Staurosporine and K-252 compounds protect hippocampal neurons against amyloid β-peptide toxicity and oxidative injury

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

1993 • 1,422 citations

K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases

1987 • 947 citations

In vitro aging of ß-amyloid protein causes peptide aggregation and neurotoxicity

1991 • 833 citations

β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

1990 • 620 citations

Vitamin E protects nerve cells from amyloid βprotein toxicity

1992 • 583 citations

Outgrowth-regulating actions of glutamate in isolated hippocampal pyramidal neurons

1988 • 557 citations

β-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease

1993 • 520 citations

Physiological production of the β-amyloid protein and the mechanism of Alzheimer's disease

1993 • 423 citations

Calcium-destabilizing and neurodegenerative effects of aggregated β-amyloid peptide are attenuated by basic FGF

1993 • 383 citations

Endogenous Neuroprotection Factors and Traumatic Brain Injury: Mechanisms of Action and Implications for Therapy

1994 • 308 citations

Oxygen Free Radicals and Brain Dysfunction

1991 • 280 citations

IGF-I and IGF-II protect cultured hippocampal and septal neurons against calcium-mediated hypoglycemic damage

1992 • 253 citations

Cellular targets and trophic functions of neurotrophin-3 in the developing rat hippocampus

1992 • 225 citations

Methodological variables in the assessment of beta amyloid neurotoxicity

1992 • 208 citations

Basic FGF, NGF, and IGFs Protect Hippocampal and Cortical Neurons against Iron-Induced Degeneration

1993 • 199 citations

Basic FGF regulates the expression of a functional 71 kDa NMDA receptor protein that mediates calcium influx and neurotoxicity in hippocampal neurons

1993 • 198 citations

Characterization of specific binding sites for [3H]-staurosporine on various protein kinases

1990 • 164 citations

K-252b, c and d, potent inhibitors of protein kinase C from microbial origin.

1986 • 139 citations

Isolated hippocampal neurons in cryopreserved long‐term cultures: Development of neuroarchitecture and sensitivity to NMDA

1988 • 124 citations

A protein kinase inhibitor, staurosporine, mimics nerve growth factor induction of neurotensin/neuromedin N gene expression.

1991 • 42 citations

Staurosporine, K‐252a, and K‐252b Stabilize Calcium Homeostasis and Promote Survival of CNS Neurons in the Absence of Glucose

1994 • 38 citations

A model for beta-amyloid aggregation and neurotoxicity based on the free radical generating capacity of the peptide: implications of "molecular shrapnel" for Alzheimer's disease.

1995 • 36 citations

Multiple and interactive responses of central neurons to neurotrophic factors

1993 • 16 citations