Water-soluble Nicotinic Acetylcholine Receptor Formed by α7 Subunit Extracellular Domains

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 Å resolution

1981 • 2,490 citations

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

1992 • 2,236 citations

Physical Chemistry of Macromolecules.

1962 • 1,093 citations

Crystal structure of the tyrosine kinase domain of the human insulin receptor

1994 • 1,071 citations

Acetylcholine receptor channel imaged in the open state

1995 • 1,002 citations

Nicotinic Acetylcholine Receptor an 9 Å Resolution

1993 • 822 citations

Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins

1995 • 614 citations

THE STRUCTURE AND BIOSYNTHESIS OF GLYCOSYL PHOSPHATIDYLINOSITOL PROTEIN ANCHORS

1993 • 585 citations

Three-dimensional structure of a complex of antibody with influenza virus neuraminidase

1987 • 556 citations

Brain α-bungarotoxin binding protein cDNAs and MAbs reveal subtypes of this branch of the ligand-gated ion channel gene superfamily

1990 • 471 citations

Three-Dimensional Structures of the Ligand-Binding Domain of the Bacterial Aspartate Receptor with and Without a Ligand

1991 • 411 citations

The X-ray structure of a growth hormone–prolactin receptor complex

1994 • 390 citations

Molecular weight in detergent solution of acetylcholine receptor from Torpedo californica

1978 • 384 citations

Crystal structure of a complex between interferon-γ and its soluble high-affinity receptor

1995 • 350 citations

Molecular basis of the two nonequivalent ligand binding sites of the muscle nicotinic acetylcholine receptor

1989 • 279 citations

Crystal Structure of the β Chain of a T Cell Antigen Receptor

1995 • 267 citations

Isolation of the Principal Neurotoxins of Two Naja naja Subspecies

1971 • 248 citations

Neuronal nicotinic alpha 7 receptor expressed in Xenopus oocytes presents five putative binding sites for methyllycaconitine.

1996 • 223 citations

[1] Affinity chromatography

1984 • 215 citations

Cell‐surface engineering with GPI‐anchored proteins

1996 • 211 citations

Homomers of alpha 8 and alpha 7 subunits of nicotinic receptors exhibit similar channel but contrasting binding site properties.

1994 • 207 citations

The Emerging Three‐Dimensional Structure of a Receptor

1996 • 197 citations

Neurotransmitter-gated ion channels as unconventional allosteric proteins

1994 • 197 citations

Molecular dissection of the agonist binding site of an AMPA receptor.

1995 • 196 citations

Assembly of the inhibitory glycine receptor: Identification of amino acid sequence motifs governing subunit stoichiometry

1993 • 183 citations

Maggot's hair and bug's eye: Role of cell interactions and intrinsic factors in cell fate specification

1995 • 180 citations

Crystal Structure of the V _α Domain of a T Cell Antigen Receptor

1995 • 178 citations

Functional significance of aromatic amino acids from three peptide loops of the α7 neuronal nicotinic receptor site investigated by site‐directed mutagenesis

1991 • 168 citations

Estimation of competitive antagonist affinity from functional inhibition curves using the Gaddum, Schild and Cheng‐Prusoíf equations

1993 • 165 citations

The N-terminal domains of acetylcholine receptor subunits contain recognition signals for the initial steps of receptor assembly

1992 • 149 citations

Identification of a New Component of the Agonist Binding Site of the Nicotinic α7 Homooligomeric Receptor

1995 • 147 citations

Structure of the Extracellular Domain of Human Tissue Factor: Location of the Factor VIIa Binding Site

1994 • 143 citations

Homomeric and native α7 acetylcholine receptors exhibit remarkably similar but non‐identical pharmacological properties, suggesting that the native receptor is a heteromeric protein complex

1993 • 122 citations

Cloning and functional expression of a cDNA encoding the catalytic subunit of bovine enterokinase.

1993 • 114 citations

Assembly intermediates of the mouse muscle nicotinic acetylcholine receptor in stably transfected fibroblasts.

1990 • 102 citations

Projection Structure of the Nicotinic Acetylcholine Receptor: Distinct Conformations of the α Subunits

1996 • 102 citations

Intersubunit contacts governing assembly of the mammalian nicotinic acetylcholine receptor

1995 • 95 citations

Extracellular domains mediating ɛ subunit interactions of muscle acetylcholine receptor

1991 • 94 citations

NMR solution structure of an .alpha.-bungarotoxin/nicotinic receptor peptide complex

1993 • 94 citations

Three-dimensional location of the main immunogenic region of the acetylcholine receptor

1995 • 94 citations

Expression of fusion proteins of the nicotinic acetylcholine receptor from mammalian muscle identifies the membrane-spanning regions in the alpha and delta subunits.

1992 • 88 citations

Role of the Endoplasmic Reticulum Chaperone Calnexin in Subunit Folding and Assembly of Nicotinic Acetylcholine Receptors

1995 • 81 citations

A model of the nicotinic receptor extracellular domain based on sequence identity and residue location

1997 • 77 citations

Identification of two amino acid residues in the ϵ subunit that promote mammalian muscle acetylcholine receptor assembly in COS cells

1991 • 75 citations

Effects of substitution of putative transmembrane segments on nicotinic acetylcholine receptor function

1987 • 75 citations

Assembly of Torpedo acetylcholine receptors in Xenopus oocytes.

1991 • 71 citations

Characterization of the Ligand-binding Domains of Glutamate Receptor (GluR)-B and GluR-D Subunits Expressed in as Periplasmic Proteins

1996 • 70 citations

Involvement of the Chaperone Protein Calnexin and the Acetylcholine Receptor β-Subunit in the Assembly and Cell Surface Expression of the Receptor

1996 • 62 citations

Bovine enterokinase. Purification, specificity, and some molecular properties

1977 • 62 citations

TE671 cells express an abundance of a partially mature acetylcholine receptor alpha subunit which has characteristics of an assembly intermediate.

1990 • 53 citations

Comparison of the toxin binding sites of the nicotinic acetylcholine receptor from Drosophila to human

1990 • 52 citations

Analysis of the amino acid sequence of the Pseudomonas aeruginosa galactophilic PA-I lectin

1992 • 50 citations

High-level expression in Escherichia coli and rapid purification of phosphatidylinositol-specific phospholipase C from Bacillus cereus and Bacillus thuringiensis

1991 • 50 citations

Role of Two Acetylcholine Receptor Subunit Domains in Homomer Formation and Intersubunit Recognition, as Revealed by .alpha.3 and .alpha.7 Subunit Chimeras

1994 • 49 citations

A sequence in the main cytoplasmic loop of the α subunit is required for assembly of mouse muscle nicotinic acetylcholine receptor

1994 • 47 citations

The N-terminal Domain of Human GABA Receptor ρ1 Subunits Contains Signals for Homooligomeric and Heterooligomeric Interaction

1997 • 42 citations

Assembly of the Nicotinic Acetylcholine Receptor

1996 • 38 citations

Expression and Circular Dichroism Studies of the Extracellular Domain of the α Subunit of the Nicotinic Acetylcholine Receptor

1997 • 37 citations

Reporter epitopes: A novel approach to examine transmembrane topology of integral membrane proteins applied to the .alpha.1 subunit of the nicotinic acetylcholine receptor

1993 • 37 citations

Sequences on the N-terminus of ACh receptor subunits regulate their assembly

1992 • 33 citations

Differential Binding of Nicotine and .alpha.-Bungarotoxin to Residues 173-204 of the Nicotinic Acetylcholine Receptor .alpha.1 Subunit

1995 • 26 citations

Recognition domains in assembly of oligomeric membrane proteins

1992 • 26 citations

The amino acid residues 1–128 in the α subunit of the nicotinic acetylcholine receptor contain assembly signals

1994 • 25 citations

Subunit folding and alpha delta heterodimer formation in the assembly of the nicotinic acetylcholine receptor. Comparison of the mouse and human alpha subunits

1992 • 23 citations

Membrane tethering enables an extracellular domain of the acetylcholine receptor alpha subunit to form a heterodimeric ligand-binding site.

1996 • 16 citations

Acetylcholine receptor subunit homomer formation requires compatibility between amino acid residues of the M 1 and M2 transmembrane segments

1996 • 12 citations

The nicotinic acetylcholine receptor at the neuromuscular junction: assembly and tyrosine phosphorylation.

1996 • 6 citations