Effects of Chronic Nicotinic Ligand Exposure on Functional Activity of Nicotinic Acetylcholine Receptors Expressed by Cells of the PC12 Rat Pheochromocytoma or the TE671/RD Human Clonal Line

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

A study of the ‘desensitization’ produced by acetylcholine at the motor end‐plate

1957 • 1,457 citations

Nicotinic Cholinergic Receptor Binding Sites in the Brain: Regulation in Vivo

1983 • 478 citations

Effects of chronic nicotine infusion on tolerance development and nicotinic receptors.

1983 • 455 citations

In Vivo Regulation of [³H]Acetylcholine Recognition Sites in Brain by Nicotinic Cholinergic Drugs

1985 • 283 citations

Time course study of the effects of chronic nicotine infusion on drug response and brain receptors.

1985 • 271 citations

Nicotinic binding sites in rat and mouse brain: comparison of acetylcholine, nicotine, and alpha-bungarotoxin.

1986 • 262 citations

On the mechanism of desensitization at cholinergic receptors.

1970 • 247 citations

alpha-Bungarotoxin binding and cholinergic receptor function on a rat sympathetic nerve line

1977 • 210 citations

Exposure to nicotine enhances the behavioral stimulant effect of nicotine and increases binding of [3H]acetylcholine to nicotinic receptors

1985 • 205 citations

Desensitization of the nicotinic acetylcholine receptor: Molecular mechanisms and effect of modulators

1989 • 198 citations

A muscle acetylcholine receptor is expressed in the human cerebellar medulloblastoma cell line TE671

1989 • 186 citations

Decamethonium both opens and blocks endplate channels.

1978 • 168 citations

Characterization of the human cell line TE671

1989 • 161 citations

Establishment of a human medulloblastoma cell line

1977 • 161 citations

A re-examination of curare action at the motor endplate

1978 • 150 citations

Release of [3H]norepinephrine from a clonal line of pheochromocytoma cells (PC12) by nicotinic cholinergic stimulation

1977 • 141 citations

Curare can open and block ionic channels associated with cholinergic receptors

1982 • 135 citations

Rapid desensitization of the acute stimulatory effects of nicotine on rat plasma adrenocorticotropin and prolactin.

1986 • 129 citations

Factors in the Inactivation of Postjunctional Membrane Receptors of Frog Skeletal Muscle

1970 • 127 citations

Acetylcholine receptor degradation measured by density labeling: Effects of cholinergic ligands and evidence against recycling

1979 • 125 citations

Substance P enhances cholinergic receptor desensitization in a clonal nerve cell line.

1980 • 119 citations

[3H]Nicotine binding in rat brain: alteration after chronic acetylcholinesterase inhibition.

1983 • 118 citations

[3H]acetylcholine and [3H](-)nicotine label the same recognition site in rat brain.

1987 • 112 citations

Effect of Chronic Nicotine Treatment on Nicotinic Autoreceptor Function and N-[³H]Methylcarbamylcholine Binding Sites in the Rat Brain

1989 • 111 citations

The human medulloblastoma cell line TE671 expresses a muscle‐like acetylcholine receptor Cloning of the α‐subunit cDNA

1988 • 110 citations

Two distinct kinetic phases of desensitization of acetylcholine receptors of clonal rat PC12 cells.

1987 • 92 citations

Effects of chronic administration of nicotine on prolactin release in the rat: inactivation of prolactin response by repeated injections of nicotine.

1990 • 79 citations

Neuronal-like features of TE671 cells: Presence of a functional nicotinic cholinergic receptor

1982 • 69 citations

Characterization of Curaremimetic Neurotoxin Binding Sites on Membrane Fractions Derived from the Human Medulloblastoma Clonal Line, TE671

1986 • 62 citations

Pharmacological distinctions between functional nicotinic acetylcholine receptors on the PC12 rat pheochromocytoma and the TE671 human medulloblastoma.

1989 • 61 citations

Action of nicotine on accumbens dopamine and attenuation with repeated administration

1989 • 60 citations

Activation and desensitization of Torpedo acetylcholine receptor: evidence for separate binding sites.

1982 • 58 citations

Cholinergic modulation of an acetylcholine receptor-like antigen on the surface of chick ciliary ganglion neurons in cell culture

1986 • 53 citations

A comparison of current‐voltage relations for full and partial agonists.

1978 • 51 citations

Regulation of acetylcholine receptor levels by a cholinergic agonist in mouse muscle cell cultures

1978 • 50 citations

Effect of long-term nicotine treatment on [3H] nicotine binding sites in the rats brain

1985 • 48 citations

Plasma from myasthenia gravis patients reduces acetylcholine receptor agonist-induced Na+ flux into TE671 cell line

1988 • 48 citations

An isotopic rubidium ion efflux assay for the functional characterization of nicotinic acetylcholine receptors on clonal cell lines

1988 • 48 citations

Acetylcholine receptor: evidence for a voltage-dependent regulatory site for acetylcholine. Chemical kinetic measurements in membrane vesicles using a voltage clamp

1983 • 44 citations

Functional properties of human skeletal muscle acetylcholine receptors expressed by the TE671 cell line.

1988 • 40 citations

Effects of dietary choline on nicotinic acetylcholine receptors in brain

1977 • 39 citations

Two components of carbamylcholine-induced loss of nicotinic acetylcholine receptor function in the neuronal cell line PC12.

1986 • 36 citations

Agonist-induced regulation of the neuronal nicotinic acetylcholine receptor of PC12 cells.

1985 • 34 citations

Acetylcholine receptor: characterization of the voltage-dependent regulatory (inhibitory) site for acetylcholine in membrane vesicles from Torpedo californica electroplax

1986 • 31 citations

Nicotinic acetylcholine receptor contains multiple binding sites: evidence from binding of alpha-dendrotoxin.

1986 • 30 citations

Chemical modification of the nicotinic cholinergic receptor of PC-12 nerve cell

1983 • 27 citations

Cholinergic agonist-induced down regulation of neuronal α-bungarotoxin receptors

1982 • 26 citations

Immunological and pharmacological heterogeneity of α-bungarotoxin binding sites extracted from TE671 cells

1988 • 26 citations

Desensitization

1980 • 25 citations

Nicotinic Agonists Regulate α‐Bungarotoxin Binding Sites of TE671 Human Medulloblastoma Cells

1988 • 25 citations

Heterogeneity of high-affinity nicotinic [3H]acetylcholine binding sites.

1990 • 25 citations

Independent sites of low and high affinity for agonists on Torpedocalifornica acetylcholine receptor

1982 • 23 citations

Cholinergic function and alpha-bungarotoxin binding in PC12 cells.

1987 • 22 citations

Attenuation of the plasma prolactin response to restraint stress after acute and chronic administration of nicotine to rats.

1987 • 20 citations

Increases in the concentration of brain α-bungarotoxin binding sites induced by dietary choline are age-dependent

1986 • 19 citations

Multiple effects of α‐toxins on the nicotinic acetylcholine receptor

1987 • 16 citations

Characterization of Curaremimetic Neurotoxin Binding Sites on Cellular Membrane Fragments Derived from the Rat Pheochromocytoma PC 12

1986 • 14 citations

Acute elevation of cyclic AMP does not alter the ion-conducting properties of the neuronal nicotinic acetylcholine receptor of PC12 cells.

1984 • 14 citations

Chapter 11 Nicotinic acetylcholine receptor diversity: agonist binding and functional potency

1989 • 13 citations

Regulation of alpha-bungarotoxin sites in chromaffin cells in culture by nicotinic receptor ligands, K+, and cAMP.

1988 • 12 citations

Characterization of nicotinic acetylcholine receptor channels of the TE671 human medulloblastoma clonal line

1989 • 7 citations

THE EFFECTS OF CARBAMYLCHOLINE, CALCIUM, AND CYCLIC NUCLEOTIDES ON ACETYLCHOLINE RECEPTOR SYNTHESIS IN CULTURED MYOTUBES*

1981 • 5 citations

Evidence for Functional and Structural Diversity of Nicotinic Acetylcholine Receptors

1988 • 5 citations