Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease.

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

1993 • 8,888 citations

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

1993 • 4,145 citations

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

1988 • 3,984 citations

Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?

1993 • 2,146 citations

The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease

1993 • 1,951 citations

Alpha-crystallin can function as a molecular chaperone.

1992 • 1,822 citations

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.

1993 • 1,480 citations

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.

1993 • 1,329 citations

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease

1991 • 1,133 citations

Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions

1993 • 1,092 citations

Apolipoprotein E: A pathological chaperone protein in patients with cerebral and systemic amyloid

1992 • 802 citations

Differential Effects of Apolipoproteins E3 and E4 on Neuronal Growth in Vitro

1994 • 797 citations

Theory of Particulate Processes

1988 • 752 citations

Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.

1987 • 696 citations

Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine-arginine interchange at a single site.

1982 • 674 citations

Three-Dimensional Structure of the LDL Receptor-Binding Domain of Human Apolipoprotein E

1991 • 661 citations

Physiological production of the β-amyloid protein and the mechanism of Alzheimer's disease

1993 • 423 citations

Abnormal in vivo metabolism of apolipoprotein E4 in humans.

1986 • 343 citations

Apolipoprotein E distribution among human plasma lipoproteins: role of the cysteine-arginine interchange at residue 112.

1990 • 289 citations

The receptor-binding domain of human apolipoprotein E. Binding of apolipoprotein E fragments.

1983 • 276 citations

Apolipoprotein E: Binding to Soluble Alzheimer′s β-Amyloid

1993 • 262 citations

Human apolipoprotein E3 in aqueous solution. II. Properties of the amino- and carboxyl-terminal domains.

1988 • 229 citations

[13] Isolation and characterization of apolipoprotein E

1986 • 155 citations

A high frequency of apolipoprotein E4 isoprotein in Japanese patients with late-onset nonfamilial Alzheimer's disease

1993 • 115 citations

Identification of the disulfide-linked homodimer of apolipoprotein E3 in plasma. Impact on receptor binding activity

1991 • 99 citations

Attenuation of the Neurotoxic Effect of Aβ Amyloid Peptide by Apolipoprotein E

1994 • 66 citations

Expression of APP in Brains of Transgenic Mice Containing the Entire Human APP Gene

1993 • 64 citations