Identification of Acetylcholine Receptor Channel-Lining Residues in the M1 Segment of the .alpha.-Subunit

Ionic Blockage of Sodium Channels in Nerve

1973 • 1,590 citations

Nicotinic Acetylcholine Receptor an 9 Å Resolution

1993 • 822 citations

Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance

1988 • 798 citations

Acetylcholine Receptor Channel Structure Probed in Cysteine-Substitution Mutants

1992 • 668 citations

Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor

1991 • 515 citations

Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic

1992 • 420 citations

N-glycosylation site tagging suggests a three transmembrane domain topology for the glutamate receptor GluR1

1994 • 419 citations

Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the α subunit

1994 • 418 citations

Evidence for voltage-dependent S4 movement in sodium channels

1995 • 396 citations

The ion channel of the nicotinic acetylcholine receptor is formed by the homologous helices M II of the receptor subunits

1986 • 313 citations

An open-channel blocker interacts with adjacent turns of α-helices in the nicotinic acetylcholine receptor

1990 • 275 citations

Electrostatic potential of the acetylcholine binding sites in the nicotinic receptor probed by reactions of binding-site cysteines with charged methanethiosulfonates

1994 • 255 citations

Structure of nicotinic acetylcholine receptors

1993 • 234 citations

Identifying the Lipid-Protein Interface of the Torpedo Nicotinic Acetylcholine Receptor: Secondary Structure Implications

1994 • 200 citations

Reactivity of small thiolate anions and cysteine-25 in papain toward methyl methanethiosulfonate

1986 • 196 citations

The noncompetitive blocker [3H]chlorpromazine labels three amino acids of the acetylcholine receptor gamma subunit: implications for the alpha-helical organization of regions MII and for the structure of the ion channel.

1990 • 186 citations

Silver as a Probe of Pore-Forming Residues in a Potassium Channel

1995 • 182 citations

Mutations affecting agonist sensitivity of the nicotinic acetylcholine receptor

1991 • 148 citations

Location of a threonine residue in the α -subunit M2 transmembrane segment that determines the ion flow through the acetylcholine receptor channel

1991 • 148 citations

Amino acid residues lining the chloride channel of the cystic fibrosis transmembrane conductance regulator.

1994 • 146 citations

Kinetics of unliganded acetylcholine receptor channel gating

1986 • 146 citations

Agonist-induced changes in the structure of the acetylcholine receptor M2 regions revealed by photoincorporation of an uncharged nicotinic noncompetitive antagonist.

1992 • 145 citations

A ring of uncharged polar amino acids as a component of channel constriction in the nicotinic acetylcholine receptor

1991 • 127 citations

Mutations in M2 alter the selectivity of the mouse nicotinic acetylcholine receptor for organic and alkali metal cations.

1992 • 114 citations

K+ pore structure revealed by reporter cysteines at inner and outer surfaces

1995 • 112 citations

Amino acids lining the channel of the gamma-aminobutyric acid type A receptor identified by cysteine substitution.

1993 • 112 citations

Mapping the alpha-subunit site photolabeled by the noncompetitive inhibitor [3H]quinacrine azide in the active state of the nicotinic acetylcholine receptor.

1990 • 104 citations

Side-chain accessibilities in the pore of a K+ channel probed by sulfhydryl-specific reagents after cysteine-scanning mutagenesis

1995 • 101 citations

Open channel structure and ion binding sites of the nicotinic acetylcholine receptor channel

1989 • 86 citations

Structure of the noncompetitive antagonist-binding site of the Torpedo nicotinic acetylcholine receptor. [3H]meproadifen mustard reacts selectively with alpha-subunit Glu-262.

1992 • 80 citations

Voltage dependence of mouse acetylcholine receptor gating: different charge movements in di‐, mono‐ and unliganded receptors.

1996 • 73 citations

Tris+/Na+ permeability ratios of nicotinic acetylcholine receptors are reduced by mutations near the intracellular end of the M2 region.

1992 • 63 citations

Covalent modification of a critical sulfhydryl group in the acetylcholine receptor: cysteine-222 of the .alpha.-subunit

1989 • 21 citations