Regulation of neurotransmitter receptor desensitization by protein phosphorylation

THE STRUCTURE AND REGULATION OF PROTEIN PHOSPHATASES

1989 • 2,518 citations

Phosphorylation-Dephosphorylation of Enzymes

1979 • 2,205 citations

PROTEIN-TYROSINE KINASES

1985 • 2,198 citations

Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family

1987 • 1,621 citations

Molecular Biology of Learning: Modulation of Transmitter Release

1982 • 1,534 citations

PROTEIN SERINE/THREONINE KINASES

1987 • 1,457 citations

β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function

1990 • 1,162 citations

Phosphorylated Proteins as Physiological Effectors

1978 • 975 citations

Molecular biology of GABA _A receptors

1990 • 947 citations

Phosphodiesterase activation by photoexcited rhodopsin is quenched when rhodopsin is phosphorylated and binds the intrinsic 48-kDa protein of rod outer segments.

1986 • 781 citations

The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors

1987 • 730 citations

Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.

1986 • 650 citations

Acetylcholine Receptor: An Allosteric Protein

1984 • 620 citations

PROTEIN KINASES IN THE BRAIN

1985 • 559 citations

The current excitement in long term potentiation

1988 • 538 citations

Structural basis of β‐adrenergic receptor function

1989 • 480 citations

Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein).

1987 • 478 citations

Glutamate receptor desensitization and its role in synaptic transmission

1989 • 459 citations

β-Adrenergic Receptor Kinase: Primary Structure Delineates a Multigene Family

1989 • 451 citations

Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization

1988 • 429 citations

Phosphorylation Sites on Two Domains of the β2-Adrenergic Receptor Are Involved in Distinct Pathways of Receptor Desensitization

1989 • 415 citations

Phosphorylation of the nicotinic acetylcholine receptor regulates its rate of desensitization

1986 • 414 citations

Nucleotide and deduced amino acid sequences of Torpedo californica acetylcholine receptor gamma subunit.

1983 • 412 citations

Identification of the alpha subunit half-cystine specifically labeled by an affinity reagent for the acetylcholine receptor binding site.

1984 • 408 citations

Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors.

1990 • 393 citations

Regulation of Adenylyl Cyclase-Coupled beta-Adrenergic Receptors

1988 • 389 citations

Light-regulated binding of rhodopsin kinase and other proteins to cattle photoreceptor membranes

1978 • 313 citations

Phosphorylation of the mammalian beta-adrenergic receptor by cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein.

1985 • 312 citations

Alpha 3, alpha 5, and beta 4: three members of the rat neuronal nicotinic acetylcholine receptor-related gene family form a gene cluster.

1990 • 303 citations

Molecular biology of the GABAA receptor: the receptor/channel superfamily

1987 • 303 citations

Primary structure and expression of β2: A novel subunit of neuronal nicotinic acetylcholine receptors

1988 • 301 citations

Structure of the Adrenergic and Related Receptors

1989 • 300 citations

The functional diversity of the neuronal nicotinic acetylcholine receptors is increased by a novel subunit: β4

1989 • 294 citations

Effect of Forskolin on Voltage-Gated K ⁺ Channels Is Independent of Adenylate Cyclase Activation

1988 • 269 citations

Functional modulation of the nicotinic acetylcholine receptor by tyrosine phosphorylation

1988 • 250 citations

Phosphorylation of the nicotinic acetylcholine receptor by an endogenous tyrosine-specific protein kinase.

1984 • 248 citations

Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor.

1983 • 247 citations

Purification and characterization of the beta-adrenergic receptor kinase.

1987 • 241 citations

Phorbol diesters promote β-adrenergic receptor phosphorylation and adenylate cyclase desensitization in duck erythrocytes

1984 • 238 citations

Cloning and expression of the 58 kd β subunit of the inhibitory glycine receptor

1990 • 237 citations

Regulation of adrenergic receptor function by phosphorylation. II. Effects of agonist occupancy on phosphorylation of alpha 1- and beta 2-adrenergic receptors by protein kinase C and the cyclic AMP-dependent protein kinase.

1987 • 235 citations

Phorbol ester induces desensitization of adenylate cyclase and phosphorylation of the beta-adrenergic receptor in turkey erythrocytes.

1984 • 233 citations

β3: A New Member of Nicotinic Acetylcholine Receptor Gene Family Is Expressed in Brain

1989 • 229 citations

Cyclic AMP-dependent protein kinase decreases GABAA receptor current in mouse spinal neurons

1990 • 225 citations

Genetic manipulation of ion channels: A new approach to structure and mechanism

1989 • 223 citations

Calcitonin gene-related peptide enhances the rate of desensitization of the nicotinic acetylcholine receptor in cultured mouse muscle cells.

1988 • 208 citations

Substance P reduces acetylcholine‐induced currents in isolated bovine chromaffin cells.

1984 • 206 citations

Regulation of adrenergic receptor function by phosphorylation. I. Agonist-promoted desensitization and phosphorylation of alpha 1-adrenergic receptors coupled to inositol phospholipid metabolism in DDT1 MF-2 smooth muscle cells.

1987 • 206 citations

Light-dependent phosphorylation of rhodopsin by β-adrenergic receptor kinase

1986 • 205 citations

Molecular studies of the neuronal nicotinic acetylcholine receptor family

1987 • 203 citations

Activation of protein kinase C differentially modulates neuronal Na+, Ca2+, and gamma-aminobutyrate type A channels.

1988 • 197 citations

cAMP-dependent protein kinase phosphorylates the nicotinic acetylcholine receptor

1983 • 187 citations

Role of protein phosphorylation in neuronal signal transduction ¹

1989 • 186 citations

Chapter 5 Interactions between photoexcited rhodopsin and light-activated enzymes in rods

1984 • 174 citations

Similar effects of substance P and related peptides on salivation and on phosphatidylinositol turnover in rat salivary glands.

1980 • 168 citations

Protein kinase C and cAMP-dependent protein kinase phosphorylate the beta subunit of the purified gamma-aminobutyric acid A receptor.

1990 • 166 citations

Agonist-dependent phosphorylation of the alpha 2-adrenergic receptor by the beta-adrenergic receptor kinase.

1987 • 156 citations

Desensitization of turkey erythrocyte adenylate cyclase. Beta-adrenergic receptor phosphorylation is correlated with attenuation of adenylate cyclase activity.

1984 • 154 citations

Modulation of Acetylcholine Receptor Desensitization by Forskolin Is Independent of cAMP

1988 • 154 citations

The carboxyl terminus of the hamster β-adrenergic receptor expressed in mouse L cells is not required for receptor sequestration

1987 • 142 citations

Agents that activate protein kinase C reduce acetylcholine sensitivity in cultured myotubes.

1985 • 140 citations

A possible involvement of cyclic AMP in the expression of desensitization of the nicotinic acetylcholine receptor

1986 • 133 citations

Phosphorylation of chick heart muscarinic cholinergic receptors by the .beta.-adrenergic receptor kinase

1989 • 133 citations

Cyclic AMP regulates the proportion of functional acetylcholine receptors on chicken ciliary ganglion neurons.

1987 • 131 citations

Homologous desensitization of adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor.

1985 • 131 citations

Regulation of tyrosine phosphorylation of the nicotinic acetylcholine receptor at the rat neuromuscular lunction

1990 • 130 citations

Calcitonin gene-related peptide regulates phosphorylation of the nicotinic acetylcholine receptor in rat myotubes

1989 • 129 citations

Regulation of receptor function by protein phosphorylation

1987 • 128 citations

A novel catecholamine-activated adenosine cyclic 3',5'-phosphate independent pathway for .beta.-adrenergic receptor phosphorylation in wild-type and mutant S49 lymphoma cells: mechanism of homologous desensitization of adenylate cyclase

1986 • 125 citations

In vitro phosphorylation of the acetylcholine receptor

1977 • 122 citations

Forskolin increases the rate of acetylcholine receptor desensitization at rat soleus endplates.

1986 • 121 citations

Substance P enhances cholinergic receptor desensitization in a clonal nerve cell line.

1980 • 119 citations

Activators of protein kinase C enhance acetylcholine receptor desensitization in sympathetic ganglion neurons.

1987 • 116 citations

Identification of a specific site required for rapid heterologous desensitization of the beta-adrenergic receptor by cAMP-dependent protein kinase.

1989 • 115 citations

Phosphorylation of acetylcholine receptor by endogenous membrane protein kinase in receptor-enriched membranes of Torpedo californica

1977 • 113 citations

Phosphorylation of γ-aminobutyrate (GABA)/benzodiazepine receptors by cyclic AMP-dependent protein kinase

1989 • 111 citations

Phosphorylation of the cardiac muscarinic receptor in intact chick heart and its regulation by a muscarinic agonist.

1986 • 110 citations

cAMP and forskolin decrease gamma-aminobutyric acid-gated chloride flux in rat brain synaptoneurosomes.

1989 • 103 citations

Correlation of agonist-induced phosphorylation of chick heart muscarinic receptors with receptor desensitization.

1987 • 98 citations

Substance P modulation of acetylcholine-induced currents in embryonic chicken sympathetic and ciliary ganglion neurons.

1984 • 95 citations

Regulation of nicotinic acetylcholine receptor phosphorylation in rat myotubes by forskolin and cAMP.

1987 • 94 citations

Phosphorylation of the GABA_a/Benzodiazepine Receptor α Subunit by a Receptor‐Associated Protein Kinase

1988 • 83 citations

Phosphorylation of the acetylcholine receptor by protein kinase C and identification of the phosphorylation site within the receptor delta subunit.

1987 • 80 citations

Agonist-promoted sequestration of the beta 2-adrenergic receptor requires regions involved in functional coupling with Gs.

1989 • 75 citations

cAMP increases the rate of GABA_A receptor desensitization in chick cortical neurons

1989 • 70 citations

Protein Phosphorylation of Nicotinic Acetylcholine Receptor

1989 • 63 citations

Determination of the sites of cAMP-dependent phosphorylation on the nicotinic acetylcholine receptor.

1987 • 63 citations

Induction of phosphorylation and cell surface redistribution of acetylcholine receptors by phorbol ester and carbamylcholine in cultured chick muscle cells.

1988 • 62 citations

Substance P modulates single-channel properties of neuronal nicotinic acetylcholine receptors

1990 • 62 citations

Phosphorylation and assembly of nicotinic acetylcholine receptor subunits in cultured chick muscle cells.

1987 • 49 citations

Regulation of phosphorylation of nicotinic acetylcholine receptors in mouse BC3H1 myocytes.

1987 • 49 citations

Acetylcholine stimulates phosphatidylinositol turnover at nicotinic receptors of cultured myotubes

1985 • 46 citations

Phosphorylation of the porcine atrial muscarinic acetylcholine receptor by cyclic AMP-dependent protein kinase

1987 • 30 citations

Agonist-independent phosphorylation of purified cardiac muscarinic cholinergic receptors by protein kinase C

1990 • 25 citations

Ca2+-dependent and cAMP-dependent Control of Nicotinic Acetylcholine Receptor Phosphorylation in Muscle Cells

1989 • 22 citations

Chapter 12 Phosphorylation of the nicotinic acetylcholine receptor

1986 • 8 citations

Molecular Biology of the Neural and Muscle Nicotinic Acetylcholine Receptors

1987 • 7 citations