The Structures of Neuronal Nicotinic Receptors

Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein

1991 • 2,613 citations

Myasthenia Gravis

1997 • 2,469 citations

Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium

1993 • 1,455 citations

Presynaptic nicotinic ACh receptors

1997 • 1,313 citations

Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine

1998 • 1,304 citations

Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus

1997 • 1,142 citations

The Enteric Nervous System

2016 • 1,113 citations

A missense mutation in the neuronal nicotinic acetylcholine receptor α4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy

1995 • 1,112 citations

Nicotinic binding in rat brain: autoradiographic comparison of [3H]acetylcholine, [3H]nicotine, and [125I]-alpha-bungarotoxin

1985 • 1,037 citations

Acetylcholine receptor channel imaged in the open state

1995 • 1,002 citations

Hippocampal synaptic transmission enhanced by low concentrations of nicotine

1996 • 955 citations

A neuronal nicotinic acetylcholine receptor subunit (α7) is developmentally regulated and forms a homo-oligomeric channel blocked by α-BTX

1990 • 923 citations

Neurobiology of the Caenorhabditis elegans Genome

1998 • 912 citations

α9: An acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells

1994 • 869 citations

A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment.

1992 • 858 citations

Nicotinic Acetylcholine Receptor an 9 Å Resolution

1993 • 822 citations

Identification of a Site in Glutamate Receptor Subunits That Controls Calcium Permeability

1991 • 774 citations

Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia

1995 • 676 citations

Autoantibodies to Glutamate Receptor GluR3 in Rasmussen's Encephalitis

1994 • 675 citations

Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain

1995 • 659 citations

Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins

1995 • 614 citations

Molecular and Cellular Aspects of Nicotine Abuse

1996 • 605 citations

Acetylcholine Receptor: Complex of Homologous Subunits

1980 • 594 citations

Horizontal integration and cortical dynamics

1992 • 589 citations

Pharmacology of Nicotine: Addiction and Therapeutics

1996 • 578 citations

The 5-HT3B subunit is a major determinant of serotonin-receptor function

1999 • 555 citations

Epitopes on protein antigens: Misconceptions and realities

1990 • 532 citations

Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor

1991 • 515 citations

Mice Deficient in the α7 Neuronal Nicotinic Acetylcholine Receptor Lack α-Bungarotoxin Binding Sites and Hippocampal Fast Nicotinic Currents

1997 • 493 citations

A New α-Conotoxin Which Targets α3β2 Nicotinic Acetylcholine Receptors

1996 • 479 citations

Brain α-bungarotoxin binding protein cDNAs and MAbs reveal subtypes of this branch of the ligand-gated ion channel gene superfamily

1990 • 471 citations

Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors

1992 • 465 citations

Pentameric structure and subunit stoichiometry of a neuronal nicotinic acetylcholine receptor

1991 • 463 citations

Monoclonal antibodies used to probe acetylcholine receptor structure: localization of the main immunogenic region and detection of similarities between subunits.

1980 • 452 citations

The enteric nervous system

1988 • 449 citations

Isolation of a cDNA clone coding for a possible neural nicotinic acetylcholine receptor α-subunit

1986 • 444 citations

Neuronal Nicotinic Acetylcholine Receptors as Targets for Drug Discovery

1997 • 440 citations

Regulation of neurotransmitter receptor desensitization by protein phosphorylation

1990 • 439 citations

Properties of neuronal nicotinic acetylcholine receptors: pharmacological characterization and modulation of synaptic function.

1997 • 431 citations

Molecular evolution of the nicotinic acetylcholine receptor: An example of multigene family in excitable cells

1995 • 422 citations

Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic

1992 • 420 citations

Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the α subunit

1994 • 418 citations

Mapping of surface structures of electrophorus acetylcholine receptor using monoclonal antibodies.

1981 • 412 citations

Identification of the alpha subunit half-cystine specifically labeled by an affinity reagent for the acetylcholine receptor binding site.

1984 • 408 citations

Chimaeric nicotinic–serotonergic receptor combines distinct ligand binding and channel specificities

1993 • 401 citations

Members of a nicotinic acetylcholine receptor gene family are expressed in different regions of the mammalian central nervous system

1987 • 393 citations

Functional contributions of α5 subunit to neuronal acetylcholine receptor channels

1996 • 389 citations

Mutations at two distinct sites within the channel domain M2 alter calcium permeability of neuronal alpha 7 nicotinic receptor.

1993 • 389 citations

Nicotine-induced increase in neuronal nicotinic receptors results from a decrease in the rate of receptor turnover.

1994 • 381 citations

Neuronal Nicotinic Receptor a6 Subunit mRNA is Selectively Concentrated in Catecholaminergic Nuclei of the Rat Brain

1996 • 379 citations

Neuronal Nicotinic Acetylcholine Receptors

1996 • 377 citations

Cigarette smoking and protection from Parkinson's disease

1995 • 372 citations

An Insertion Mutation of the CHRNA4 Gene in a Family With Autosomal Dominant Nocturnal Frontal Lobe Epilepsy

1997 • 357 citations

Immunohistochemical localization of neuronal nicotinic receptors in the rodent central nervous system

1987 • 350 citations

Specificities of antibodies to acetylcholine receptors in sera from myasthenia gravis patients measured by monoclonal antibodies.

1982 • 342 citations

Myasthenia Gravis

1988 • 341 citations

Assembly of Human Neuronal Nicotinic Receptor α5 Subunits with α3, β2, and β4 Subunits

1996 • 338 citations

Synaptic Potentials Mediated via α-Bungarotoxin-Sensitive Nicotinic Acetylcholine Receptors in Rat Hippocampal Interneurons

1998 • 334 citations

Choline and Selective Antagonists Identify Two Subtypes of Nicotinic Acetylcholine Receptors that Modulate GABA Release from CA1 Interneurons in Rat Hippocampal Slices

1999 • 334 citations

E.E. Just Lecture, 1996

1997 • 326 citations

Nicotinic receptor stimulation protects neurons against β‐amyloid toxicity

1997 • 320 citations

Influence of Subunit Composition on Desensitization of Neuronal Acetylcholine Receptors at Low Concentrations of Nicotine

1997 • 320 citations

Functional Expression of a New Pharmacological Subtype of Brain Nicotinic Acetylcholine Receptor

1988 • 314 citations

Neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes have a pentameric quaternary structure

1991 • 313 citations

Ivermectin: A Positive Allosteric Effector of the α7 Neuronal Nicotinic Acetylcholine Receptor

1998 • 308 citations

Alpha 3, alpha 5, and beta 4: three members of the rat neuronal nicotinic acetylcholine receptor-related gene family form a gene cluster.

1990 • 303 citations

Neurons assemble acetylcholine receptors with as many as three kinds of subunits while maintaining subunit segregation among receptor subtypes

1993 • 303 citations

Primary structure and expression of β2: A novel subunit of neuronal nicotinic acetylcholine receptors

1988 • 301 citations

Prenatal nicotine increases pulmonary α7 nicotinic receptor expression and alters fetal lung development in monkeys

1999 • 300 citations

Purification and characterization of a nicotinic acetylcholine receptor from rat brain.

1987 • 300 citations

α7 Nicotinic Receptor Subunits Are Not Necessary for Hippocampal-Dependent Learning or Sensorimotor Gating: A Behavioral Characterization of Acra7-Deficient Mice

1998 • 295 citations

α-Conotoxin AuIB Selectively Blocks α3β4 Nicotinic Acetylcholine Receptors and Nicotine-Evoked Norepinephrine Release

1998 • 295 citations

The functional diversity of the neuronal nicotinic acetylcholine receptors is increased by a novel subunit: β4

1989 • 294 citations

Neurons Can Maintain Multiple Classes of Nicotinic Acetylcholine Receptors Distinguished by Different Subunit Compositions

1995 • 293 citations

Molecular basis of the two nonequivalent ligand binding sites of the muscle nicotinic acetylcholine receptor

1989 • 279 citations

An evaluation of neuronal nicotinic acetylcholine receptor activation by quaternary nitrogen compounds indicates that choline is selective for the α7 subtype

1996 • 278 citations

Time course study of the effects of chronic nicotine infusion on drug response and brain receptors.

1985 • 271 citations

Nicotinic receptors that bind α-bungarotoxin on neurons raise intracellular free ca2+

1992 • 263 citations

α-Bungarotoxin- and methyllycaconitine-sensitive nicotinic receptors mediate fast synaptic transmission in interneurons of rat hippocampal slices

1998 • 263 citations

Neuronal acetylcholine receptors that bind α-bungarotoxin with high affinity function as ligand-gated ion channels

1994 • 254 citations

Human endplate acetylcholinesterase deficiency caused by mutations in the collagen-like tail subunit (ColQ) of the asymmetric enzyme

1998 • 249 citations

Identification of a novel amino acid alpha-tyrosine 93 within the cholinergic ligands-binding sites of the acetylcholine receptor by photoaffinity labeling. Additional evidence for a three-loop model of the cholinergic ligands-binding sites.

1990 • 247 citations

Immunocytochemical localization of the α7 subunit of the nicotinic acetylcholine receptor in the rat central nervous system

1994 • 247 citations

Neuronal acetylcholine receptors that bind alpha-bungarotoxin mediate neurite retraction in a calcium-dependent manner

1994 • 246 citations

alpha 5 Subunit alters desensitization, pharmacology, Ca++ permeability and Ca++ modulation of human neuronal alpha 3 nicotinic receptors.

1998 • 245 citations

Characterization of bovine and human neuronal nicotinic acetylcholine receptors using monoclonal antibodies

1988 • 241 citations

Rat α3/β4 Subtype of Neuronal Nicotinic Acetylcholine Receptor Stably Expressed in a Transfected Cell Line: Pharmacology of Ligand Binding and Function

1998 • 240 citations

Unconventional pharmacology of a neuronal nicotinic receptor mutated in the channel domain.

1992 • 238 citations

Mutation Causing Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Alters Ca²⁺Permeability, Conductance, and Gating of Human α4β2 Nicotinic Acetylcholine Receptors

1997 • 235 citations

Nicotinic Receptor-Induced Apoptotic Cell Death of Hippocampal Progenitor Cells

1998 • 234 citations

Human and Rodent Bronchial Epithelial Cells Express Functional Nicotinic Acetylcholine Receptors

1998 • 233 citations

Neuronal nicotinic ACh receptor antibody in subacute autonomic neuropathy and cancer‐related syndromes

1998 • 231 citations

β3: A New Member of Nicotinic Acetylcholine Receptor Gene Family Is Expressed in Brain

1989 • 229 citations

Neuronal nicotinic alpha 7 receptor expressed in Xenopus oocytes presents five putative binding sites for methyllycaconitine.

1996 • 223 citations

Role of Ca²⁺Ions in Nicotinic Facilitation of GABA Release in Mouse Thalamus

1997 • 221 citations

alpha-Bungarotoxin binding and cholinergic receptor function on a rat sympathetic nerve line

1977 • 210 citations

Human alpha 7 acetylcholine receptor: cloning of the alpha 7 subunit from the SH-SY5Y cell line and determination of pharmacological properties of native receptors and functional alpha 7 homomers expressed in Xenopus oocytes.

1994 • 210 citations

Alpha-conotoxin MII blocks nicotine-stimulated dopamine release in rat striatal synaptosomes.

1997 • 210 citations

Rapsyn may function as a link between the acetylcholine receptor and the agrin-binding dystrophin-associated glycoprotein complex

1995 • 209 citations

Increased neurodegeneration during ageing in mice lacking high-affinity nicotine receptors

1999 • 207 citations

Homomers of alpha 8 and alpha 7 subunits of nicotinic receptors exhibit similar channel but contrasting binding site properties.

1994 • 207 citations

The α5 gene product assembles with multiple acetylcholine receptor subunits to form distinctive receptor subtypes in brain

1992 • 205 citations

Assembly in vivo of mouse muscle acetylcholine receptor: Identification of an α subunit species that may be an assembly intermediate

1983 • 204 citations

A mutated acetylcholine receptor subunit causes neuronal degeneration in C. elegans

1995 • 203 citations

The α-Bungarotoxin-binding Nicotinic Acetylcholine Receptor from Rat Brain Contains Only the α7 Subunit

1997 • 200 citations

Differential regulation of muscle acetylcholine receptor γ‐and ϵ‐subunit mRNAs

1987 • 197 citations

Neurotransmitter-gated ion channels as unconventional allosteric proteins

1994 • 197 citations

Structural and pharmacological characterization of the major brain nicotinic acetylcholine receptor subtype stably expressed in mouse fibroblasts.

1991 • 196 citations

The Location of the Gate in the Acetylcholine Receptor Channel

1998 • 196 citations

Identification of channel-lining residues in the M2 membrane-spanning segment of the GABA(A) receptor alpha1 subunit.

1996 • 193 citations

Stimulation of α4β2 nicotinic acetylcholine receptors inhibits β-amyloid toxicity

1998 • 192 citations

α-Conotoxin MII Blocks Nicotine-Stimulated Dopamine Release in Rat Striatal Synaptosomes

1997 • 189 citations

Synaptic Currents Generated by Neuronal Acetylcholine Receptors Sensitive to α-Bungarotoxin

1996 • 189 citations

Nicotine Selectively Enhances NMDA Receptor-Mediated Synaptic Transmission during Postnatal Development in Sensory Neocortex

1998 • 185 citations

Chronic Nicotine Treatment Up-regulates Human α3β2 but Not α3β4 Acetylcholine Receptors Stably Transfected in Human Embryonic Kidney Cells

1998 • 184 citations

Chronic Nicotine Treatment Up-Regulates α3 and α7 Acetylcholine Receptor Subtypes Expressed by the Human Neuroblastoma Cell Line SH-SY5Y

1997 • 184 citations

Transmembrane topography of the nicotinic acetylcholine receptor: immunochemical tests contadict theoretical predictions based on hydrophobicity profiles

1986 • 183 citations

Identification of Acetylcholine Receptor Channel-Lining Residues in the M1 Segment of the .alpha.-Subunit

1995 • 179 citations

Presynaptic Nicotinic Receptors Facilitate Monoaminergic Transmission

1998 • 174 citations

Chronic nicotine exposure differentially affects the function of human alpha3, alpha4, and alpha7 neuronal nicotinic receptor subtypes.

1997 • 174 citations

Identification of calcium binding sites that regulate potentiation of a neuronal nicotinic acetylcholine receptor.

1996 • 173 citations

Nicotine enhances expression of the alpha 3, alpha 4, alpha 5, and alpha 7 nicotinic receptors modulating calcium metabolism and regulating adhesion and motility of respiratory epithelial cells.

1997 • 173 citations

Passive transfer of experimental autoimmune myasthenia gravis by monoclonal antibodies to the main immunogenic region of the acetylcholine receptor

1987 • 172 citations

Stable expression, pharmacologic properties and regulation of the human neuronal nicotinic acetylcholine alpha 4 beta 2 receptor.

1996 • 172 citations

Functional significance of aromatic amino acids from three peptide loops of the α7 neuronal nicotinic receptor site investigated by site‐directed mutagenesis

1991 • 168 citations

Arrangement of the acetylcholine receptor subunits in the resting and desensitized states, determined by cryoelectron microscopy of crystallized Torpedo postsynaptic membranes.

1988 • 167 citations

Purification and characterization of a nicotinic acetylcholine receptor from chick brain

1986 • 167 citations

Stable expression and pharmacological properties of the human α7 nicotinic acetylcholine receptor

1995 • 166 citations

Monoclonal antibodies as probes of acetylcholine receptor structure. 2. Binding to native receptor

1981 • 157 citations

An amino acid exchange in the second transmembrane segment of a neuronal nicotinic receptor causes partial epilepsy by altering its desensitization kinetics

1996 • 155 citations

Brain and muscle nicotinic acetylcholine receptors are different but homologous proteins.

1985 • 154 citations

The N-terminal domains of acetylcholine receptor subunits contain recognition signals for the initial steps of receptor assembly

1992 • 149 citations

Identification of a New Component of the Agonist Binding Site of the Nicotinic α7 Homooligomeric Receptor

1995 • 147 citations

Location of antigenic determinants of primary sequences of the subunits of nicotinic acetylcholine receptor by peptide mapping

1986 • 146 citations

Regulation of alpha4beta2 nicotinic receptor desensitization by calcium and protein kinase C.

1999 • 142 citations

Nicotinic α7 receptors protect against glutamate neurotoxicity and neuronal ischemic damage

1998 • 142 citations

Three subtypes of alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors are expressed in chick retina

1993 • 142 citations

Reductions in Acetylcholine and Nicotine Binding in Several Degenerative Diseases

1988 • 141 citations

Demonstration of a main immunogenic region on acetylcholine receptors from human muscle using monoclonal antibodies to human receptor

1983 • 139 citations

Perfection of a synaptic receptor: kinetics and energetics of the acetylcholine receptor.

1989 • 137 citations

Structurally different neuronal nicotinic acetylcholine receptor subtypes purified and characterized using monoclonal antibodies

1987 • 137 citations

Shared antigenic determinant between the Electrophorus acetylcholine receptor and a synaptic component on chicken ciliary ganglion neurons.

1984 • 136 citations

Neuronal nicotinic acetylcholine receptor β‐subunit is coded for by the cDNA clone α₄

1987 • 134 citations

Host Cell‐Specific Folding and Assembly of the Neuronal Nicotinic Acetylcholine Receptor α7 Subunit

1997 • 134 citations

The long internal loop of the α3 subunit targets nAChRs to subdomains within individual synapses on neurons in vivo

1998 • 134 citations

A role for the nicotinic α-bungarotoxin receptor in neurite outgrowth in PC12 cells

1993 • 133 citations

Diversity of nicotinic acetylcholine receptors in rat brain. V. alpha-Bungarotoxin-sensitive nicotinic receptors in olfactory bulb neurons and presynaptic modulation of glutamate release.

1996 • 133 citations

cDNA clones coding for the structural subunit of a chicken brain nicotinic acetylcholine receptor

1988 • 131 citations

Neuronal Nicotinic Acetylcholine Receptors on Bovine Chromaffin Cells: Cloning, Expression, and Genomic Organization of Receptor Subunits

1997 • 130 citations

The kinetic properties of neuronal nicotinic receptors: Genetic basis of functional diversity

1993 • 130 citations

Perisynaptic surface distribution of multiple classes of nicotinic acetylcholine receptors on neurons in the chicken ciliary ganglion

1995 • 129 citations

Characteristics of monoclonal antibodies to denatured Torpedo and to native calf acetylcholine receptors: Species, subunit and region specificity

1986 • 127 citations

Pharmacological properties of immuno-isolated neuronal nicotinic receptors

1986 • 127 citations

Effects of chronic nicotine treatment on expression of diverse nicotinic acetylcholine receptor subtypes. I. Dose- and time-dependent effects of nicotine treatment.

1998 • 126 citations

Recombinant nicotinic receptors, expressed in Xenopus oocytes, do not resemble native rat sympathetic ganglion receptors in single‐channel behaviour.

1997 • 126 citations

Physiological Properties of Neuronal Nicotinic Receptors Reconstituted from the Vertebrate β2 Subunit and Drosophilaα Subunits

1994 • 125 citations

Homomeric and native α7 acetylcholine receptors exhibit remarkably similar but non‐identical pharmacological properties, suggesting that the native receptor is a heteromeric protein complex

1993 • 122 citations

Rapid Synaptic Transmission in the Avian Ciliary Ganglion Is Mediated by Two Distinct Classes of Nicotinic Receptors

1997 • 121 citations

Formation of the alpha-bungarotoxin binding site and assembly of the nicotinic acetylcholine receptor subunits occur in the endoplasmic reticulum.

1987 • 119 citations

Assembly of the mammalian muscle acetylcholine receptor in transfected COS cells.

1991 • 116 citations

Native folding of an acetylcholine receptor alpha subunit expressed in the absence of other receptor subunits.

1988 • 114 citations

Synaptic transmission at vertebrate hair cells

1996 • 113 citations

“Orphan” α6 Nicotinic AChR Subunit Can Form a Functional Heteromeric Acetylcholine Receptor

1997 • 112 citations

Distributions of nicotinic acetylcholine receptor α7 and β2 subunits on cultured hippocampal neurons

1999 • 112 citations

Primary structure and functional expression of the α‐, β‐, γ‐, δ‐ and ɛ‐subunits of the acetylcholine receptor from rat muscle

1990 • 110 citations

Expression of nicotinic acetylcholine receptor subtypes in brain and retina

1991 • 110 citations

Ethanol inhibition of nicotinic acetylcholine type alpha 7 receptors involves the amino-terminal domain of the receptor.

1996 • 110 citations

Neuronal Acetylcholine Receptors with α7 Subunits Are Concentrated on Somatic Spines for Synaptic Signaling in Embryonic Chick Ciliary Ganglia

1999 • 108 citations

Prolyl isomerase requirement for the expression of functional homo-oligomeric ligand-gated ion channels

1994 • 108 citations

Surface and intracellular distribution of a putative neuronal nicotinic acetylcholine receptor.

1986 • 107 citations

The ion channel properties of a rat recombinant neuronal nicotinic receptor are dependent on the host cell type

1997 • 107 citations

Neuronal-type alpha-bungarotoxin receptors and the alpha 5-nicotinic receptor subunit gene are expressed in neuronal and nonneuronal human cell lines.

1992 • 106 citations

Interaction of the 43 kd postsynaptic protein with all subunits of the muscle nicotinic acetylcholine receptor

1993 • 106 citations

Role of the main immunogenic region of acetylcholine receptor in myasthenia gravis. An Fab monoclonal antibody protects against antigenic modulation by human sera.

1985 • 106 citations

Nicotine for the treatment of Tourette's syndrome

1997 • 105 citations

Immunohistochemical localization of monoclonal antibodies to the nicotinic acetylcholine receptor in chick midbrain.

1983 • 105 citations

Critical Elements Determining Diversity in Agonist Binding and Desensitization of Neuronal Nicotinic Acetylcholine Receptors

1998 • 104 citations

Evidence for unpredicted transmembrane domains in acetylcholine receptor subunits.

1985 • 103 citations

Functional expression of nicotinic acetylcholine receptors containing rat α7 subunits in human SH‐SY5Y neuroblastoma cells

1994 • 103 citations

The α9 Nicotinic Acetylcholine Receptor Shares Pharmacological Properties with Type A γ-Aminobutyric Acid, Glycine, and Type 3 Serotonin Receptors

1999 • 103 citations

Assembly intermediates of the mouse muscle nicotinic acetylcholine receptor in stably transfected fibroblasts.

1990 • 102 citations

Activation of α₇ nicotinic acetylcholine receptor promotes survival of spinal cord motoneurons

1997 • 101 citations

Pathological mutations of nicotinic receptors and nicotine-based therapies for brain disorders

1997 • 100 citations

Structure of the Nicotinic Receptor Acetylcholine-binding Site

1995 • 100 citations

A Reporter Mutation Approach Shows Incorporation of the “Orphan” Subunit β3 into a Functional Nicotinic Receptor

1998 • 99 citations

α-Bungarotoxin used as a Probe for Acetylcholine Receptors of Cultured Neurones

1973 • 98 citations

Pharmacology and Biophysical Properties of α7 and α7 ‐ α8 α‐Bungarotoxin Receptor Subtypes Immunopurified from the Chick Optic Lobe

1994 • 97 citations

Intersubunit contacts governing assembly of the mammalian nicotinic acetylcholine receptor

1995 • 95 citations

Single channel properties of human α3 AChRs: impact of β2, β4 and α5 subunits

1999 • 95 citations

Extracellular domains mediating ɛ subunit interactions of muscle acetylcholine receptor

1991 • 94 citations

Three-dimensional location of the main immunogenic region of the acetylcholine receptor

1995 • 94 citations

Neuronal Nicotinic Acetylcholine Receptors Are Blocked by Intracellular Spermine in a Voltage-Dependent Manner

1998 • 94 citations

Functional acetylcholine receptor in PC12 cells reacts with a monoclonal antibody to brain nicotinic receptors

1987 • 93 citations

α-Bungarotoxin blocks the nicotinic receptor mediated increase in cell number in a neuroendocrine cell line

1994 • 92 citations

Nicotinic acetylcholine receptor-like molecules in the retina, retinotectal pathway, and optic tectum of the frog

1989 • 92 citations

Similarity Between Rat Brain Nicotinic α‐Bungarotoxin Receptors and Stably Expressed α‐Bungarotoxin Binding Sites

1996 • 92 citations

Acetylcholine Receptor Synthesis in Retina and Transport to Optic Tectum in Goldfish

1986 • 91 citations

Structure and transmembrane nature of the acetylcholine receptor in amphibian skeletal muscle as revealed by cross-reacting monoclonal antibodies.

1984 • 90 citations

Immunohistochemical localization of the nicotinic acetylcholine receptor subunit α6 to dopaminergic neurons in the substantia nigra and ventral tegmental area

1997 • 90 citations

Immunohistochemical localization of nicotinic acetylcholine receptors in the guinea pig bowel and pancreas

1998 • 90 citations

Characterization of human recombinant neuronal nicotinic acetylcholine receptor subunit combinations alpha2beta4, alpha3beta4 and alpha4beta4 stably expressed in HEK293 cells.

1998 • 88 citations

Mammalian Muscle Acetylcholine Receptor: A Supramolecular Structure Formed by Four Related Proteins

1982 • 88 citations

Spatiotemporal Patterns of Activity in an Intact Mammalian Network with Single-Cell Resolution: Optical Studies of Nicotinic Activity in an Enteric Plexus

1999 • 87 citations

Serotonin release and cell proliferation are under the control of α‐bungarotoxin‐sensitive nicotinic receptors in small‐cell lung carcinoma cell lines

1994 • 86 citations

Formation of Oligomers Containing the β3 and β4 Subunits of the Rat Nicotinic Receptor

1997 • 86 citations

Neuroprotective and memory-related actions of novel alpha-7 nicotinic agents with different mixed agonist/antagonist properties.

1998 • 85 citations

Sustained Nicotine Exposure Differentially Affects α3β2 and α4β2 Neuronal Nicotinic Receptors Expressed in Xenopus Oocytes

1996 • 84 citations

Detection of Functional Nicotinic Receptors Blocked by α-Bungarotoxin on PC12 Cells and Dependence of Their Expression on Post-Translational Events

1997 • 83 citations

Immunohistochemical localization of nicotinic acetylcholine receptor subunits in the mesencephalon and diencephalon of the chick (Gallus gallus)

1992 • 82 citations

Initial Characterization of the Nicotinic Acetylcholine Receptors in Rat Hippocampal Neurons

1991 • 82 citations

Effects of Chronic Nicotinic Ligand Exposure on Functional Activity of Nicotinic Acetylcholine Receptors Expressed by Cells of the PC12 Rat Pheochromocytoma or the TE671/RD Human Clonal Line

1991 • 81 citations

Cytoprotective actions of 2,4‐dimethoxybenzylidene anabaseine in differentiated PC12 cells and septal cholinergic neurons

1994 • 78 citations

Recovery from Desensitization of Neuronal Nicotinic Acetylcholine Receptors of Rat Chromaffin Cells Is Modulated by Intracellular Calcium through Distinct Second Messengers

1998 • 77 citations

Two Distinct Nicotinic Receptors, One Pharmacologically Similar to the Vertebrate α7-Containing Receptor, Mediate Cl Currents inAplysiaNeurons

1998 • 77 citations

Direct recording of nicotinic responses in presynaptic nerve terminals.

1997 • 76 citations

Identification of two amino acid residues in the ϵ subunit that promote mammalian muscle acetylcholine receptor assembly in COS cells

1991 • 75 citations

Cholinoceptive neurons in the retina of the chick: an immunohistochemical study of the nicotinic acetylcholine receptors

1988 • 72 citations

Paradoxical allosteric effects of competitive inhibitors on neuronal α7 nicotinic receptor mutants

1997 • 72 citations

Assembly of Torpedo acetylcholine receptors in Xenopus oocytes.

1991 • 71 citations

Contribution of nicotinic receptors to the function of synapses in the central nervous system: The action of choline as a selective agonist of α7 receptors

1998 • 70 citations

Effects of Zn ²⁺ on wild and mutant neuronal α ₇ nicotinic receptors

1998 • 69 citations

The main immunogenic region (MIR) of the nicotinic acetylcholine receptor and the anti-MIR antibodies

1991 • 68 citations

Functional Deactivation of the Major Neuronal Nicotinic Receptor Caused by Nicotine and a Protein Kinase C-Dependent Mechanism

1997 • 67 citations

Direct Recording of Nicotinic Responses in Presynaptic Nerve Terminals

1997 • 67 citations

Volatile general anaesthetic actions on recombinant nACh_α7, 5‐HT₃ and chimeric nACh_α7‐5‐HT₃ receptors expressed in Xenopus oocytes

1997 • 66 citations

The potential of subtype-selective neuronal nicotinic acetylcholine receptor agonists as therapeutic agents

1998 • 66 citations

Contributions of N‐Linked Glycosylation to the Expression of a Functional α7‐Nicotinic Receptor in Xenopus Oocytes

1998 • 65 citations

The neuronal α₆ subunit forms functional heteromeric acetylcholine receptors in human transfected cells

1998 • 65 citations

Determination of amino acids critical to the main immunogenic region of intact acetylcholine receptors by in vitro mutagenesis

1990 • 64 citations

Brief research communication: No evidence for linkage of the CHRNA7 gene region in Canadian schizophrenia families

1998 • 64 citations

Identification of Acetylcholine Receptor Channel-Lining Residues in the M1 Segment of the β-Subunit

1997 • 63 citations

Pharmacological characterization of alpha-bungarotoxin-sensitive acetylcholine receptors immunoisolated from chick retina: contrasting properties of alpha 7 and alpha 8 subunit-containing subtypes.

1993 • 61 citations

Neuronal‐type nicotinic receptors in human neuroblastoma and small‐cell lung carcinoma cell lines

1992 • 60 citations

Cyclic AMP-dependent phosphorylation of a neuronal acetylcholine receptor alpha-type subunit

1990 • 59 citations

Modulation of alpha7 nicotinic receptor-mediated calcium influx by nicotinic agonists.

1997 • 59 citations

Two mutations linked to nocturnal frontal lobe epilepsy cause use‐dependent potentiation of the nicotinic ACh response

1998 • 57 citations

Promiscuous coassembly of serotonin 5-HT ₃ and nicotinic α4 receptor subunits into Ca ²⁺ -permeable ion channels

1998 • 56 citations

Alpha-conotoxin-ImI: a competitive antagonist at alpha-bungarotoxin-sensitive neuronal nicotinic receptors in hippocampal neurons.

1996 • 55 citations

The Contributions of Aspartyl Residues in the Acetylcholine Receptor γ and δ Subunits to the Binding of Agonists and Competitive Antagonists

1996 • 55 citations

Antagonist activities of mecamylamine and nicotine show reciprocal dependence on beta subunit sequence in the second transmembrane domain

1999 • 54 citations

α7 and α8 Nicotinic Receptor Subtypes Immunopurified from Chick Retina have Different Immunological, Pharmacological and Functional Properties

1997 • 54 citations

α5 Subunit forms functional α3β4α5 nAChRs in transfected human cells

1997 • 53 citations

TE671 cells express an abundance of a partially mature acetylcholine receptor alpha subunit which has characteristics of an assembly intermediate.

1990 • 53 citations

Expression of α 7 neuronal nicotinic receptors during postnatal development of the rat cerebellum

1997 • 50 citations

Expression and Transcriptional Regulation of the Human α3 Neuronal Nicotinic Receptor Subunit in T Lymphocyte Cell Lines

1998 • 49 citations

Role of Two Acetylcholine Receptor Subunit Domains in Homomer Formation and Intersubunit Recognition, as Revealed by .alpha.3 and .alpha.7 Subunit Chimeras

1994 • 49 citations

A sequence in the main cytoplasmic loop of the α subunit is required for assembly of mouse muscle nicotinic acetylcholine receptor

1994 • 47 citations

Neurons of the chick brain and retina expressing both α-bungarotoxin-sensitive and α-bungarotoxin-insensitive nicotinic acetylcholine receptors: an immunohistochemical analysis

1992 • 46 citations

Formation of the Nicotinic Acetylcholine Receptor Binding Sites

1998 • 46 citations

Differential development of α‐bungarotoxin‐sensitive and α‐bungarotoxin‐insensitive nicotinic acetylcholine receptors in the chick retina

1994 • 45 citations

Nicotine Enhances the Cyclic AMP‐Dependent Protein Kinase‐Mediated Phosphorylation of α4 Subunits of Neuronal Nicotinic Receptors

1997 • 45 citations

Are nicotinic receptors activated or inhibited following chronic nicotine treatment?

1996 • 43 citations

Water-soluble Nicotinic Acetylcholine Receptor Formed by α7 Subunit Extracellular Domains

1998 • 42 citations

Transmembrane orientation of an early biosynthetic form of acetylcholine receptor delta subunit determined by proteolytic dissection in conjunction with monoclonal antibodies

1983 • 42 citations

Epitope mapping of polyclonal and monoclonal antibodies against two α-bungarotoxin-binding α subunits from neuronal nicotinic receptors

1992 • 41 citations

Phosphorylation of the predicted major intracellular domains of the rat and chick neuronal nicotinic acetylcholine receptor α7 Subunit by cAMP-dependent protein kinase

1996 • 41 citations

Epitope mapping of antibodies to acetylcholine receptor .alpha. subunits using peptides synthesized on polypropylene pegs

1991 • 41 citations

Host Cell‐Specific Folding of the Neuronal Nicotinic Receptor α8 Subunit

1998 • 41 citations

Neuronal-type acetylcholine receptors and regulation of ?7 gene expression in vertebrate skeletal muscle

1997 • 40 citations

Antisera against an acetylcholine receptor α3 fusion protein bind to ganglionic but not to brain nicotinic acetylcholine receptors

1989 • 40 citations

Evidence for spare nicotinic acetylcholine receptors and a beta 4 subunit in bovine adrenal chromaffin cells: studies using bromoacetylcholine, epibatidine, cytisine and mAb35.

1997 • 40 citations

The Nicotinic Receptor Genes

1991 • 39 citations

Native Nicotinic Acetylcholine Receptors in Human Imr32 Neuroblastoma Cells: Functional, Immunological and Pharmacological Properties

1995 • 39 citations

The keratinocyte cholinergic system with acetylcholine as an epidermal cytotransmitter

1997 • 39 citations

Reporter epitopes: A novel approach to examine transmembrane topology of integral membrane proteins applied to the .alpha.1 subunit of the nicotinic acetylcholine receptor

1993 • 37 citations

Post-translational regulation of neuronal acetylcholine receptors stably expressed in a mouse fibroblast cell line

1996 • 35 citations

Expression of the Nicotinic Receptor α7 Gene in Tendon and Periosteum During Early Development

1997 • 35 citations

Chick Ciliary Ganglion Neurons Contain Transcripts Coding for Acetylcholine Receptor-Associated Protein at Synapses (Rapsyn)

1997 • 34 citations

The main immunogenic region of the nicotinic acetylcholine receptor: Interaction of monoclonal antibodies with synthetic peptides

1989 • 34 citations

Phosphorylation of rat brain nicotinic acetylcholine receptor by cAMP-dependent protein kinase in vitro

1993 • 34 citations

Biochemistry of Nicotinic Acetylcholine Receptors in the Vertebrate Brain

1988 • 30 citations

Effects of retinal lesions upon the distribution of nicotinic acetylcholine receptor subunits in the chick visual system

1994 • 29 citations

Gain of function mutation of the α7 nicotinic receptor: distinct pharmacology of the human α7V274T variant

1999 • 29 citations

Stable expression in HEK‐293 cells of the rat α3/β4 subtype of neuronal nicotinic acetylcholine receptor

1996 • 28 citations

REVIEW ■ : Molecular Basis of Congenital Myasthenic Syndromes: Mutations in the Acetylcholine Receptor

1998 • 27 citations

Pharmacokinetics of nicotine carbomer enemas: A new treatment modality for ulcerative colitis

1997 • 26 citations

The role of autoimmunity to glutamate receptors in neurological disease

1996 • 25 citations

Bipolar cells of the chick retina containing α-bungarotoxin-sensitive nicotinic acetylcholine receptors

1994 • 24 citations

High affinity single-chain Fv antibody fragments protecting the human nicotinic acetylcholine receptor

1999 • 23 citations

Epibatidine Activates Muscle Acetylcholine Receptors with Unique Site Selectivity

1998 • 23 citations

Nucleotide sequence of the rat muscle acetylcholine receptor -subunit

1988 • 23 citations

Nicotinic Receptors and Cholinergic Neurotransmission in the Central Nervous System

1995 • 22 citations

Evidence that porcine native 5-HT3 receptors do not contain nicotinic acetylcholine receptor subunits

1998 • 21 citations

α4β2 subunit combination specific pharmacology of neuronal nicotinic acetylcholine receptors in N1E-115 neuroblastoma cells

1994 • 20 citations

Interaction of monoclonal antibodies to electroplaque acetylcholine receptors with the α-bungarotoxin binding site of goldfish brain

1986 • 20 citations

The α4 subunit of rat α4β2 nicotinic receptors is phosphorylated in vivo

1998 • 19 citations

Organizing Effects of Rapsyn on Neuronal Nicotinic Acetylcholine Receptors

1998 • 19 citations

Functional Effects on the Acetylcholine Receptor of Multiple Mutations of γAsp174 and δAsp180

1997 • 18 citations

Epitope mapping of monoclonal antibodies to Torpedo acetylcholine receptor γ subunits, which specifically recognize the ϵ subunit of mammalian muscle acetylcholine receptor

1992 • 18 citations

The role of cigarettes and nicotine in the onset and treatment of ulcerative colitis

1996 • 17 citations

Distribution of the α7 nicotinic acetylcholine receptor subunit in the developing chick cerebellum

1998 • 16 citations

Functional Properties of the Neuronal Nicotinic Acetylcholine Receptor β3 Promoter in the Developing Central Nervous System

1998 • 14 citations

Membrane Clustering and Bungarotoxin Binding by the Nicotinic Acetylcholine Receptor: Role of the β Subunit

1994 • 13 citations

Determinants of channel gating located in the N-terminal extracellular domain of nicotinic alpha7 receptor.

1998 • 13 citations

Expression and characterization of the rat ?4 ?2 neuronal nicotinic cholinergic receptor in baculovirus-infected insect cells

1996 • 13 citations

Mapping the mab 383C epitope to α 2 (187–199) of the Torpedo acetylcholine receptor on the three-dimensional model 1 1Edited by B. Holland

1998 • 12 citations

Acetylcholine receptor subunit homomer formation requires compatibility between amino acid residues of the M 1 and M2 transmembrane segments

1996 • 12 citations

Differential surface accessibility of α(187–199) in the Torpedo acetylcholine receptor α subunits 1 1Edited by B. Holland

1998 • 11 citations

Interaction of monoclonal antibodies with alpha-bungarotoxin and (-)-nicotine binding sites in goldfish brain. Identification of putative nicotinic acetylcholine receptor subtypes.

1988 • 10 citations

Identification of a New Amino Acid Residue Capable of Modulating Agonist Efficacy at the Homomeric Nicotinic Acetylcholine Receptor, α7

1999 • 5 citations