Activation of the Sphingomyelin Cycle Through the Low-Affinity Neurotrophin Receptor

The Nerve Growth Factor 35 Years Later

1987 • 3,107 citations

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

1994 • 1,920 citations

Programmed Cell Death Induced by Ceramide

1993 • 1,779 citations

The trk proto-oncogene encodes a receptor for nerve growth factor

1991 • 1,396 citations

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

1991 • 1,232 citations

A Receptor for Tumor Necrosis Factor Defines an Unusual Family of Cellular and Viral Proteins

1990 • 977 citations

Expression and structure of the human NGF receptor

1986 • 956 citations

Gene transfer and molecular cloning of the rat nerve growth factor receptor

1987 • 946 citations

Induction of Apoptosis by the Low-Affinity NGF Receptor

1993 • 774 citations

Ceramide activates heterotrimeric protein phosphatase 2A

1993 • 657 citations

Sphingomyelin turnover induced by vitamin D3 in HL-60 cells

1989 • 629 citations

Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation.

1991 • 621 citations

Expression of nerve growth factor receptors by Schwann cells of axotomized peripheral nerves: ultrastructural location, suppression by axonal contact, and binding properties

1988 • 539 citations

The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3

1991 • 530 citations

Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation.

1990 • 476 citations

Binding of neurotrophin-3 to its neuronal receptors and interactions with nerve growth factor and brain-derived neurotrophic factor.

1992 • 458 citations

Nerve growth factor mediates signal transduction through trk homodimer receptors

1992 • 458 citations

Activation of the Sphingomyelin Signaling Pathway in Intact EL4 Cells and in a Cell-Free System By IL-1β

1993 • 433 citations

Ceramide stimulates a cytosolic protein phosphatase.

1992 • 406 citations

Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha.

1991 • 376 citations

The p75 nerve growth factor receptor mediates survival or death depending on the stage of sensory neuron development.

1994 • 371 citations

Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha.

1994 • 340 citations

Nerve growth factor and its low-affinity receptor promote Schwann cell migration.

1994 • 319 citations

High affinity nerve growth factor binding displays a faster rate of association than p140trk binding. Implications for multi-subunit polypeptide receptors.

1994 • 313 citations

Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness.

1993 • 292 citations

Sphingolipid breakdown products: anti-proliferative and tumor-suppressor lipids

1993 • 281 citations

Interleukin-1-mediated PGE2 production and sphingomyelin metabolism. Evidence for the regulation of cyclooxygenase gene expression by sphingosine and ceramide.

1992 • 272 citations

Characterization of the human melanoma nerve growth factor receptor.

1985 • 162 citations

Molecular investigations on the high-affinity nerve growth factor receptor

1991 • 154 citations

Positive and negative effects of neurotrophins on the isthmo-optic nucleus in chick embryos

1994 • 133 citations

Sphingomyelinase and cell-permeable ceramide analogs stimulate cellular proliferation in quiescent Swiss 3T3 fibroblasts.

1992 • 128 citations

Mediation of NGF-stimulated extracellular matrix invasion by the human melanoma low-affinity p75 neurotrophin receptor: melanoma p75 functions independently of trkA.

1993 • 122 citations

Membrane Depolarization Induces p140 ^trk and NGF Responsiveness, but Not p75 ^LNGFR , in MAH Cells

1992 • 120 citations

Chimeric NGF-EGF Receptors Define Domains Responsible for Neuronal Differentiation

1991 • 116 citations

Changes in bioactive lipids, alkylacylglycerol and ceramide, occur in HIV-infected cells

1992 • 106 citations

Deletion of cytoplasmic sequences of the nerve growth factor receptor leads to loss of high affinity ligand binding.

1990 • 94 citations

Association of protein kinases ERK1 and ERK2 with p75 nerve growth factor receptors.

1993 • 63 citations

Identification of a conserved protein motif in a group of growth factor receptors

1990 • 57 citations

Glycosyl-phosphatidylinositol/inositol phosphoglycan: a signaling system for the low-affinity nerve growth factor receptor.

1991 • 53 citations

Nerve growth factor (NGF) receptor on rat glial cell lines. Evidence for NGF internalization via p75NGFR.

1992 • 37 citations

Modulation of growth and of morphological characteristics in glioma cells by nerve growth factor and glia maturation factor.

1987 • 32 citations

Nerve growth factor induces the association of a 130-Kd phosphoprotein with its receptor in PC-12 pheochromocytoma cells.

1991 • 26 citations