Loss of high‐affinity agonist binding to M1 muscarinic receptors in Alzheimer's disease: Implications for the failure of cholinergic replacement therapies

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

1982 • 3,563 citations

Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation

1983 • 3,028 citations

Diagnosis of Alzheimer's Disease

1985 • 2,482 citations

Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.

1978 • 2,036 citations

A graphic method for the determination and presentation of binding parameters in a complex system

1967 • 1,524 citations

Identification of a Family of Muscarinic Acetylcholine Receptor Genes

1987 • 1,439 citations

APRIORITY

1961 • 1,293 citations

Oral Tetrahydroaminoacridine in Long-Term Treatment of Senile Dementia, Alzheimer Type

1986 • 1,148 citations

Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities

1969 • 1,043 citations

Reduced somatostatin-like immunoreactivity in cerebral cortex from cases of Alzheimer disease and Alzheimer senile dementa

1980 • 866 citations

Loss of M2 Muscarine Receptors in the Cerebral Cortex in Alzheimer's Disease and Experimental Cholinergic Denervation

1985 • 697 citations

Loss of neurons of origin of the adrenergic projection to cerebral cortex (nucleus locus ceruleus) in senile dementia

1982 • 677 citations

A quantitative analysis of beta-adrenergic receptor interactions: resolution of high and low affinity states of the receptor by computer modeling of ligand binding data.

1980 • 545 citations

Mechanisms of action of acetylcholine in the guinea‐pig cerebral cortex in vitro.

1986 • 509 citations

Nicotinic acetylcholine binding sites in Alzheimer's disease

1986 • 485 citations

Molecular Properties of the Muscarinic Acetylcholine Receptor

1987 • 478 citations

Physostigmine: Improvement of Long-Term Memory Processes in Normal Humans

1978 • 442 citations

Neurochemical Studies of Early-Onset Alzheimer's Disease

1985 • 356 citations

Protein kinase C injection into hippocampal pyramidal cells elicits features of long term potentiation

1987 • 340 citations

Differential Alteration of Various Cholinergic Markers in Cortical and Subcortical Regions of Human Brain in Alzheimer's Disease

1988 • 334 citations

Characterization of <scp>l</scp>‐[³H]Nicotine Binding in Human Cerebral Cortex: Comparison Between Alzheimer's Disease and the Normal

1986 • 288 citations

Decreased levels of protein kinase C in Alzheimer brain

1988 • 242 citations

Mechanisms of cholinesterase inhibition in senile dementia of the alzheimer type: Clinical, pharmacological, and therapeutic aspects

1988 • 196 citations

Hippocampal long-term potentiation: Mechanisms and implications for memory.

1982 • 195 citations

The Coupling of the Neuronal Muscarinic Receptor to Responses

1984 • 120 citations

Slow cholinergic excitation — a mechanism for increasing neuronal excitability

1983 • 109 citations

Relative affinities of drugs acting at cholinoceptors in displacing agonist and antagonist radioligands: the NMS/Oxo‐M ratio as an index of efficacy at cortical muscarinic receptors

1988 • 108 citations

Decreased brain [3H]inositol 1,4,5-trisphosphate binding in Alzheimer's disease

1988 • 102 citations

Reduced Protein Kinase C Immunoreactivity and Altered Protein Phosphorylation in Alzheimer's Disease Fibroblasts

1989 • 100 citations

Correlation of agonist-induced phosphorylation of chick heart muscarinic receptors with receptor desensitization.

1987 • 98 citations

Guanine nucleotide regulation of agonist binding to muscarinic cholinergic receptors. Relation to efficacy of agonists for stimulation of phosphoinositide breakdown and Ca2+ mobilization

1985 • 96 citations

Effects of oral physostigmine in Alzheimer's disease

1987 • 87 citations

Distribution of muscarinic receptor subtypes within architectonic subregions of the primate cerebral cortex

1988 • 82 citations

No response to high‐dose muscarinic agonist therapy in Alzheimer's disease

1988 • 80 citations

Brain muscarinic receptor subtypes are differently affected in Alzheimer's disease and Parkinson's disease

1989 • 76 citations

Decreased muscarinic receptor binding in cerebral cortex and hippocampus in alzheimer's disease

1987 • 66 citations

Pharmacological differences between the high-affinity muscarinic agonist binding states of the rat heart and cerebral cortex labeled with (+)-[3H]cismethyldioxolane.

1984 • 50 citations

Alzheimer's disease: is there a problem beyond recognition?

1990 • 50 citations

Affinities of different cholinergic agonists for the high and low affinity states of hippocampal M1 muscarine receptors.

1989 • 34 citations

Increased in vitro phosphorylation of a Mr 60,000 protein in brain from patients with Alzheimer disease.

1986 • 33 citations

Different agonist binding properties of M1 and M2 muscarinic receptors in calf brain cortex membranes

1987 • 16 citations

Agonist binding to M1 muscarinic receptors is sensitive to guanine nucleotides

1989 • 5 citations