Molecular basis of the two nonequivalent ligand binding sites of the muscle nicotinic acetylcholine receptor

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

On the nature of allosteric transitions: A plausible model

1965 • 8,699 citations

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

1986 • 4,785 citations

Quantitative Film Detection of 3H and 14C in Polyacrylamide Gels by Fluorography

1975 • 4,693 citations

Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family

1987 • 1,621 citations

A study of the ‘desensitization’ produced by acetylcholine at the motor end‐plate

1957 • 1,457 citations

Molecular distinction between fetal and adult forms of muscle acetylcholine receptor

1986 • 979 citations

Structural homology of Torpedo californica acetylcholine receptor subunits

1983 • 798 citations

The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors

1987 • 730 citations

Acetylcholine Receptor: An Allosteric Protein

1984 • 620 citations

Isolation of a cDNA clone coding for a possible neural nicotinic acetylcholine receptor α-subunit

1986 • 444 citations

Continuous tissue culture cell lines derived from chemically induced tumors of Japanese quail

1977 • 443 citations

Mapping of surface structures of electrophorus acetylcholine receptor using monoclonal antibodies.

1981 • 412 citations

Identification of the alpha subunit half-cystine specifically labeled by an affinity reagent for the acetylcholine receptor binding site.

1984 • 408 citations

Members of a nicotinic acetylcholine receptor gene family are expressed in different regions of the mammalian central nervous system

1987 • 393 citations

The Cell surface and neuronal function

1980 • 379 citations

Amino acids of the Torpedo marmorata acetylcholine receptor .alpha. subunit labeled by a photoaffinity ligand for the acetylcholine binding site

1988 • 314 citations

Structure and function of an acetylcholine receptor

1982 • 281 citations

Quaternary structure of the acetylcholine receptor

1985 • 281 citations

Multiple sites of action for noncompetitive blockers on acetylcholine receptor rich membrane fragments from Torpedo marmorata

1983 • 250 citations

Equilibrium binding of [3H]tubocurarine and [3H]acetylcholine by torpedo postsynaptic membranes: stoichiometry and ligand interactions

1979 • 243 citations

Immunological evidence for a change in subunits of the acetylcholine receptor in developing and denervated rat muscle

1988 • 218 citations

Assembly in vivo of mouse muscle acetylcholine receptor: Identification of an α subunit species that may be an assembly intermediate

1983 • 204 citations

Location of subunits within the acetylcholine receptor by electron image analysis of tubular crystals from Torpedo marmorata.

1987 • 195 citations

Inhibition of glycosylation with tunicamycin blocks assembly of newly synthesized acetylcholine receptor subunits in muscle cells.

1982 • 193 citations

Functional consequences of agonist-mediated state transitions in the cholinergic receptor. Studies in cultured muscle cells.

1979 • 191 citations

Oxygenation-linked subunit interactions in human hemoglobin: experimental studies on the concentration dependence of oxygenation curves

1976 • 167 citations

An analysis of the dose‐response relationship at voltage‐clamped frog neuromuscular junctions.

1978 • 162 citations

Cooperative Interactions of Hemoglobin

1975 • 160 citations

Relationship between reversible antagonist occupancy and the functional capacity of the acetylcholine receptor.

1981 • 158 citations

Isolation and characterization of a cDNA clone for the complete protein coding region of the delta subunit of the mouse acetylcholine receptor.

1984 • 155 citations

Binding of Naja nigricollis (3H)alpha-toxin to membrane fragments from Electrophorus and Torpedo electric organs. II. Effect of cholinergic agonists and antagonists on the binding of the tritiated alpha-neurotoxin.

1974 • 148 citations

Location of antigenic determinants of primary sequences of the subunits of nicotinic acetylcholine receptor by peptide mapping

1986 • 146 citations

The properties and interactions of the isolated α and β chains of human haemoglobin

1965 • 141 citations

The relationship between agonist occupation and the permeability response of the cholinergic receptor revealed by bound cobra alpha-toxin.

1980 • 140 citations

Monoclonal antibodies to cytoplasmic domains of the acetylcholine receptor.

1983 • 118 citations

The arrangement of the subunits of the acetylcholine receptor of Torpedo californica.

1983 • 115 citations

Local anesthetics and histrionicotoxin are allosteric inhibitors of the acetylcholine receptor. Studies of clonal muscle cells.

1982 • 114 citations

Native folding of an acetylcholine receptor alpha subunit expressed in the absence of other receptor subunits.

1988 • 114 citations

Mapping the binding of monoclonal antibodies to the acetylcholine receptor from Torpedo californica

1983 • 99 citations

Direct structural localization of two toxin-recognition sites on an ACh receptor protein

1982 • 95 citations

Functional properties of nicotinic acetylcholine receptor subunits expressed in various combinations

1987 • 95 citations

A universal oligonucleotide probe for acetylcholine receptor genes. Selection and sequencing of cDNA clones for the mouse muscle beta subunit.

1986 • 81 citations

Crosslinking of α‐bungarotoxin to the acetylcholine receptor from Torpedo marmorata by ultraviolet light irradiation

1982 • 79 citations

Acetylcholine receptor subunits transit a precursor pool before acquiring alpha-bungarotoxin binding activity.

1981 • 76 citations

Photoaffinity labeling of the acetylcholine binding sites on the nicotinic receptor by an aryldiazonium derivative

1988 • 74 citations

Mouse muscle nicotinic acetylcholine receptor γ subunit: cDNA sequence and gene expression

1986 • 72 citations

Functional consequences of agonist-mediated state transitions in the cholinergic receptor

1979 • 60 citations

Molecular weight and structural nonequivalence of the mature alpha subunits of Torpedo californica acetylcholine receptor.

1984 • 48 citations

Image analysis of the heavy form of the acetylcholine receptor from Torpedo marmorata

1984 • 45 citations

Relative locations of the beta and delta chains of the acetylcholine receptor determined by electron microscopy of isolated receptor trimer.

1981 • 44 citations

Monoclonal antibodies specific for each of the two toxin binding sites of Torpedo acetylcholine receptor

1987 • 43 citations

A postnatal change in the immunological properties of the acetylcholine receptor at rat muscle endplates

1985 • 38 citations

Oligodeoxynucleotide-Directed Mutagenesis ofEscherichia coliand Yeast by Simple Cotransformation of the Primer and Template

1986 • 29 citations

The effects of a myasthenic serum on the acetylcholine receptors of C2 myotubes. I. Immunological distinction between the two toxin-binding sites of the receptor.

1985 • 20 citations

Proteins of excitable membranes

1988 • 18 citations

The effects of a myasthenic serum on the acetylcholine receptors of C2 myotubes. I. Immunological distinction between the two toxin-binding sites of the receptor

1985 • 15 citations

Function of nicotinic acetylcholine receptors.

1987 • 6 citations