Complement activation by beta-amyloid in Alzheimer disease.

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

1986 • 3,430 citations

The molecular pathology of Alzheimer's disease

1991 • 2,603 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.

1989 • 1,752 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

Clinical, pathological, and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques

1988 • 1,186 citations

Immunochemical identification of the serine protease inhibitor α1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease

1988 • 899 citations

β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

1990 • 620 citations

The Classical Complement Pathway: Activation and Regulation of the First Complement Component

1985 • 514 citations

Evidence for a membrane defect in Alzheimer disease brain.

1992 • 514 citations

Immune System Response in Alzheimer's Disease

1989 • 457 citations

Immunoglobulins and complement factors in senile plaques

1982 • 427 citations

Activation of the classical complement pathway in brain tissue of Alzheimer patients

1989 • 385 citations

Calcium and the aging nervous system

1987 • 384 citations

Axonal disruption and aberrant localization of tau protein characterize the neuropil pathology of Alzheimer's disease

1987 • 348 citations

Dynamics of gene expression for a hippocampal glycoprotein elevated in Alzheimer's disease and in response to experimental lesions in rat

1990 • 334 citations

The Alzheimer amyloid precursor protein. Identification of a stable intermediate in the biosynthetic/degradative pathway.

1990 • 283 citations

Molecular, cellular, and pathologic characterization of HLA-DR immunoreactivity in normal elderly and Alzheimer's disease brain

1990 • 194 citations

Complement gene expression in human brain: comparison between normal and Alzheimer disease cases

1992 • 149 citations

Diffuse type of senile plaques in the cerebellum of Alzheimer-type dementia demonstrated by? protein immunostain

1989 • 139 citations

Immunohistochemical localization of vitronectin, its receptor and beta-3 integrin in Alzheimer brain tissue

1991 • 122 citations

Detection of the membrane inhibitor of reactive lysis (CD59) in diseased neurons of Alzheimer brain

1991 • 104 citations

Acute phase proteins are present in amorphous plaques in the cerebral but not in the cerebellar cortex of patients with Alzheimer's disease

1990 • 99 citations

Autoantibodies to neurofibrillary tangles and brain tissue in Alzheimer's disease. Establishment of Epstein-Barr virus-transformed antibody-producing cell lines.

1987 • 61 citations

Immunology and Alzheimer’s Disease

1988 • 39 citations

Leakage and neuronal uptake of serum protein in aged and Alzheimer brains. A postmortem phenomenon with antemortem etiology.

1991 • 39 citations