Pathological alterations of the cerebral microvasculature in Alzheimer's disease and related dementing disorders

Clinical diagnosis of Alzheimer's disease

1984 • 27,279 citations

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

1993 • 8,888 citations

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1991 • 4,120 citations

Observations on the brains of demented old people

1970 • 2,066 citations

Apolipoprotein E polymorphism and atherosclerosis.

1988 • 2,007 citations

The Topographical and Neuroanatomical Distribution of Neurofibrillary Tangles and Neuritic Plaques in the Cerebral Cortex of Patients with Alzheimer's Disease

1991 • 1,344 citations

Cortical blood vessels of the human brain

1981 • 803 citations

Apolipoprotein E: A pathological chaperone protein in patients with cerebral and systemic amyloid

1992 • 802 citations

The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease

1991 • 801 citations

Laminar and regional distributions of neurofibrillary tangles and neuritic plaques in Alzheimer's disease: a quantitative study of visual and auditory cortices

1987 • 569 citations

The Human Hippocampus

2013 • 551 citations

Quantitative morphology and regional and laminar distributions of senile plaques in Alzheimer's disease

1985 • 414 citations

Quantitative analysis of a vulnerable subset of pyramidal neurons in Alzheimer's disease: I. Superior frontal and inferior temporal cortex

1990 • 367 citations

Amyloid fibril formation requires a chemically discriminating nucleation event: studies of an amyloidogenic sequence from the bacterial protein OsmB

1992 • 319 citations

The role of cortical connectivity in Alzheimer's disease pathogenesis: A review and model system

1993 • 251 citations

Human apolipoprotein E. Determination of the heparin binding sites of apolipoprotein E3.

1986 • 242 citations

Ultrastructural studies of the cells forming amyloid in the cortical vessel wall in Alzheimer's disease

1992 • 213 citations

Proteoglycans in the pathogenesis of Alzheimer's disease and other amyloidoses

1989 • 211 citations

High affinity interactions between the Alzheimer's beta-amyloid precursor proteins and the basement membrane form of heparan sulfate proteoglycan

1991 • 211 citations

Effects of Sulfate Ions on Alzheimer β/A4 Peptide Assemblies: Implications for Amyloid Fibril‐Proteoglycan Interactions

1992 • 211 citations

Differential distribution of neurofibrillary tangles in the cerebral cortex of dementia pugilistica and Alzheimer's disease cases

1992 • 208 citations

Morphometric comparison of hippocampal microvasculature in ageing and demented people: Diameters and densities

1981 • 188 citations

The Seminal Role of β-Amyloid in the Pathogenesis of Alzheimer Disease

1992 • 182 citations

Microangiopathy, the vascular basement membrane and Alzheimer's disease: a review

1990 • 178 citations

Altered angioarchitecture in selected areas of brains with Alzheimer's disease

1990 • 176 citations

The Human Hippocampus

1988 • 170 citations

Association of heparan sulfate proteoglycan with the neurofibrillary tangles of Alzheimer's disease

1991 • 167 citations

A comparative study of histological and immunohistochemical methods for neurofibrillary tangles and senile plaques in Alzheimer's disease

1992 • 164 citations

Localization of heparan sulfate glycosaminoglycan and proteoglycan core protein in aged brain and Alzheimer's disease

1992 • 161 citations

The use of osmium-thiocarbohydrazide-osmium (OTO) and ferrocyanide-reduced osmium methods to enhance membrane contrast and preservation in cultured cells.

1984 • 158 citations

A morphometric study of the blood-brain barrier in Alzheimer's disease.

1992 • 148 citations

Neuropathological observations in a case of autism presenting with self-injury behavior

1991 • 144 citations

The blood-brain barrier and cerebral microcirculation in Alzheimer disease.

1992 • 131 citations

Microangiopathy and the colocalization of heparan sulfate proteoglycan with amyloid in senile plaques of Alzheimer's disease

1990 • 128 citations

Pathological proteins Tau 64 and 69 are specifically expressed in the somatodendritic domain of the degenerating cortical neurons during Alzheimer's disease

1990 • 122 citations

Astroglia in Alzheimer's disease

1992 • 113 citations

Sulfated glycosaminoglycans in Alzheimer's disease

1987 • 98 citations

Vascular changes in senile brains

1965 • 89 citations

Vascular changes in the human senile brain.

1978 • 87 citations

The effect of age and Alzheimer's disease on pyramidal neuron density in the individual fields of the hippocampal formation

1992 • 85 citations

Binding of secreted human neuroblastoma proteoglycans to the Alzheimer's amyloid A4 peptide

1993 • 84 citations

Neuritic plaques and vessels of visual cortex in aging and Alzheimer's dementia

1990 • 81 citations

The disaccharide repeating-units of heparan sulfate

1974 • 78 citations

Neurofibrillary tangle distribution in the cerebral cortex of parkinsonism-dementia cases from Guam: differences with Alzheimer's disease

1991 • 74 citations

DENERVATION MICROANGIOPATHY IN SENILE DEMENTIA, ALZHEIMER TYPE

1987 • 73 citations

Quantitative changes in cerebral cortical microvasculature in ageing and dementia

1986 • 72 citations

Binding of vascular heparan sulfate proteoglycan to Alzheimer's amyloid precursor protein is mediated in part by the N-terminal region of A4 peptide

1993 • 66 citations

Cloning of a major heparan sulfate proteoglycan from brain and identification as the rat form of glypican

1992 • 53 citations

Chemotactic response of embryonic limb bud mesenchymal cells and muscle-derived fibroblasts to transforming growth factor-β

1988 • 51 citations

Alzheimer's disease: A new evidence for common epitopes between microtubule associated protein Tau and paired helical filaments (PHF): Demonstration at the electron microscope level by a double immunogold labelling

1988 • 38 citations

Monoclonal antibodies to heparan sulfate proteoglycan: Development and application to the study of normal tissue and pathologic human kidney biopsies

1988 • 37 citations

Differential vulnerability, connectivity, and cell typology

1993 • 36 citations

On the possible relationship of cortical microvascular pathology to blood brain barrier changes in Alzheimer's disease

1988 • 24 citations

Blood brain barrier in ageing and Alzheimer's disease

1988 • 20 citations