Age- and peroxidative stress-related modifications of the cerebral enzymatic activities linked to mitochondria and the glutathione system

Reactive Oxygen Species and the Central Nervous System

1992 • 2,931 citations

Protein Oxidation and Aging

1992 • 2,687 citations

The molecular pathology of Alzheimer's disease

1991 • 2,603 citations

Hydrogen peroxide mediates amyloid β protein toxicity

1994 • 2,065 citations

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

1993 • 1,422 citations

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

1991 • 1,290 citations

Mitochondrial Genetics: A Paradigm for Aging and Degenerative Diseases?

1992 • 1,268 citations

Effects of Tocopherol and Deprenyl on the Progression of Disability in Early Parkinson's Disease

1993 • 1,208 citations

MITOCHONDRIAL DNA MUTATIONS AS AN IMPORTANT CONTRIBUTOR TO AGEING AND DEGENERATIVE DISEASES

1989 • 1,179 citations

Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia

1994 • 1,120 citations

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.

1994 • 1,085 citations

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

1994 • 1,020 citations

The oxidant stress hypothesis in Parkinson's disease: Evidence supporting it

1992 • 925 citations

Glutathione deficiency produced by inhibition of its synthesis, and its reversal; Applications in research and therapy

1991 • 906 citations

The Generation of Hydrogen Peroxide, Superoxide Radical, and Hydroxyl Radical by 6-Hydroxydopamine, Dialuric Acid, and Related Cytotoxic Agents

1974 • 894 citations

Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

1992 • 878 citations

ROLE OF REVERSIBLE OXIDATION-REDUCTION OF ENZYME THIOLS-DISULFIDES IN METABOLIC REGULATION

1985 • 840 citations

In vitro aging of ß-amyloid protein causes peptide aggregation and neurotoxicity

1991 • 833 citations

Glutathione-ascorbic acid antioxidant system in animals

1994 • 825 citations

Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

1994 • 785 citations

Oxidative damage to mitochondrial DNA shows marked age‐dependent increases in human brain

1993 • 759 citations

Glutathione: Toxicological Implications

1990 • 750 citations

Deficiencies in Complex I subunits of the respiratory chain in Parkinson's disease

1989 • 735 citations

Intramuscular desferrioxamine in patients with Alzheimer's disease

1991 • 723 citations

The oxidative inactivation of mitochondrial electron transport chain components and ATPase.

1990 • 718 citations

Altered Brain Metabolism of Iron as a Cause of Neurodegenerative Diseases?

1994 • 701 citations

A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues.

1992 • 633 citations

Function of Quinones in Energy Conserving Systems

1982 • 596 citations

Functions of glutathione. Biochemical, physiological, toxicological and clinical aspects

1984 • 595 citations

Vitamin E protects nerve cells from amyloid βprotein toxicity

1992 • 583 citations

Aggregation and secondary structure of synthetic amyloid βA4 peptides of Alzheimer's disease

1991 • 580 citations

Advances in Our Understanding of the Mechanisms of the Neurotoxicity of MPTP and Related Compounds

1993 • 541 citations

Do Mitochondria Produce Oxygen Radicals in vivo?

1978 • 530 citations

Vitamin E: Interactions with Free Radicals and Ascorbate

1985 • 527 citations

Brain Cytochrome Oxidase in Alzheimer's Disease

1992 • 526 citations

Copper- and zinc-containing superoxide dismutase, manganese-containing superoxide dismutase, catalase, and glutathione peroxidase in normal and neoplastic human cell lines and normal human tissues.

1982 • 490 citations

Electron transport chain defects in Alzheimer's disease brain

1994 • 483 citations

Selective accumulation of aluminum and iron in the neurofibrillary tangles of Alzheimer's disease: A laser microprobe (LAMMA) study

1992 • 474 citations

Autopsy Samples of Alzheimer's Cortex Show Increased Peroxidation In Vitro

1990 • 456 citations

A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains

1992 • 450 citations

Glutathione peroxidase, glial cells and Parkinson's disease

1993 • 448 citations

Secreted Forms of β-Amyloid Precursor Protein Protect Hippocampal Neurons against Amyloid β-Peptide-Induced Oxidative Injury

1994 • 445 citations

Glutathione deficiency leads to mitochondrial damage in brain.

1991 • 428 citations

Glutathione is present in high concentrations in cultured astrocytes but not in cultured neurons

1989 • 414 citations

Vitamin E, Ascorbate, Glutathione, Glutathicne Disulfide, and Enzymes of Glutathione Metabolism in Cultures of Chick Astrocytes and Neurons: Evidence that Astrocytes Play an Important Role in Antioxidative Processes in the Brain

1994 • 413 citations

β-Amyloid Peptide Free Radical Fragments Initiate Synaptosomal Lipoperoxidation in a Sequence-Specific Fashion: Implications to Alzheimer′s Disease

1994 • 406 citations

Maintenance of Neuronal Glutathione by Glial Cells

1993 • 398 citations

Dopamine turnover and glutathione oxidation: implications for Parkinson disease.

1989 • 394 citations

Partners in defense, vitamin E and vitamin C

1993 • 385 citations

On the antioxidant effects of ascorbic acid and glutathione

1992 • 382 citations

Free radicals, aging, and degenerative diseases

1987 • 375 citations

Irreversible Inhibition of Mitochondrial Complex I by 1‐Methyl‐4‐Phenylpyridinium: Evidence for Free Radical Involvement

1992 • 371 citations

Alterations in mitochondrial membrane fluidity by lipid peroxidation products

1994 • 367 citations

Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease.

1992 • 362 citations

Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence

1990 • 345 citations

Amyloidogenicity of beta A4 and beta A4-bearing amyloid protein precursor fragments by metal-catalyzed oxidation.

1992 • 344 citations

BRAIN, SKELETAL MUSCLE AND PLATELET HOMOGENATE MITOCHONDRIAL FUNCTION IN PARKINSON'S DISEASE

1992 • 341 citations

Chemical Neurotoxins as Denervation Tools in Neurobiology

1980 • 318 citations

Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body disease

1994 • 316 citations

Free radicals in aging

1988 • 314 citations

Aluminium salts accelerate peroxidation of membrane lipids stimulated by iron salts

1985 • 313 citations

Glutathione peroxidase activity in Parkinson's disease brain

1985 • 301 citations

Oxygen Radicals in Chemistry and Biology

1985 • 285 citations

High-affinity transport of glutathione is part of a multicomponent system essential for mitochondrial function.

1990 • 283 citations

Mitochondrial oxidative damage, hydrogen peroxide release, and aging

1994 • 273 citations

Immunohistochemical studies on complexes I, II, III, and IV of mitochondria in parkinson's disease

1991 • 269 citations

Age‐Dependent Impairment of Mitochondrial Function in Primate Brain

1993 • 265 citations

Biokinetics of and discrimination between dietaryRRR‐ andSRR‐α‐tocopherols in the male rat

1987 • 256 citations

Histochemical evaluation of glutathione in brain

1987 • 253 citations

Calcium ions and oxidative cell injury

1992 • 246 citations

Oxidation of glutathione during hydroperoxide metabolism

1984 • 243 citations

Oxygen toxicity protecting enzymes in Parkinson's disease

1988 • 239 citations

Comparison of mitochondrial pro-oxidant generation and anti-oxidant defenses between rat and pigeon: possible basis of variation in longevity and metabolic potential

1993 • 234 citations

Regional brain trace-element studies in Alzheimer's disease.

1988 • 231 citations

Pro‐oxidants and mitochondrial Ca²⁺: their relationship to apoptosis and oncogenesis

1993 • 218 citations

Neuroleptic medications inhibit complex I of the electron transport chain

1993 • 213 citations

Methodological variables in the assessment of beta amyloid neurotoxicity

1992 • 208 citations

Superoxide dismutase, glutathione peroxidase, catalase, and lipid peroxidation in the major organs of the aging rats

1989 • 204 citations

Free Radicals in Molecular Biology, Aging, and Disease

1985 • 203 citations

Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease

1994 • 203 citations

[59] Glutathione disulfide (GSSG) efflux from cells and tissues

1984 • 197 citations

Age-related changes in antioxidant enzymes and prooxidant generation in tissues of the rat with special reference to parameters in two insect species

1990 • 193 citations

Effect of age on the expression of antioxidant enzymes in male Fischer F344 rats

1990 • 189 citations

Alzheimer’s and Parkinson’s disease

1991 • 186 citations

Respiratory Activity of Isolated Rat Brain Mitochondria followingin vitroExposure to Oxygen Radicals

1983 • 181 citations

Role of dopamine autoxidation, hydroxyl radical generation, and calcium overload in underlying mechanisms involved in MPTP-induced parkinsonism.

1993 • 177 citations

A Mechanism for the Stimulatory Effect of Aluminum on Iron-Induced Lipid Peroxidation

1994 • 176 citations

Electrochemistry of ubiquinones

1983 • 174 citations

Retention of oxidized glutathione by isolated rat liver mitochondria during hydroperoxide treatment

1988 • 167 citations

Reduced and oxidized glutathione in human and monkey brain

1987 • 164 citations

Altered mitochondrial function, iron metabolism and glutathione levels in Parkinson's disease

1993 • 163 citations

Regional Distributions of Thiobarbituric Acid‐Reactive Products, Activities of Enzymes Regulating the Metabolism of Oxygen Free Radicals, and Some of the Related Enzymes in Adult and Aged Rat Brains

1986 • 163 citations

Glutathione Turnover in Cultured Astrocytes: Studies with [¹⁵N]Glutamate

1990 • 158 citations

Senile Dementias: Early Detection

1986 • 140 citations

Chronic levodopa administration alters cerebral mitochondrial respiratory chain activity

1993 • 140 citations

Induction of cystine and glutamate transport activity in human fibroblasts by diethyl maleate and other electrophilic agents.

1984 • 140 citations

Aging, cytochrome oxidase activity, and hydrogen peroxide release by mitochondria

1993 • 138 citations

Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in alzheimer's brains

1992 • 138 citations

Glutathione depletion and formation of glutathione-protein mixed disulfide following exposure of brain mitochondria to oxidative stress

1990 • 137 citations

Age-related changes in antioxidant enzyme activities are region and organ, as well as sex, selective in the rat

1992 • 133 citations

Neurotoxicity of levodopa on catecholamine‐rich neurons

1992 • 133 citations

The mitochondrial electron transfer alteration as a factor involved in the brain aging

1992 • 132 citations

Normal Mitochondrial Genome in Brain from Patients with Parkinson's Disease and Complex I Defect

1990 • 131 citations

Phospholipid hydroperoxide glutathione peroxidase: specific activity in tissues of rats of different age and comparison with other glutathione peroxidases

1989 • 131 citations

ENERGY-COUPLING MECHANISMS IN MITOCHONDRIA: KINETIC, SPECTROSCOPIC, AND THERMODYNAMIC PROPERTIES OF AN ENERGY-TRANSDUCING FORM OF CYTOCHROME b

1970 • 130 citations

Superoxide Dismutase in the Rat and Mouse as a Function of Age and Longevity

1976 • 125 citations

Anti-oxidant defences and peroxidation in liver and brain of aged rats

1990 • 124 citations

Cellular and regional distribution of reduced glutathione in the nervous system of the rat: Histochemical localization by mercury orange and o-phthaldialdehyde-induced histofluorescence

1991 • 122 citations

6-Hydroxydopamine releases iron from ferritin and promotes ferritin-dependent lipid peroxidation

1989 • 121 citations

Dopaminergic system and monoamine oxidase-B Activity in Alzheimer's disease

1988 • 116 citations

Suppressive effect of <scp>L</scp>‐dopa on dopamine cells remaining in the ventral tegmental area of rats previously exposed to the neurotoxin 6‐hydroxydopamine

1993 • 115 citations

Effects of aluminum on brain lipid peroxidation

1990 • 112 citations

Expression of supreoxide dismutase and catalase in rat brain as a function of age

1991 • 111 citations

The Effect of Aging on Glutathione and Cysteine Levels in Different Regions of the Mouse Brain

1989 • 110 citations

Glutathione in Parkinson's disease: A link between oxidative stress and mitochondrial damage?

1992 • 108 citations

MPP+ and MPDP+ induced oxygen radical formation with mitochondrial enzymes

1993 • 106 citations

Differential Changes in Superoxide Dismutase Activity in Brain and Liver of Old Rats and Mice

1983 • 105 citations

Mitochondrial function in Parkinson's disease

1992 • 103 citations

Effect of aging on aqueous-phase antioxidants in tissues of male Fischer rats

1988 • 103 citations

Age-associated changes in superoxide dismutase activity, thiobarbituric acid reactivity and reduced glutathione level in the brain and liver in senescence accelerated mice (SAM): a comparison with ddY mice

1993 • 102 citations

Cu/Zn superoxide dismutase mRNA and enzyme activity, and susceptibility to lipid peroxidation, increases with aging in murine brains

1992 • 98 citations

Low glutathione levels in brain regions of aged rats

1989 • 98 citations

Respiratory chain and mitochondrial DNA in muscle and brain in Parkinson's disease patients

1993 • 98 citations

L-DOPA increases nigral production of hydroxyl radicals in vivo

1994 • 96 citations

The relationships between aging, monoamine oxidase, striatal dopamine and the effects of MPTP in C57BL/6 mice: a critical reassessment

1992 • 96 citations

Age‐Related Regional Changes in Hydroxyl Radical Stress and Antioxidants in Gerbil Brain

1993 • 93 citations

Biochemical mechanisms of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity

1991 • 90 citations

Age-related alterations in antioxidant capacity and lipid peroxidation in brain, liver, and lung homogenates of normal and vitamin E-deficient rats

1992 • 89 citations

Functional Alterations in Alzheimerʼs Disease

1993 • 88 citations

Preferential localization of copper zinc superoxide dismutase in the vulnerable cortical neurons in Alzheimer's disease

1988 • 88 citations

Quantitation of a mitochondrial DNA deletion in Parkinson's disease

1992 • 87 citations

Bypasses of the antimycin A block of mitochondrial electron transport in relation to ubisemiquinone function

1984 • 86 citations

Some properties of mitochondrial glutathione

1975 • 86 citations

Reduction of Brain Glutathione by <scp>l</scp>‐Buthionine Sulfoximine Potentiates the Dopamine‐Depleting Action of 6‐Hydroxydopamine in Rat Striatum

1989 • 86 citations

GLUTATHIONE PEROXIDASE LEVELS IN BRAIN

1974 • 81 citations

Age-Related Elevation of Lipid Peroxidation Products: Diminution of Superoxide Dismutase Activity in the Central Nervous System of Rats

1991 • 78 citations

Superoxide Dismutase Activities in Aging Rat Brain

1982 • 78 citations

Reduced synthesis of mtRNA in isolated mitochondria of senescent rat brain

1991 • 77 citations

Oxidative damage and cerebral aging

1992 • 76 citations

Changes with age in copper and superoxide dismutase levels in brains of C57BL/6J mice

1979 • 74 citations

Distribution of glutathione peroxidases glutathione reductase in rat brain mitochondria

1991 • 73 citations

Monoamine oxidase and oxidative stress at dopaminergic synapses

1990 • 71 citations

Generation of superoxide radicals as byproduct of cellular respiration.

1994 • 70 citations

Sensitivity of mitochondrial transcription to different free radical species

1994 • 69 citations

Superoxide radical formation and associated biochemical alterations in the plasma membrane of brain, heart, and liver during the lifetime of the rat

1992 • 68 citations

Age-related modifications of cytochrome c oxidase activity in discrete brain regions

1990 • 68 citations

Age‐Dependent Variations in Peroxide‐Utilizing Enzymes from Rat Brain Mitochondria and Cytoplasm

1984 • 65 citations

Glutathione: New candidate neuropeptide in the central nervous system

1992 • 63 citations

Hippocampal membrane alteration in Alzheimer's disease

1986 • 63 citations

Sequential damage in mitochondrial complexes by peroxidative stress

1991 • 57 citations

New aspects of brain oxidative stress induced by tert-butylhydroperoxide

1993 • 56 citations

Age-dependent changes in rat brain mitochondria of synaptic and non-synaptic origins

1987 • 56 citations

Is a point mutation in the mitochondrial ND2 gene associated with alzheimer's disease?

1992 • 55 citations

Effect of hyperoxia on glutathione levels and glutamic acid uptake in endothelial cells

1987 • 53 citations

Effect of Age on Vitamin E Concentrations in Various Regions of the Brain and a Few Selected Peripheral Tissues of the Rat, and on the Uptake of Radioactive Vitamin E by Various Regions of Rat Brain

1984 • 53 citations

The ability of (−)deprenyl to increase superoxide dismutase activities in the rat is tissue and brain region selective

1992 • 53 citations

High concentrations of antioxidants may not improve defense against oxidative stress

1993 • 53 citations

Age-related effect induced by oxidative stress on the cerebral glutathione system

1989 • 52 citations

Analyses of energy metabolism and mitochondrial genome in post-mortem brain from patients with Alzheimer's disease

1993 • 50 citations

A mitochondrial DNA deletion in normally aging and in Alzheimer brain tissue

1993 • 49 citations

Age Dependence of the Level of the Enzymes Involved in the Protection against Active Oxygen Species in the Rat Brain

1987 • 48 citations

Role of glutathione in repair of free radical damage in hippocampus in vitro

1992 • 47 citations

Protection by vitamin E, selenium, trolox C, ascorbic acid palmitate, acetylcysteine, coenzyme Q, beta-carotene, canthaxanthin, and (+)-catechin against oxidative damage to liver slices measured by oxidized heme proteins

1994 • 46 citations

beta-Amyloid neurotoxicity.

1993 • 46 citations

Electrochemical and Spectral Properties of Ubiquinone and Synthetic Analogs: Relevance to Bacterial Photosynthesis

1982 • 46 citations

Differential expression of cytochrome oxidase (COX) genes in different regions of monkey brain

1992 • 45 citations

Changes of mitochondrial membrane proteins in rat cerebellum during aging

1988 • 45 citations

Mitochondrial mutations, cellular instability and ageing: modelling the population dynamics of mitochondria

1993 • 44 citations

Neuronal Localization of Copper-Zinc Superoxide Dismutase Protein and mRNA within the Human Hippocampus from Control and Alzheimer'S Disease Brains

1991 • 44 citations

Antioxidants reduce peroxyl-mediated inhibition of mitochondrial transcription

1994 • 43 citations

Influence of aging and drug treatment on the cerebral glutathione system

1988 • 43 citations

Action ofl-acetylcarnitine on different cerebral mitochondrial populations from hippocampus and striatum during aging

1991 • 42 citations

Age and GSH metabolism in rat cerebral cortex, as related to oxidative and energy parameters

1993 • 42 citations

Increase in rat brain glutathione following intracerebroventricular administration of γ-glutamylcysteine

1992 • 42 citations

Methods for depleting brain glutathione

1989 • 41 citations

Age-related decline in multiple unit action potentials of ca3 region of rat hippocampus: Correlation with lipid peroxidation and lipofuscin concentration and the effect of centrophenoxine

1993 • 41 citations

Superoxide dismutase and cytochrome oxidase activities in light and heavy synaptic mitochondria from rat cerebral cortex during aging

1989 • 40 citations

Neurotoxicity and neuroprotection in Parkinson's disease.

1992 • 40 citations

Synergism of tocopherol and ascorbate on the survival of cultured brain neurones.

1993 • 39 citations

Deprenyl effects on levodopa pharmacodynamics, mood, and free radical scavenging

1992 • 39 citations

(?)-Deprenyl can induce soluble superoxide dismutase in rat striata

1991 • 38 citations

Evidence for a membrane lipid defect in Alzheimer disease

1993 • 37 citations

Enzyme activities in perikaryal and synaptic mitochondrial fractions from rat hippocampus during development

1989 • 37 citations

Influence of oxidative stress on the age‐linked alterations of the cerebral glutathione system

1990 • 37 citations

Age-related changes in lipid peroxidation and protective enzymes in the central nervous system.

1989 • 33 citations

The presence of glutathione in primary neuronal and astroglial cultures from rat cerebral cortex and brain stem

1991 • 32 citations

Effects of ageing on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxic effects on striatum and brainstem in the rat

1993 • 28 citations

&lt;b&gt;SENSITIVE IMMUNOASSAY OF RAT Cu/Zn SUPEROXIDE DISMUTASE: CONCENTRATIONS IN THE BRAIN, LIVER, AND KIDNEY ARE NOT AFFECTED BY &lt;/b&gt;&lt;b&gt;AGING &lt;/b&gt;

1990 • 25 citations

Mechanism for the changes in levels of glutathione upon exposure of cultured mammalian cells to tertiary-butylhydroperoxide and diamide

1993 • 21 citations

THE BIOCHEMICAL ROLE OF UBIQUINONE AND UBIQUINONE-DERIVATIVES IN THE GENERATION OF HYDROXYL-RADICALS FROM HYDROGEN-PEROXIDE

1984 • 21 citations

Effect of CDP‐choline treatment on mitochondrial and synaptosomal protein composition in different brain regions during aging

1993 • 20 citations

Age‐related acute depletion of cerebral glutathione by peroxidative stress

1991 • 19 citations

Effective depletion of glutathione in rat striatum and substantia nigra by L-buthionine sulfoximine in combination with 2-cyclohexene-1-one

1990 • 19 citations

Susceptibility of Brains from Patients with Alzheimer's Disease to Oxygen-Stimulated Lipid Peroxidation and Differential Scanning Calorimetry

1992 • 18 citations

Synaptic Membrane Aging in the Central Nervous System

1990 • 14 citations

Brain cytochrome oxidase activity of synaptic and nonsynaptic mitochondria during aging.

1989 • 13 citations

Brain monoamine oxidase and aging: A review

1992 • 11 citations

Age‐related modification of enzyme activities in synaptosomes isolated from rat cerebral cortex

1989 • 10 citations

Influence of aging on the acute depletion of reduced glutathione induced by electrophilic agents

1991 • 9 citations

Calory restriction counteracts some of the neurochemical changes in the cortical neurons of senescent rats

1992 • 3 citations

Deleted Work

1955 • 0 citations