G-proteins involved in the calcium channel signalling system

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Diversity of G Proteins in Signal Transduction

1991 • 1,990 citations

Calcium channels, potassium channels, and voltage dependence of arterial smooth muscle tone

1990 • 1,098 citations

G proteins

1992 • 871 citations

GTP-binding proteins couple cardiac muscarinic receptors to a K channel

1985 • 868 citations

Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence

1989 • 815 citations

Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents

1991 • 576 citations

A G Protein Directly Regulates Mammalian Cardiac Calcium Channels

1987 • 551 citations

Uncoupling of cardiac muscarinic and β-adrenergic receptors from ion channels by a guanine nucleotide analogue

1985 • 527 citations

Ca2+ current is regulated by cyclic GMP-dependent protein kinase in mammalian cardiac myocytes.

1991 • 475 citations

Receptor-to-effector signaling through G proteins: Roles for βγ dimers as well as α subunits

1992 • 441 citations

Direct Activation of Mammalian Atrial Muscarinic Potassium Channels by GTP Regulatory Protein G _k

1987 • 441 citations

Mode of regulation of the ACh-sensitive K-channel by the muscarinic receptor in rabbit atrial cells

1984 • 436 citations

Ionic Channels and Their Regulation by G Protein Subunits

1990 • 413 citations

An enzymatic mechanism for calcium current inactivation in dialysed Helix neurones.

1986 • 409 citations

Voltage-activated calcium channels that must be phosphorylated to respond to membrane depolarization.

1987 • 393 citations

Selectivity in Signal Transduction Determined by γ Subunits of Heterotrimeric G Proteins

1993 • 393 citations

Different β-subunits determine G-protein interaction with transmembrane receptors

1992 • 390 citations

Regulation of Cardiac L-Type Calcium Current by Phosphorylation and G Proteins

1990 • 359 citations

Noradrenaline contracts arteries by activating voltage-dependent calcium channels

1988 • 340 citations

Effects of dopamine and noradrenaline on Ca channels of cultured sensory and sympathetic neurons of chick

1986 • 316 citations

Kinase C activator 1,2-oleoylacetylglycerol attenuates voltage-dependent calcium current in sensory neurons.

1986 • 313 citations

Rapid β-Adrenergic Modulation of Cardiac Calcium Channel Currents by a Fast G Protein Pathway

1989 • 307 citations

Stimulation of protein kinase C recruits covert calcium channels in Aplysia bag cell neurons

1987 • 291 citations

Noradrenaline and β-adrenoceptor agonists increase activity of voltage-dependent calcium channels in hippocampal neurons

1987 • 283 citations

Dynorphin A selectively reduces a large transient (N-type) calcium current of mouse dorsal root ganglion neurons in cell culture.

1987 • 266 citations

Effects of protein kinase C activators on cardiac Ca2+ channels

1988 • 264 citations

Modulation of Ca current during the phosphorylation cycle in the guinea pig heart

1986 • 254 citations

Newly Identified Brain Potassium Channels Gated by the Guanine Nucleotide Binding Protein G _o

1988 • 236 citations

β-Adrenergic Inhibition of Cardiac Sodium Channels by Dual G-Protein Pathways

1989 • 232 citations

Splice Variants of the α Subunit of the G Protein G _s Activate Both Adenylyl Cyclase and Calcium Channels

1989 • 225 citations

Differential G protein-mediated coupling of D2 dopamine receptors to K+ and Ca2+ currents in rat anterior pituitary cells

1992 • 216 citations

Pertussis toxin and voltage dependence distinguish multiple pathways modulating calcium channels of rat sympathetic neurons

1992 • 192 citations

Specificity of G protein beta and gamma subunit interactions.

1992 • 190 citations

Reconstitution of Somatostatin and Muscarinic Receptor Mediated Stimulation of K⁺Channels by Isolated G_KProtein in Clonal Rat Anterior Pituitary Cell Membranes *

1987 • 188 citations

Somatostatin blocks a calcium current in rat sympathetic ganglion neurones.

1989 • 178 citations

cGMP-dependent protein kinase enhances Ca2+ current and potentiates the serotonin-induced Ca2+ current increase in snail neurones

1986 • 154 citations

Role of G Proteins in Calcium Channel Modulation

1990 • 153 citations

Angiotensin II-induced stimulation of voltage-dependent Ca2+ currents in an adrenal cortical cell line.

1988 • 134 citations

Modulation of Ca-channel current by an adenosine analog mediated by a GTP-binding protein in chick sensory neurons

1989 • 133 citations

Dynorphin A and cAMP-dependent protein kinase independently regulate neuronal calcium currents.

1990 • 104 citations

Voltage‐ and time‐dependent inhibition of neuronal calcium channels by a GTP‐binding protein in a mammalian cell line.

1992 • 104 citations

Cholecystokinin induces a decrease in Ca2+ current in snail neurons that appears to be mediated by protein kinase C

1987 • 102 citations

Cyclic AMP-independent, dual regulation of voltage-dependent Ca2+ currents by LHRH and somatostatin in a pituitary cell line.

1988 • 101 citations

Neuropeptide modulation of single calcium and potassium channels detected with a new patch clamp configuration

1990 • 99 citations

Short term and long term effects of beta-adrenergic effectors and cyclic AMP on nitrendipine-sensitive voltage-dependent Ca2+ channels of skeletal muscle.

1985 • 98 citations

Altered Prevalence of Gating Modes in Neurotransmitter Inhibition of N-Type Calcium Channels

1993 • 93 citations

Involvement of pertussis toxin-sensitive G-proteins in the hormonal inhibition of dihydropyridine-sensitive Ca2+ currents in an insulin-secreting cell line (RINm5F).

1991 • 90 citations

GTP-dependent regulation of myometrial KCa channels incorporated into lipid bilayers.

1990 • 86 citations

Gi2 and protein kinase C are required for thyrotropin-releasing hormone-induced stimulation of voltage-dependent Ca2+ channels in rat pituitary GH3 cells.

1993 • 82 citations

Protein kinase C-activated calcium channel in the osteoblast-like clonal osteosarcoma cell line UMR-106.

1987 • 80 citations

Hormones and cell regulation

1977 • 76 citations

Tonic inhibition and rebound facilitation of a neuronal calcium channel by a GTP-binding protein.

1991 • 76 citations

Photoactivation of intracellular guanosine triphosphate analogues reduces the amplitude and slows the kinetics of voltage-activated calcium channel currents in sensory neurones

1988 • 74 citations

Guanine nucleotide-binding protein, alpha i-3, directly activates a cation channel in rat renal inner medullary collecting duct cells.

1989 • 62 citations

Differential regulation of amounts of the guanine-nucleotide-binding proteins Gi and Go in neuroblastoma x glioma hybrid cells in response to dibutyryl cyclic AMP.

1988 • 60 citations

A Gs protein couples P2-purinergic stimulation to cardiac Ca channels without cyclic AMP production.

1992 • 58 citations

T-type calcium channels in adrenal glomerulosa cells: GTP-dependent modulation by angiotensin II.

1993 • 57 citations

Correlation between G protein activation and reblocking kinetics of Ca2+ channel currents in rat sensory neurons

1991 • 50 citations

Role of the GTP-binding protein Gs in the ?-adrenergic modulation of cardiac Ca channels

1991 • 43 citations

G-proteins are involved in contractile responses of isolated mesenteric resistance arteries to agonists

1990 • 36 citations

Differential effect of μ, δ, and κ ligands on G protein α subunits in cultured brain cells

1990 • 29 citations

Activation of protein kinase C reduces L-type calcium channel activity of GH3 pituitary cells

1992 • 29 citations

Involvement of the guanine nucleotide-binding protein, No, in the inhibitory regulation of neuronal calcium channels.

1988 • 13 citations

Inhibition of Ca2+-induced calcitonin secretion by somatostatin: Roles of voltage dependent Ca2+ channels and G-proteins

1992 • 12 citations

[31] Whole-cell clamp analysis for G-protein regulation of channels

1994 • 5 citations