Tumor Antigens and Proteomics from the Point of View of the Major Histocompatibility Complex Peptides

An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database

1994 • 6,412 citations

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

SYFPEITHI: database for MHC ligands and peptide motifs

1999 • 2,307 citations

Rapid degradation of a large fraction of newly synthesized proteins by proteasomes

2000 • 1,477 citations

Error-Tolerant Identification of Peptides in Sequence Databases by Peptide Sequence Tags

1994 • 1,475 citations

Progress in human tumour immunology and immunotherapy

2001 • 1,327 citations

A comparison of selected mRNA and protein abundances in human liver

1997 • 1,274 citations

Method to Correlate Tandem Mass Spectra of Modified Peptides to Amino Acid Sequences in the Protein Database

1995 • 1,269 citations

A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening

1997 • 1,235 citations

Escape of Human Solid Tumors from T–Cell Recognition: Molecular Mechanisms and Functional Significance

1999 • 1,168 citations

Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor.

1994 • 1,108 citations

The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.

1993 • 986 citations

A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.

1994 • 934 citations

Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo.

1996 • 922 citations

Identification of a Peptide Recognized by Five Melanoma-Specific Human Cytotoxic T Cell Lines

1994 • 841 citations

Does the Immune System See Tumors as Foreign or Self?

2003 • 746 citations

Protease degradomics: A new challenge for proteomics

2002 • 732 citations

A fresh look at tumor immunosurveillance and immunotherapy

2001 • 723 citations

A listing of human tumor antigens recognized by T cells

2001 • 708 citations

A nonapeptide encoded by human gene MAGE-1 is recognized on HLA-A1 by cytolytic T lymphocytes directed against tumor antigen MZ2-E.

1992 • 694 citations

ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum

2002 • 620 citations

Antigen processing by the proteasome

2001 • 620 citations

BAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes

1995 • 598 citations

Tumor antigens recognized by T cells

1997 • 552 citations

Phenotypic analysis of antigen-specific T lymphocytes. Science. 1996. 274: 94-96.

2011 • 539 citations

HLA-A2.1-Associated Peptides from a Mutant Cell Line: A Second Pathway of Antigen Presentation

1992 • 522 citations

Quantitating Protein Synthesis, Degradation, and Endogenous Antigen Processing

2003 • 508 citations

Dendritic Cell Vaccines for Cancer Immunotherapy

1999 • 497 citations

Active specific immunotherapy for stage II and stage III human colon cancer: a randomised trial

1999 • 495 citations

An overview of the MAGE gene family with the identification of all human members of the family.

2001 • 477 citations

Defective ribosomal products (DRiPs): a major source of antigenic peptides for MHC class I molecules?

1996 • 440 citations

Processing of Some Antigens by the Standard Proteasome but Not by the Immunoproteasome Results in Poor Presentation by Dendritic Cells

2000 • 418 citations

A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma.

1995 • 416 citations

An HLA-A2-restricted tyrosinase antigen on melanoma cells results from posttranslational modification and suggests a novel pathway for processing of membrane proteins.

1996 • 416 citations

The major substrates for TAP in vivo are derived from newly synthesized proteins

2000 • 408 citations

Cancer Immunotherapy With Peptide-Based Vaccines: What Have We Achieved? Where Are We Going?

2002 • 400 citations

Dynamics of Protein Turnover, a Missing Dimension in Proteomics

2002 • 396 citations

Discrete Cleavage Motifs of Constitutive and Immunoproteasomes Revealed by Quantitative Analysis of Cleavage Products

2001 • 367 citations

HLA class I antigen downregulation in human cancers: T-cell immunotherapy revives an old story

1999 • 366 citations

Prediction of MHC class I binding peptides using profile motifs

2002 • 362 citations

Protein degradation and the generation of MHC class I-presented peptides

2002 • 340 citations

The nature of the MHC class I peptide loading complex

1999 • 332 citations

Prediction of MHC class I binding peptides, using SVMHC

2002 • 325 citations

Serological identification of human tumor antigens

1997 • 318 citations

Proteomic analysis of lung adenocarcinoma: identification of a highly expressed set of proteins in tumors.

2002 • 311 citations

Producing Nature’s Gene-Chips: The Generation of Peptides for Display by MHC Class I Molecules

2002 • 309 citations

The HLA-A*0201-Restricted H-Y Antigen Contains a Posttranslationally Modified Cysteine That Significantly Affects T Cell Recognition

1997 • 294 citations

Immunotherapy with Dendritic Cells Directed against Tumor Antigens Shared with Normal Host Cells Results in Severe Autoimmune Disease

2000 • 258 citations

Spontaneous cytotoxic T-cell responses against survivin-derived MHC class I-restricted T-cell epitopes in situ as well as ex vivo in cancer patients.

2001 • 258 citations

CTL induction by a tumour-associated antigen octapeptide derived from a murine lung carcinoma

1994 • 254 citations

CDR3 loop flexibility contributes to the degeneracy of TCR recognition

2003 • 253 citations

Direct evidence that leukemic cells present HLA-associated immunogenic peptides derived from the BCR-ABL b3a2 fusion protein

2001 • 251 citations

A peptide recognized by human cytolytic T lymphocytes on HLA-A2 melanomas is encoded by an intron sequence of the N-acetylglucosaminyltransferase V gene.

1996 • 235 citations

Proteolysis and class I major histocompatibility complex antigen presentation

1999 • 232 citations

Identification of T-Cell Epitopes

1993 • 232 citations

The nature of molecular recognition by T cells

2003 • 228 citations

Peptide-induced conformational change of the class I heavy chain

1991 • 221 citations

The thymus and negative selection

2002 • 216 citations

Serological analysis of human tumor antigens: molecular definition and implications

1997 • 216 citations

Induction of Tumor-Specific Cytotoxic T Lymphocytes in Cancer Patients by Autologous Tumor RNA-Transfected Dendritic Cells

2002 • 206 citations

Phosphorylated Peptides Are Naturally Processed and Presented by Major Histocompatibility Complex Class I Molecules in Vivo

2000 • 205 citations

Differential processing of class-I-restricted epitopes by the standard proteasome and the immunoproteasome

2001 • 194 citations

Integrated functional genomics approach for the design of patient-individual antitumor vaccines.

2002 • 190 citations

PAProC: a prediction algorithm for proteasomal cleavages available on the WWW

2001 • 187 citations

Inducing autoimmune disease to treat cancer

1999 • 187 citations

ER aminopeptidases generate a unique pool of peptides for MHC class I molecules

2001 • 184 citations

Biomedical informatics for proteomics

2003 • 183 citations

Neural network-based prediction of candidate T-cell epitopes

1998 • 180 citations

Antigen degradation or presentation by MHC class I molecules via classical and non-classical pathways

2002 • 180 citations

Predicting peptides that bind to MHC molecules using supervised learning of hidden markov models

1998 • 176 citations

Grafting primary human T lymphocytes with cancer-specific chimeric single chain and two chain TCR

2000 • 171 citations

Dendritic cells up-regulate immunoproteasomes and the proteasome regulator PA28 during maturation

1999 • 170 citations

Not such a dismal science: the economics of protein synthesis, folding, degradation and antigen processing

2001 • 147 citations

Endogenous peptides of a soluble major histocompatibility complex class I molecule, H-2Lds: sequence motif, quantitative binding, and molecular modeling of the complex.

1992 • 146 citations

Methods for Prediction of Peptide Binding to MHC Molecules: A Comparative Study

2002 • 142 citations

Translation of a Retained Intron in Tyrosinase-related Protein (TRP) 2 mRNA Generates a New Cytotoxic T Lymphocyte (CTL)-defined and Shared Human Melanoma Antigen Not Expressed in Normal Cells of the Melanocytic Lineage

1998 • 141 citations

A New Antigen Recognized by Cytolytic T Lymphocytes on a Human Kidney Tumor Results from Reverse Strand Transcription

1999 • 137 citations

Clinical cancer vaccine trials

2002 • 134 citations

Identification of tumor-associated MHC class I ligands by a novel T cell-independent approach

2000 • 134 citations

Evaluation of the interferon-γ ELISPOT-assay for quantification of peptide specific T lymphocytes from peripheral blood

1997 • 133 citations

Excess β2 microglobulin promoting functional peptide association with purified soluble class I MHC molecules

1991 • 129 citations

Direct identification of an endogenous peptide recognized by multiple HLA-A2.1-specific cytotoxic T cells.

1993 • 128 citations

The Production of a New MAGE-3 Peptide Presented to Cytolytic T Lymphocytes by HLA-B40 Requires the Immunoproteasome

2002 • 127 citations

Proteasomes Can Either Generate or Destroy MHC Class I Epitopes: Evidence for Nonproteasomal Epitope Generation in the Cytosol

1998 • 124 citations

The use of HLA-A*0201-transfected K562 as standard antigen-presenting cells for CD8+ T lymphocytes in IFN-γ ELISPOT assays

2002 • 124 citations

A sensitive ELISPOT assay for detection of CD8+ T lymphocytes specific for HLA class I-binding peptide epitopes derived from influenza proteins in the blood of healthy donors and melanoma patients.

1997 • 124 citations

MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression.

2000 • 122 citations

Inhibition of an allospecific T cell hybridoma by soluble class I proteins and peptides: Estimation of the affinity of a T cell receptor for MHC

1989 • 121 citations

Tumor-specific T-bodies: towards clinical application

1997 • 121 citations

Direct selection of a human antibody fragment directed against the tumor T-cell epitope HLA-A1–MAGE-A1 from a nonimmunized phage-Fab library

2000 • 119 citations

Generation of NY-ESO-1-specific CD4+ and CD8+ T cells by a single peptide with dual MHC class I and class II specificities: a new strategy for vaccine design.

2002 • 117 citations

A Statistical Basis for Testing the Significance of Mass Spectrometric Protein Identification Results

2000 • 116 citations

Cut and trim: generating MHC class I peptide ligands

2001 • 111 citations

Melanoma inhibitor of apoptosis protein (ML-IAP) is a target for immune-mediated tumor destruction

2003 • 109 citations

The generation of MHC class I-associated peptides is only partially inhibited by proteasome inhibitors: involvement of nonproteasomal cytosolic proteases in antigen processing?

1997 • 108 citations

Optimizing vaccine design for cellular processing, MHC binding and TCR recognition

2002 • 105 citations

Presentation of Out-of-Frame Peptide/MHC Class I Complexes by a Novel Translation Initiation Mechanism

1999 • 103 citations

Evaluation of the Modified ELISPOT Assay for Gamma Interferon Production in Cancer Patients Receiving Antitumor Vaccines

2000 • 101 citations

Dimerization of soluble major histocompatibility complex-peptide complexes is sufficient for activation of T cell hybridoma and induction of unresponsiveness.

1995 • 101 citations

Cutting Edge: Neosynthesis Is Required for the Presentation of a T Cell Epitope from a Long-Lived Viral Protein

2001 • 101 citations

Isolation and characterization of human recombinant antibodies endowed with the antigen-specific, major histocompatibility complex-restricted specificity of T cells directed toward the widely expressed tumor T-cell epitopes of the telomerase catalytic subunit.

2002 • 97 citations

Degeneracy of Antigen Recognition as the Molecular Basis for the High Frequency of Naive A2/Melan-A Peptide Multimer+ CD8+ T Cells in Humans

2002 • 97 citations

Prediction of promiscuous peptides that bind HLA class I molecules

2002 • 96 citations

Enzyme-linked immunospot, cytokine flow cytometry, and tetramers in the detection of T-cell responses to a dendritic cell-based multipeptide vaccine in patients with melanoma.

2003 • 96 citations

Identification and modulation of a naturally processed T cell epitope from the diabetes-associated autoantigen human glutamic acid decarboxylase 65 (hGAD65)

2001 • 93 citations

Direct visualization of distinct T cell epitopes derived from a melanoma tumor-associated antigen by using human recombinant antibodies with MHC- restricted T cell receptor-like specificity

2002 • 91 citations

Two Novel Routes of Transporter Associated with Antigen Processing (TAP)-independent Major Histocompatibility Complex Class I Antigen Processing

1997 • 91 citations

Analysis of endogenous peptides bound by soluble MHC class I molecules: a novel approach for identifying tumor-specific antigens

2002 • 91 citations

At the crossroads of cell biology and immunology: DRiPs and other sources of peptide ligands for MHC class I molecules

2001 • 90 citations

Antigen‐presenting cells pulsed with unfractionated tumor‐derived peptides are potent tumor vaccines

1997 • 90 citations

From cancer genomics to cancer immunotherapy: toward second-generation tumor antigens

2001 • 88 citations

Towards patient‐specific tumor antigen selection for vaccination

2002 • 86 citations

Interrogating the human genome using uninterpreted mass spectrometry data

2001 • 86 citations

A MAGE-A4 peptide presented by HLA-A2 is recognized by cytolytic T lymphocytes

1999 • 86 citations

Differences in the Expression of Human Class I MHC Alleles and Their Associated Peptides in the Presence of Proteasome Inhibitors

2001 • 79 citations

A Structure-Based Algorithm to Predict Potential Binding Peptides to MHC Molecules with Hydrophobic Binding Pockets

1997 • 77 citations

TCR-Like Human Antibodies Expressed on Human CTLs Mediate Antibody Affinity-Dependent Cytolytic Activity

2002 • 75 citations

Therapeutic Vaccination for Cancer

2000 • 74 citations

A phage display selected Fab fragment with MHC class I-restricted specificity for MAGE-A1 allows for retargeting of primary human T lymphocytes

2001 • 74 citations

Application of the IFN-γ ELISPOT assay to quantify T cell responses against proteins

2001 • 74 citations

The ELISPOT Assay: An Easily Transferable Method for Measuring Cellular Responses and Identifying T Cell Epitopes

2002 • 73 citations

Proteome analysis and its impact on the discovery of serological tumor markers

2001 • 72 citations

Beyond the proteasome: trimming, degradation and generation of MHC class I ligands by auxiliary proteases

2002 • 71 citations

Description and prediction of peptide-MHC binding: the ‘human MHC project’

1999 • 70 citations

Insights into antigen processing gained by direct analysis of the naturally processed class I MHC associated peptide repertoire

2002 • 69 citations

Use of two predictive algorithms of the world wide web for the identification of tumor-reactive T-cell epitopes.

2000 • 68 citations

Cancer: the evolved consequence of a destabilized genome

2001 • 68 citations

Large-scale production of class I bound peptides: assigning a signature to HLA-B * 1501

1997 • 67 citations

Cancer immunoprevention: tracking down persistent tumor antigens

2003 • 67 citations

Matching peptide mass spectra to EST and genomic DNA databases

2001 • 66 citations

Quantitative aspects of T cell activation—peptide generation and editing by MHC class I molecules

1999 • 66 citations

To DRiP or not to DRiP: generating peptide ligands for MHC class I molecules from biosynthesized proteins

2002 • 66 citations

Poor correspondence between predicted and experimental binding of peptides to class I MHC molecules

2000 • 65 citations

Challenges in the Development of Effective Peptide Vaccines for Cancer

2002 • 65 citations

Generating MHC class I ligands from viral gene products

1999 • 63 citations

Loss of HLA class‐I alleles, heavy chains and β₂‐microglobulin in colorectal cancer

1992 • 61 citations

Genetic engineering of T cell specificity for immunotherapy of cancer

2002 • 58 citations

Adjuvant immunotherapy for solid tumors: from promise to clinical application

2002 • 58 citations

A Proteomic Approach to the Identification of Lung Cancer Markers

2001 • 56 citations

Population of the HLA Ligand Database

2003 • 55 citations

HLA-B15 Peptide Ligands Are Preferentially Anchored at Their C Termini

1999 • 54 citations

Direct detection and quantitation of a distinct T-cell epitope derived from tumor-specific epithelial cell-associated mucin using human recombinant antibodies endowed with the antigen-specific, major histocompatibility complex-restricted specificity of T cells.

2002 • 52 citations

Using the World Wide Web for predicting CTL epitopes

2003 • 50 citations

Peptide-based cancer vaccines

2002 • 49 citations

A recombinant, soluble, single-chain class I major histocompatibility complex molecule with biological activity.

1992 • 48 citations

Contribution of mass spectrometry to contemporary immunology

1998 • 46 citations

Dendritic Cells in Cancer Immunotherapy

2001 • 45 citations

Genetic engineering of an H-2Dd/Q10b chimeric histocompatibility antigen: purification of soluble protein from transformant cell supernatants.

1986 • 45 citations

Exploitation of the B cell repertoire for the identification of human tumor antigens

2000 • 44 citations

Vaccine-induced CD8+ T-cell responses to MAGE-3 correlate with clinical outcome in patients with melanoma.

2003 • 43 citations

Global profiling of gene expression in cancer using genomics and proteomics.

2001 • 38 citations

Identification of Tumor-Associated Antigens Using Proteomics

2002 • 37 citations

Sequential Cleavage by Metallopeptidases and Proteasomes Is Involved in Processing HIV-1 ENV Epitope for Endogenous MHC Class I Antigen Presentation

2000 • 36 citations

Analysis of the association of peptides of optimal length to class I molecules on the surface of cells.

1992 • 35 citations

Molecular immunology databases and data repositories

2000 • 33 citations

Electrospray mass spectrometry for the identification of MHC class I-associated peptides expressed on cancer cells

2002 • 27 citations

Prospects for immunotherapy of malignant disease

2003 • 27 citations

Third Keystone Symposium on Cellular Immunology and the Immunotherapy of Cancer Antigen Processing and Presentation TAP-Independent Delivery of Antigenic Peptides to the Endoplasmic Reticulum

1998 • 26 citations

A post‐translational modification of nuclear proteins, N^G,N^G‐dimethyl‐Arg, found in a natural HLA class I peptide ligand

2000 • 26 citations

A phase II study of active specific immunotherapy and5-FU/Leucovorin as adjuvant therapy for stage III colon carcinoma

2002 • 26 citations

Complexity among constituents of the HLA-B*1501 peptide motif

1998 • 26 citations

Specific Proteolytic Cleavages Limit the Diversity of the Pool of Peptides Available to MHC Class I Molecules in Living Cells

1999 • 25 citations

Large-scale analysis of HLA peptides presented by HLA-Cw4

2003 • 23 citations

Immunochemical analysis of a recombinant, genetically engineered, secreted HLA-A2/Q10b fusion protein

1991 • 17 citations

Peptide Vaccination in Clinical Oncology

2000 • 16 citations

Functional Regulation of Immunoproteasomes and Transporter Associated with Antigen Processing

2001 • 16 citations

Immunotherapy against antigenic tumors: a game with a lot of players

2002 • 16 citations

Reading within the lines: naturally processed peptides displayed by MHC class I molecules

1998 • 14 citations

MHC-Binding Peptides as Immunotherapeutics for Cancer

2000 • 11 citations

Cancer immunotherapy with MAGE antigens.

2002 • 8 citations

Peptide motif of the class I molecule HLA-B*1503

1999 • 8 citations

From genomics to cancer vaccines: patient-tailored or universal vaccines?

2002 • 7 citations

Self Peptides and the Peptidic Self

2001 • 3 citations

Harnessing the cellular immune system to the gene-prediction cart

2001 • 2 citations