by calcium-dependent and calcium-independent pathways. Stimulation by thapsigargin and epidermal growth factor.

1992 • 240 citations

Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices.

1993 • 236 citations

Calcium, Excitotoxins, and Neuronal Death in the Brain^a

1989 • 235 citations

Excitatory and inhibitory neurotransmitters in the generation and degeneration of hippocampal neuroarchitecture

1989 • 230 citations

Cellular targets and trophic functions of neurotrophin-3 in the developing rat hippocampus

1992 • 225 citations

Glucose metabolism as the site of the primary abnormality in early-onset dementia of Alzheimer type?

1988 • 223 citations

Basic Fibroblast Growth Factor Protects against Hypoxia-Ischemia and NMDA Neurotoxicity in Neonatal Rats

1993 • 218 citations

Trophic effect of β-amyloid precursor protein on cerebral cortical neurons in culture

1991 • 213 citations

Receptors, ion channels and synaptic potentials underlying the integrative actions of excitatory amino acids

1987 • 211 citations

The role of calcium regulation in brain aging: reexamination of a hypothesis

1989 • 211 citations

Methodological variables in the assessment of beta amyloid neurotoxicity

1992 • 208 citations

Role of heterotrimeric G proteins in membrane traffic.

1992 • 206 citations

Selective induction of Kunitz-type protease inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia in rat cerebral cortex

1991 • 206 citations

Basic FGF, NGF, and IGFs Protect Hippocampal and Cortical Neurons against Iron-Induced Degeneration

1993 • 199 citations

Basic FGF regulates the expression of a functional 71 kDa NMDA receptor protein that mediates calcium influx and neurotoxicity in hippocampal neurons

1993 • 198 citations

NMDA receptor agonist and antagonists alter retinal ganglion cell arbor structure in the developing frog retinotectal projection

1990 • 196 citations

‘Increased calcium-current’ hypothesis of brain aging

1987 • 192 citations

β-Amyloid protein promotes neuritic branching in hippocampal cultures

1990 • 188 citations

Regulation of synaptic transmission in the central nervous system: Long-term potentiation

1989 • 186 citations

Interactions between entorhinal axons and target hippocampal neurons: A role for glutamate in the development of hippocampal circuitry

1988 • 183 citations

A metalloproteinase inhibitor domain in Alzheimer amyloid protein precursor

1993 • 171 citations

Microtubule-associated protein tau is phosphorylated by protein kinase C on its tubulin binding domain.

1992 • 171 citations

Role of nerve growth factor in oxidant‐antioxidant balance and neuronal injury. I. Stimulation of hydrogen peroxide resistance

1990 • 164 citations

NGF restores decrease in catalase activity and increases superoxide dismutase and glutathione peroxidase activity in the brain of aged rats

1992 • 158 citations

Secreted forms of β‐amyloid precursor protein modulate dendrite outgrowth and calcium responses to glutamate in cultured embryonic hippocampal neurons

1994 • 154 citations

Corticosterone impairs hippocampal neuronal calcium regulation — possible mediating mechanisms

1993 • 140 citations

Cortisol and Alzheimer's disease, II: Dexamethasone suppression, dementia severity, and affective symptoms

1986 • 140 citations

Glucose deprivation elicits neurofibrillary tangle-like antigenic changes in hippocampal neurons: Prevention by NGF and bFGF

1992 • 137 citations

Cytosolic free calcium and cell spreading decrease in fibroblasts from aged and Alzheimer donors.

1986 • 135 citations

Neurodegenerative disorders of the western pacific: the search for mechanisms of pathogenesis

1986 • 134 citations

Nerve and epidermal growth factors induce the release of the Alzheimer Amyloid precursor from PC 12 cell cultures

1989 • 133 citations

The expression of amyloid beta protein precursor protects nerve cells from β-amyloid and glutamate toxicity and alters their interaction with the extracellular matrix

1993 • 130 citations

Corticosterone Exacerbates Kainate‐Induced Alterations in Hippocampal Tau Immunoreactivity and Spectrin Proteolysis In Vivo

1993 • 129 citations

Controlled induction of paired helical filaments of the Alzheimer type in cultured human neurons, by glutamate and aspartate

1985 • 128 citations

Potassium channel dysfunction in fibroblasts identifies patients with Alzheimer disease.

1993 • 124 citations

Effects of elevated intracellular calcium levels on the cytoskeleton and tau in cultured human cortical neurons

1991 • 112 citations

B- Amyloid increases neuronal susceptibility to injufy by glucose deprivation

1991 • 111 citations

Amyloid beta protein precursor is a mitogen

1989 • 105 citations

Cyclic GMP and cell death in rat cerebellar slices

1988 • 92 citations

Evidence for the involvement of protein kinase C in neurodegenerative changes in cultured human cortical neurons

1991 • 85 citations

Nerve growth factor increases in adult rat brain after hypoxic injury

1989 • 83 citations

Involvement of amyloid precursor protein in memory formation in the rat: an indirect antibody approach

1993 • 74 citations

Identification of p42 Mitogen‐Activated Protein Kinase as a Tyrosine Kinase Substrate Activated by Maximal Electroconvulsive Shock in Hippocampus

1993 • 72 citations

Casein kinase II alteration precedes tau accumulation in tangle formation.

1992 • 72 citations

β-Amyloid Protein Amplifies Calcium Signaling in Central Neurons from the Adult Mouse

1993 • 62 citations

Bacterial expression, purification, and functional mapping of the amyloid beta/A4 protein precursor.

1992 • 62 citations

Acetylcholine potentiates glutamate-induced neurodegeneration in cultured hippocampal neurons

1989 • 58 citations

p^44mpk MAP kinase induces aizheimer type alterations in tau function and in primary hippocampal neurons

1993 • 58 citations

Fibroblast growth factor induces β-amyloid precursor mRNA in glial but not neuronal cultured cells

1990 • 58 citations

Differential Phosphorylation of τ by Cyclic AMP‐Dependent Protein Kinase and Ca²⁺/Calmodulin‐Dependent Protein Kinase II: Metabolic and Functional Consequences

1992 • 57 citations

The Amyloid Precursor-like Protein (APLP) Gene Maps to the Long Arm of Human Chromosome 19

1993 • 56 citations

Amyloid beta-protein activates tachykinin receptors and inositol trisphosphate accumulation by synergy with glutamate.

1993 • 55 citations

Neurotrophic factor mediated protection from excitotoxicity and disturbances in calcium and free radical metabolism

1993 • 54 citations

β‐Amyloid protein enhances the mitogen‐induced calcium response in circulating human lymphocytes

1993 • 41 citations

Staurosporine, K‐252a, and K‐252b Stabilize Calcium Homeostasis and Promote Survival of CNS Neurons in the Absence of Glucose

1994 • 38 citations

Serum- and bradykinin-induced calcium transients in familial Alzheimer's fibroblasts

1993 • 36 citations

Tau antigenic changes induced by glutamate in rat primary culture model: A biochemical approach

1992 • 31 citations

Memory loss following domoic acid intoxication from ingestion of toxic mussels.

1990 • 21 citations